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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su pin-Yu Lai Pei-Hsuan Hu Je-Ming Hu pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin Chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-Ching Lin Yu-Ching chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

教育情怀:基于“需要—满足”框架的阐释与生成

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教育理论与实践 2021年第19期41卷 16-20页

作者：陈太忠皮武淮阴师范学院教育科学学院淮阴师范学院高等教育研究中心江苏淮安223300

教育情怀是教师对教育持久而稳定的关切和喜爱之情,表现为乐于从教的态度以及享受教育生活的独特能力。教育情怀的本质是"需要—满足"的心理结构,包含压力体验、行动倾向和享用状态,并伴随着教师的职业成熟过程而不断深化。教育情怀具... 详细信息

教育情怀是教师对教育持久而稳定的关切和喜爱之情,表现为乐于从教的态度以及享受教育生活的独特能力。教育情怀的本质是"需要—满足"的心理结构,包含压力体验、行动倾向和享用状态,并伴随着教师的职业成熟过程而不断深化。教育情怀具有超越性功能、统整性功能、成全性功能。教师对教育功能的充分认知、对国家富强和民族进步的强烈责任感、对教育生活的审美建构,以及对学生和自身的深切关爱,都有助于促进教育情怀的生成。

关键词：教育情怀教师 “需要—满足”心理结构压力体验行动倾向享用状态教育功能责任感审美建构关爱学生

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课程决策:大学“金课”建设的关键环节

黑龙江高教研究 2021年第4期39卷 153-156页

作者：陈太忠皮武淮阴师范学院江苏淮安223300

大学课程成为"金课"或是"水课",不仅取决于课程实施即"教"的过程,还与课程决策环节密切相关。目前在大学课程决策过程中,存在决策主体主要由行政权力决定、决策过程深受非理性因素的冲击、决策空间构建随意化、决策评价被忽视等问题。... 详细信息

大学课程成为"金课"或是"水课",不仅取决于课程实施即"教"的过程,还与课程决策环节密切相关。目前在大学课程决策过程中,存在决策主体主要由行政权力决定、决策过程深受非理性因素的冲击、决策空间构建随意化、决策评价被忽视等问题。提高课程决策质量是建设大学"金课"的基础,为此,必须优化大学内部的权力配置,完善课程决策的制度体系,发挥决策评价的保障作用。

关键词：课程决策 “金课” “水课”

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流媒体代理缓存技术研究

计算机科学 2006年第1期33卷 18-21,44页

作者：余江刘威王泰 chou Chun-Tung 华中科技大学电子与信息工程系武汉430074 新南威尔士州大学计算机科学和工程学院

随着流媒体技术在互联网上的广泛应用,原有用于加速 Web 内容分发的代理缓存技术也被应用于流媒体内容分发领域。然而,由于流媒体对象的一些独特特点,需要在传统 Web 缓存技术的基础上提出适用于流媒体对象的缓存技术。本文分析了基于... 详细信息

随着流媒体技术在互联网上的广泛应用,原有用于加速 Web 内容分发的代理缓存技术也被应用于流媒体内容分发领域。然而,由于流媒体对象的一些独特特点,需要在传统 Web 缓存技术的基础上提出适用于流媒体对象的缓存技术。本文分析了基于代理缓存的流媒体分发中的关键问题和技术挑战,对现有的各种流媒体缓存方案进行了综述、分类和比较,最后对流媒体代理缓存的未来发展方向进行了展望。

关键词：流媒体代理缓存 Web内容分发 Web缓存技术流媒体技术内容分发应用互联

MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in taiwan

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World Journal of Gastroenterology 2021年第34期27卷 5737-5752页

作者： Chia-Cheng Lee Yu-Cheng Kuo Je-Ming Hu pi-Kai Chang Chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-Huang Lin Chih-Hsiung Hsu Yu-Ching chou Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Medical Informatics Office Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Health Business Administration Meiho UniversityPingtung 91202TaiwanChina Department and Graduate Institute of Microbiology and Immunology National Defense Medical CenterTaipei 114TaiwanChina Institute of Preventive Medicine National Defense Medical CenterNew Taipei City 237TaiwanChina

BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy *** plays a major role in managing the circadian rhythm and exerts oncostatic effects on different kinds of *** To explore the relationship between MTNR1B single-nucleotide polymorphism(SNPs)combined with gene hypermethylation and CRC *** A total of 94 CRC tumour tissues were *** for the four MTNR1B SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)was performed using multiplex polymerase chain *** relationships between the MTNR1B SNPs and CRC 5-year overall survival(OS)was assessed by calculating hazard ratios with 95%*** All SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)were correlated with decreased 5-year *** stratified analysis,rs1387153,rs10830963,and rs1447352 risk genotype combined with CDKN2A and MGMT methylation status were associated with 5-year OS.A strong cumulative effect of the four polymorphisms on CRC prognosis was *** haplotypes of MTNR1B SNPs were also associated with the 5-year ***1B SNPs combined with CDKN2A and MGMT gene methylation status could be used to predict shorter CRC *** The novel genetic biomarkers combined with epigenetic biomarkers may be predictive tool for CRC prognosis and thus could be used to individualise treatment for patients with CRC.

关键词： Colorectal cancer Melatonin Hypermethylation Polymorphism Prognosis Biomarker

Impact of intracellular innate immune receptors on immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 337-351页

作者： Wei-Chun chou Elena Rampanelli Xin Li Jenny P-Y.Ting Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC27599USA Amsterdam UMC(University Medical Center location AMC)Department of Experimental Vascular MedicineAGEM(Amsterdam Gastroenterology Endocrinology Metabolism)InstituteMeibergdreef 91105 AZAmsterdamThe Netherlands Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing100193China

Immunometabolism,which is the metabolic reprogramming of anaerobic glycolysis,oxidative phosphorylation,and metabolite synthesis upon immune cell activation,has gained importance as a regulator of the homeostasis,activation,proliferation,and differentiation of innate and adaptive immune cell subsets that function as key factors in *** changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection,inflammation,cancer,autoimmune diseases,and metabolic *** crosstalk between the pi3K-AKT-mTOR and LKB1-AMPK signaling pathways is critical for modulating both immune and nonimmune cell *** bidirectional interaction between immune cells and metabolism is a topic of intense ***-like receptors(TLRs),cytokine receptors,and T and B cell receptors have been shown to activate multiple downstream metabolic ***,how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well *** goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors,such as nucleotide-binding and leucine-rich repeat-containing receptors(NLRs,or NOD-like receptors),absent in melanoma 2(AIM2)-like receptors(ALRs),and the cyclic dinucleotide receptor stimulator of interferon genes(STING).We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic *** appropriate,this review will provide a brief contextual connection to pathogenic infections,autoimmune diseases,cancers,metabolic disorders,and/or inflammatory bowel diseases.

关键词： Immunometabolism NLRs NLRP3/AIM2 inflammasomes innate sensors/receptors STING AKT-mTOR

Syntheses of Fe-Ni Magnetic Nanoparticles and Their Applications on Biologic Labeling

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Syntheses of Fe-Ni Magnetic Nanoparticles and Their Applicat...

IGF1-pi3K-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

中国颗粒学会2006年年会暨海峡两岸颗粒技术研讨会

作者： Ming-Fong tai Jong-Kai Hsiao Yi-Fong chou Kuo-Chih Wang Bor-Zin La Shin-tai Chen Department of Optoelectronic System Engineering Minghsin University of Science and Technology HsinchuChina Department of Medical Imaging taiwan University Hospital and College of Medicine TaipeiChina Department of Electronic Engineering WeFeng Institute of Technology ChiayiChina Department of Electric Engineering WeFeng Institute of Technology ChiayiChina Musculoskeletal Disease Center J.L.Pettis VA Medical Center Loma Linda CA 92357USA Department of Biochemistry Loma Linda University Loma Linda CA 92357 USA

In this study, we compared FeNi alloy magnetic nanoparticles (MNPs) prepared by either combustion or chemical precipitation methods. We found that the FeNi MNPs generated by combustion method have a rather high saturation magnetization Ms of -180 emu/g and a coercivity field Hc of near zero. However, the alloy nanoparticles are easily aggregated and are not well dispersive such that size distribution of the nanoparticle clusters are wide and clusters are rather big (around 5000 nm). To prepare a better quality and well dispersed Fe-Ni MNPs, we also developed a thermal reflux chemical precipitation method to synthesize FeNi3 alloy MNPs. The precursor chemicals of Fe(acac)3 and Ni(acac)2 in a molecular ratio of 1:3 reacted in octyl ether solvent at the boiling point of solvent (00 ℃) by the thermal reflux process. The 1,2-hexadecandiol and tri-n-octylphosphine oxide (TOPO) were used as reducer and surfactant, respectively. The chemically precipitated FeNi3 MNPs are well dispersed and have well-controlled particle sizes around 10-20 nm with a very narrow size distribution (±1.2 nm). The highly monodispersive FeNi3 NPs present good uniformity in particle shape and crystallinity on particle surfaces. The MNPs exhibit well soft magnetism with saturation magnetization of -61 emu/g and Hc. The biomedical compatible FeNi MNPs which were coated with biocompatible polyethyleneimine (PEI) polymer were also synthesized. We demonstrated that the PEI coated FeNi MNPs can enter the mammalian cells in vitro and can be used as a magnetic resonance imagine (MRI) contrast agent. The results demonstrated that FeNi MNPs potentially could be applied in the biomedical field. The functionalized magnetic beads with biocompatible polymer coated on MNPs are also completed for biomedical applications.

关键词： magnetic nanoparticles Fe-Ni alloy chemical precipitation method biologic labeling

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer Celeste M.K.tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(pi3K)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1pi3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize pi3K-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced pi3K ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac pi3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 pi3K Therapies

Nursing care in old patients with heart failure： current status and future perspectives

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Journal of Geriatric Cardiology 2016年第5期13卷 387-390页

作者： Hong-Ying pi Xin HU Nursing Department Chinese PLA General Hospital Beijing China Vasculocardiology Department Chinese PLA General Hospital Beijing China

The prognosis of heart failure （HF） patients has significantly improved in the last 20 years, given the advent of therapies such as angiotensin-converting enzyme （ACE） inhibitors/angiotensin receptor blockers （ARBs）, beta-block- ers, and implantable cardioverter-defibrillator （ICD）/cardiac resynchronization therapy devices （CRT）. In addition to these promising therapies, proper nursing-care is also important. Here we summarize recent progress of nursing-care strategies in older HF patients, including routine nursing care, transitional care model, self-care, and role of exercise training in old patients with HF.

关键词： Heart failure Nursing care tai Chi The elderly