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Laser acupuncture combined with auricular acupressure improves low-back pain and quality of life in nurses:A randomized controlled trial

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Journal of Integrative Medicine 2023年第1期21卷 26-33页

作者： Hsueh-Hua Yang Yu-Chu Chung pai-pei szeto Mei-Ling Yeh Jaung-Geng Lin School of Nursing National Taipei University of Nursing and Health SciencesTaipei 11219TaiwanChina Nursing Department En Chu Kong HospitalNew Taipei 23702TaiwanChina Department of Nursing Yuanpei University of Medical TechnologyHsinchu 30015TaiwanChina Cochrane Taiwan Taipei Medical UniversityTaipei 11031TaiwanChina School of Chinese Medicine China Medical UniversityTaichung 40402TaiwanChina

Background Low-back pain(LBP)in nurses is a major health concern that affects their quality of life and ability to work,with consequences for their economic *** This study evaluates the effect of low-level laser acupuncture combined with auricular acupressure(LAA)on pain intensity,pain interference and quality of life in nurses with ***,setting,participants and interventions This randomized controlled trial recruited a convenience sample of hospital-based nurses from one teaching hospital in Taiwan,*** were randomly assigned to the LAA group(n=38)receiving low-level laser acupuncture and auricular acupressure for 4 weeks,and the control group(n=38)receiving only sham laser acupuncture treatment without laser energy *** outcome measures Data were collected for the primary pain outcome using the Short Form of the Brief pain Inventory,while the secondary outcome,quality of life,was evaluated using the Roland-Morris Disability *** primary and secondary outcomes were scored before the intervention,and after 2-week and 4-week *** rate of LBP recurrence was evaluated at the 4th week and 8th week after the end of *** After controlling for prior pain,the result of linear mixed model analysis showed trends in significant between-group differences in the level of current pain occurring in week 4(Ppain in week 2(Ppain in week 2(P=0.032)and week 4(Ppain interference in week 2(P=0.009)and week 4(Ppain intensity and pain interference,and improved quality of life for hospital-based nurses with *** effects were maintained continuously for at least 4

关键词： Acupuncture Acupressure Low-backpain Low-level laser Qualityof life Randomized controlled trial

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Carbon storage potential of avenue trees:a comparison of Barringtonia racemosa,Cyclobalanopsis glauca,and Alnus formosana

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Journal of Forestry Research 2015年第2期26卷 307-314页

作者： Jyh-Shyan Tsay pei-Hsin Ko pai-Tsang Chang Department of Horticultural Science National Chiayi University

Trees in cities play a valuable public health role for they are able to use photosynthesis to absorb atmospheric carbon dioxide（CO2）,which is then stored as tree *** present study compared the potential for carbon storage in the aboveground tree biomass of 3-year-old specimens of Barringtonia racemosa,Cyclobalanopsis glauca,and Alnus formosana grown in Chiayi City,*** of the carbon storage of avenue trees was based on measurement of the photosynthetic rate and leaf area,as well as the biomass of timbers,from October 2008 to *** on photosynthetic rates and leaf area,the estimated carbon stocks of ***,***,and *** are 756,615,and2738 kg Cha-1a-1,*** addition,carbon storage can be estimated based on timber volume,and these results are 1170,720,and 1995 kg Cha-1a-1for ***,***,and ***,*** on these findings,*** has the highest carbon fixation potential of these three *** the photosynthetic rate measurements can provide detailed data on the diurnal changes in carbon stocks,this requires more time and *** contrast,timber volume measurements provide a rapid and convenient way to estimate carbon stocks.

关键词： Carbon dioxide Carbon stock Greenhouse gas Leaf area Timber volume

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Erythromycin Resistance Study by Label-free Quantitative Proteomics Analysis in Methicillin-resistance Staphylococcus aureus

Erythromycin Resistance Study by Label-free Quantitative Pro...

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第十二届全国抗生素学术会议

作者： Xiaofen Liu Yingwei Hu pei-Jing pai Daijie Chen Henry Lam Department of Chemical and Biomolecular Engineering the Hong Kong University of Science and Technology China State Institute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical Industry Division of Biomedical Engineering the Hong Kong University of Science and Technology

Background: Staphylococcus aureusis a virulent pathogen that is commonly found in hospitals and community ***-resistance ***(MRSA),which has developed resistance to almost all kinds of antibiotics,is a pathogen that is responsible for over 50%*** worldwide and the mortality rate of MRSA infection is more than 20%.Due to its multi-drug resistance,it is challenging to control and treat this pathogen with standard antibiotic *** has been considered the last-resort treatment;however,even vancomycin-resistant *** has been reported ***, there is an urgent need to develop new antibiotic drugs or new strategies ***,a label-free quantitative proteomics method has been developed to study the MRSA resistance study to oxacillin in our *** method not only recovered the main resistance mechanism to oxacillin-treated MRSA,but also provided a system-wide view of how MRSA respondto *** this paper,erythromycinresistance mechanism is studied by the same label-free quantitative proteomics method. Methods A sub-lethal dose of erythromycin was applied to MRSA strain ATCC 43300,which is resistance to *** control group was ATCC 43300 cultured without antibiotic *** bacteria were cultured in Muller Hinton brothand grew to OD *** cells were collected and lysed by sonicationin 8 M *** were precipitated by cold *** shotgun proteomics techniques were applied to prepare and analyze the samples on a Thermo Scientific LTQ Velos *** biological replicates were performed for the erythromycin treated and control *** technical replicates were prepared and analyzed for each biological replicate to validate the reproducibility of the sample preparation and the performance of the LC-MS/MS instrument.A customized Staphylococcus aureus protein database was constructed from 23Staphylococcus aureusstrains with complete proteome(redundan

关键词： Erythromycin,Methicillin-resistanceStaphylococcus aureus label-free quantitativeproteomics

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Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(Ⅱ)metallacycle-loaded biomimic melanin dots

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Science China Chemistry 2021年第1期64卷 134-142页

作者： Chonglu Li pei-pei Jia Yu-Ling Xu Feng Ding Wen-Chao Yang Yao Sun Xiao-Peng Li Guang-Qiang Yin Lin Xu Guang-Fu Yang Key Laboratory of Pesticide&Chemical Biology Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal University.Shanghai 200062China Department of Chemistry University of South FloridaTampa 33620USA

Pt(Ⅱ)-based metallacycles,as an important family of supramolecular coordination complexes(SCCs),have exhibited excellent antitumor activity at the cell ***,the biomedical applications of Pt(Ⅱ)-based metallacycles for animal studies are still hindered by their poor stability,non-targeted tumour,and lack of detectable feedback for evaluating therapeutic ***,we propose a strategy that introduces melanin dots as a biomedical platform to load bright-emission Pt(Ⅱ)-based metallacycles,thereby constructing a theranostic agent that enables photoacoustic imaging(pai)-guided chemo-photothermal combinational *** dots act as a protective carrier to preserve the integrity of Pt(Ⅱ)-based metallacycles before uptake by tumour ***,the pai signal from melanin dots furnishes more comprehensive information on the ***,the heat generated after NIR laser irradiation can not only trigger the apoptosis of tumour cells but also promote the deeper penetration of Pt(Ⅱ)-based SCCs into tumour tissue,thus enhancing the efficiency of chemotherapy.

关键词： metallacycles supramolecular coordination complexes chemo-photothermal therapy photoacoustic imaging melanin dots

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Hematopoiesis reconstitution and anti-tumor effectiveness of pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation

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World Journal of Clinical Cases 2022年第14期10卷 4425-4435页

作者： Jiao-Jiao Yuan Ying Lu Jun-Jie Cao Ren-Zhi pei Rui-Lan Gao Department of Hematology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHang Zhou 310006Zhejiang ProvinceChina

BACKGROUND With the rapid development of haploidentical hematopoietic stem cell transplantation(haplo-HSCT),primary poor graft function(PGF)has become a lifethreatening *** therapies for PGF are *** Chinese patent medicine pai-Neng-Da(PND)Capsule exerts dual effect in promoting hematopoiesis recovery and regulating ***,the application of PND capsule in hematopoietic stem cell transplantation,especially in the haplo-HSCT setting,has not yet been *** To evaluate the role of PND capsule in acute leukemia patients with *** We retrospectively collected data of acute leukemia patients who underwent haplo-HSCT at the Affiliated People’s Hospital of Ningbo University between April 1,2015 and June 30,***-nine consecutive patients received oral PND capsule from the sixth day to the first month after haplo-HSCT were included in the PND *** addition,31 patients who did not receive PND capsule during haplo-HSCT were included in the non-PND ***,we compared the therapeutic efficacy according to the western medical evaluation indexes and Chinese medical symptom scores,and the survival between the PND group and the non-PND group,using the chi-square test,Fisher’s exact test,and the Kaplan-Meier *** The duration of platelet engraftment was shorter in the PND group than in the non-PND group(P=0.039).The PND group received a lower frequency of red blood cells and platelet transfusions than the non-PND group(P=0.033 and P=0.035,respectively).In addition,PND capsule marginally reduced the rate of PGF(P=0.027)and relapse(P=0.043).After 33(range,4-106)months of follow-up,the 3-year relapse-free survival(P=0.046)and progression-free survival(P=0.049)were improved in the PND group than in the non-PND ***,the therapeutic efficacy of the PND group according to Chinese medical symptom scores was significantly better than that of the non-PND group(P=0.022).Moreover,the adverse events

关键词： pai-Neng-Da capsule Hematopoiesis reconstitution Anti-tumor Acute leukemia Haploidentical hematopoietic stem cell transplantation Effectiveness

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纳米二氧化钛与葡萄糖亚慢性经口联合暴露对幼年大鼠凝血功能的影响

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环境与职业医学 2020年第5期37卷 503-507,519页

作者：陈章健韩硕郑湃周淑佩贾光北京大学医学部公共卫生学院劳动卫生与环境卫生学系北京100191 北京大学医学部实验动物科学部北京100191

[背景]动物实验结果表明纳米二氧化钛(TiO_2)经口暴露可以影响机体血液系统的凝血功能。TiO_2作为食品添加剂,常用于高糖食物,且由于儿童喜食甜食而成为其高暴露人群。[目的]探讨纳米TiO_2与葡萄糖联合暴露对幼年大鼠凝血功能的影响。[... 详细信息

[背景]动物实验结果表明纳米二氧化钛(TiO_2)经口暴露可以影响机体血液系统的凝血功能。TiO_2作为食品添加剂,常用于高糖食物,且由于儿童喜食甜食而成为其高暴露人群。[目的]探讨纳米TiO_2与葡萄糖联合暴露对幼年大鼠凝血功能的影响。[方法 ] 3周龄清洁级SD大鼠80只,适应性喂养一周后,随机分为8组(每组10只,雌雄各半)。采用4×2析因设计方法,大鼠每天灌胃给予0、2、10、50 mg·kg^-1(以体重计)纳米TiO_2,分别加或不加1.8 g·kg^-1(以体重计)葡萄糖。实验期间,大鼠体重每周监测一次。染毒90 d后进行凝血指标检测,包括活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原(FIB)。利用响应面模型和一般线性模型进行交互作用分析。[结果 ]纳米TiO_2与葡萄糖经口暴露对大鼠体重未产生影响。纳米TiO2单独暴露时,仅雌性大鼠在10 mg·kg^-1剂量下APTT[(33.90±2.05)s]高于对照组[(25.88±3.59)s](P <0.05)。纳米TiO2与葡萄糖联合暴露时,雌性大鼠在50 mg·kg^-1剂量下,与对照组相比APTT[(44.10±18.12)s vs (25.88±3.59)s]和PT[(26.40±4.21)s vs (21.38±1.04)s]增加;雄性大鼠在2 mg·kg^-1和10 mg·kg^-1剂量下,与对照组相比,PT[(22.64±1.53)s和(21.68±2.19)s vs (24.96±1.05)s]降低,并在50 mg·kg^-1剂量下,与对照组相比,FIB[(1.47±0.07)g·L^-1 vs (1.76±0.08)g·L^-1]降低(P <0.05)。交互作用分析发现,在雄性大鼠中,纳米TiO_2和葡萄糖在影响APTT和FIB时存在拮抗作用(P <0.05)。[结论]亚慢性纳米TiO_2和葡萄糖联合经口暴露可以对幼年SD大鼠凝血功能产生影响,两者存在拮抗作用。纳米TiO_2和葡萄糖经口联合暴露比纳米TiO_2单独暴露效应更加明显。实际暴露情况下,纳米TiO_2与糖的联合暴露效应需引起关注。

关键词：纳米二氧化钛葡萄糖幼年SD大鼠凝血功能拮抗作用

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纳米二氧化钛与葡萄糖亚慢性联合经口暴露对幼年大鼠血清叶酸和维生素B12水平的影响

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北京大学学报（医学版） 2020年第3期52卷 451-456页

作者：陈章健韩硕郑湃周淑佩贾光北京大学公共卫生学院劳动卫生与环境卫生学系北京100191 北京大学医学部实验动物科学部北京100191

目的:探讨纳米二氧化钛与葡萄糖亚慢性联合暴露对幼年大鼠血清叶酸和维生素B12的影响。方法:对实验所用纳米二氧化钛的粒径、形状、晶型和溶液体系中的团聚程度等物理化学性质进行详细表征。80只4周龄清洁级SD大鼠按体质量随机分为8组(... 详细信息

目的:探讨纳米二氧化钛与葡萄糖亚慢性联合暴露对幼年大鼠血清叶酸和维生素B12的影响。方法:对实验所用纳米二氧化钛的粒径、形状、晶型和溶液体系中的团聚程度等物理化学性质进行详细表征。80只4周龄清洁级SD大鼠按体质量随机分为8组(每组10只,雌雄各半)。每天灌胃给予0、2、10、50 mg/kg纳米二氧化钛,分别加或不加1.8 g/kg葡萄糖。染毒90 d后进行血清叶酸和维生素B12含量检测。结果:纳米二氧化钛晶型为锐钛矿,近球形,平均粒径为(24±5)nm。在雄性幼年大鼠中,与对照组相比,纳米二氧化钛(10 mg/kg)加葡萄糖染毒可导致血清叶酸浓度明显增加,差异具有统计学意义(P<0.05)。在雌性和雄性幼年大鼠中,与单纯葡萄糖(1.8 g/kg)染毒组相比,高剂量纳米二氧化钛(50 mg/kg)加葡萄糖可导致血清叶酸浓度明显降低,差异具有统计学意义(P<0.05)。经过联合作用分析,纳米二氧化钛与葡萄糖联合暴露对雌性幼年SD大鼠血清叶酸浓度的影响存在明显拮抗作用。纳米二氧化钛与葡萄糖联合暴露对幼年SD大鼠血清维生素B12浓度的影响较小,未见明显交互作用。仅发现与单纯葡萄糖(1.8 g/kg)染毒组相比,雄性大鼠低剂量(2 mg/kg)纳米二氧化钛加葡萄糖染毒组血清维生素B12浓度明显上升,差异具有统计学意义(P<0.05)。结论:纳米二氧化钛和葡萄糖亚慢性联合经口暴露可以对幼年SD大鼠血清叶酸浓度产生影响,两者存在拮抗作用。

关键词：叶酸纳米二氧化钛葡萄糖大鼠,Sprague-Dawle 维生素B12

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硬膜外腔吗啡对全髋置换术围手术期D-二聚体的影响

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南方医科大学学报 2006年第4期26卷 523-525页

作者：王刚孙怡罗刚健林派冲刘培庆广东省人民医院麻醉科广东广州510080 中山大学附属第三医院麻醉科广东广州510630 中山大学药学院广东广州510080

目的研究阿片类药物硬膜外腔持续注射对全髋置换手术围术期D-二聚体的影响。方法选择40例择期全髋关节置换手术患者,随机分成两组。吗啡组:手术开始前15 min于硬膜外腔给予吗啡4mg+0．9％生理盐水10ml,术毕硬膜外腔吗啡80μg/h持续给药4... 详细信息

目的研究阿片类药物硬膜外腔持续注射对全髋置换手术围术期D-二聚体的影响。方法选择40例择期全髋关节置换手术患者,随机分成两组。吗啡组:手术开始前15 min于硬膜外腔给予吗啡4mg+0．9％生理盐水10ml,术毕硬膜外腔吗啡80μg/h持续给药48 h;对照组:术前15 min给予0．9％生理盐水10 ml,术毕硬膜外腔给予0．15％罗哌卡因 2．0 ml／h持续给药48 h。分别于麻醉前5 min、术毕、术后24 h、术后48 h4个时点抽取静脉血测定血浆IL-6、D-二聚体含量和凝血酶原时间。结果两组患者术毕、术后24、48 h的IL-6、D-二聚体含量较麻醉前均显著升高(P<0．01),术毕时达到峰值,随后逐渐回落。吗啡组患者术毕、术后24、48 h时间点IL-6、D-二聚体含量均显著低于对照组(P<0．05);硬膜外腔注射吗啡对围手术期凝血酶原时间和出血量均无明显影响。结论硬膜外腔注射吗啡可抑制凝血系统的过度激活,减少D-二聚体的生成,改善围术期高凝状态。

关键词：吗啡硬膜外关节置换炎性细胞因子 D-二聚体

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