Impact of intracellular innate immune receptors on immunometabolism

作     者：Wei-Chun Chou Elena Rampanelli Xin Li Jenny P-Y.Ting 

作者机构：Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillNC27599USA Department of GeneticsUniversity of North Carolina at Chapel HillChapel HillNC27599USA Amsterdam UMC(University Medical Centerlocation AMC)Department of Experimental Vascular MedicineAGEM(Amsterdam Gastroenterology Endocrinology Metabolism)InstituteMeibergdreef 91105 AZAmsterdamThe Netherlands Comparative Immunology Research CenterCollege of Veterinary MedicineChina Agricultural UniversityBeijing100193China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第3期

页      面：337-351页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：The following funding supports are acknowledged:NIH(R35 CA232109 PO1 DK094779 U19 AI067798 R01 AI141333 and R01 AI029564) 

主　　题：Immunometabolism NLRs NLRP3/AIM2 inflammasomes innate sensors/receptors STING AKT-mTOR 

摘      要：Immunometabolism,which is the metabolic reprogramming of anaerobic glycolysis,oxidative phosphorylation,and metabolite synthesis upon immune cell activation,has gained importance as a regulator of the homeostasis,activation,proliferation,and differentiation of innate and adaptive immune cell subsets that function as key factors in *** changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection,inflammation,cancer,autoimmune diseases,and metabolic *** crosstalk between the PI3K-AKT-mTOR and LKB1-AMPK signaling pathways is critical for modulating both immune and nonimmune cell *** bidirectional interaction between immune cells and metabolism is a topic of intense ***-like receptors(TLRs),cytokine receptors,and T and B cell receptors have been shown to activate multiple downstream metabolic ***,how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well *** goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors,such as nucleotide-binding and leucine-rich repeat-containing receptors(NLRs,or NOD-like receptors),absent in melanoma 2(AIM2)-like receptors(ALRs),and the cyclic dinucleotide receptor stimulator of interferon genes(STING).We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic *** appropriate,this review will provide a brief contextual connection to pathogenic infections,autoimmune diseases,cancers,metabolic disorders,and/or inflammatory bowel diseases.