Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis

作     者：Peter William French Russell Ian Ludowyke Gilles J.Guillemin 

作者机构：School of MedicineUniversity of New South WalesSydneyNSWAustralia WilloughbySydneyNSWAustralia Neuroinflammation GroupDepartment of Biological SciencesFaculty of Medicine and Health SciencesMacquarie UniversitySydneyNSWAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第9期

页      面：1490-1493页

核心收录：

学科分类：10[医学] 

主　　题：amyotrophic lateral sclerosis fungi motor neurone disease mycotoxins neurotoxins ALS well water sporadic ALS 

摘      要：Fungi are important infectious disease-causing agents,but are often overlooked as environmental factors in *** review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis(ALS),the most common form of motor neurone *** 90%cases of ALS are sporadic,and the aetiology of sporadic ALS is still *** have previously postulated that grass or soil-associated fungal infections may be a leading cause of sporadic *** we extend this proposal to water-associated fungi.A wide variety of fungi have been reported in drinking water including Acremonium,Alternaria,Aspergillus,Cladosporium,Fusarium,Penicillium and *** of these are known to produce neurotoxic *** this,drinking water is not routinely monitored for fungal *** contamination could explain the close correlation between distribution of well water and cases of sporadic ALS in the United *** propose several mechanisms by which an opportunistic fungal infection from environmental exposure(to water,soil or plants)can lead to long term neuronal degradation resulting in the hallmarks of *** confirmed,the association between fungal infection and sporadic ALS could lead to novel treatment strategies for this progressive and fatal disease.