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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Store-operated calcium channels and pro-inflammatory signals

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Acta Pharmacologica Sinica 2006年第7期27卷 813-820页

作者： Wei-chiao chang~1 Department of Physiology,Anatomy and Genetics,University of Oxford,Oxford,UK Department of Physiology Anatomy and Genetics University of Oxford Oxford UK

In non-excitable cells such as T lymphocytes,hepatocytes,mast cells,endotheliaand epithelia,the major pathway for calcium(Ca2+)entry is through store-oper-ated Ca2+channels in the plasma *** channels are activated by theemptying of intracellular Ca2+stores,however,neither the gating mechanism northe downstream targets of these channels has been clear ***,Ireview some of the proposed gating mechanisms of store-operated Ca2+channelsand the functional implications in regulating pro-inflammatory signals.

关键词： calcium channels store-operated Ca2+ entry capacitative Ca2+entry calcium signaling mast cells

Synergistic effect of fatty liver and smoking on metabolic syndrome

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World Journal of Gastroenterology 2009年第42期15卷 5334-5339页

作者： po-Hsin Chiang Tsui-Yen chang Jong-Dar Chen Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital#95 Wen Chang RoadShih LinTaipei 111TaiwanChina School of Medicine Fu Jen Catholic University#510 Chung Cheng RoadHsinchuangTaipei 242TaiwanChina

AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its ***:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final *** liver was diagnosed using abdominal ultrasonography by trained *** modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic *** associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic ***:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P poprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P ponents,especially for hypertriglyceridemia and low serum HDL-C.

关键词： Smoking Fatty liver Synergistic effect Metabolic syndrome

Code Transform Model Producing High-Performance Program

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 253-277页

作者： Bao Rong chang Hsiu-Fen Tsai po-Wen Su Department of Computer Science and Information Engineering National University of KaohsiungKaohsiungTaiwan Department of Fragrance and Cosmetic Science Kaohsiung Medical UniversityKaohsiungTaiwan

This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance ***,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within *** proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application *** addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned *** code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative *** addition to texts,the proposed approach can also prove the other media,including images,sounds,and *** a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.

关键词： Newly generated programs GPT-2 predetermined generative programs variational Simhash algorithm piecewise longest common subsequence

Distinguish models mimicking the SM Higgs

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Frontiers of physics 2013年第3期8卷 285-293页

作者： Jung chang Kingman Cheung po-Yan Tseng Tzu-Chiang Yuan Department of Physics Tsing Hua University Hsinchu 300 Taiwan China Division of Quantum Phases and Devices School of Physics Konkuk University Seoul 143-701 Republic of Korea Institute of Physics Academia Sinica Nangang Taipei 11529 Taiwan China

The new particle around 125 GeV observed at the LHC is almost consistent with the standard model Higgs boson, except that the diphoton decay mode may be excessive. We summarize a number of possibilities. We propose to use the vector-boson fusion to test the underlying model for electroweak symmetry breaking. Using the well known dijet-tagging technique to single out the vector-boson fusion mechanism, we investigate potential of vector-boson fusion to discriminate a number of models suggested to give an enhanced inclusive diphoton production rate.

关键词： Higgs boson vector-boson fusion diphoton electroweak svmmetrv breaking

Effects of intravascular photobiomodulation on motor deficits and brain perfusion images in intractable myasthenia gravis: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8718-8727页

作者： chiao-Hsin Lan Yu-Che Wu Cheng-Chun Chiang Shin-Tsu chang School of Medicine National Defense Medical CenterTaipei 114201Taiwan Department of Medical Education and Research Kaohsiung Veterans General HospitalKaohsiung 813414Taiwan Department of Physical Medicine and Rehabilitation Kaohsiung Veterans General HospitalKaohsiung 813414Taiwan Department of Physical Medicine and Rehabilitation Tri-Service General HospitalTaipei 114202Taiwan

BACKGROUND Myasthenia gravis(MG)is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and *** herein report a case of MG that received intravascular laser irradiation of blood(ILIB)interventions and regained muscle power and better quality of *** our knowledge,no previous study has investigated the benefits of ILIB treatment on patients with *** also evaluated the changes in brain perfusion scan and the MG activities of daily living(MG-ADL)and quantitative MG(QMG)*** SUMMARY A 59-year-old man presented to our outpatient hospital experiencing ptosis,diplopia,fibromyalgia,muscle fatigue,and fluctuating weakness in his limbs for 1 *** on his history,physical examination,and laboratory investigations,the final diagnosis was a flare-up of MG with poor endurance and muscle *** patient agreed to receive *** single-photon emission computed tomography(SPECT)was performed both before and after ILIB *** receiving three courses of ILIB,the brain SPECT images showed greatly increased perfusion of the frontal lobe and anterior cingulate *** patient’s MG-ADL scale score decreased markedly from 17/24 to 3/*** QMG scale score also decreased remarkably from 32/39 to 9/*** symptoms of MG became barely detectable and the patient was able to perform his activities of daily living and regain muscle *** ILIB might have beneficial effects on MG,and brain SPECT images provided direct evidence of a positive correlation between ILIB and clinical performance.

关键词： Myasthenia gravis Intravascular laser irradiation of blood Myasthenia gravisactivities of daily living scale Quantitative myasthenia gravis scale Single-photon emission computed tomography Case report

Transient ischemic attack after mRNA-based COVID-19 vaccination during pregnancy:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9929-9935页

作者： Chi-Han chang Sheng-po Kao Dah-Ching Ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi UniversityHualien 970Taiwan

BACKGROUND Thrombocytopenia with thrombosis syndrome has been reported after vaccination against severe acute respiratory syndrome coronavirus 2 with two mRNA *** syndrome is characterized by thrombosis,especially cerebral venous sinus thrombosis,and may lead to *** women with stroke show higher rates of pregnancy loss and experience serious pregnancy *** present the case of a 24-year-old pregnant woman with a transient ischemic attack(TIA) that developed after vaccination with the Moderna mRNA-1273 vaccine(at 37 2/7 wk).CASE SUMMARY TIA occurred 13 d following the coronavirus disease *** 39 1/7 wk of pregnancy,the patient presented with sudden onset of right eye blurred vision with headache,dizziness with nausea,right-hand weakness,anomia,and *** symptoms lasted 3 h;TIA was *** test results revealed elevated D-dimer,cholesterol,and triglyceride *** magnetic resonance imaging showed no acute hemorrhagic or ischemic *** pregnancy 37 6/7 wk,she was admitted for cesarean delivery to reduce subsequent risk of stroke during *** mass index on admission was 19.8 kg/m~*** resonance angiography and transesophageal echocardiography showed no *** next day,a mature female baby weighing 2895 g and measuring 50 cm was *** scores were 8 and 9 in the first and fifth minutes.D-dimer levels decreased on postoperative day *** discharge,the autoimmune panel was within normal limits,including antinuclear and antiphospholipid *** TIA might be developed after the mRNA vaccines in pregnant women.

关键词： Pregnancy mRNA vaccine COVID-19 Stroke Transient ischemic attack Case report

Add-on perceptual learning on refractive amblyopia in children

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1850-1856页

作者： Heng-chiao Huang Wan-Hua Cho po-Chiung Fang Pei-Wen Lin Yi-Hao Chen Hsiu-Mei Huang Department of Ophthalmology Chang Gung Memorial HospitalChiayi 613TaiwanChina Department of Ophthalmology Chi-Mei Medical CenterTainan 710TaiwanChina Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung City 833TaiwanChina School of Medicine Chang Gung UniversityTaoyuan City 333TaiwanChina

AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment ***:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)*** add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard *** success was defined as best-corrected visual acuity(BCVA)≥20/*** age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were ***:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were ***-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment *** children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control *** initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM ***,sex,and types of refractive error were not associated with treatment ***:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.

关键词： amblyopia amblyopic children add-on Cambridge Visual Stimulator training astigmatism