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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

A Data Collection on Secondary School Students’STEM Performance and Reading Practices in an Emerging Country

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Data Intelligence 2021年第2期3卷 336-356页

作者： Quan-hoang vuong Viet-Phuong La Manh-Toan Ho Thanh-Hang pham Thu-Trang vuong Ha-My vuong Minh-hoang Nguyen Centre for Interdisciplinary Social Research Phenikaa UniversityYen Nghia WardHa Dong DistrictHanoi 100803Vietnam A.I.for Social Data Lab Vuong&AssociatesDong Da DistrictHanoi 100000Vietnam School of Business and Management RMIT Vietnam UniversityHanoi 100000Vietnam

Science,technology,engineering,and mathematics(STEM)education has become a critical factor in promoting sustainable ***,book reading is still an essential method for cognitive development and knowledge *** developing countries where STEM teaching and learning resources are limited,book reading is an important educational tool to promote ***,public data sets about STEM education and book reading behaviors in emerging countries are *** article,therefore,aims to present a data set of 4,966 secondary school students from a school-based data collection in *** data set comprises of five major categories:1)students’personal information(including STEM performance),2)family-related information,3)book reading preferences,4)book reading frequency/habits,and 5)classroom *** introducing the designing principles,the data collection method,and the variables in the data set,we aim to provide researchers,policymakers,and educators with well-validated resources and guidelines to conduct low-cost research,pedagogical programs in emerging countries.

关键词： STEM education Socio-economic status Book reading Emerging country Students

Improving Energy and Power Efficiency Using NComputing and Approaches for Predicting Reliability of Complex Computing Systems

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International Journal of Automation and computing 2010年第2期7卷 153-159页

作者： hoang pham hoang pham Jr. Department of Industrial and Systems Engineering Rutgers University Timothy Christian School

Opting to follow the computing-design philosophy that the best way to reduce power consumption and increase energy efficiency is to reduce waste, we propose an architecture with a very simple ready-implementation by using an NComputing device that can allow multi-users but only one computer is needed. This intuitively can save energy, space as well as cost. In this paper, we propose a simple and realistic NComputing architecture to study the energy and power-efficient consumption of desktop computer systems by using the NComputing device. We also propose new approaches to estimate the reliability of k-out-of-n systems based on the delta method. The k-out-of-n system consisting of n subsystems works if and only if at least k-of-the-n subsystems work. More specificly, we develop approaches to obtain the reliability estimation for the k-out-of-n systems which is composed of n independent and identically distributed subsystems where each subsystem （or energy-efficient usage application） can be assumed to follow a two-parameter exponential lifetime distribution function. The detailed derivations of reliability estimation of k-out-of-n systems based on the biased-corrected estimator, known as delta method, the uniformly minimum variance unbiased estimate （UMVUE） and maximum likelihood estimate （MLE） are discussed. An energy-management NComputing application is discussed to illustrate the reliability results in terms of the energy consumption usages of a computer system with qua（t-core, 8 GB of RAM, and a GeForce 9800GX-2 graphics card to perform various complex applications. The estimated reliability values of systems based on the UMVUE and the delta method differ only slightly. Often the UMVUE of reliability for a complex system is a lot more difficult to obtain, if not impossible. The delta method seems to be a simple and better approach to obtain the reliability estimation of complex systems. The results of this study also show that, in practice, the NComputing archite

关键词： Energy efficiency Ncomputing k-out-of-n system exponential distribution reliability estimation uniformly minimum variance unbiased estimate (UMVUE) maximum likelihood estimate (MLE).

An Imperfect-debugging Fault-detection Dependent-parameter Software

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International Journal of Automation and computing 2007年第4期4卷 325-328页

作者： hoang pham Department of Industrial and Systems Engineering Rutgers UniversityNew JerseyNJ 08855-8018USA

Software reliability growth models （SRGMs） incorporating the imperfect debugging and learning phenomenon of developers have recently been developed by many researchers to estimate software reliability measures such as the number of remaining faults and software reliability. However, the model parameters of both the fault content rate function and fault detection rate function of the SRGMs are often considered to be independent from each other. In practice, this assumption may not be the case and it is worth to investigate what if it is not. In this paper, we aim for such study and propose a software reliability model connecting the imperfect debugging and learning phenomenon by a common parameter among the two functions, called the imperfect-debugging fault-detection dependent-parameter model. Software testing data collected from real applications are utilized to illustrate the proposed model for both the descriptive and predictive power by determining the non-zero initial debugging process.

关键词： Non-homogeneous Poisson process software reliability growth least squares estimate predictive power predictive-ratio risk.

A THREE-PARAMETER FAULT-DETECTION SOFTWARE RELIABILITY MODEL WITH THE UNCERTAINTY OF OPERATING ENVIRONMENTS

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Journal of Systems Science and Systems Engineering 2017年第1期26卷 121-132页

作者： Kwang Yoon Song In Hong Chang hoang pham Department of Computer Science and Statistics Chosun University Gwangju 62022 Korea Department of Industrial and Systems Engineering Rutgers University NJ 08855-8018 USA

As requirements for system quality have increased, the need for high system reliability is also increasing. Soflnvare systems are extremely important, in terms of enhanced reliability and stability, for providing high quality services to customers. However, because of the complexity of software systems, soft-ware development can be time-consuming and expensive. Many statistical models have been developed in the past years to estimate soflnvare reliability. In this paper, we propose a new three-parameter fault-detection software reliability model with the uncertainty of operating environments. The explicit mean value function solution for the proposed model is presented. Examples are presented to illustrate the goodness-of-fit of the proposed model and several existing non-homogeneous Poisson process （NHPP） models based on three sets of failure data collected from software applications. The results show that the proposed model fits significantly better than other existing NHPP models based on three criteria such as mean squared error （MSE）, predictive ratio risk （PRR）, and predictive power （PP）.

关键词： Nonhomogeneous Poisson process ratio risk predictive power fault detection software reliability mean squared error predictive

Building 3-D Human Data Based on Handed Measurement and CNN

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Computers, Materials & Continua 2023年第2期74卷 2431-2441页

作者： Bich Nguyen Binh Nguyen Hai Tran vuong pham Le Nhi Lam Thuy pham The Bao Faculty of Information Science Sai Gon UniversityHo Chi Minh70000Vietnam Faculty of Information Technology University of EducationHo Chi Minh70000Vietnam

3-dimension(3-D)printing technology is growing strongly with many applications,one of which is the garment *** application of human body models to the garment industry is necessary to respond to the increasing personalization demand and still guarantee *** paper proposes amethod to construct 3-D human models by applying deep *** calculate the location of the main slices of the human body,including the neck,chest,belly,buttocks,and the rings of the extremities,using pre-existing ***,on the positioning frame,we find the key points(fixed and unaltered)of these key slices and update these points tomatch the current *** add points to a star slice,we use a deep learning model tomimic the form of the human body at that slice *** use interpolation to produce sub-slices of different body sections based on the main slices to create complete body parts *** combine all slices to construct a full 3-D representation of the human body.

关键词： 3-D human model deep learning interpolation

An isogeometric analysis approach for dynamic response of doubly-curved magneto electro elastic composite shallow shell subjected to blast loading

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Defence Technology（防务技术） 2024年第11期41卷 159-180页

作者： pham hoang Tu Tran Van Ke Vu Khac Trai Le Hoai Faculty of Automotive Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 700000Viet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Viet Nam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Viet Nam HUTECH Institute of Engineering HUTECH UniversityHo Chi Minh City 700000Viet Nam

For the first time, the isogeometric analysis(IGA) approach is used to model and analyze free and forced vibrations of doubly-curved magneto-electro-elastic(MEE) composite shallow shell resting on the visco-Pasternak foundation in a hygro-temperature environment. The doubly-curved MEE shallow shell types include spherical shallow shell, cylindrical shallow shell, saddle shallow shell, and elliptical shallow shell subjected to blast load are investigated. The Maxwell equation and electromagnetic boundary conditions are used to determine the vary of the electric and magnetic potentials. The MEE shallow shell's equations of motion are derived from Hamilton's principle and refined higher-order shear theory. Then, the IGA method is used to derive the laws of natural frequencies and dynamic responses of the shell under various boundary conditions. The accuracy of the model and method is verified through reliable numerical comparisons. Aside from this, the impact of the input parameters on the free and forced vibration of the doubly-curved MEE shallow shell is examined in detail. These results may be useful in the design and manufacture of military structures such as warships, fighter aircraft, drones and missiles.

关键词： IGA approach Free and forced vibration Doubly-curved MEE shallow shell Blast load

Diabetic neuropathy research: from mouse models to targets for treatment

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Neural Regeneration Research 2019年第11期14卷 1870-1879页

作者： vuong M. pham Shinji Matsumura Tayo Katano Nobuo Funatsu Seiji Ito Department of Medical Chemistry Kansai Medical UniversityHirakataOsakaJapan Singapore Institute for Neurotechnology (SINAPSE) National University of SingaporeSingapore Department of Anesthesiology Osaka Medical CollegeTakatsukiOsakaJapan

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

关键词： brain derived neurotrophic factor diabetes extrinsic factors nerve growth factor nerve regeneration neurotrophic factors non-obese type 2 diabetes phosphatase and tensin homolog stem cell streptozotocin

Evidence based medicine:clinical trials that guide the management of ST-elevation myocardial infarction of elderly patients

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Journal of Geriatric Cardiology 2006年第2期3卷 120-127页

作者： hoang pham James Nguyen Thach Nguyen St.Mary Medical Center 1500 South Lake Park AveHobart IN 46342USA.

　　Cardiovascular disease is the most frequent diagnosis in elderly people and is the leading cause of death in both men and women older than 65 years. Every year in the United States more than 700,000 patients arrive at the emergency room with ST-segment elevation myocardial infarction(STEMI). About 60 percent of hospital admissions for AMI are of people older than 65 years. Their in-hospital, 1-month,and 1-year mortality is high. 1 In this article, we will provide a review on clinical trials that guide the management of STelevation myocardial infarction of the elderly patients.……

关键词： STEMI Evidence based medicine PCI AMI TIMI UFH CHF