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Stress granules: friend or foe in neurodegenerative disorders?

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Neural Regeneration Research 2024年第2期19卷 403-404页

作者： Shanshan Xu Nico p.Dantuma Department of Cell and Molecular Biology(CMB) Karolinska InstitutetSolnavägen 9S-17165 StockholmSweden

Neurodegenerative diseases,such as Alzheimer’s disease,parkinson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded proteins that are sequestered in intraneuronal inclusion *** mutations in disease-associated proteins that render them aggregation-prone,the decline of protein homeostasis(***)with aging is also believed to be a contributing factor to the accumulation of protein aggregates.

关键词： degenerative homeostasis clinical

Unveiling the culprit:the fusobacterium lineage that populates colorectal cancer

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Signal transduction and targeted therapy 2024年第6期9卷 2349-2350页

作者： Johannes Betge Matthias p.Ebert Department of Medicine Ⅱ Medical Faculty MannheimHeidelberg UniversityMannheimGermany Junior Clinical Cooperation Unit translational Gastrointestinal Oncology and preclinical Models German Cancer Research Center(DKFZ)HeidelbergGermany DKFZ Hector Cancer Institute at University Medical Center MannheimGermany MMpU Microbiota Drug Metabolism and Cancer therapy European Molecular Biology LaboratoryHeidelbergGermany

In a recent study published in Nature,Zepeda-Rivera et al.1 discovered that one distinct clade of Fusobacterium nucleatum animalis(Fna)dominates the colorectal cancer(CRC)tumor *** work unravels a more precise understanding of a major bacterial species associated with CRC progression,thereby establishing a new focus for future studies,which may aid to develop improved microbiome-based diagnostics and treatments(Fig.1).

关键词： colorectal al. cancer

the Radcliffe Wave parameters from Data on Open Star Clusters

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Research in Astronomy and Astrophysics 2024年第3期24卷 106-109页

作者： V.V.Bobylev A.t.Bajkova pulkovo Astronomical Observatory St-Petersburg 196140Russia

A spectral analysis of the vertical positions and velocities of 374 open star clusters(OSCs)was carried *** took these OSCs from the Hunt and Reffert catalog;they have an average age of about 10 million years,and are located on the galactic plane XY in a narrow zone inclined by 25°to the galactic axis *** following estimates of the parameters of the Radcliffe wave were obtained:(a)the maximum value in periodic perturbations of vertical coordinates Z_(max)=92±10pc with the wavelength of these perturbations λ_(z)=4.82±0.09 kpc;(b)the maximum value of the velocity of vertical disturbances Wmax=4.36±0.12km s^(-1) with disturbance wavelengthλ_(W)=1.78±0.02 *** that the results of the vertical velocity analysis are first-class in accuracy and completely new.

关键词： (Galaxy) local interstellar matter-Galaxy structure-(Galaxy) solar neighborhood

Voids size distribution in gelled waxy crude oil under dynamic and static cooling

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petroleum Research 2024年第1期9卷 109-114页

作者： Girma t.Chala Shaharin A.Sulaiman Department of Mechanical Engineering(Well Engineering) International College of Engineering and ManagementP.O.Box 2511C.P.O Seeb 111MuscatOman Department of Mechanical Engineering Universiti Teknologi PETRONASBandar Seri Iskandar37500TronohPerakMalaysia

Waxy crude oil is known for its high wax contents that can potentially result in gelling following sufficient cooling of the transportation line in the subsea bed at offshore *** gelling over the entire lines requires an accurately predicted restart pressure to restart the clogged and idle ***,the common way of predicting the restart pressure has been reported to result in over-designed and predicted piping *** research findings evidenced the formation of voids which would reduce the restart pressure *** study conducted in this paper is aimed at investigating the voids size distribution in gelled crude oil across and along transportation *** of experiments simulating crude oil transportation during both static and dynamic cooling were *** gelled crude oil below the pour point temperature was then scanned using a Magnetic Resonance Imaging(MRI)system to detect the voids *** resulting voids at each scanning cross-section were quantified,and their distributions were *** was observed that dynamic cooling had minimal impacts on the voids size difference along the pipeline with the difference in voids areas within 10 mm^(2) to be twice and uniform for the entire flow rates ***,voids size in statically cooled waxy crude oil was found to be highly distributed with a maximum of 6 voids size distribution in 10 mm2 *** low-end temperature had the highest size difference while the difference was decreasing with higher end *** study shows that the voids amount in dynamically cooled waxy crude oil could also be estimated with lower numbers of cross-sectional voids ***,the higher cross-sectional voids detection is recommended while estimating voids in statically cooled waxy crude oil.

关键词： Gelled crude oil Voids size distribution Dynamic cooling Static cooling

海上丝路与中国天文历法在日本的传播及影响研究

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自然辩证法通讯 2024年第4期46卷 57-65页

作者：萨日娜上海交通大学科学史与科学文化研究院上海200240

经过海上丝路有大量汉文科学典籍传入日本并产生了重要的影响,天文历法知识是其中重要的一个方面。文中通过史料调查和实证考察,探索了魏晋南北朝时期,中国天文知识传日背景;研究隋唐时期,随着海上丝路的发展,日本留学生(僧)把中国天文... 详细信息

经过海上丝路有大量汉文科学典籍传入日本并产生了重要的影响,天文历法知识是其中重要的一个方面。文中通过史料调查和实证考察,探索了魏晋南北朝时期,中国天文知识传日背景;研究隋唐时期,随着海上丝路的发展,日本留学生(僧)把中国天文知识传至日本的详情,尤其考察了唐历《宣明历》在日本使用八百多年之久的缘由;继而分析了宋元明时期,中国传统天文历法持续传日,并对其传统学术建构产生的深远影响。结论认为研究中日传统天文历法的关联性,不仅有助于认识海上丝路文明对日本传统科技的影响,对提升中华传统文化的国际传播力和影响力也有一定的借鉴意义。

关键词：海上丝路天文历法传统科技中日交流

Impacts of multiple demand-side management strategies on microgrids planning:a literature survey

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Clean Energy 2024年第1期8卷 36-54页

作者： Rasha Elazab Ahmed t.Abdelnaby A.A.Ali Electrical power and Machines Department Faculty of Engineering at Helwan UniversityCairoEgypt

Demand-side management(DSM)schemes play a crucial role in managing renewable energy generation and load fluctuations by uti-lizing demand-response programmes(DRps).this paper aims to provide a detailed overview of DRps that help microgrid operators to keep costs and reliability within acceptable ***,this review paper provides a detailed economic load model for DRps based on initial load,demand-response(DR)incentive,DR penalty and elasticity *** article also aims to guide researchers in identifying research gaps in DSM applications in microgrids by comparing various DSM schemes from different countries and regions in terms of DSM strategies,objective functions and optimization ***,this study analyses the impact of DRps on microgrid configuration from the perspective of utilities and customers,considering technical and economic performance *** a result,it can be concluded that none of the studied cases provides models or guidelines for choosing appropriate DSM schemes that consider different consumer interests or load-type ***,a few researchers have addressed the features of a modern price-based DR strategy,renewable generation-based dynamic pricing DR,which offers higher customer satisfaction than traditional DRps.

关键词： demand-side management optimal sizing demand-response strategies renewable generation-based dynamic pricing

proteins as nanomagnets and magnetoreceptors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.J.Hore Department of Chemistry University of OxfordUK

It is an appealing notion that a protein molecule could act as a nanomagnet.A genetically encodable biomolecule with a permanent magnetic moment at room temperature could have a range of applications:a magnetogenetic actuator,a magnetic tag for purifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name just a few.A magnetic protein could perhaps also function as the sensor in the magnetic compass that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such possibilities may be,how realistic are they?

关键词： magnetic magnets enable

Why and how to use the SeqCode

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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whitman Maria Chuvochina Brian p.Hedlund Konstantinos t.Konstantinidis Marike palmer Luis M.Rodriguez-R lain Sutcliffe Fengping Wang Deparment of Microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemistry and Molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia University of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environmental Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Department of Microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Department of Microbiology and Digital Science Center(DiSC) University of InnsbruckInnsbruckAustria Faculty of Health&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanography International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

the SeqCode,formally called the Code of Nomenclature of prokaryotes Described from Sequence Data,is a new code of nomenclature in which genome sequences are the nomenclatural types for the names of prokaryotic *** similar to the International Code of Nomenclature of prokaryotes(ICNp)in structure and rules of priority,it does not require the deposition of type strains in international culture ***,it allows for the formation of permanent names for uncultured prokaryotes whose nearly complete genome sequences have been obtained directly from environmental DNA as well as other prokaryotes that cannot be deposited in culture *** the diversity of uncultured prokaryotes greatly exceeds that of readily culturable prokaryotes,the SeqCode is the only code suitable for naming the majority of prokaryotic *** start date of the SeqCode was January 1,2022,and the online Registry(https://***)was created to ensure valid publication of *** SeqCode recognizes all names validly published under the ICNp before *** that date,names validly published under the SeqCode compete with ICNp names for *** a result,species can have only one name,either from the SeqCode or ICNp,enabling effective communication and the creation of unified taxonomies of uncultured and cultured *** SeqCode is administered by the SeqCode Committee,which is comprised of the SeqCode Community and elected administrative *** with an interest in the systematics of prokaryotes is encouraged to join the SeqCode Community and participate in the development of this resource.

关键词： genome sequences metagenome-assembled genomes nomenclature SeqCode

Non-participation of asymptomatic candidates in screening protocols reduces early diagnosis and worsens prognosis of colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3198-3200页

作者： Sergio pérez-Holanda Office of Regional Viceministry of Health Regional Viceministry of HealthOviedo 33005AsturiasSpain

the Agatsuma et al’s study shows that despite the evidence of the benefits of an early colorectal cancer(CRC)diagnosis,through screening in asymptomatic subjects,up to 50%of candidates reject this option and many of those affected are diagnosed later,in advanced *** efficacy of screening programs has been well-established for several years,which reduces the risk of CRC morbidity and mortality,without taking into account the test used for screening,or other ***,a significant proportion of patients remain unscreened,so understanding the factors involved,as well as the barriers of the population to adherence is the first step to possibly modify the participation *** barriers could include a full range of social and political aspects,especially the type of financial provision of each health *** Japan,health services are universal,and this advantageous situation makes it easier for citizens to access to these services,contributing to the detection of various diseases,including ***,the symptomatic CRC group had a lower early-stage diagnosis rate than the patients detected during follow-up for other comorbidities,and symptomatic and cancer screening groups showed similar early-stage diagnosis.

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis