Exogenous nerve growth factor protects the hypoglossal nerve against crush injury

作     者：Li-yuan Fan Zhong-chao Wang Pin Wang Yu-yan Lan Ling Tu 

作者机构：Department of ProsthodonticsStomatological Hospital of Sichuan Medical University Orofacial Reconstruction and Regeneration LaboratorySichuan Medical University Department of EndodonticsStomatological Hospital of Sichuan Medical University Department of Anatomy and PhysiologyCollege of StomatologyCentral South University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第12期

页      面：1982-1988页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：nerve regeneration p38MAPK mitogen-activated protein kinase nerve growth factor hypoglossal nerve crush injury nerve injury neural regeneration 

摘      要：Studies have shown that sensory nerve damage can activate the p38 mitogen-activated protein kinase（MAPK）pathway,but whether the same type of nerve injury after exercise activates the p38MAPK pathway remains unclear.Several studies have demonstrated that nerve growth factor may play a role in the repair process after peripheral nerve injury,but there has been little research focusing on the hypoglossal nerve injury and repair.In this study,we designed and established rat models of hypoglossal nerve crush injury and gave intraperitoneal injections of exogenous nerve growth factor to rats for 14 days.p38MAPK activity in the damaged neurons was increased following hypoglossal nerve crush injury;exogenous nerve growth factor inhibited this increase in acitivity and increased the survival rate of motor neurons within the hypoglossal nucleus.Under transmission electron microscopy,we found that the injection of nerve growth factor contributed to the restoration of the morphology of hypoglossal nerve after crush injury.Our experimental findings indicate that exogenous nerve growth factor can protect damaged neurons and promote hypoglossal nerve regeneration following hypoglossal nerve crush injury.