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Bipolarized intrinsic faradaic layer on a semiconductor surface under illumination

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National Science Review 2023年第4期10卷 114-122页

作者： Mengfan Xue Zhiqiang Chu Dongjian Jiang Hongzheng Dong Pin Wang Gengzhi Sun Yingfang Yao Wenjun Luo Zhigang Zou Eco-Materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures and Department of Physics Nanjing University National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University

Interface charge transfer plays a key role in the performance of semiconductors for different kinds of solar energy utilization, such as photocatalysis, photoelectrocatalysis, photochromism and photo-induced superhydrophilicity. In previous studies, different mechanisms have been used to understand interface charge transfer processes. However, the charge transfer mechanism at the solid/liquid interface remains a controversial topic. Here, taking TiO2as a model, we find and prove, via experiments, the new characteristic of photo-induced bipolarity of the surface layer(reduction faradaic layer and oxidation faradaic layer) on a semiconductor for the first time. Different from energy level positions in the classic surface states transfer mechanism, the potential window of a surface faradaic layer is located out of the forbidden band. Moreover,we find that the reduction faradaic layer and oxidation faradaic layer serve as electron and hole transfer mediators in photocatalysis, while the bipolarity or mono-polarity of the surface layer on a semiconductor depends on the applied potential in photoelectrocatalysis. The new characteristic of bipolarity can also offer new insights into the charge transfer process at the semiconductor/liquid interface for solar energy utilization.

关键词： semiconductor surface interface charge transfer reduction faradaic layer oxidation faradaic layer faradaic layer descriptor

A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： pin Zhang Lin wang Yueying Zhen Zhihong wang Hesheng Zhang Richard Jones Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer patients.Methods: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg QD and 300 mg BID. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day cycles.Pharmacokinetic samples were obtained on d 1 and d 28. Clinical responses were assessed every eight weeks.Results: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(DCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 months.Conclusions: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial

A new evaluation model of comprehensive radio frequency stealth performance of radar

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第3期7卷 367-385页

作者： Yang Zhao Chaoxuan Shang Zhuangzhi Han Pin Wang Department of Electronic and Optical Engineering Mechanical Engineering College Shijiazhuang Hebei 050003 P.R.China Mechanical Technology College Wuhan Hubei 430075P.R.China

The detection capabilities of passive electronic warfare reconnaissance equipment have substantially increased during recent years.Correspondingly,the radar equipment is required to take various means to improve the radio frequency(RF)stealth performance to ensure the transmitted RF signal does not get intercepted.However,traditional evaluation methods on RF stealth performance cannot accurately evaluate the RF stealth capabilities of new system radar.In this study,a joint interception probability evaluation model on RF stealth performance was established,which divided the interception process into two parts:front interception and system interception.Various RF stealth means adopted by different radar equipment were taken into consideration to improve the applicability of this model.Simulation results show that this model is able to effectively characterize almost all the aspects of the RF stealth features and can serve as a good reference to evaluate RF radar stealth performance comprehensively.

关键词： Radio frequency stealth joint intercept probability front interception system interception measurement of recognition rate

Prediction of electric-powered fixed-wing UAV endurance

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航空动力学报 2017年第9期32卷 2170-2179页

作者： CHENG Feng wang Hua CUI pin School of Astronautics Beijing University of Aeronautics and Astronautics Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle Technology

To overcome the problems encountered in predicting the endurance of electricpowered fixed-wing unmanned aerial vehicles(UAVs),which were stemmed from the dynamic changes in electric power system efficiency and battery discharge characteristics under different operating conditions,the required battery power model and battery discharge model were studied.The required battery power model was determined using an approximate model of electric power system efficiency based on wind tunnel testing and the self-adaptive penalty function.Furthermore,current correction and ambient temperature correction terms were proposed for the trained Kriging model representing the discharge characteristics under standard operation,and then the discharged capacity-terminal voltage model was established.Through numerical integration of this model with the required battery power model,the electric-powered fixed-wing UAV endurance prediction model was obtained.Laboratory tests indicated that the proposed endurance model could precisely calculate the battery discharge time and accurately describe the battery discharge process.The similarity of the theoretical and flight test results reflected the accuracy of the proposed endurance model as well as the importance of considering dynamic changes in power system efficiency in endurance calculations.The proposed endurance model meeting precision requirements can be used in practical engineering applications.

关键词： fixed-wing unmanned aerial vehicle(UAV) endurance Peukert equation self-adaptive penalty function power system efficiency

Exogenous nerve growth factor protects the hypoglossal nerve against crush injury

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Neural Regeneration Research 2015年第12期10卷 1982-1988页

作者： Li-yuan Fan Zhong-chao wang Pin Wang Yu-yan Lan Ling Tu Department of Prosthodontics Stomatological Hospital of Sichuan Medical University Orofacial Reconstruction and Regeneration Laboratory Sichuan Medical University Department of Endodontics Stomatological Hospital of Sichuan Medical University Department of Anatomy and Physiology College of StomatologyCentral South University

Studies have shown that sensory nerve damage can activate the p38 mitogen-activated protein kinase（MAPK）pathway,but whether the same type of nerve injury after exercise activates the p38MAPK pathway remains unclear.Several studies have demonstrated that nerve growth factor may play a role in the repair process after peripheral nerve injury,but there has been little research focusing on the hypoglossal nerve injury and repair.In this study,we designed and established rat models of hypoglossal nerve crush injury and gave intraperitoneal injections of exogenous nerve growth factor to rats for 14 days.p38MAPK activity in the damaged neurons was increased following hypoglossal nerve crush injury;exogenous nerve growth factor inhibited this increase in acitivity and increased the survival rate of motor neurons within the hypoglossal nucleus.Under transmission electron microscopy,we found that the injection of nerve growth factor contributed to the restoration of the morphology of hypoglossal nerve after crush injury.Our experimental findings indicate that exogenous nerve growth factor can protect damaged neurons and promote hypoglossal nerve regeneration following hypoglossal nerve crush injury.

关键词： nerve regeneration p38MAPK mitogen-activated protein kinase nerve growth factor hypoglossal nerve crush injury nerve injury neural regeneration

Theoretical and numerical simulation investigation of deep hole dispersed charge cut blasting

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International Journal of Coal Science & Technology 2023年第1期10卷 87-107页

作者： Chengxiao Li Renshu Yang Yanbing wang Yiqiang Kang Yuantong Zhang pin Xie School of Mechanics and Civil Engineering ChinaUniversity of Mining and Technology-BeijingBeijing 100083China School of Civil and Resource Engineering Universityof Science and Technology BeijingBeijing 100083China Gubei Coal Mine of Huaizhe Coal and Electricity Co. LtdHuainan 232150China

Drilling and blasting methods have been used as a common driving technique for shallow-hole driving and blasting in rock roadways.With the advent of digital electronic detonators and the need for increased production efciency,the traditional blasting design is no longer suitable for deep hole blasting.In this paper,a disperse charge cut blasting method was proposed to address the issues of low excavation depth and high block rate in deep hole undercut blasting.First,a blasting model was used to illustrate the mechanism of the deep hole dispersive charge cut blasting process.Then,continuous charge and dispersed charge blasting models were developed using the smooth particle hydrodynamics-fnite element method(SPHFEM).The cutting parameters were determined theoretically,and the cutting efciency was introduced to evaluate the cutting efect.The blasting efects of the two charging models were analyzed utilizing the evolution law of rock damage,the number of rock particles thrown,and the cutting efciency.The results show that using a dispersed charge improves the cutting efciency by about 20%and the rock breakage for the deep hole cut blasting compared to the traditional continuous charge.In addition,important parameters such as cutting hole spacing,cutting hole depth and upper charge proportion also have a signifcant impact on the cutting efect.Finally,the deep hole dispersed charge cut blasting technology is combined with the digital electronic detonator through the feld engineering practice.It provides a reference for the subsequent deep hole cutting blasting and the use of electronic detonators in rock roadways.

关键词： Deep hole blasting Cut blasting Dispersed charge SPH-FEM Digital electronic detonator

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系统功能语法的隐性语法本质

外语学刊 2024年第3期 19-25页

作者：王品上海交通大学外国语学院上海200240

系统功能语法关注语言中的显性类型,同时更加注重在隐性类型方面探赜钩深。隐性类型指不依靠外在形态体现的潜在语法特征,这一概念最早由美国语言学家Whorf提出。系统功能语法的创始人Halliday将Whorf的这一创见称颂为20世纪语言学的主... 详细信息

系统功能语法关注语言中的显性类型,同时更加注重在隐性类型方面探赜钩深。隐性类型指不依靠外在形态体现的潜在语法特征,这一概念最早由美国语言学家Whorf提出。系统功能语法的创始人Halliday将Whorf的这一创见称颂为20世纪语言学的主要贡献之一,其开创的系统功能语法也在多方面借鉴隐性类型的思想,英语小句语法的诸多方面本质上都是隐性语法。本文回顾隐性类型的提出,阐释系统功能语法的隐性语法本质,介绍系统功能语法作为隐性语法的描写方式,并探讨隐性语法对汉语系统功能语法研究的借鉴意义。

关键词：系统功能语法隐性类型隐性语法

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

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Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming Zou Zhongling wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer.Herein,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose.This polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering.Moreover,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy.Furthermore,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4.We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser dose.Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

Rotorcraft flight endurance estimation based on a new battery discharge model

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Chinese Journal of Aeronautics 2017年第4期30卷 1561-1569页

作者： Feng CHENG Hua wang pin CUI School of Astronautics Beihang University Beijing 100083 China Science and Technology on Space Physics Laboratory Beijing 100076 China

To avoid the numerical complexities of the battery discharge law of electric-powered rotorcrafts,this study uses the Kriging method to model the discharge characteristics of Li-Po batteries under standard conditions.A linear current compensation term and an ambient temperature compensation term based on radial basis functions are then applied to the trained Kriging model,leading to the complete discharged capacity-terminal voltage model.Using an orthogonal experimental design and a sequential method,the coefficients of the current and ambient temperature compensation terms are determined through robust optimization.An endurance calculation model for electric-powered rotorcrafts is then established,based on the battery discharge model,through numerical integration.Laboratory tests show that the maximum relative error of the proposed discharged capacity-terminal voltage model at detection points is 0.0086,and that of the rotorcraft endurance calculation model is 0.0195,thus verifying their accuracy.A flight test further demonstrates the applicability of the proposed endurance model to general electric-powered rotorcrafts.

关键词： Kriging model Orthogonal experimental design Robust optimization Rotorcraft endurance Sequential method