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Controllable highly regular triangulation

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Science China(Information Sciences) 2011年第6期54卷 1172-1183页

作者： huaNG Jin, ZHANG MuYang, pei WenJie, hua wei & BAO HuJun CAD&CG State Key Lab of Zhejiang University, Hangzhou 310058, China 1. CAD&CG State Key Lab of Zhejiang University Hangzhou 310058 China

This paper presents a novel algorithm for generating a highly regular triangle mesh under various user requirements. Three scalar fields are first computed on the input mesh. Then, the intersections of their isocontours with one another are used to construct the highly regular mesh result. The proposed algorithm uses the N-symmetry direction field to guide the edge orientation. Size control is achieved by using a density function on the surface. All user requirements are incorporated into an energy optimization framework of the scalar fields, and then the isocontours of the generated scalar fields are used to construct a high quality result that satisfies all requirements. The experimental results show that the proposed method can successfully handle various user requirements and complex shapes.

关键词： surface remeshing triangulation semi-regular mesh highly regular mesh N-symmetry direction field

A novel linear microprobe array for the fabrication of neural microelectrodes

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Science China(Technological Sciences) 2015年第2期58卷 346-351页

作者： ZHAO Shan Shan pei wei hua ZHAO Hui WANG Yi Jun CHEN San Yuan CHEN Yuan Fang ZHANG He GUO Dong Mei GUI Qiang CHEN Hong Da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Institute for Neural Computation University of California San Diego

A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from *** LMPA leverages the properties of conventional microwire with additional features of naturally formed regular *** the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the *** fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo *** SNR of the spikes recorded was 6.

关键词： LMPA regular spacing cleavage fracture V-groove

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植入式多通道神经微电极的发展

分析化学 2019年第10期47卷 1455-1465页

作者：魏春蓉裴为华中国科学院半导体研究所集成光电子学国家重点联合实验室中国科学院大学

人类的大脑约由800亿神经细胞构成,这些神经元之间的连接将大脑组成了一个超复杂的神经网络,要研究大脑的功能机制,破译其神经网络的信息编码原理,一个重要的方法是在大脑神经元网络中,同时观察、记录尽可能多的单个神经元活动信号。植... 详细信息

人类的大脑约由800亿神经细胞构成,这些神经元之间的连接将大脑组成了一个超复杂的神经网络,要研究大脑的功能机制,破译其神经网络的信息编码原理,一个重要的方法是在大脑神经元网络中,同时观察、记录尽可能多的单个神经元活动信号。植入式多通道神经微电极作为一种可实时记录多个神经元峰电位信号的器件,在神经信号的时间分辨率和设备的便捷性方面有着其它神经成像技术不可替代的优点。在不影响大脑功能甚至动物行为的前提下,为了在大脑中植入通道数更多的电极,需要在植入式多通道电极的材料、结构、集成方式和植入及封装方法等方面不断地进行改进创新和优化。本文简要回顾了多通道微电极技术的发展历史,重点介绍了采用微加工技术制备植入式多通道微电极的发展历程和研究现状,对未来的发展趋势进行了展望。

关键词：植入式神经微电极微加工技术微通道电极薄膜电极电极阵列评述

An implantable wireless powered light source

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Optoelectronics Letters 2020年第2期16卷 81-86页

作者： LI Ya-min pei wei-hua TANG Jun WANG Yu-guang YAO Zhao-lin LIU Zhi-duo CHEN Hong-da State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200000China Peking University Hospital of Stomatology Beijing 100083China

A wireless powered small volume light source composed of light emitting diode(LED) array is developed for implantation. According to the volt-ampere characteristics of LED and the load characteristics of coil coupling power supply, the light power and work distance of implant LED-array are optimized by changing the number and series-parallel connection mode of LEDs in receiver. The wireless powered implant can provide 5.4 m W light. The entire implant is seamlessly packaged within parylene, a biocompatible material, coating by chemical vapor depositing. The volume of the implant is 9 mm×4 mm×3 mm, the weight of which is only 0.25 g. The device can work continuously for more than three weeks in 0.9% saline and the prime prototype of the device has been validated by animal implantation.

关键词： wireless light source

Study and Analysis of a Landing Gear Actuating Cylinder Inner-lock

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International Journal of Plant Engineering and Management 2011年第2期16卷 97-103页

作者： AO Wen-wei pei hua-ping CHEN Hong WU Yun-sheng Design-Research Department Jiangxi Hongdu Aviation Industry Co. LtdNanchang 330024 P.R. China

Three kinds of landing gear actuating cylinder inner-locks of an aircrafi ： block ring lock, steel ball lock, finger lock are taken as the study object based on the mechanics, geometry, materials, technology etc and some aircrafi typical inner-lock practical applications. The working principle of the three typical actuating cylinder innerlocks are expounded and the stress and workmanship requirements of the three inner-lock core components are analyzed. The advantages and disadvantages of different kinds are compared and the characteristics and applications of the three inner-locks investigated. The research and analysis results provide valuable information for the actuating cylinder inner-lock of the aircraft landing gear design.

关键词： actuating cylinder inner-lock core components workmanship requirements

An implantable optrode composed of fiber and flexible thin-film electrode

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Optoelectronics Letters 2018年第4期14卷 271-275页

作者： WANG Fei GUO Dong-mei XIE Yu-xing ZHANG Liang pei wei-hua CHEN Hong-da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China University of Chinese Academy of Sciences Beijing 100049 China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200000 China Hebei Vocational College of Rail Transportation Shijiazhuang 050000 China

An implantable optrode composed of fiber and multi-channel flexible thin-film electrode is developed. The flexible recording electrode is made from polyimide and is wrapped around the optical fiber. The front end of the fiber is tapered by wet etching. With the tapered shape, the light can leak from the sidewall of the fiber, and the tapered tip makes it easy to be implanted. The flexible electrode is attached with its recording sites aligning to the tapered part on the fiber. With this method, the fiber acts as an optical waveguide, as well as a support probe for flexible thin-film electrode. This novel device simplifies the fabrication process and decreases the size of the optrode. The device works well in vivo and the optical caused spike can be recorded with signal-to-noise ratio of 6:1.

关键词：光纤维电极植入电影创作制造过程 vivo 多信道

Channel Arrangement for optical communication subsystems with 12 parallel channels

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Optoelectronics Letters 2006年第4期2卷 296-298页

作者： CHEN Xiong-bin JIA Jiu-chun ZHOU Yi TANG Jun pei wei-hua LIU Bo CHEN Hong-da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of sciences Beijing 100083 China

This paper devoted to report the design and the achievement of an optical communication subsystem with 12 parallel channels in one *** system is capable of transmitting 10 Gbps bidirectional date over hundreds of *** can provide error detection and correction by using 8B/10B encoding and Cyclical Redundancy Checking (CRC) encoding when only single-channel *** design scheme has already passed the simulation in *** technique is useful to enhance the capability and the reliability of the very short reach (VSR) transmission systems.

关键词：光学通信子系统并行通道误差检测循环冗余检测

肝细胞生长因子在骨骼肌再生中的作用研究进展

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生理科学进展 2016年第6期47卷 407-412页

作者：郑莉芳陈佩杰肖卫华上海体育学院运动科学学院上海200438

骨骼肌损伤后的修复包括炎症反应期、修复期、组织重塑期三个阶段。而骨骼肌卫星细胞的激活、增殖与分化和骨骼肌伤后的修复有着密切的关系。骨骼肌损伤后,肝细胞生长因子(HGF)可以自分泌、旁分泌或内分泌的形式,调控肌卫星细胞功能,从... 详细信息

骨骼肌损伤后的修复包括炎症反应期、修复期、组织重塑期三个阶段。而骨骼肌卫星细胞的激活、增殖与分化和骨骼肌伤后的修复有着密切的关系。骨骼肌损伤后,肝细胞生长因子(HGF)可以自分泌、旁分泌或内分泌的形式,调控肌卫星细胞功能,从而影响损伤骨骼肌的再生。其机制研究表明,HGF可能通过与其受体c-met结合,启动相关信号途径,参与骨骼肌卫星细胞激活、增殖、分化和迁移,从而影响骨骼肌再生进程。

关键词：肌卫星细胞肝细胞生长因子骨骼肌再生

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy