Epigenetic interventions for brain rejuvenation：anchoring age-related transposons

作     者：Adonis Sfera Lisa Fayard Carolina Osorio Amy Price 

作者机构：Department of PsychiatryPatton State HospitalPattonCAUSA Department of PsychiatryLoma Linda UniversityLoma LindaCAUSA Evidence-Based MedicineUniversity of OxfordOxfordUK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第4期

页      面：635-636页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Epigenetic interventions for brain rejuvenation:anchoring age-related transposons PUFAs DNA Figure TE cycle 

摘      要：Highlights：*** and homocysteine accumulation in aging neurons alter genomic *** altered methylome reactivates neuronal cell cycle,enabling transposable element *** R29/p53 axis restores age-related methylation shifts,reactivating neuronal *** of mi R-29/p53 axis may preempt neurodegenerative disorders.