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American Journal of Operations Research 2024年第2期14卷 87-103页

作者： Tanzim S. Shaikh Santosh p. Gite Department of Statistics University of Mumbai Mumbai India

The objective is to develop a model considering demand dependent on selling price and deterioration occurs after a certain period of time, which follows two-parameter Weibull distribution. Shortages are allowed and fully backlogged. Fuzzy optimal solution is obtained by considering hexagonal fuzzy numbers and for defuzzification Graded Mean Integration Representation Method. A numerical example is provided for the illustration of crisp and fuzzy, both models. To observe the effect of changes in parameters, sensitivity analysis is carried out.

关键词： Deterioration Selling price Dependent Demand Fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Representation Method

Epigenetic interventions for brain rejuvenation：anchoring age-related transposons

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Neural Regeneration Research 2018年第4期13卷 635-636页

作者： Adonis Sfera Lisa Fayard Carolina Osorio Amy price Department of psychiatry Patton State HospitalPattonCAUSA Department of psychiatry Loma Linda UniversityLoma LindaCAUSA Evidence-Based Medicine University of OxfordOxfordUK

Highlights：*** and homocysteine accumulation in aging neurons alter genomic *** altered methylome reactivates neuronal cell cycle,enabling transposable element *** R29/p53 axis restores age-related methylation shifts... 详细信息

关键词： Epigenetic interventions for brain rejuvenation:anchoring age-related transposons pUFAs DNA Figure TE cycle

Lessons learned from the Youngstown, Ohio induced earthquake sequence from January 2011 to January 2012

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 783-796页

作者： A.p.Morris D.A.Ferrill G.R.Walter A.M.price K.J.Smart R.J.Skoumal M.R.Brudzinski B.S.Currie Southwest Research Institute Culebra Road 6220 San Antonio TX 78238-5166 USA United States Geological Survey Earthquake Science Center 345 Middlefield Rd Building 3A RM 113 Menlo Park CA 94025 USA Department of Geology and Environmental Earth Science Miami University Oxford OH 45056 USA

The Youngstown earthquake sequence of 2011 is one of the clearest examples of inadvertently induced seismicity for which detailed documentation is *** this paper,we investigate(i) likely stress states in the vicinity of the injection well,(ii) a range of likely permeability scenarios,and(iii) relatively simple methods by which induced seismicity can be evaluated and *** use relocated hypocenters from the seismic sequence to construct a basement fault structure,which is then used to serve as a reference surface within the basement,and on which we calculate the effects of pore pressure changes induced by the injection activities of the Northstar #1 injection *** also deduce an in situ(preinjection) strike-slip stress regime,where ρ2≈ρ3,and it is consistent with both recent earthquake data and published stress estimates for the *** the reactivation characteristics of the basement are known or assumed,a critical or threshold slip tendency can be determined and the basement faults can be analyzed for the likelihood of reactivation in a perturbed pore pressure *** of well injection pressures and simulated pore pressure perturbations within the basement below the injection well indicates that permeability anisotropy is necessary to generate sufficient pore pressure perturbation to induce fault *** of the well’s injection history show that our estimate of in situ stress state,coupled with a highly anisotropic permeability structure,can generate sufficient pore pressure perturbation on the inferred basement structure to cause reactivation,potentially slipping an area of approximately 4×10~5 m~2.

关键词： Induced seismicity Wastewater injection Slip tendency

The dependences of osteocyte network on bone compartment, age, and disease

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Bone Research 2015年第2期3卷 72-82页

作者： Xiaohan Lai Christopher price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang Department of Mechanical Engineering University of Delaware Biomedical Engineering program University of Delaware DBI Bioimaging Center University of Delaware Department of physical Therapy Indiana University Department of Biological Sciences University of Delaware

Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system （LCS） buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compa~ tments, at different ages, and in two disease conditions with altered mechanosensing （perlecan deficiency and diabetes）. LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae （similar to the ＂nodes＂ in a computer network）, and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi （similar to the ＂bandwidth＂ of individual links in a computer network）. Age, in the range of our study （15-32 weeks）, affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation.

关键词： The dependences of osteocyte network on bone compartment age and disease bone

Bisphosphonate rescue post-traumatic osteoarthritis by promoting the calcium signaling in chondrocytes

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医用生物力学 2013年第S1期28卷 56-60页

作者： Yilu Zhou Wen Li Liyun Wang Christopher price X.Lucas Lu Department of Mechanical Engineering University of Delaware

Introduction post-traumatic osteoarthritis(pTOA)is a long-term adverse consequence of joint trauma,e.g.,meniscus or ligament tears,which are among the most common injuries for young adults with excessive physical activities,such as athletes and military ***,few preventive treatments exist for pTOA,with typical outcomes being gradual cartilage degeneration and eventual loss of joint *** and altered etabolism of chondrocytes,the sole cell type in cartilage,may be responsible for the development of pTOA in a subset of patients without traumatic cartilage destruction but with persistent altered joint loading post-trauma,which is the focus of this study.

关键词： traumatic cartilage ligament altered degeneration Apoptosis military destruction consequence medial

Sex-specific sterility caused by extreme temperatures is likely to create cryptic changes to the operational sex ratio in Drosophila virilis

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Current Zoology 2021年第3期67卷 341-343页

作者： Benjamin S.Walsh Natasha L.M.Manimion Tom A.R.price Steven R.parratt Institute of Integrative Biology University of LiverpoolCrown StreetLiverpoolL697ZBUK

Climate change is increasing the frequency and severity of short-term heat shocks that threaten the persistence of natural ***,most work addressing the evolutionary consequences of anthropogenic environmental change has focused on natural selection,with less attention paid to the impacts on sexual *** conditions under which sexual selection operates is a topic of debate,but a generally observed pattern is that the oper-ational sex ratio(OSR)of a population is key to determining both the extent of competition for fertilizations and the scope for mate choice(Weir et al.2011)

关键词： climate change reproduction sexual selection fertility

The Global Boundary Stratotype Section and point （GSSp） for the base of the pliensbachian Stage （Lower Jurassic）, Wine Haven, Yorkshire, UK

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Episodes 2006年第2期29卷 93-106页

作者： Christian Meister Martin Aberhan Joachim Blau Jean-Louis Dommergues Susanne Feist-Burkhardt Ernie A. Hailwood Malcom Hart Stephen p. Hesselbos Mark W. Hounslow Mark Hylton Nicol Morton Kevin page Greg D. price Département de Géologie et de paléontologie 1 route de Malagnou c.p. 6434 CH-1211 Genève 6 Switzerland Museum der Naturkunde Zentralinstitut der Humboldt-Universitat zu Berlin Institut für Palaiontolgie Invalidenstr. 43 D-10115 Berlin Germany Institut für Geowissenschaften Diezstrasse 15 D-35390 Giessen Germany Centre des Sciences de la Terre de I＇Université de Bourgogne UMR CNRS 5561： Paléontologie analytique et Géologie sédimentaire 6 Boulevard Gabriel F-21100 Dijon. France Department of palaeontology The Natural History Museum Cromwell Road London SW7 5BD UK Core Magnetics The Green Sedbergh Cumbria LA10 5JS UK Department of Geological Sciences University of Plymouth Drake Circus Plymouth Devon PL4 8AA UK Department of Earth Sciences University of Oxford Parks Road Oxford OXI 3PR UK CEMp Geography Dept. Lancaster Environment Centre Lancaster University Bailrigg Lancaster UK. LA1 4YB Le Chardon Quarrier Brugière F-07200 Vogüé France

Following votes by the pliensbachian Working Group, the Jurassic Subcommission and the International Commission on Stratigraphy, lUGS ratified the proposed Global Boundary Stratotype Section and point （GSSp） for the base of the pliensbachian Stage （Lower Jurassic） at the base of bed 73b in the Wine Haven section, Robin Hood＇s Bay, Yorkshire Coast, UK. This level contains the characteristic ammonite association Bifericeras donovani Dommergues and Meister and Apoderoceras sp. Complementary data include： a） Strontium-isotope stratigraphy, based on analysis of belemnites which yield a calcite 87Sr/^86Sr ratio for the boundary level of 0. 707425 and data supporting interpretation of continuous sedimentation; b） Belemnite oxygen-isotope data indicate a significant temperature drop （-5 ℃） across the boundary at this locality; c） A Transgressive Systems Tract （TST） initiated in the Aplanaturn Subzone （uppermost Sinemurian） continues into the Lowermost pliensbachian （Taylori Subzone）; it forms part of a transgressive facies cycle sensu Graciansky et al. （1998）; d） The Upper Sinemurian to lowermost plensbachian at Wine Haven section has a predominantly norreal magnetic polarity, but two discrete reversed polarity magnetozones are present. The first spans much of the latest Sinemurian Aplanatum Subzone. It terminates 〈0.5m below the Sinemurian-pliensbachian boundary and may prove a valuable chronostratigraphic marker The second extends from the latest Oxynotum Subzone probably through to the lower part of the Raricostatum Subzone.

关键词：普连斯巴奇阶侏罗纪 GSSp 全球界线层型剖面点

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ArcGIS地理信息系统教程 1版

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

丛书名：高等学校教材

2012年

作者：（美）Maribeth price

本书以GIS和ArcGIS 10为两条主线，阐述了GIS基本概念及相关理论，编写了循序渐进的教学说明，结合恰当的实际案例应用，系统介绍了ArcGIS 10的概念、功能和用途。

ISBN: (数字)9787121158582

ISBN: (纸本)9787121158582

关键词：地理信息系统应用软件

来源：畅想之星图书光盘版（南... 评论

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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij Wouter N.Leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.plugge Kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.p.van Westen Bob van de Water Leo S.price Dorien j.M.peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands present address:NEXUS personalized Health Technologies ETH ZurichSwitzerland Department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of Medicinal Chemistry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

polycystic kidney disease(pKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative *** signalling rewiring in pKD that drives cyst formation is highly complex and not fully *** a consequence,the effects of drugs are sometimes difficult to *** previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst ***,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved *** identified 81 active molecules that inhibit cyst ***-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in *** an in vivo iKspCre-pkd1^lox,lox mouse model for pKD,celastrol inhibited the growth of renal cysts and maintained kidney function.

关键词： pKD celastrol pyrvinium pamoate high-content screening 3D

Controlling brown locusts with a myco-insecticide

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Controlling brown locusts with a myco-insecticide