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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto e.muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez pablo Salgado Gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for end-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe.muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety efficiency

Fecal incontinence in men:Causes and clinical and manometric features

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World Journal of Gastroenterology 2014年第24期20卷 7933-7940页

作者： Teresa munoz-Yagüe pablo Solis-munoz Constanza Ciriza de los Rios Francisco muoz-Garrido Jesus Vara Jose Antonio Solis-Herruzo Department of Gastroenterology the University Hospital "12 de Octubre"28041-MadridSpain Institute of Liver Studies King’s College HospitalLondon SE5 9RSUnited Kingdom Pelvic Floor Unit the University Hospital "12 de Octubre"28041-MadridSpain Research Center University Hospital "12 de Octubre"Complutense University28041-MadridSpain

AIM:To determine the causes and characteristics of fecal incontinence in men and to compare these features with those presented by a group of women with the same ***:We analyzed the medical history,clinical and manometric data from 119 men with fecal incontinence studied in our unit and compared these data with those obtained from 645 women studied for the same *** to treatment was evaluated after 6 mo of ***:Fifteen percent of patients studied in our unit for fecal incontinence were *** took longer than women before asking for medical *** surgery was the most common risk factor for men related to fecal *** diarrhea was present in more than 40%of patients in both *** resting and external anal sphincter pressures were more frequent in *** significant differences existed between the sexes regarding rectal sensitivity and recto-anal inhibitory *** 17.8%of men,all presenting soiling,manometric findings did not justify fecal *** to treatment was good in both groups,as 80.4%of patients improved and fecal incontinence disappeared in 13.2%of ***:In our series,it was common that men waited longer in seeking medical help for fecal ***-rectal surgery was the major cause of this *** diarrhea was a predisposing factor in both *** differences between groups were limited to an increased frequency of hypotony of the external anal sphincter in *** incontinence was controllable in most patients.

关键词： Fecal Incontinence Gender Ano-rectal surgery Ano-rectal manometry Treatment Biofeedback

A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field for fixed boundary equilibria

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Plasma Science and Technology 2024年第11期26卷 65-70页

作者： Ricardo FAReNGO pablo L GARCÍA-MARTÍNeZ Hugo e FeRRARI Centro Atómico Bariloche Comisión Nacional de Energía AtómicaBariloche 8400Argentina Instituto Balseiro Universidad Nacional de CuyoBariloche 8400Argentina CONICeT CCT-Patagonia Norte Bariloche 8400Argentina

A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field consistent with a given internal magnetohydrodynamic(MHD) equilibrium and coil geometry is presented. The constrained optimization technique employed allows to fix the exact position of the X-points. The external poloidal flux and field are calculated using Green's functions expressed in terms of elliptic integrals that are calculated using a fast and accurate *** calculation can be limited to the region between the plasma and the device wall. An example for a double null configuration is presented.

关键词： MHD equilibrium Green's functions tokamak

effects of absolute fasting on reproduction and survival of the invasive apple snail Pomacea canaliculata in its native range

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Current Zoology 2016年第4期62卷 369-375页

作者： Nicolas e. TAMBURI pablo R. MARTIN INBIOSUR (UNS-CONICeT) Universidad Nacional del Sur Departamento de Biologla Bioquimica y Farmacia San Juan 670 8000 Bahia Blanca Argentina

A South American freshwater gastropod, the apple snail Pomacea canaliculata, has become a driver of ecosystemic changes in wetlands and an important rice pest after its introduction to various parts of the world, mainly Asia. The objective of this study was to study the effect of an abrupt interruption in food availability in the short term （up to 4 weeks） and long term （up to 8 months） on survival and re- productive activity. The main results indicate that short-term fasting mainly affects the survival of males, but only when they are raised together with females, probably due to a greater mate-searching activity that increases mortality in the individuals with lower reserves. The number of copulating snails or egg-laying females shows an abrupt drop when fasting and a rapid recovery after the food supply is restored. The strategy of discontinuing reproductive activity prioritizes energy conservation for the survival of the females. Interpopulation variation in resistance to starvation was observed in adults, which can be explained to some extent by the food availability that they experienced in their natural environment. No interpopulational differences in survival were seen in hatchlings. The mean maximum values of survival under starvation were 52.6 days in hatchlings and the 3.3% of adults survive over than 200 days, which may be a relevant trait in dispersal and establishment in new habitats.

关键词： GASTROPODA POMACeA canaliculata WeTLANDS STARVATION eNeRGY conservation

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz Gonzalez pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective.mutants identified a methionine synthase(MeTS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of MeTS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

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Neural Regeneration Research 2020年第12期15卷 2207-2216页

作者： Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores muñoz-Mingarro Meugenia González-Rosende encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-Solís Biomedical Sciences Institute Universidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Biomedical Sciences Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacy Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacology Pharmacognosy and BotanyUniversidad Complutense de MadridMadridSpain Department of Pharmaceutical and Health Sciences Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain Department of Chemistry and Biochemistry Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain ICBiBe-Botanical Garden University of ValenciaValenciaSpain

The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may *** of them is age-related macular degeneration,which causes progressive loss of vision due to retina *** of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation *** phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor *** review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and *** study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products.

关键词： age-related macular degeneration bilberry blueberry curcuma carotenoids ginkgo polyphenols saffron vitamins

The immunomodulating effect of bifidobacteria is modified by the anticoagulant acenocoumarol

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Food Bioscience 2023年第2期52卷 1166-1174页

作者： Sabrina e.Assad Melisa Fragomeno Martin Rumbo Jessica Minnaard pablo F.Perez Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos-UNLP-CONICeT CCT La PlataArgentina Catedra de Microbiologia FCEUNLPCalle 47 y 116CP 1900La PlataBs.AsArgentina Instituto de estudios Inmunologicos y Fisiopatologicos-UNLP-CONICeT-CCT La PlataArgentina

Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host *** study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial *** bifidum CIDCA 5310 and *** CIDCA 5317 were grown in MRS broth in anaerobic *** experiments were done in the presence of ***-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,***,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow *** using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by *** decreased phagocytosis of bifidobacteria but intracellular routing was not ***,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 ***,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 *** increased CCL20 expression and it was partially abrogated by strain CIDCA *** of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.

关键词： Bifidobacterium Acenocoumarol THP-1 cells Caco-2 ccl20:luc reporter system Immune response Anticoagulant

Calcium-signaling proteins mediate the plant transcriptomic response during a well-established Xanthomonas campestris *** infection

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Horticulture Research 2019年第1期6卷 422-431页

作者： Maria Tortosa Maria e.Cartea pablo Velasco Pilar Soengas Victor M.Rodriguez Group of Genetics Breeding and Biochemistry of BrassicasMisión Biológica de GaliciaSpanish Council for Scientific Research(CSIC)PO Box 28 E-36080 PontevedraSpain

The plant immune system is divided into two branches;one branch is based on the recognition of pathogenassociated molecular patterns(PAMP-triggered immunity),and the other relies on pathogenic effector detection(effector-triggered immunity).Despite each branch being involved in different complex mechanisms,both lead to transcription reprogramming and,thus,changes in plant *** study the defense mechanisms involved in the Brassica oleracea–Xanthomonas campestris ***(Xcc)interaction,we analyzed the plant transcriptome dynamics at 3 and 12 days postinoculation(dpi)by using massive analysis of 3′-cDNA *** identified more induced than repressed transcripts at both 3 and 12 dpi,although the response was greater at 12 *** in the expression of genes related to the early infection stages were only detected at 12 dpi,suggesting that the timing of triggered defenses is crucial to plant *** analyses in susceptible and resistant plants allowed us to highlight the potential role of two calcium-signaling proteins,CBP60g and SARD1,in the resistance against *** role was subsequently confirmed using Arabidopsis knockout mutants.

关键词： branch immunity campestris

On fixity of arc-transitive graphs

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Science China Mathematics 2021年第12期64卷 2603-2610页

作者： Florian Lehner Primoz Potocnik pablo Spiga Institute of Discrete Mathematics Graz University of TechnologyGraz 8010Austria Faculty of Mathematics and Physics University of LjubljanaLjubljana 1000Slovenia Dipartimento di Matematica Pura e Applicata University of Milano-BicoccaMilano 20126Italy

The relative xity of a pe.mutation group is the maximum proportion of the points xed by a non-trivial element of the group,and the relative xity of a graph is the relative xity of its automorphism group,viewed as a pe.mutation group on the vertex-set of the *** prove in this paper that the relative xity of connected 2-arc-transitive graphs of a xed valence tends to 0 as the number of vertices grows to in *** prove the same result for the class of arc-transitive graphs of a xed prime valence,and more generally,for any class of arc-transitive locally-L graphs,where L is a xed quasiprimitive graph-restrictive pe.mutation group.

关键词： pe.mutation group xity minimal degree graph automorphism group vertex-transitive arc-transitive xed points

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