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迷走神经刺激治疗难治性癫痫:欧洲347例儿童24个月随访研究

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癫痫杂志 2016年第5期2卷 454-460页

作者： Iren Orosz David McCormic Nelia Zamponi Sophia Varadkar Martha Feucht Dominique Parain Roger Griens Louis Vallee paul boon Christopher Rittey Amara K. Jayewardene Mark Bunker Alexis Arzimanoglou Lieven Lagae 刘文钰(译) 慕洁(审) 不详

为了进一步探究迷走神经刺激术(Vagus nerve stimulation,VNS)在儿童难治性癫痫中的作用,进行了连续随访达24个月,系迄今最大样本量的多中心回顾性研究.主要目标是评估VNS术后癫痫主要发作类型(定义为最易致残的发作类型)的频率变化,连... 详细信息

为了进一步探究迷走神经刺激术(Vagus nerve stimulation,VNS)在儿童难治性癫痫中的作用,进行了连续随访达24个月,系迄今最大样本量的多中心回顾性研究.主要目标是评估VNS术后癫痫主要发作类型(定义为最易致残的发作类型)的频率变化,连续收集从基线开始一直到植入术后6、12及24个月的患者数据.统计人群包括347例患者(年龄6个月~17.9岁).在植入后第6、12及24月,分别有32.5%、37.6%及43.8%的患者主要发作类型的发作与基线相比,有50%减少.亚组分析中,在试验期间没有更换抗癫痫药物(AEDs)的患者有更好的反应.较好的结果也存在于所有次要指标,包括癫痫发作持续时间、严重程度和发作后严重程度、生活质量、安全性等.多组分析表明VNS每天总放电量与反应效率有相关性.VNS治疗被认为是局灶性结构性癫痫患儿的附加治疗,指那些经过两种及以上AEDs治疗后仍不适合外科手术的患者.全面性发作,有遗传及结构异常的,如Dravet综合征和Lennox-Gastaut综合征的患者能从VNS治疗中获益.结果表明随访24个月后,难治性癫痫患儿通过附加的VNS治疗能够减少癫痫发作频率,安全性良好;多组分析表明VNS有剂量相关性.

关键词：临床试验癫痫儿童生活质量迷走神经刺激术

Hemorrhagic pancreatitis from fenofibrate and metformin toxicity:a case report

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World Journal of Emergency Medicine 2023年第6期14卷 495-498页

作者： Marcus Aik Beng Lee Mingwei Ng paul Yugendra Yiju Yao R Ponampalam boon Kiat Kenneth Tan Department of Emergency Medicine Singapore General HospitalSingapore 169608Singapore Analytical Toxicology Laboratory Health Sciences AuthoritySingapore 169078Singapore

Fibrates have been used for over forty-odd years to manage dyslipidemia and are generally considered safe and well-tolerated.^([1])However,little is known about the toxicity offibrates in overdose,[2]and most of the knowledge about fibrate toxicity comes from extrapolated observations of adverse effects encountered at therapeutic doses instead.

关键词： doses pancreatitis

Improved reliability in the interpretation of geochemical measurements by the quantification of uncertainty from sampling

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Chinese Journal Of Geochemistry 2006年第B8期25卷 209-210页

作者： Michael H. Ramsey paul D. Taylor Katy A. boon Centre for Environmental Research Department of Biology and Environmental Science School of Life Sciences University of Sussex Brighton UK

应用AccuMap多焦视觉诱发电位客观视野检测法观察晶状体混浊对青光眼视野检测结果的影响

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中华眼科杂志 2006年第11期42卷 972-976页

作者：才瑜 LIM boon Ang CHI Luu POR Yongming OEN Francis 晏晓明 CHEW paul SEAH Steve 北京大学第一医院眼科 100034 Department of Ophthalmology Tan Tock Seng Hospital Singapore Eye Research Institute Singapore National Eye Centre Department of Ophthalmology National University Hospital

目的探讨AccuMap多焦视觉诱发电位客观视野检测法观察晶状体混浊对青光眼视野检测结果的影响及与Humphrey自动视野检测结果之间的相关性。方法观察和比较原发性青光眼伴有中等程度晶状体混浊患者白内障术前后AccuMap与Humphrey视野计检... 详细信息

目的探讨AccuMap多焦视觉诱发电位客观视野检测法观察晶状体混浊对青光眼视野检测结果的影响及与Humphrey自动视野检测结果之间的相关性。方法观察和比较原发性青光眼伴有中等程度晶状体混浊患者白内障术前后AccuMap与Humphrey视野计检测结果。术前由同一位有经验的眼科医师观察并记录(采用LOCSⅢ标准)患者晶状体的混浊程度。结果符合入选标准并完成观察者共22例。(1)AccuMap视野检测平均振幅术前为(308.0±96.6)nV,术后为(382.6±146.7)nV,术前与术后平均振幅差异有统计学意义(P=0.01)。平均视野损害严重程度指数(accumapseverityindex,ASI)术前为90.0±54.8,术后为48.6±42.4,术后比术前ASI显著下降(P<0.001)。潜伏期术前后无明显变化,术前平均为(1207.5±67.7)ms,术后为(1191.2±61.9)ms(P=0.289)。(2)晶状体混浊程度与AccuMap振幅的变化AccuMap振幅的变化与晶状体混浊程度无明显相关性(Spearman秩相关分析,P=0.09)。(3)Humphrey视野计检测结果术前平均偏差(meandeviation,MD)为-12.2±7.8,术后为-9.6±8.8,术后与术前MD差异有统计学意义(P<0.001);而模式标准差(patternstandarddeviation,PSD)术前为6.5±3.2,术后为6.3±4.0,差异无统计学意义(P=0.748)。(4)ASI与MD比较术前、术后ASI分别与MD具有相关性(Pearson相关分析,术前P=0.013,术后P<0.001);且术后与术前ASI的变化与MD的变化也具有相关性(Pearson相关分析,P=0.017)。结论AccuMap视野检测法显示晶状体混浊影响青光眼患者的视野检测结果,其中振幅受影响更明显。与Humphrey视野检测结果比较,AccuMap检测的ASI与MD具有相关性。(中华眼科杂志,2006,42972-976)

关键词：视野检查法诱发电位,视觉青光眼白内障

Towards a sustainable geoliner construction in landflls by potential blending of fly ash with kaolin clay alternative:a review with an insight to Indian scenario

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Waste Disposal and Sustainable Energy 2024年第2期6卷 243-258页

作者： Kshitij Kumar Biswajit paul Department of Environmental Science and Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad 826004JharkhandIndia

Electricity generated through coal-based Thermal Power Plants(TPPs)has played a pivotal role in shaping modern civiliza-tion,revolutionizing industries,and improving the quality of life for billions of people *** TPPs contribute to about 37%-40%of the global energy *** production,in turn,has a direct impact on the economy of any *** from this boon to humankind,these TPPs combusting coal as their primary fuel also have specific environmen-tal impacts,the major ones being water,air,and soil pollution due to unscientific disposal of high-quantity fly ash produced *** we can put this ash to good use,it may assist us in mitigating the pollution caused by *** there are many conventional uses of fly ash,such as a pozzolanic material in the cement industry,more pathways need to be discovered to balance the high generation quantities with ***,a detailed description of its use in potential geoliner applications is presented in this article.A geoliner or a landfill liner acts as a virtually impenetrable layer to mitigate the leachate penetration into the underneath subsoil and groundwater,thus preventing *** are presently some studies that support the use of only fly ash in such ***,the properties of the geoliners using it are not so good to significantly mitigate environmental degradation owing to its high permeability and low densification *** bentonite conventionally used has limited deposits and is mined intensively for its use as a natural *** depos-its must also be conserved,and an alternative material that may serve similar application benefits,like bentonite,must be *** desired aim can be fulfilled if we blend this combustion residue with other suitable materials(such as kaolinite clay)with low ***,the article focuses on the possibilities of blending fly ash with different clays for geoliner construction to improve the in

关键词： Fly ash-Geoliner Environmental management Composite liner systems Bentonite Kaolin clay

Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

应用AccuMap多焦视觉诱发电位客观视野检查法观察白内障对青光眼视野影响的研究

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应用AccuMap多焦视觉诱发电位客观视野检查法观察白内障对青光眼...

Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering

第三届全球华人眼科学术大会暨中华医学会第十一届全国眼科学术大会

作者：才瑜 LIM boon Ang CHI luu POR Yongming OEN Francis 晏晓明 CHEW paul SEAH Steve 北京大学第一医院眼科

目的:本研究应用AccuMap多焦视觉诱发电位客观视野检查法,探讨白内障对青光眼视野的影响,并比较与Hum- phrey自动视野检查结果之间的相关性。方法:本研究前瞻性观察原发性青光眼并伴有中等程度白内障患者,在白内障术前和术后AccuMap和Hu...

目的:本研究应用AccuMap多焦视觉诱发电位客观视野检查法,探讨白内障对青光眼视野的影响,并比较与Hum- phrey自动视野检查结果之间的相关性。方法:本研究前瞻性观察原发性青光眼并伴有中等程度白内障患者,在白内障术前和术后AccuMap和Humphrey视野的改变。晶状体的混浊程度在术前由同一名有经验的眼科医师观察并记录(采

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BioDesign Research 2020年第1期2020卷 138-140页

作者： paul E.Abraham Jessy L.Labbé Amber A.McBride Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Biosciences Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA

In the last decade,the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome ***,this democratized technology is both a boon and a bane,for which we have yet to understand the full potential to investigate and rewrite genomes(also named“genome biodesign”).Rapid CRISPR advances in a range of applications in basic research,agriculture,and clinical applications pose new risks and raise several biosecurity *** such a fast-moving field of research,we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.

关键词： Genome properly simplicity