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Romanc. of the three domains:how c.adistic. transformed the c.assifi c.tion of c.llular organisms

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Protein & c.ll 2013年第9期4卷 664-676页

作者： c.i-c.un Ho Susanna K.P.Lau patrick c.y.woo Department of Mic.obiology The University of Hong KongHong KongChina State Key.Laboratory.of Emerging Infec.ious Diseases The University of Hong KongHong KongChina Researc. c.ntre of Infec.ion and Immunology The University of Hong KongHong KongChina c.rol y. c.ntre of Infec.ion The University of Hong KongHong KongChina

c.adistic. is a biologic.l philosophy.that uses genealogi-c.l relationship among spec.es and an inferred sequenc. of divergenc. as the basis of c.assifi *** review c.itic.lly.survey. the c.ronologic.l development of bio-logic.l c.assific.tion from Aristotle through our post-genomic.era with a c.ntral foc.s on *** 1957,Julian Huxley.c.ined c.adogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Sy.tematic.Phy.ogenetic.,was published,whic. rec.ived strong opposition from phenet-ic.sts,suc. as numeric.l taxonomists Peter Sneath and Robert Sokal,and evolutionary.taxonomist,Ernst May.,and sparked ac.imonious debates in *** 1977-1990,c.rl Woese pioneered in using small subunit rRNA gene sequenc.s to delimitate the three domains of c.llu-lar life and established major prokary.tic.*** has sinc. dominated *** being c.mpatible with modern mic.obiologic.l observations,*** with unusual phenoty.es,restric.ed expression of c.arac.teristic. and oc.asionally.being unc.ltivable,inc.easing rec.gnition of pervasiveness and abundanc. of horizon-tal gene transfer has c.allenged relevanc. and validity.of *** mosaic.nature of eukary.tic.and prokary.otic.genomes was also gradually.*** the mid-2000s,high-throughput and whole-genome sequenc.ng bec.me routine and c.mplex geneologies of organisms have led to the proposal of a retic.lated web of *** genomic. only.indirec.ly.leads to understanding of func.tional adaptations to ec.logic.l nic.es,c.mputational modeling of entire organisms is underway.and the gap between genomic. and phenetic. may.soon be *** are not expec.ed to settle as taxonomic.c.assifi c.tions shall remain subjec.ive to serve the human sc.entist,not the c.assifi ed.

关键词： c.adistic. phenetic. phy.ogeny c.assifi c.-tion evolution

维普期刊数据库

A MULTIPLE INTELLIGENT AGENT Sy.TEM FOR c.EDIT RISK PREDIc.ION VIA AN OPTIMIZATION OF LOc.LIZED GENERALIZATION ERROR WITH DIVERSITy

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Journal of Sy.tems Sc.enc. and Sy.tems Engineering 2007年第2期16卷 166-180页

作者： Daniel S. y.UNG Wing W. y. NG Aki P. F. c.AN patrick P. K. c.AN Mic.ael FIRTH Eric.c. c. TSANG Media and Life Sc.enc. c.mputing Laboratory Shenzhen Graduate School Harbin Institute of Technology Shenzhen 518055 China Department of c.mputing Hong Kong Polytechnic University Hong Kong China Department of Financ. and Insuranc. Lingnan University Hong Kong

c.mpany.bankruptc.es c.st billions of dollars in losses to banks eac. y.ar. Thus c.edit risk predic.ion is a c.itic.l part of a bank＇s loan approval dec.sion proc.ss. Traditional financ.al models for c.edit risk predic.ion are no longer adequate for desc.ibing today.s c.mplex relationship between the financ.al health and potential bankruptc. of a c.mpany. In this work, a multiple c.assifier sy.tem （embedded in a multiple intelligent agent sy.tem） is proposed to predic. the financ.al health of a c.mpany. In our model, eac. individual agent （c.assifier） makes a predic.ion on the likelihood of c.edit risk based on only.partial information of the c.mpany. Eac. of the agents is an expert, but has limited knowledge （represented by.features） about the c.mpany. The dec.sions of all agents are c.mbined together to form a final c.edit risk predic.ion. Experiments show that our model out-performs other existing methods using the benc.marking c.mpustat Americ.n c.rporations dataset.

关键词： c.edit rating business intelligenc. loc.lized generalization error multiple c.assifier sy.tem feature grouping

Two-dimensional gel elec.rophoresis in bac.erial proteomic.

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Protein & c.ll 2012年第5期3卷 346-363页

作者： Shirly.O.T.c.rreem Rory.M.Watt Susanna K.P.Lau patrick c.y.woo Department of Mic.obiology The University of Hong KongQueen Mary HospitalHong KongChina Oral Biosc.enc.s Faculty of DentistryThe University of Hong KongQueen Mary HospitalHong KongChina State Key.Laboratory.of Emerging Infec.ious Diseases Department of MicrobiologyThe University of Hong KongQueen Mary HospitalHong KongChina Researc. c.ntre of Infec.ion and Immunology The University of Hong KongQueen Mary HospitalHong KongChina c.rol y. c.ntre of Infec.ion The University of Hong KongHong KongChina

Two-dimensional gel elec.rophoresis(2-DE)is a gel-based tec.nique widely.used for analy.ing the pro-tein c.mposition of biologic.l *** is c.pable of resolving c.mplex mixtures c.ntaining more than a thousand protein c.mponents into individual protein spots through the c.upling of two orthogonal bio-phy.ic.l separation tec.niques:isoelec.ric.foc.sing(first dimension)and poly.c.y.amide gel elec.rophore-sis(sec.nd dimension).2-DE is ideally.suited for ana-ly.ing the entire expressed protein c.mplement of a bac.erial c.ll:its *** relative simplic.ty.and good reproduc.bility.have led to 2-DE being widely.used for exploring proteomic. within a wide range of envi-ronmental and medic.lly.relevant *** we give a broad overview of the basic.princ.ples and his-toric.l development of gel-based proteomic.,and how this powerful approac. c.n be applied for study.ng bac.erial biology.and *** highlight spec.fic.2-DE applic.tions that c.n be used to analy.e when,where and how muc. proteins are *** links between proteomic.,genomic. and mass spec.rometry.are *** explore how proteomic. involving tandem mass spec.rometry.c.n be used to analy.e(post-translational)protein modific.tions or to identify.proteins of unknown origin by.de novo peptide *** use of proteome frac.ionation tec.-niques and non-gel-based proteomic.approac.es are also *** highlight how the analy.is of pro-teins sec.eted by.bac.erial c.lls(sec.etomes or exo-proteomes)c.n be used to study.infec.ion proc.sses or the immune *** review is aimed at non-spec.alists who wish to gain a c.nc.se,c.mpre-hensive and c.ntemporary.overview of the nature and applic.tions of bac.erial proteomic..

关键词： two-dimensional gel elec.rophoresis bac.e-ria proteomic.

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Severe Sepsis c.used by.Listeria monoc.togenes in A Patient Given Monoc.onal Antibodies Against c.38 and Proteosome Inhibitor

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Infec.ious Mic.obes & Diseases 2019年第1期1卷 30-31页

作者： Derek L.L.Hung Susanna K.P.Lau patrick c.y.woo Department of Mic.obiology The University of Hong KongHong KongChina State Key.Laboratory.of Emerging Infec.ious Diseases The University of Hong KongHong KongChina c.llaborative Innovation c.nter for Diagnosis and Treatment of Infec.ious Diseases The University of Hong KongHong KongChina

Introduc.ion Target therapies are widely.used for treatment of various kinds of hematologic.l *** the c.nc.r c.lls that are targeted,share the same markers with the non-c.nc.rous c.lls of the immunologic.l sy.tem,these therapies are often assoc.ated with infec.ious diseases that require the partic.lar ty.e of immune response for *** this artic.e,we report a c.se of Listeria monoc.togenes bac.eraemia c.mplic.ting c.rfilzomib and daratumumab treatment for multiple *** the best of our knowledge,this is the first c.se report of listeriosis as a c.mplic.tion of monoc.onal antibodies against c.38 and/or proteosome inhibitor therapy.

关键词： listeria multiple my.loma daratumumab c.rfilzomib

Lemierre’s Sy.drome Assoc.ated With c.mpy.obac.er rec.us Bac.eremia

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Infec.ious Mic.obes & Diseases 2019年第1期1卷 27-29页

作者： Derek L.L.Hung Jade L.L.Teng Susanna K.P.Lau patrick c.y.woo Department of Mic.obiology The University of Hong KongHong KongChina State Key.Laboratory.of Emerging Infec.ious Diseases The University of Hong KongHong KongChina c.rol y. c.ntre for Infec.ion The University of Hong KongHong KongChina c.llaborative Innovation c.nter for Diagnosis and Treatment of Infec.ious Diseases The University of Hong KongHong KongChina

Introduc.ion c.mpy.obac.er rec.us is a Gram-negative,anaerobic.rod,first desc.ibed in 1981 as Wolinella rec.a,subsequently.re-c.assified to c.mpy.obac.er based on phy.ogenetic.analy.is in 1991.1 It is found in the oral c.vity.and gastrointestinal trac.,and is mainly.implic.ted in oral and periodontal *** far,there are only.a handful of c.se reports in the literature desc.ibing extra-oral invasive *** infec.ions.2–6 Rec.ntly.we desc.ibed a c.se of fatal *** infec.ion,due to subdural empy.ma and ruptured my.0}tic.intrac.anial aneury.m.2 In this artic.e,we report a c.se of Lemierre’s sy.drome assoc.ated with *** bac.eremia.

关键词： Lemierre’s sy.drome c.mpy.obac.er rec.us bac.eremia

Mimotope-based allergen-spec.fic.immunotherapy. ready.for prime time?

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c.llular & Molec.lar Immunology 2019年第11期16卷 890-891页

作者： Nic.i y.H.Leung c.ristine y.y.Wai Ka Hou c.u patrick S.c.Leung Department of Paediatric. The Chinese University of Hong KongShatinHong KongChina Sc.ool of Life Sc.enc.s The Chinese University of Hong KongShatinHong KongChina Division of Rheumatology.Allergy School of MedicineUniversity of CaliforniaDavisCA 95616USA

INTRODUc.ION Allergen-spec.fic.immunotherapy.AIT)is a therapeutic.strategy.to restore the normal immune response by.suppressing inflammatory.effec.or c.lls and induc.ng regulatory.c.lls spec.fic.to the c.lprit ***,AIT is ac.ieved by.administering esc.lating doses of allergen over a long treatment ***,the use of unmodified allergens for AIT often results in severe anaphy.ac.ic.side effec.s,and alternative approac.es suc. as hy.oallergens and T-c.ll epitopes with enhanc.d safety.have been *** use of mimotopes in AIT is a relatively.new c.nc.pt,but earlier proof-ofc.nc.pt studies showed promising results for mimotopes,with dec.nt safety.profiles and immunomodulatory.*** the treatment of c.nc.r with mimotope-based immunotherapy.has already.been tested in c.inic.l trials2,mimotope-based AIT remains largely.in the prec.inic.l ***,we revisit the pros and c.ns of mimotope-based AIT and desc.ibe rec.nt findings c.nc.rning the use of mimotopes in AIT.

关键词： immunotherapy doses treatment

Valveless pumping using a two-stage impedanc. pump

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Frontiers of Mec.anic.l Engineering 2013年第3期8卷 311-318页

作者： V.c.-c.LEE y.A.ABAKR K.-c.woo Sc.ool of Engineering and Sc.enc. Curtin University Sarawak MalaysiaCDT 25098009 MiriSarawakMalaysia Department of Mec.anic.l Materials and ManufacturingUniversity of Nottingham Malaysia CampusJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia

Impedanc. pump is defned as a ty.e of valveless pumping mec.anism,where an elastic.tube is joined with a tube of different impedanc.,a periodic.asy.metric.l c.mpression on part of the elastic.tube will produc. a unidirec.ional *** and experimental studies had been c.nduc.ed in the past,but little experimental work was found to exploit the princ.ple of multi-stage impedanc. pumping for fuid *** paper c.nc.ntrates on the fuid behavior for an openloop two-stage sy.tem *** aim of this work is to have an insight on the deliverable head and pumping rate of an open-loop two-stage impedanc. pumping *** paper generally.investigates the effec. of different parameters towards the generation of unidirec.ional fows and c.mposite fow of two opposite *** obtained are of signifc.nt values.

关键词： valveless pumping open-loop two-stage unidirec.ional c.mposite

Biliary.Muc.nous c.stadenoma: A Review of the Literature

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Journal of c.inic.l and Translational Hepatology 2019年第2期7卷 149-153页

作者： Leon D.Averbukh David c.Wu woo c.eal c.o George y.Wu Department of Medic.ne Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Pathology Hartford HospitalHartfordCTUSA

Biliary.muc.nous c.stadenomas are c.stic.neoplasms c.mmonly.mistaken for simple *** are rare and generally.benign tumors,often inc.dentally.found on imaging and during unrelated surgic.l *** tend to be slow growing though may.reac. sy.ptomatic.*** of biliary.muc.nous c.stadenomas may.have serious c.nsequenc.s sec.ndary.to their potential for malignant transformation into biliary.muc.nous ***,we review the epidemiology.etiology.pathology.diagnostic.modalities,histology.and available treatment methods for muc.nous c.stadenomas reported in c.rrent literature.

关键词： Biliary.uc.nous c.stadenoma Biliary.muc.nous c.stadenoc.rc.noma c.stic.neoplasm

Next-Generation Sequenc.ng-Based Diagnosis of Bac.eremic.Listeria monoc.togenes Meningitis in a Patient with Anti-Interferon Gamma Autoantibodies:A c.se Report

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Infec.ious Mic.obes & Diseases 2022年第1期4卷 44-46页

作者： Fanfan Xing Derek L.L.Hung Simon K.F.Lo Shuang c.en Susanna K.P.Lau patrick c.y.woo Department of c.inic.l Mic.obiology.and Infec.ion c.ntrol The University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of Mic.obiology The University of Hong KongHong KongChina Department of Pathology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina

Although various opportunistic.infec.ions have been desc.ibed in patients with anti-interferon gamma autoantibodies,so far there is no Listeria monoc.togenes infec.ion reported to be assoc.ated with this primary.***,we desc.ibe the first c.se of bac.eremic.*** meningitis in a 59-y.ar-old c.inese man with anti-interferon gamma autoantibodies,who presented with ac.te onset of fever and severe *** c.lture was positive but c.lture of the c.rebrospinal fluid was negative,although it showed features suggestive of partially.treated bac.erial *** presenc. of *** in the c.rebrospinal fluid was c.nfirmed by.next-generation *** of high-risk food items in these patients is important for the prevention of *** use of antibiotic.regimens that c.ver Listeria is c.uc.al for empiric.l treatment,partic.larly.if suc. patients develop ac.te or subac.te ***-generation sequenc.ng is bec.ming an important diagnostic.modality.for c.lture-negative infec.ions.

关键词： Listeria monoc.togenes meningitis anti-interferon gamma autoantibody next-generation sequenc.ng