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DNAzymes directed to HPV-16 E6/E7 mRNA

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DNAzymes directed to HPV-16 E6/E7 mRNA

Greenlight Photoselective Vaporisation of the Prostate in 133 High Surgical Risk Patients: A 5-Year Outcome Study

24th International Papillomavirus Conference and Clinical Workshop

作者： Alvarez-Salas Luis Reyes-gutierrez pablo Laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav Laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav

＜正＞The World Health Organization（WHO）estimates that 400 million Human Papillomavirus（HPV）cases are reported worldwide per *** is a necessary cause of cervical cancer and is responsible for approximately 510,000 cases *** under- developed regions of the world,it is the most common cause of death from cancer in women,accounting for 80% of the cases reported *** Coherence Tomography（OCT）is an optical imaging technique that uses near infrared light to

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Open Journal of Urology 2013年第2期3卷 90-95页

作者： Ignacio Gómez García Marta Romero Molina Emilio Rubio Hidalgo Luis álvarez Buitrago Natanael García Betancourt Larissa Lara pablo gutierrez Antonio Sampietro Crespo Fernando álvarez Férnandez Antonio Gómez Rodríguez LMR Group Madrid Spain Urology Service Hospital Río Ortega Valladolid Spain Urology Service Hospital Virgen de la Salud Toledo Spain

Greenlight photoselective vaporisation of the prostate (GPVP) is progressively becoming an established treatment in patients with LUTS because it is a minimally invasive technique that achieves efficient haemostasis, making it the ideal technique for patients at high surgical risk. Material and Methods: To study of 133 patients with an ASA surgical risk score of 3 or 4, undergoing GPVP, with an analysis of perioperative outcome, IPSS, Qmax, IIEF-5 and complications during a five-year follow-up. Results: At 5 years the mean annual improvement in IPSS was stable, and at 5 years there was a 15.2 point improvement versus the preoperative score (p 0.05). The Qmax showed an improvement of 14.9 ml/sec and was maintained at five years after surgery (p 0.05). No patients were transfused or suffered urinary incontinence. 2.25% suffered major complications and there were no deaths. 3.1% of patients suffered de novo urgency. In the 5-year follow-up, five patients had to be reoperated. The quality of sexual health assessed by IIEF-5 before the procedure was scored at 14 points;the 5-year follow-up covering the preoperative period and all revisions did not show any worsening in the IIEF-5 score (p > 0.05). Conclusions: Due to its physical characteristics, in our opinion GPVP is now the treatment of choice in patients at high surgical risk. In our series, the risk of major/minor complications and transfusions was much lower than the same risks in conventional techniques. The objective results (Qmax and quality of life questionnaire) are equivalent to conventional techniques and persist over a 5-year follow-up.

关键词： Greenlight Vaporisation PVP High Risk ASA

Meteorological indicators of dengue epidemics in non-endemic Northwest Argentina

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Infectious Disease Modelling 2022年第4期7卷 823-834页

作者： Javier Armando gutierrez Karina Laneri Juan pablo Aparicio Gustavo Javier Sibona Departamento de Física-FCE-Universidad Nacional de Salta SaltaArgentina Grupo de Física Estadística e Interdisciplinaria CONICETCentro Atòmico Bariloche-CNEASan Carlos de BarilocheRío NegroArgentina Instituto de Investigaciones en Energía no Convencional(INENCO)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Salta Av.Bolivia 51004400SaltaArgentina Simon A.Levin Mathematical Computational and Modeling Sciences Center Arizona State UniversityPO Box 871904TempeAZ85287-1904USA IFEG-CONICET and Fa.M.A.F.-Universidad Nacional de Cordoba CordobaArgentina

In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin *** the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller *** pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic *** develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic *** variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological *** mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole *** tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to *** assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic *** found that the number of vectors per host and the effective reproductive number are proxies for large *** proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.

关键词： Mathematical modelling Dengue Outbreak Mosquitoes population

Agronomic assessment of two populations of intermediate wheatgrass—Kernza^(®)(Thinopyrum intermedium)in temperate South America

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Grassland Research 2022年第4期1卷 262-278页

作者： Andres Locatelli Lucia gutierrez Olivier Duchene pablo R.Speranza Valentin D.Picasso Risso Polo agro-alimentario Centro Universitario Litoral NorteEstacion Experimental Mario Antonio CassinoniUniversidad de la RepúblicaPaysanduUruguay Departamento de Producción Vegetal Facultad de AgronomiaUniversidad de la RepúblicaPaysanduUruguay Departamento de Biometría Estadística y ComputaciónFacultad de AgronomíaUniversidad de la RepúblicaMontevideoUruguay Department of Agronomy University of Wisconsin–MadisonMadisonWisconsinUSA Agroecology and Environment Research Unit ISARALyonFrance Departamento de Biología Vegetal Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay Departamento de Producción Animal y Pasturas Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay

Background Kernza®intermediate wheatgrass is a perennial grain and forage crop that can provide several ecosystem *** research efforts focused on Kernza have taken place in high *** goal of this study was to evaluate,for the first time,the agronomic performance of Kernza in a low-latitude region with mild *** A KS-cycle 4 Kernza population(A)was planted in spring in Wisconsin,USA,and selected in one cycle for lower vernalization requirements,obtaining a new population(B).These two populations,at three nitrogen(N)fertilization rates,were evaluated in a full factorial,completely randomized field experiment in Uruguay over 2 *** The populations were similar in grain yields and flowering time in the 1st year,but population B had 63%lower grain yield in the 2nd year and 20%lower forage yield throughout the *** the N rate to 160 kg ha−1 led to a 63%increase in grain yield and 28%increase in forage yield across *** yields and nutritive values were similar to those reported in the northern ***,grain yields for both the 1st(316 kg ha−1)and 2nd year(41 kg ha−1)were lower due to reduced flowering and weed *** Expansion of Kernza to lower-latitude regions will require further breeding to improve reproductive performance.

关键词： low-latitude regions nitrogen fertilization rates perennial grains Thinopyrum intermedium vernalization requirements

Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 135-139页

作者： Roberto Gonzalez-Salinas Maria C Garcia-gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga pablo Garcia-Solis David G Garcia-gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S Biomedical Research Department Autonomous University of QueretaroQueretaro 76170Mexico Retina Department Asociation to Prevent Blindness in MexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness in MexicoMexico City 04030Mexico Retina Department General Hospital of Queretaro(ISSSTE)Queretaro 76000Mexico Universidad La Salle School of Medicine Mexico City 06140Mexico

AIM： To assess if the included vascular endothelial growth factor （VEGF） polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus （T2DM）. METHODS： A case-control study was conducted in adult individuals with T2DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study （ETDRS） standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by qPCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype ***： In total 142 individuals were enrolled, 71 individuals with T2DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher’s exact test was performed for rs3025021 [OR （95% CI）=0.44（0.08-2.2）; P=0.25] and rs2010963 [OR （95% CI）=0.63（0.25-1.6）; P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows： rs3025021 vs rs3025035： D’=1.0, r2=0.1043, P≤0.0001; rs3025021 vs rs2010963： D’=0.442, r2=0.0446, P=0.149; rs3025035 vs rs2010963： D’=0.505, r2=0.0214, P=***： This is the first analysis involving VEGF polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that differ

关键词： vascular endothelial growth factor polymor-phism proliferative diabetic retinopathy non-proliferative diabetic retinopathy rs3025021 rs3025035 rs2010963

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Cardiac tamponade as a rare complication after giant coronary fistula percutaneous closure

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World Journal of Cardiovascular Diseases 2013年第2期3卷 215-217页

作者： pablo Diez Villanueva Fernando Sarnago Cebada Enrique gutierrez Ibanes Ricardo Sanz-Ruiz Jaime Elizaga-Corrales Francisco Fernandez-Aviles Cardiology Department Hospital General Universitario Gregorio MaranonMadridSpain

We present the case of an unusual complication after percutaneous closure of a giant coronary artery fis-tula. A 76-year-old man with previous admissions due to right heart failure and previous history of atrial fibrillation under acenocumarol, was admitted to our hospital for new onset of symptoms, characterized by progressive dyspnoea and peripheral edema. Physical examination revealed signs of congestive heart failure and a continuous murmur loudest along the lower sternal border. X-Ray showed cardiomegaly due to right chambers dilatation. Transthoracic echocardiography showed right chambers pressure and volume overload, with right ventricular enlargement and dysfunction, tricuspid annulus dilatation and severe tricuspid regurgitation. Cardiac catheterization showed significant elevation of right atrial pressure, as well as significant step-up of oxygen saturation in this chamber. Coronary angiography revealed the presence of a large fistula between the circumflex coronary artery (CCA) and coronary sinus (CS), with severe dilation of the CCA (maximum diameter20 mm). An Amplatzer? PDA was implanted in a distal elbow of the fistula with initailly good results. Anticoagulant therapy was then reinitiated, and a few days later, the patient developed clinical worsening of heart failure and dyspnoea. Echocardiogram showed significant pericardial effusion. Pleuropericardial window was then made draining a500 cm3 of bloody pericardial effusion. The postoperative outcome was excellent, with symptomatic relief and no signs of heart failure.

关键词： Giant Coronary Fistula Circumflex Coronary Artery Coronary Sinus Percutaneous Transcatheter Closure Pericardial Effusion Cardiac Tamponade

Differential effect of biotin on carboxylase activity and mice skeletal muscle metabolism

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Advances in Bioscience and Biotechnology 2013年第7期4卷 43-50页

作者： Marco Antonio Parra Montes de Oca Gabriel gutierrez-Ospina pablo Hofmann Salcedo Alma Lilia Fuentes-Farias Esperanza Melendez-Herrera Margarita Gomez-Chavarin Armida Baez-Saldana Departamento de Biologia Celular y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoCiudad UniversitariaD.F.Mexico Laboratorio de Eco-fisiologia Animal Instituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico

In mammalian skeletal muscle there are four carboxylases involved in several biochemical processes like gluconeogenesis, tricarboxylic acid cycle anaplerosis, metabolism of fatty acids and metabolism of various amino acids. It has been shown that biotin deficiency reduces body weight at the expense of muscular mass. When necessary, the liver uses skeletal muscle protein to provide glucose and amino acids to organs in need of such compounds. In this paper we analyzed carboxylase specific activities in hind limb skeletal muscle of 3 weeks old BALB/c male mice, at 0, 1, 4, 7, and 14 days of a specific diet with different biotin concentrations. Biotin was used at 0.0, 1.8 or 98.2 mg per kg of food;and was referred to as biotin deficient, sufficient and supplemented, respectively. Water and food supply and consumption by the three groups of mice were the same. Therefore, the observed effects were directly related to biotin ingestion. The body weight of biotin supplemented mice was the same as the body weight of mice in the biotin sufficient group, while biotin deficiency caused body weight reduction after 7 days of biotin depletion. We found that the total protein concentration in the vastus lateralis muscle is associated with the biotin content in the diet. After 7 days, the muscle total protein content was lower in mice of the biotin deficient group while it was higher in the mice from the biotin supplemented group

关键词： Biotin Deficiency Biotin Supplementation Biotin Sufficiency Skeletal Muscle Carboxylases Body Growth

Corrosion in Control Systems Decrease the Lifetime of the Electronic Devices of the Industrial Plants of Mexicali,BC,Mexico

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Open Journal of Air Pollution 2013年第2期2卷 29-35页

作者： Gustavo Lopez Badilla Maria Marcela Acosta Gomez Elizabeth Romero Samaniego Sandra Luz Toledo Perea Rodolfo Thomas Guevara Garduno Carlos Omar gutierrez Marquez Juan pablo Quezada Hinojosa Researcher-Academic Instituto Tecnologico de Mexicali(ITM)MexicaliMexico Researcher-Academic Instituto Tecnologico de Ensenada(ITE)EnsenadaMexico Students of the Electronic Engineering Instituto Tecnologico de Mexicali(ITM)MexicaliMexico

The principal factor to determine the economical value of the products manufactured in the electronics industry is due to the productive yielding. This is important for the cost of the articles fabricated in this type of industrial plants installed in Mexicali city, where around 80% of companies are, and which fabricate electronic devices and systems, or have industrial electronic systems and machines to their manufacturing process. Mexicalicity is located in theBaja CaliforniaStateof the northwest ofMexico, which is a border city with Calexico in theCaliforniaStateof the United States of America (USA). The region located in Mexicali, is a desert area. Geothermal plant is located in this area, which is an important industry and supplies electricity to this city and its valleys and some cities on southwest of United States for daily activities. This company emits hydrogen sulfide (H2S) as a main air pollutant that reacts with oxygen in the atmosphere, generating sulfur oxides (SOX). This chemical is dispersed to the city of Mexicali in which industrial plants are located with electronic control systems, and penetrates to indoor rooms. Those cause the corrosion process. The presence of corrosion leads to the deterioration of electrical connectors, the connections of electronic systems and the decreasing of the lifetime of these control systems. Other air pollutants that are considered as chemical agents which cause damage to materials used in the electronics industry, are the sulfurs and nitrogen oxides (NOX), emitted from the traffic vehicle and some industries. This causes the low productive yielding of electrical and electronic devices and systems used in the companies of this city, and is a major concern to specialized people, managers and owners. To analyze the productive yielding of electronic devices and systems installed in indoor of the electronics industry. For this reason, to know the principal causes of it, a study in three industrial plants, to determine

关键词： Corrosion Electronic Devices Control Systems Industrial Plants