Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering

作     者：Paul E.Abraham Jessy L.Labbé Amber A.McBride 

作者机构：Chemical Sciences DivisionOak Ridge National LaboratoryOak RidgeTennessee 37831USA Biosciences DivisionOak Ridge National LaboratoryOak RidgeTennessee 37831USA 

出 版 物：《BioDesign Research》 (生物设计研究（英文）)

年 卷 期：2020年第2020卷第1期

页      面：138-140页

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：This work was supported by the U.S.Department of Energy(DOE),Office of Biological and Environmental Research(BER)and the Genomic Sciences Program as a part of the Secure Biosystems Design program The manuscript has been authored by UT-Battelle,LLC,under contract no.DE-AC05-00OR22725 with the U.S.Department of Energy 

主　　题：Genome properly simplicity 

摘      要：In the last decade,the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome ***,this democratized technology is both a boon and a bane,for which we have yet to understand the full potential to investigate and rewrite genomes(also named“genome biodesign).Rapid CRISPR advances in a range of applications in basic research,agriculture,and clinical applications pose new risks and raise several biosecurity *** such a fast-moving field of research,we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.