Next-Generation Sequencing-Based Diagnosis of Bacteremic Listeria monocytogenes Meningitis in a Patient with Anti-Interferon Gamma Autoantibodies:A Case Report

作     者：Fanfan Xing Derek L.L.Hung Simon K.F.Lo Shuang Chen Susanna K.P.Lau Patrick C.Y.Woo Fanfan Xing;Derek L.L.Hung;Simon K.F.Lo;Shuang Chen;Susanna K.P.Lau;Patrick C.Y.Woo

作者机构：Department of Clinical Microbiology and Infection ControlThe University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of MicrobiologyThe University of Hong KongHong KongChina Department of PathologyThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina 

出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)

年 卷 期：2022年第4卷第1期

页      面：44-46页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was partly supported by funding from the seed fund of The University of Hong Kong-Shenzhen Hospital(HKUSZH201901036) 

主　　题：Listeria monocytogenes meningitis anti-interferon gamma autoantibody next-generation sequencing 

摘      要：Although various opportunistic infections have been described in patients with anti-interferon gamma autoantibodies,so far there is no Listeria monocytogenes infection reported to be associated with this primary ***,we describe the first case of bacteremic *** meningitis in a 59-year-old Chinese man with anti-interferon gamma autoantibodies,who presented with acute onset of fever and severe *** culture was positive but culture of the cerebrospinal fluid was negative,although it showed features suggestive of partially treated bacterial *** presence of *** in the cerebrospinal fluid was confirmed by next-generation *** of high-risk food items in these patients is important for the prevention of *** use of antibiotic regimens that cover Listeria is crucial for empirical treatment,particularly if such patients develop acute or subacute ***-generation sequencing is becoming an important diagnostic modality for culture-negative infections.