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The Giant Radio Array for Neutrino Detection(GRAND):Science and design

Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 1-43页

作者： Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Fisica de Particulas&lnstituto Galego de Fisica de Altas enerxias Universidad de Santiago de CompostelaSantiago de Compostela 15782Spain Instituto de Astronomia Geofisica e Ciencias AtmosfericasUniversidade de Sao PauloSao Paulo-SP 05508-090Brazil Department of Physics-Astrophysics University of OxfordDWBOxford 0X13RHUK Institute of experimental Particle Physics(eTP) Karlsruhe Institute of Technology(KIT)Karlsru he D-76021Germany Laboratoire de Physique Nucleeaire et de Hautes energies(LPNHe) Sorbonne UniversiteUniversite Paris DiderotSorbonne Paris CiteCNRS place Jussieu F-75252Paris Cedex 5France Niels Bohr International Academy and DARK Niels Bohr InstituteCopenhagen 2100Denmark Discovery Center Niels Bohr InstituteCopenhagen 2100Denmark Center for Cosmology and AstroParticle Physics(CCA.PP)&Department of Physics Ohio State UniversityColumbus OH 43210USA Universidade de Santiago de Compostela Santiago de Compostela 15782Spain 0SUBATeCH Institut Mines-Telecom Atlantique-CNRS/IN2P3-Universite de NantesNantes 44300France Laboratoire de Physique et Chimie de Kenvironnement et de Vespace LPC2e CNRS-Universite d'Orleans Orleans F-45071France Station de Radioastronomie de Nancay Observatoire de ParisCNRS/INSU F-18330 NangayFrance Sorbonne Universite UMR 7095Institut d'Astrophysique de Paris98 bis bd AragoParis 75014France Institute for Mathematics Astrophysics and Particle Physics(IMAPP)Radboud UniversiteitNijmegen 6500Netherlands Nationaal Instituut voor Kemfysica en Hoge energie Fysica(NIKHeF) Amsterdam NL-1009Netherlands IIHe/eLeM Vrije Universiteit BrusselPleinlaan 2Brussels 1050Belgium Institute for Nuclear Physics(IKP) Karlsruhe Institute of Technology(KIT)Karlsruhe D-76021Germany einstein Fellow Stanford UniversityStanford CA 94305USA Department of Astronomy University of MarylandCollege Park MD 20742-2421USA Joint Space-Science Institute College Park MD 20742-2421USA Oskar Klein Centre Stockholm UniversityStockholm SE-10691Sweden Department of Phy

The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHe)cosmic particles,with energies exceeding 10~8 Ge *** goal is to solve the long-standing mystery of the origin of UHe cosmic *** do this,GRAND will detect an unprecedented number of UHe cosmic rays and search for the undiscovered UHe neutrinos and gamma rays associated to them with unmatched *** will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHe particles in the *** design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals *** we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation:sources galactic and extragalactic cosmic rays:galactic and extragalactic

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QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVeNIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC Biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern european *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

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A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif philippe Berthelot Carole Pélissier Guillaume Thiery elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

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超声多普勒测定左心室舒张充盈在估价扩张型心肌病患者预后中的意义

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中国循环杂志 1993年第6期8卷 324-325页

作者：沈卫峰冯媛媛王国叨龚兰生 Christophe Tribouilloy Jean-philippe Lesbre 上海第二医科大学附属瑞金医院心脏科法国Amiens大学医院心脏科

对62例扩张型心肌病患者进行超声多普勒检查发现,37例临床心功能≥Ⅲ级患者较之25例心功能≤Ⅱ级患者,左心室舒张早期亢盈速率(e)增高,舒张晚期充盈速率(A)减低,e/A比值增高,以及舒张早期减速时间(DT)缩短。前者死亡率显著增高。对31例... 详细信息

对62例扩张型心肌病患者进行超声多普勒检查发现,37例临床心功能≥Ⅲ级患者较之25例心功能≤Ⅱ级患者,左心室舒张早期亢盈速率(e)增高,舒张晚期充盈速率(A)减低,e/A比值增高,以及舒张早期减速时间(DT)缩短。前者死亡率显著增高。对31例存活者于38.6±6.5月治疗后重复超声多普勒检查,18例临床心功能改善者,其e减低,A增高,e/A比值减低,DT延长。而另13例临床心功能不变或恶化患者,其测值无显著改变。因此,用脉冲多普勒测定左心室舒张充盈情况,这在估价扩张型心肌病患者预后及观察疗效中,具有重要的临床价值。

关键词：心肌病心室功能左超声波诊断

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effect of Soil Fertility and Planting Density on the Partitioning of the Above-Ground Biomass of eucalyptus in a Plantation (Pointe-Noire, Republic of Congo)

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Open Journal of ecology 2024年第10期14卷 814-830页

作者： Hugues-Yvan Gomat Chrissy Garel Makouanzi-ekomono Suspense Averti Ifo Nzaba Miyouna Dulvin Ulrich Mayinguindi Ruben Pambou Florian Mézerette philippe Santenoise Saint-Andre Laurent ecole Normale Suprieure Brazzaville Rpublique du Congo Centre de Recherche sur la Durabilit et Productivit des Plantations Industrielles Pointe-Noire Rpublique du Congo IRF Brazzaville Rpublique du Congo ecole Nationale dAgronomie et de Foresterie Brazzaville Rpublique du Congo Unit Biogochimie des ecosystmes Forestiers Centre INRAE Grand-Est Nancy France

Afforestation and reforestation are useful approaches to improve carbon sequestration. With the advent of forest plantations, growing environment conditions have become increasingly restrictive for light, soil nutrients, and interactions between trees to acquire available resources. Tree biomass data are essential for understanding the forest carbon cycle and plant adaptations to the environment. The distribution of tree biomass depends on the sum of multiple stand conditions. The data are from a dedicated experiment with two very contrasting areas of fertility, and two planting densities, including a high density at planting in order to achieve thinning. The plant material consists of the high-performance clones of eucalyptus urophylla × e. grandis and the reference clone e. PF1. We hypothesize that the distribution of biomass changes as the intensity of competition changes and that this is accelerated by the fertility of the sites in time. The results indicate that fertilization, planting density and clones have an impact on biomass partitioning.

关键词： Biomass Carbon Plantation eucalyptus Competition effect Soil Fertility

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“东西方的艺术家们,团结起来!”--安德烈•克罗多在中国的艺术计划(1926-1930)

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美术研究 2021年第3期 71-77页

作者： [法]菲利普·杰奎琳徐佩旎(译) 法国高等院校考古学与艺术史教授协会中国人民大学徐悲鸿艺术研究院上海外国语大学法语系上海市对外文化交流协会不详

英国历史学家迈克尔•苏立文对安德烈•克罗多(Andr e Claudot,1892-1982)的评述寥寥几笔,亦不甚佳:“他至多是一名小众艺术家,而他予林风眠(1900-1991)对中国画重新探寻的影响程度也很难回答。”[1]此时,他提及了另一名画家,捷克人沃伊捷... 详细信息

英国历史学家迈克尔•苏立文对安德烈•克罗多(Andr e Claudot,1892-1982)的评述寥寥几笔,亦不甚佳:“他至多是一名小众艺术家,而他予林风眠(1900-1991)对中国画重新探寻的影响程度也很难回答。”[1]此时,他提及了另一名画家,捷克人沃伊捷赫•齐蒂尔(Vojtech Chytil,1896-1936),将其偶然抬到了与克罗多同等的位置,甚至更高,似乎是为了消弥对这位法国先生的第一印象。但他至少举了一幅克罗多于1927年在北京创作的墨水画,[2]-名挑担者,但仅此而已。苏立文笔下的克罗多一章极其简短。

关键词：林风眠苏立文安德烈第一印象英国历史学家克罗中国画东西方

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Major clades in tropical Agaricus

Major clades in tropical Agaricus

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中国菌物学会第五届会员代表大会暨2011年学术年会

作者： Samantha KARUNARATHNA Olivier.RASP Luis A.PARRA Jacque GUINBeRTeAU Magalie MOINARD Andre De KeSeL Grard.BARROSO Rgis COURTeCUISSe Kevin D.HYDe Atsu K.GUeLLY Dennis e.DeSJARDIN philippe CALLAC School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 11442Saudi Arabia

＜正＞Agaricus（Basidiomycota） is a genus of saprobic fungi that includes edible cultivated species such as Agaricus bisporus,the button *** has been considerable ecological,nutritional and medicinal interest in the genus,yet its biodiversity remains poorly known,particularly in subtropical and tropical areas. Classification of the tropical taxa has for a large part followed the classification of temperate *** objective of our study was to examine to what extent this system of classification is appropriate for tropical Agaricus *** from temperate sections were therefore compared to the major clades of tropical taxa using a phylogenetic *** 1+2 sequence data from 128 taxa were used in the phylogenetic analysis. Specimens included four species of genera closely related to Agaricus,37 temperate species representing the eight classical sections of the genus,and 87 putative species of Agaricus from tropical areas of Africa,Asia and *** and maximum likelihood analyses produced relatively congruent trees and almost identical *** data showed that（i） only about one-third of tropical taxa belong to the classical sections;the systematics of the genus therefore needs to be reconsidered;（ii） basal clades and branches contain only African and Asian tropical taxa suggesting that the genus originated from these areas;（iii） among the remaining two-thirds of tropical taxa,those from America and those from Africa and/or Asia grouped in distinct clades,suggesting that secondary diversification occurred in these two areas and that direct migration between these areas has never or rarely occurred;（iv） in contrast,several clades of classical sections contain American and African+Asian species along with temperate *** two conclusions added to the fact that the distribution range of some temperate species extends to both europe and North America,suggest that the genus would have migrated from tropical Africa +Asia to tropical

关键词： Agaricus tropical biodiversity biogeography ITS phylogeny

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extraspinal Incidental Findings at Lumbar Spine Magnetic Resonance Imaging in Two Hospitals:Prevalence and Clinical Importance

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Open Journal of Radiology 2017年第4期7卷 241-248页

作者： Odile Fernande Zeh emilienne Guegang Goujou Armel philippe Awana Julienne Onguene Medza Joshua Tambe Claude Sandra Raissa Abomo Ngodo Maxwell Goudjou Sandjong Joseph Gonsu Fotsin Faculty of Medicine and Biomedical Sciences University of Yaounde IYaoundeCameroon Yaounde Gynaecology Obstetrics and Pediatrics Hospital YaoundeCameroon Jordan Medical Center YaoundeCameroon Yaounde General Hospital YaoundeCameroon Yaounde Jamot Hospital YaoundeCameroon Jacques Monod Hospital Le Havre MontivilliersFrance

Objective: To assess the importance of incidental extraspinal findings on Magnetic Resonance Imaging of the lumbar spine in two hospital facilities. Materials and Methods: It was a descriptive and retrospective study from November 2015 to March 2016. The records of patients who had done a Magnetic Resonance Imaging (MRI) scan of the lumbar spine were re-read in search of incidental findings. The incidental findings found were classified using Colonography Reporting and Data System(C-RADS) classification of extracolonic lesions to assess clinical significance. The prevalence of incidental findings was calculated for each facility, as well as the distribution according to age, the organs involved and the clinical importance. A non-detection rate was calculated by confronting the findings of the study with the original reports. Results: The prevalence of incidental findings was respectively 33% (19 out of 36) in Jordan Medical Center (JMC) in Yaounde and 27.74% (106 out of 292) in Jacques Monod Hospital. The extraspinal incidental findings were classified mainly as extracolonic 2 (e2): 58% in each facility. The percentage detection of incidental findings was 5% at JMS and 1.7% at Jacques Monod Hospital. Conclusion: extraspinal incidental findings are frequent in both hospitals. However, the rate of detection remains very low.

关键词： Incidental Findings Magnetic Resonance Imaging Lumbar Spine extraspinal Lesions

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Simultaneous Determination by HPLC-UV Vis of Tartrazine and Sunset Yellow in Soft Drinks Sold in Benin

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American Journal of Analytical Chemistry 2022年第8期13卷 277-288页

作者： Janvier engelbert Agbokponto André philippe S. Kpaibe Loconon Achille Yemoa Assogba Gabin Assanhou Habib Ganfon Gildas Komenan Gbassi Michèle Aké N’cho Christoph Amin Laboratoire de Chimie Analytique et d’Analyse des Médicaments UFR Pharmacie Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin UFR Pharmacie Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Département de Chimie Analytique Bromatologie Chimie Générale et Minérale UFR des Sciences Pharmaceutiques et Biologiques Université Félix Houphou&euml t-Boigny Abidjan C&ocirc te d’Ivoire

The use of dyes such as tartrazine (e102) and sunset yellow (e102) in food, beverages and health products for technological and commercial purposes is common. The adverse effects caused by these dyes, such as allergies and hyperactivity disorder have been reported, especially in children. In the present study, a chromatographic method was developed and validated for simultaneous determination of tartrazine and sunset yellow. The chromatographic separation was performed on a Lichrocart® C18 column (125 × 4.6 mm;5 μm) with a security Guard-C18 column (4 × 2.0 mm, 5 μm;Phenomenex, Torrance, CA, USA) maintained at 30°C. The mobile phase consisted of a mixture of acetonitrile/ammonium acetate buffer pH 6.8 in gradient mode with a flow rate of 1 mL/min. The injection volume was 10 μL. The detection wavelength was set at 455 nm. The parameters of specificity, linearity, precision, repeatability, accuracy and sensitivity were examined for validation. The developed method is linear in the range of 1 μg/mL to 100 μg/mL with a R2> 0.998. The intra-day and inter-day precisions (RSD) were less than 0.6% and 3.1% respectively. The detection limit was 0.03 μg/mL and the quantification limit was 0.1 μg/mL. The retention time of tartrazine was 2.86 min, while sunset yellow was detected at 5.67 min. A simple, rapid, accurate and robust HPLC/UV-Visible method was developed and validated for simultaneous identification and quantification of tartrazine and sunset yellow. This developed method was successfully applied for the simultaneous determination of tartrazine and sunset yellow in soft drinks sold in Benin.

关键词： Tartrazine Sunset Yellow HPLC-UV Food Dyes

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配有BGO晶体阵列的L3强子量能器性能的模拟测试

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高能物理与核物理 1991年第10期15卷 865-874页

作者：吴义根陈国明陈和生张守宇唐孝威童国梁 M.Bocciolini C.Civinini R.D'alessandro M.Meschini M.Pieri P.Spillantini 王贻芳 H.Hofer P.LeCoultre B.spiess J.Ulbricht 中国科学院高能物理研究所北京100039 意大利佛罗伦萨大学物理系瑞士苏黎世高等工业大学

本文介绍了配有BGO(锗酸铋)晶体阵列的L3铀强子量能器性能的模拟测试。对L3强子量能器以及测试实验作了简要介绍,并给出了该量能器对4—20GeV能量范围的π介子的能量分辨率、e/π响应比、角分辨、能量分辨率随入射π介子方向的变化以及... 详细信息

本文介绍了配有BGO(锗酸铋)晶体阵列的L3铀强子量能器性能的模拟测试。对L3强子量能器以及测试实验作了简要介绍,并给出了该量能器对4—20GeV能量范围的π介子的能量分辨率、e/π响应比、角分辨、能量分辨率随入射π介子方向的变化以及强子穿透率等实验结果。

关键词： L3谱仪 BGO 晶体阵列强子量能器

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