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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

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Liver Research 2021年第4期5卷 195-203页

作者： Fang Wang peter Breslin S j Wei Qiu Department of Surgery and Cancer Biology Loyola University Chicago Stritch School of MedicineMaywoodILUSA Department of Molecular/Cellular Physiology Cancer BiologyCardinal Bernardin Cancer CenterLoyola University Medical Centerand BiologyLoyola University ChicagoChicagoILUSA

Hepatocellular carcinoma(HCC)is a very deadly *** initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor *** of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell *** this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five *** findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.

关键词： Hepatocellular carcinoma(HCC) Oncogene Tumor suppressor Activation Loss-of-function

Endoscopic Management of Pediatric Cholesteatoma

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journal of Otology 2020年第1期15卷 17-26页

作者： peter j.Ryan Nirmal P.Patel Department of Otolaryngology and Head and Neck Surgery Royal North Shore HospitalSt LeonardsNSWAustralia Kolling Deafness Research Centre Macquarie University and University of SydneyNSWAustralia

Pediatric cholesteatoma occurs in one of two forms:congenital cholesteatoma,developing from embryonic epidermal cell rests or acquired cholesteatoma,associated with a focal defect in the tympanic *** disease has been traditionally managed with the operating microscope,often requiring mastoidectomy for adequate visualization of and access to the middle ear and mastoid ***,advances in endoscopic equipment have enabled otologists to manage most cases of pediatric cholesteatoma via a minimally-invasive,transcanal endoscopic *** review discusses the current literature relating to the etiopathogenesis,assessment and endoscopic management of pediatric *** outcomes of endoscopic treatment,emerging trends and technologies are also reviewed.

关键词： Cholesteatoma Pediatric Endoscopic Minimally-invasive Middle ear Mastoid

Aortic valve replacement reduces mortality in moderate aortic stenosis:a systematic review and meta-analysis

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journal of Geriatric Cardiology 2023年第1期20卷 61-67页

作者： Kyle B Franke Dimple Bhatia Ross L Roberts-Thomson peter j Psaltis Adelaide Medical School The University of AdelaideAdelaideAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia Department of Cardiology Royal Adelaide HospitalAdelaideAustralia

BACKGROUND With the introduction of transcatheter aortic valve replacement and an evolving understanding of the natural progression and history of aortic stenosis,the potential for earlier intervention in appropriate patients is promising;however,the benefit of aortic valve replacement in moderate aortic stenosis remains *** Pubmed,Embase,and the Cochrane Library databases were searched up until 30th of December 2021 using keywords including moderate aortic stenosis and aortic valve *** reporting all-cause mortality and outcomes in early aortic valve replacement(AVR)compared to conservative management in patients with moderate aortic stenosis were *** ratios were generated using random-effects meta-analysis to determine effect *** 3470 publications were screened with title and abstract review,which left 169 articles for full-text *** these studies,7 met inclusion criteria and were included,totalling 4,827 *** studies treated AVR as a time-dependent co-variable in cox-regression multivariate analysis of all-cause *** with surgical or transcatheter AVR was associated with a 45% decreased risk of all-cause mortality(HR=0.55[0.42-0.68],I2=51.5%,P<0.001).All studies were representative of the overall cohort with appropriate sample sizes,with no evidence of publication,detection,or information biases in any of the *** In this systematic review and meta-analysis,we report a 45% reduction in all-cause mortality in patients with moderate aortic stenosis who were treated with early aortic valve replacement compared to a strategy of conservative *** control trials are awaited to determine the utility of AVR in moderate aortic stenosis.

关键词： aortic stenosis analysis

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) supports adhesion and migration of mesenchymal stem cells and tenocytes

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World journal of Stem Cells 2012年第9期4卷 94-100页

作者： Alex j lomas George GQ Chen Alicia j El Haj Nicholas R Forsyth Guy Hilton Research Centre Keele University Stoke on Trent ST4 7QB United Kingdom Department Biological Sciences and Biotechnology School of Life Science Tsinghua University

AIM: To establish the potential of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) as a material for tendon repair. METHODS: The biocompatibility of PHBHHx with both rat tenocytes (rT) and human mesenchymal stem cells (hMSC) was explored by monitoring adhesive characteristics on films of varying weight/volume ratios coupled to a culture atmosphere of either 21% O2 (air) or 2% O2 (physiological normoxia). The diameter and stiffness of PHBHHx films was established using optical coherence tomography and mechanical testing, respectively. RESULTS: Film thickness correlated directly with weight/volume PHBHHx (r2 = 0.9473) ranging from 0.1 mm (0.8% weight/volume) to 0.19 mm (2.4% weight/volume). Film stiffness on the other hand displayed a biphasic response which increased rapidly at values > 1.6% weight/volume. Optimal cell attachment of rT required films of ≥ 1.6% and ≥ 2.0% weight/volume PHBHHx in 2% O2 and 21% O2 respectively. A qualitative adhesion increase was noted for hMSC in films ≥ 1.2% weight/volume, becoming significant at 2% weight/volume in 2% O2. An increase in cell adhesion was also noted with ≥ 2% weight/volume PHBHHx in 21% O2. Cell migration into films was not observed. CONCLUSION: This evaluation demonstrates that PHBHHx is a suitable polymer for future cell/polymer replacement strategies in tendon repair.

关键词： Mesenchymal stem cell Tenocytes Polyhydroxyalkanoates Hypoxia Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)

Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping

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Photonic Sensors 2015年第4期5卷 289-297页

作者： Md. Arafat HOSSAIN john CANNING Sandra AST peter j. RUTLEDGE Abbas jAMALIPOUR interdisciplinary Photonics Laboratories (iPL) School of Chemistry The University of Sydney NSW 2006 Australia School of Chemistry The University of Sydney NSW 2006 Australia Wireless Networking Group (WING) School of Electrical and Information Engineering The University of Sydney NSW2006 Australia

Early detection of environmental disruption, unintentional or otherwise, is increasingly desired to ensure hazard minimization in many settings. Here, using a field-portable, smartphone fluorimeter to assess water quality based on the pH response of a designer probe, a map of pH of public tap water sites has been obtained. A custom designed Android application digitally processed and mapped the results utilizing the global positioning system （GPS） service of the smartphone. The map generated indicates no disruption in pH for all sites measured, and all the data are assessed to fall inside the upper limit of local government regulations, consistent with authority reported measurements. This implementation demonstrates a new security concept： network environmental forensics utilizing the potential of novel smartgrid analysis with wireless sensors for the detection of potential disruption to water quality at any point in the city. This concept is applicable across all smartgrid strategies within the next generation of the Internet of Things and can be extended on national and global scales to address a range of target analytes, both chemical and biological.

关键词： Lab-in-a-phone Intemet of Things optical sensing and sensor smartphone sensor photonic sensor fluorescence water security

Hepatocellular transport proteins and their role in liver disease

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World journal of Gastroenterology 2001年第2期7卷 157-169页

作者： Carmen Stanca Diana jung peter j.Meier Gerd A.Kullak-Ublick Division of Gastroenterology and Hepatology and Division of Clinical Pharmacology and Toxicology Department of Internal MedicineUniversity HospitalCH-8091 Zurich/Switzerland

MOLECULAR PHYSIOLLGY OF HEPATOCELLULAR TRANSPORT PROTEINS Basolaferal transport systems Na+-dependent bile salt uptake Uptake of bile salts into the liver was first isolated perfused rat liver[1],isolated hepatocyte... 详细信息

关键词： ATP-Binding Cassette Transporters Animals Carrier Proteins Hepatocytes Humans Liver Liver Diseases Organic Anion Transporters Organic Cation Transport Proteins Research Support, Non-U.S. Gov't

A new mixed agent-based network and compartmental simulation framework for joint modeling of related infectious diseases-application to sexually transmitted infections

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Infectious Disease Modelling 2023年第1期8卷 84-100页

作者： Chaitra Gopalappa Hari Balasubramanian peter j.Haas University of Massachusetts Amherst 160 Governors DriveAmherstMA01003USA

Background:A model that jointly simulates infectious diseases with common modes of transmission can serve as a decision-analytic tool to identify optimal intervention combinations for overall disease *** the United States,sexually transmitted infections(STIs)are a huge economic burden,with a large fraction of the burden attributed to *** also show interactions between HIV and other sexually transmitted infections(STIs),such as higher risk of acquisition and progression of co-infections among persons with HIV compared to persons ***,given the wide range in prevalence and incidence burdens of STIs,current compartmental or agent-based network simulation methods alone are insufficient or computationally burdensome for joint disease ***,causal factors for higher risk of coinfection could be both behavioral(i.e.,compounding effects of individual behaviors,network structures,and care behaviors)and biological(i.e.,presence of one disease can biologically increase the risk of another).However,the data on the fraction attributed to each are ***:We present a new mixed agent-based compartmental(MAC)framework for jointly modeling *** uses a combination of a new agent-based evolving network modeling(ABENM)technique for lower-prevalence diseases and compartmental modeling for higher-prevalence *** a demonstration,we applied MAC to simulate lower-prevalence HIV in the United States and a higher-prevalence hypothetical Disease 2,using a range of transmission and progression rates to generate burdens replicative of the wide range of *** simulated sexual transmissions among heterosexual males,heterosexual females,and men who have sex with men(men only and men and women).Setting the biological risk of co-infection to zero,we conducted numerical analyses to evaluate the influence of behavioral factors alone on disease ***:The contribution of behavioral factors to risk of coinfection was sensitive to disease

关键词： joint-modeling diseases Multi-disease modeling Simulation modeling HIV and STIs Diseases and social determinants SDOH

Hybrid polymer biomaterials for bone tissue regeneration

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Frontiers of Medicine 2019年第2期13卷 189-201页

作者： Bo Lei Baolin Guo Kunal j.Rambhia peter X.Ma Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710054China Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Department of Biologic and Materials Sciences University of MichiganAnn ArborMI 48109USA Macromolecular Science and Engineering Center University of MichiganAnn ArborMI 48109USA Department of Material Science and Engineering University of MichiganAnn ArborMI 48109USA

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

关键词： hybrid polymer bone regeneration tissue engineering biomaterials

Control of Cell Wall Extensibility during Pollen Tube Growth

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Molecular Plant 2013年第4期6卷 998-1017页

作者： peter K. Hepler Caleb M. Rounds Lawrence j. Winship Biology Department University of Massachusetts Amherst MA 01003 USA School of Natural Science Hampshire College Amherst MA 01002 USA

In this review, we address the question of how the tip-growing pollen tube achieves its rapid rate of elongation while maintaining an intact cell wall. Although turgor is essential for growth to occur, the local expansion rate is controlled by local changes in the viscosity of the apical wall. We focus on several different structures and underly- ing processes that are thought to be major participants including exocytosis, the organization and activity of the actin cytoskeleton, calcium and proton physiology, and cellular energetics. We think that the actin cytoskeleton, in particular the apical cortical actin fringe, directs the flow of vesicles to the apical domain, where they fuse with the plasma mem- brane and contribute their contents to the expanding cell wall. While pH gradients, as generated by a proton-ATPase located on the plasma membrane along the side of the clear zone, may regulate rapid actin turnover and new polymeri- zation in the fringe, the tip-focused calcium gradient biases secretion towards the polar axis. The recent data showing that exocytosis of new wall material precedes and predicts the process of cell elongation provide support for the idea that the intussusception of newly secreted pectin contributes to decreases in apical wall viscosity and to cell expansion. Other prime factors will be the localization and activity of the enzyme pectin methyl-esterase, and the chelation of calcium by pectic acids. Finally, we acknowledge a role for reactive oxygen species in the control of wall viscosity.

关键词： cell expansion cell walls cytoskeleton dynamics polarity pollen development.