Stress granules: friend or foe in neurodegenerative disorders?

作     者：Shanshan Xu Nico P.Dantuma Shanshan Xu;Nico P.Dantuma

作者机构：Department of Cell and Molecular Biology(CMB)Karolinska InstitutetSolnavägen 9S-17165 StockholmSweden 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第2期

页      面：403-404页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Swedish Research Council (2016-02479) the Swedish Cancer Society (CAN 2018/693) Joint Programme Neurodegenerative Diseases (JPND) (Cure ALS, 2015-06794, PP-829-050) supported by a scholarship from Chinese Scholarship Council (CSC) 

主　　题：degenerative homeostasis clinical 

摘      要：Neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded proteins that are sequestered in intraneuronal inclusion *** mutations in disease-associated proteins that render them aggregation-prone,the decline of protein homeostasis(***)with aging is also believed to be a contributing factor to the accumulation of protein aggregates.