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Neuroscience Bulletin 2023年第12期39卷 1873-1886页

作者： Charlotte Sleurs paul fletcher Conor Mallucci Shivaram Avula Thankamma Ajithkumar Department of Cognitive Neuropsychology Tilburg University5037 ABTilburgThe Netherlands Department of Oncology KU Leuven3000LeuvenBelgium Department of Psychiatry University of CambridgeAddenbrookes HospitalCambridgeCB20QQUK Wellcome Trust MRC Institute of Metabolic Science University of CambridgeCambridge Biomedical CampusCambridgeCB20QQUK Department of Neurosurgery Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Radiology Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Oncology Cambridge University Hospital NHS TrustCambridgeCB20QQUK

The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological *** the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to *** number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after *** this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor *** on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.

关键词： Connectome Pediatric brain tumor Neuroimaging Neurocognition-Neuropsychological assessment

Children with specific language impairment

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Children with specific language impairment

中华医学会第十五次全国物理医学与康复学学术会议

作者： paul fletcher University College Cork Ireland

＜正＞In the English-speaking world in the last thirty years or so,a great deal of attention has been paid to a group of children with no identifiable physical or cognitive problems who have difficulty learning *** are familiar with language learning difficulties which result from identifiable congenital problems such as hearing impairment:children who are born deaf,unless they can be provided with hearing aids or cochlear implants,will not be able to communicate

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美学冠延长术中应用比例测量尺的生物学原理

中国口腔医学继续教育杂志 2012年第3期15卷 135-140页

作者： paul fletcher 乔敏(译) 徐莉(审) 不详北京大学口腔医学院牙周科北京市中关村南大街22号100081

本研究的目的是估算冠延长手术中需暴露的牙齿结构的量。在口腔的前牙美学区，冠延长术可能会导致生物学宽度问题和继发的美学问题。本文展示了以生物学基础为前提，行牙周美学冠延长术的步骤和方法。本研究采用一系列新的测量标准（测... 详细信息

本研究的目的是估算冠延长手术中需暴露的牙齿结构的量。在口腔的前牙美学区，冠延长术可能会导致生物学宽度问题和继发的美学问题。本文展示了以生物学基础为前提，行牙周美学冠延长术的步骤和方法。本研究采用一系列新的测量标准（测量尺），依据已知的合理的牙齿比例关系，测量牙齿理想的临床冠高度，和邻面牙间乳头处的适宜骀龈位置。牙冠的生物学高度的定义是切缘到牙槽嵴顶的距离，其后从功能角度确定牙冠高度，最终的目的是确立和形成适宜的牙齿结构，利于修复边缘的放置，建立健康的牙龈复合体和达到令人满意的美学效果。

关键词：美学冠延长

数字化时代义务后教育融资机制创新:双重挑战与应对策略

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职业技术教育 2019年第6期40卷 16-19页

作者： (英)Mick fletcher paul Grainger 董衍美(编译) 伦敦大学学院教育研究院14岁后教育与工作中心伦敦大学教育、实践和社会系创新与企业部吉林工程技术师范学院职业技术教育研究院长春130052

进入数字化时代,许多国家都越来越重视为义务后教育制定新的更有效的融资机制,但政策制定者面临双重挑战。为此,本文提出两个建议,一是T20开发跨国资源,收集、整理和分析不同国家义务后教育融资方式创新的案例信息,并发布案例分析报告,... 详细信息

进入数字化时代,许多国家都越来越重视为义务后教育制定新的更有效的融资机制,但政策制定者面临双重挑战。为此,本文提出两个建议,一是T20开发跨国资源,收集、整理和分析不同国家义务后教育融资方式创新的案例信息,并发布案例分析报告,方便政策制定者学习借鉴。二是提出构建义务后教育融资机制评估标准,用以评判各个融资机制的适切性,从而选择最适合的融资机制。其中,'内部'标准包括效率、透明度、可预测性、灵活性、可接受性和重要性六个指标;而'外部'标准则是从提高效率、提高可持续性、促进公平、促进发展、确定优先顺序这最重要的6个政策目标入手,分析融资机制的适切性。

关键词：义务后教育融资机制适切性评估内部标准外部标准

Understanding the Experiences of Anxiety in Community Dwelling Older Adults—Understanding Anxiety in Older Adults

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Open Journal of Nursing 2017年第11期7卷 1197-1208页

作者： Margaret H. Roberts paul L. Merrick Richard B. fletcher Kirsty Furness School of Clinical Sciences Auckland University of Technology Auckland New Zealand School of Psychology Massey University Auckland New Zealand

Objectives: Anxiety is commonly reported as being experienced by older adult patients. However most of the theories on anxiety in older adults are developed from clinical measures rather than open-ended questionnaires. Consequently, little is known about the day to day experiences of anxiety in the lives of older adults, and the functional impairment that may result. Method: Community dwelling older adults (n = 135) were administered an open-ended questionnaire eliciting their experiences of anxiety using a cognitive behavioural framework. Directed content analysis was applied to discover the shared experiences of anxiety in older adults. Results: Although 64% of older adults reported avoidance behaviour that appeared anxiety driven, they generally denied experiencing anxiety themselves. Thought content and processes were idiosyncratic however commonalities were thinking positively (34%), problem solving (31%), rumination (31%) and difficulty concentrating (19%). A broad range of physical symptoms including those that may relate to medical conditions and depression were reported as resulting from anxiety, most commonly headaches (26%) and gastrointestinal disturbances (26%). Conclusion: Anxiety driven behaviours were common and appeared to negatively impact their quality of life through avoidance behaviours. Older adults may benefit from education to destigmatise the experiences of anxiety and improve reporting of functional impairment due to anxiety.

关键词： Anxiety Beliefs Qualitative Methods Assessment Older-Adults

The ULT1 and ULT2 trxG Genes Play Overlapping Roles in Arabidopsis Development and Gene Regulation

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Molecular Plant 2013年第5期6卷 1564-1579页

作者： Mona M. Monfared Cristel C. Caries Pascale Rossignol Helena R. Pires Jennifer C. fletcher Plant Gene Expression Center USDA-ARS/UC Berkeley 800 Buchanan Street. Albany CA 94710 USA Department of Plant and Microbial Biology University of California Berkeley 111 Koshland Hall Berkeley CA 94720 USA CNRS UMR5168 F-38054 Grenoble France Universite Grenoble Alpes UMR5168 F-38041 Grenoble France CEA iRTSV Laboratoire Physiologie Cellulaire et Vegetale F-38054 Grenoble France INRA F-38054 Grenoble France Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06520 USA Faculdade de Ciencias da Universidade do Porto Porto Portugal

The epigenetic regulation of gene expression is critical for ensuring the proper deployment and stability of defined genome transcription programs at specific developmental stages. The cellular memory of stable gene expression states during animal and plant development is mediated by the opposing activities of Polycomb group （PcG） factors and trithorax group （trxG） factors. Yet, despite their importance, only a few trxG factors have been characterized in plants and their rotes in regulating plant development are poorly defined. In this work, we report that the closely related Arabidopsis trxG genes ULTRAPETALA1 （ULT1） and ULT2 have overlapping functions in regulating shoot and floral stem cell accumula- tion, with ULT1 playing a major role but ULT2 also making a minor contribution. The two genes also have a novel, redun- dant activity in establishing the apical-basal polarity axis of the gynoecium, indicating that they function in differentiating tissues. Like ULT1 proteins, ULT2 proteins have a dual nuclear and cytoplasmic localization, and the two proteins physically associate in planta. Finally, we demonstrate that ULT1 and ULT2 have very similar overexpression phenotypes and regulate a common set of key development target genes, including floral MADS-box genes and class I KNOX genes. Our results reveal that chromatin remodeling mediated by the ULT1 and ULT2 proteins is necessary to control the development of mer- istems and reproductive organs. They also suggest that, like their animal counterparts, plant trxG proteins may function in multi-protein complexes to up-regulate the expression of key stage- and tissue-specific developmental regulatory genes.

关键词： trxG factor epigenetics stem cells Arabidopsis polarity ULTRAPETALA.

Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

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Emerging Contaminants 2016年第3期2卷 166-172页

作者： Miren Pena-Abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael fletcher paul A..Helm Eric J.Reiner Department of Analysis CEPSA Research CenterAlcala de Henares28805Spain Department of Chemistry University of TorontoTorontoONM5S 3H6Canada Ontario Ministry of the Environment and Climate Change TorontoONM9P 3V6Canada Conservation Ontario NewmarketONL3Y 2P5Canada Department of Chemistry Brock UniversitySt.CatharinesONL2S 3A1Canada Wellington Laboratories Inc. GuelphONN1G 3M5Canada Department of Chemistry University of GuelphGuelphONN1G 2W1Canada Matson&Associates Inc.State CollegePA16801USA Veterinary Medicine&Biomedical Sciences Texas A&M UniversityTexasTX77843e4461USA Ministry of Northern Development and Mines SudburyONP3E 6B5Canada School of the Environment University of TorontoONM5S 3EBCanada

The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples,1,8-dibromo-3,6-dichloro-9H-carbazole(BCCZ).Concentrations and the relative effect potency(REP)were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario,*** levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants(POPs)in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination(<1%e95%;average 37%).The corresponding dioxin toxic equivalencies(TEQs)of BCCZ in the sediment extracts were estimated from experimental REP *** experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental *** potential emission sources could not be identified,this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.

关键词： Halogenated carbazoles Levels GC×GC REP TEQ Dioxin-like Risk assessment Regulation

流感疫苗对流感高发期额外死亡的影响:老年人队列研究

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英国医学杂志中文版 2005年第1期8卷 62-62页

作者： Ben G Armstrong Punam Mangtani Astrid fletcher Sari Kovats Anthony McMichael Sam Pattenden paul Wilkinson 胡恩坦

目的：评价流感疫苗对流感所致死亡的预防作用。研究设计：前瞻性队列研究，随访社区确诊并计入国家流感统计周报的人群。

关键词：老年人流感疫苗前瞻性队列研究死亡高发期人群预防作用周报统计国家