Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors:Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

作     者：Charlotte Sleurs Paul Fletcher Conor Mallucci Shivaram Avula Thankamma Ajithkumar 

作者机构：Department of Cognitive NeuropsychologyTilburg University5037 ABTilburgThe Netherlands Department of OncologyKU Leuven3000LeuvenBelgium Department of PsychiatryUniversity of CambridgeAddenbrookes HospitalCambridgeCB20QQUK Wellcome Trust MRC Institute of Metabolic ScienceUniversity of CambridgeCambridge Biomedical CampusCambridgeCB20QQUK Department of NeurosurgeryAlder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of RadiologyAlder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of OncologyCambridge University Hospital NHS TrustCambridgeCB20QQUK 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第12期

页      面：1873-1886页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：funded by the Fonds voor Wetenschappelijk Onderzoek for a senior post-doctoral fellowship.PCF is supported by funding from the Bernard Wolfe Health Neuroscience Fund(206368/Z/17/Z) His research is also supported by the NIHR Cambridge Biomedical Research Centre(BRC-1215-20014) 

主　　题：Connectome Pediatric brain tumor Neuroimaging Neurocognition-Neuropsychological assessment 

摘      要：The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological *** the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and challenging to *** number of neurocognitive studies in this population grows exponentially worldwide,motivating modern neuroscience to provide guidance in follow-up before,during and after *** this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor *** on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.