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Chinese Medical journal 1997年第8期110卷 72-79页

作者： S.y.W.Shiu L.Li j.T.y.wong S.F.Pang Department of Physiology Faculty of Medicine The University of Hong Kong Li Shu Fan Bldg. 5 Sasson Road Hong Kong China Department of Biology Hong Kong University of Science and Technology Kowloon Hong Kong China

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关键词： protein-coupled melatonin Biology and

Population-Based and Personalized Design of Total Knee Replacement Prosthesis for Additive Manufacturing Based on Chinese Anthropometric Data

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Engineering 2021年第3期7卷 386-394页

作者： C.S.Chui K.S.Leung j.Qin D.Shi P.Augat R.M.y.wong S.K.H.Chow X.y.Huang C.y.Chen y.X.Lai P.S.H.yung L.Qin W.H.Cheung Department of Orthcpaedics and Traumatology Faculty of MdicineThe Chinese University of Hong KongHong Kong 999077China Genter for Transiational Medicine Resarch and Development herzhet Institues of Advaned TechnologyChinese Academy of ScenesShenzhen 518055China Department of Orthopedirs and Traumatology Nanjing Drum Tower Hospital The Affiliated HospitalNanjing University Medial SchoolNanjing 210008China Institute for Biomechanics Berufgenos senschaftliche Unfallklinik MurnauMurnanu am Staffelsee 82418Cermany Instinute for Biomechanic Paracelsus Medical University SazburgSatzburg 5020Austria

At present,most total knee replacement(TKR)prostheses on the market are designed according to the sizes of ***,extensive studies have indicated that human anatomies differ among different ethnicities.A number of reports have indicated that Chinese TKR patients do not match with available *** this study,computed tomography(CT)images of 52 knees of Chinese men and women were used for anthropometric *** and geometric measurements were definedand used for correlation *** parameters from the measurement results were *** geometries of knees were measured as coordinates.A deformable three-dimensional(3D)knee modelbased on anatomical coordinates correlating with the identified key parameters was generated.A pros-thesis was then designed according to the analyzed *** matching analysis,bone resectionanalysis,and cadaveric trials were conducted and compared with commercial products to validate theproposed *** femoral component designed by this study resulted in the highest accuracy(rootmean square point-to-surface(RMS PS),(1.08±0.20)mm)and lowest amount of resected bone volume(27412mm^(3))in comparison with two commercial knee *** study suggests a new approachfor population-based patient-specific femoral prosthesis design With a single,easilty acquired dimen-sion-namely,epicondyle width(ECW)-as input,a patient-specific femoral prosthesis can be designed according to the analyzed measured data and manufactured by additive manufacturing(AM)***,the reconstructed femoral condylar surface was compared with the femoral condylar surfacein the original CT scanning data The average RMS PS distance of the reconstructed femoral condylar surface among all data was(1.10±0.18)mm,which is comparable to other statistical shape modeling methods using multiple radiographs as input *** is a need to develop an anthropometric-based knee prosthesis for the Chinese *** on

关键词： Additive manufacturing Population-based design Total knee replacement Knee prosthesis Anthropometric measurement

Ultrastructure of multicellular dwarf males with external gametangium in Oedogonium macrandrium(Oedogoniales,Chlorophyta)

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BIOCELL 2013年第3期37卷 85-90页

作者： Silvana L.D’AMICO patricia I.LEONARDI Eduardo j.CÁCERES Laboratorio de Ficología y Micología Departamento de BiologíaBioquímica y FarmaciaUniversidad Nacional del SurBahía BlancaArgentina CERZOS-CONICET Camino La Carrindanga Km 7Bahía BlancaArgentina

This is the first comprehensive ultrastructural study on dwarf males with external gametangia in the ge in the genus Oedogonium,from androspore germination to the liberation of mature male *** ultrastructure of the process in *** Wittrok is similar to that of Bulbochaete hiloensis(Nordstedt)Tiffany,butwith two remarkable *** ***:(1)instead of a true transverse wall,only condensed mucilage appears between the gametes of each antheridial cell,and (2)the cell wall between the basal cell and the basal most antheridial cell has simple plasmodesmata similar to those present in the transverse walls of vegetative cells,which are absent in ***.

关键词： androspores Chlorophyta dwarf males Oedogoniales Oedogonium macrandrium ultrastructure

Lanthanide mechanoluminescence

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journal of Rare Earths 2018年第1期36卷 1-41页

作者： jean-Claude G.Bünzli Ka-Leung wong Institute of Chemical Sciences and Engineering Swiss Federal Institute of Technology Lausanne (EPFL) CH-1015 Lausanne Switzerland Department of Chemistry Hong Kong Baptist University Kowloon Tong Hong Kong China

Mechanoluminescence （ML） is the emission of light consecutive to a mechanical force or stress imposed to a crystalline material. Many inorganic and organic compounds present this phenomenon that is known for over 400 years. Lanthanide and uranyl salts were among the first substances investigated for this property. Mechanoluminescence, also referred to as triboluminescence, is often considered as being a badly understood phenomenon. In fact it is because of two main reasons. Firstly, a variety of different mechanical stresses, from simple rubbing, to applied pressure, crushing, impact of a weight, ultrasound, laser-generated shock wave, crystallization, dissolution of crystals, or even wind can trigger it. Secondly, ML is very sensitive to the purity and morphology of the sample： in inorganic compounds, generation of traps by doping ＂impurities＂（e.g. lanthanide ions） is responsible for light emission so that the exact composition of the sample has to be known to a very detailed level; for chelates, the crystallization conditions are crucial since they often generate extended networks of weak interactions that are instrumental in triggering ML when they are broken. In fact mechanisms of ML are relatively well known and theories and models often reproduce very well the experiments. Additionally, practical applications are at hand, for example stress, crack, and impact sensors based on SrAI204：Eu11 or Et3NH[Eu（dbm）4] are used to test structures and materials as diverse as road bridges, reinforced concrete elements, pressur- ized containers or airplane wings and to image the propagation of cracks or stress distribution. Military and security applications involve detecting the passage of vehicle or soldiers and producing counter- feiting inks while more joyful applications are luminous balls, wrapping papers and adhesive tapes. Not only bulk materials, but micro- and nanoparticles feature mechanoluminescent properties and single particle manipulation under an AFM allows

关键词： MechanoluminescenceRare earthsStress sensorsPressure sensorsImpact sensors

Single crystal growth, structural and transport properties of bad metal RhSb2

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Chinese Physics B 2020年第3期29卷 1-6页

作者： D S Wu y T Qian Z y Liu W Wu y j Li S H Na y T Shao P Zheng G Li j G Cheng H M Weng j L Luo Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

We have successfully grown an arsenopyrite marcasite type RhSb2 single crystal, and systematically investigated its crystal structure, electrical transport, magnetic susceptibility, heat capacity, and thermodynamic properties. We found that the temperature-dependent resistivity exhibits a bad metal behavior with a board peak around 200 K. The magnetic susceptibility of RhSb2 shows diamagnetism from 300 K to 2 K. The low-temperature specific heat shows a metallic behavior with a quite small electronic specific-heat coefficient. No phase transition is observed in both specific heat and magnetic susceptibility data. The Hall resistivity measurements show that the conduction carriers are dominated by electrons with ne = 8.62 × 10^(18) cm^(-3) at 2 K, and the electron carrier density increases rapidly above 200 K without change sign. Combining with ab-initio band structure calculations, we showed that the unusual peak around 200 K in resistivity is related to the distinct electronic structure of RhSb_2. In addition, a large thermopower S(T) about -140 μV/K is observed around 200 K, which might be useful for future thermoelectric applications.

关键词： single crystal growth ab-initio band calculations susceptibility heat capacity thermodynamic transport properties

Enhanced depth resolution in optical scanning holography using a configurable pupil

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Photonics Research 2014年第2期2卷 64-70页

作者： Haiyan Ou Ting-Chung Poon Kenneth K.y.wong Edmund y.Lam Department of Electrical and Electronic Engineering University of Hong KongPokfulamHong KongChina Institute of Applied Physics University of Electronic Science and Technology of China610054ChengduChina Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVirginia 24061USA

The optical scanning holography(OSH)technique can capture all the three-dimensional volume information of an object in a hologram via a single raster *** digital hologram can then be processed to reconstruct individual sectional images of the *** this paper,we present a scheme to reconstruct sectional images in OSH with enhanced depth resolution,where a spatial light modulator(SLM)is adopted as a configurable point *** switching the SLM between two states,different Fresnel zone plates(FZPs)are generated based on the same optical *** extra information provided by different FZPs,a depth resolution at 0.7μm can be achieved.

关键词： resolution sectional Fresnel

Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content

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eLight 2022年第1期2卷 68-74页

作者： jiawei Shi Mingsheng Li Huajun Tang jiqiang Kang Najia Sharmin Amir Rosenthal Kenneth K.y.wong Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam RoadHong KongChina.2 Department of Electrical EngineeringTechnion–Israel Institute of TechnologyTechnion City32000 HaifaIsrael Advanced Biomedical Instrumentation Centre Hong Kong Science ParkShatinNew TerritoriesHong KongChina

Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively,such as leveraging the vibrational absorption peak of the O-H ***,due to the lack of an efficient laser source,it was challenging to image the water content in the deep tissue with micron-level spatial *** address this problem,we develop a high-power hybrid optical parametrically-oscillating emitter(HOPE)at 1930 nm,at which the vibrational absorption peak of the O-H bond *** maximum pulse energy is over 1.74μj with a pulse repetition rate of 50 kHz and a pulse width of 15 *** employ this laser source in the optical-resolution photoacoustic microscopy(OR-PAM)system to image the water content in the phantom and the biological tissue in *** 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution,deep penetration depth,improved sensitivity,and suppressed artifact signal of the lipid.

关键词： Fiber optical parametric oscillator Thulium-doped fiber laser Photoacoustic microscopy

Dinoflagellates chromosomes as a model for studying plant telomeric nucleosomes

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Dinoflagellates chromosomes as a model for studying plant te...

Alpha-fetoprotein testing for hepatocellular carcinoma may not be helpful in nonalcoholic steatohepatitis

中国植物学会植物细胞生物学2010年学术年会

作者： yan,T.H.K. wong,j.T.y. Division of Life sciences Hong Kong University of Science and TechnologyClearwater BayKowloonHong Kong

Telomeres and telomerases are responsible for the protection and maintenance of chromosome ends in *** little is known about the role of telomeric *** chromosomes are uniquely characterized in having permanently condensed *** ubiquitous condensin complexes are responsible for chromosome condensation in both prokaryotes and *** report here that the dinoflagellate condensing subunit ccSMC2 and ccSMC4 genes,in two separate phylogenetic trees,form closest clade with orthologs from *** studies revealed a low protein(acid-soluble) to DNA ratio in dinoflagellate chromosomes and that there are no nucleosomes in the bulk of dinoflagellate ***,recent Expressed Sequence Tagged(EST) projects reported several core histone orthologs from dinoflagellate *** preliminary immunoblot data confirmed the presence of multimeric histones in isolated chromosomes of *** addition to the absence of nucleosomes in the chromosome bulk,dinoflagellate chromosomes are also devoid of apparent centromeres,consistent with the core histones being required for possible stabilization of *** recent work demonstrated that dinoflagellates have large telomere sizes as observed in higher eukaryotes,with canonical plant telomeric repeats(TTTAGGG). Telomerase activities were demonstrated with standard TRAP assay using primers from plantae-origin. Our immunofluorescent studies confirm that dinoflagellate histone H3 are indeed localized to chromosome *** nuclease protection assay confirms that most genomic DNA are not protected by nucleosomes and protected DNAs react positively to plant telomeric probe in southern blot *** quantity of highly purified dinoflagellate chromosomes and nuclei(over 10 urn in size) can be prepared *** summary,we propose dinoflagellates chromosomes as a model for studying plant telomeric *** present work was partly

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Open journal of Gastroenterology 2013年第1期3卷 49-54页

作者： Linda L. wong Christopher j. Kim Sandi A. Kwee Brenda y. Hernandez Department of Medicine University of Hawaii John A. Burns School of Medicine Honolulu USA Department of Surgery University of Hawaii John A. Burns School of Medicine Honolulu USA University of Hawaii Cancer Center Honolulu USA

Background & Objectives: Diagnosing hepatocellular carcinoma (HCC) often utilizes serum tumor markers. Although the most commonly used tumor marker in clinical practice, alpha-fetoprotein (AFP) is not included in recent guidelines for diagnosing HCC. The overall performance characteristics of AFP as a tumor marker is viewed as insufficiently sensitive or specific. The diagnostic value of AFP specifically in nonalcoholic steatohepatitis (NASH) related HCC is unknown. We aimed to determine the utility of AFP testing in NASH-related HCC. Methods: Retrospective review of 737 HCC patients referred from 1993- 2011 to a single facility treating the majority of chronic liver disease in Hawaii. HCC was diagnosed histologically by percutaneous biopsy, liver biopsy at the time of surgery, or examination of the resected liver. Patients were classified according to HCC risk factors including NASH, hepatitis B and C infection, and alcohol-related. Other data collected included: demographics, ethnicity, presence of cirrhosis, tumor characteristics (size, number, vascular invasion), diabetes, hyperlipidemia, body mass index (BMI) and blood testing to calculate Model for End-Stage Liver Disease (MELD) score. Elevated AFP was defined as >20 ng/mL. Sensitivity of AFP was determined and compared between various subgroups. Results: Elevated AFP levels were detected in 64.3% of patients. AFP sensitivity was 47% for NASH-related HCC (n = 100), and 67.2% for HCC with viral or alcoholic risk factors (n = 637) (OR 0.43, 95% CI 0.28 - 0.66, p = 0.0001). Elevated AFP had higher sensitivity in females (71.9% vs. 61.8%, OR 1.58, 95% CI 1.1 - 2.27, p = 0.013), non-diabetics (67.4% vs. 57.2%, OR 0.65, 95% CI 0.47 - 0.89, p = 0.0093), and cirrhotics (67.1% vs. 56.8%, OR 1.55, 95% CI 1.10 - 2.19, p = 0.0012).AFP did not vary significantly with regard to hyperlipidemia or BMI. AFP was more sensitive in advanced disease including tumors > 5 cm, multiple tumors, or vascular invasion (all with p < 0.05)

关键词： Hepatocellular Cancer Nonalcoholic Steatohepatitis Alpha-Fetoprotein