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Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Journal of Cancer Therapy 2013年第6期4卷 1085-1090页

作者： ozgur emre Halit Demir Erkan Dogan Ramazan Esen Tugba Gur Canan Demir Edip Gonullu Nedim Turan Mehmet Fatih Ozbay Division of Biochemistry Department of ChemistryScience FacultyYuzuncu Yil UniversityVanTurkey Department of Medical Oncology Medical FacultyYuzuncu Yil UniversityVanTurkey Department of Hematology Medical FacultyYuzuncu Yil UniversityVanTurkey Division of Biochemistry Health FacultyYuzuncu Yil UniversityVanTurkey Department of Biostatics Faculty of MedicineYuzuncu Yil UniversityVanTurkey Department of Anesthesiology and Reanimation Regional Training and Research Hospital of VanVanTurkey Department of Medical Oncology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Internal Medicine Regional Training and Research Hospital of VanVanTurkey

Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

关键词： Colon Cancer Trace Element Heavy Metal Essential Element

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Low Cost Scan Test by Test Correlation Utilization

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Journal of Computer Science & Technology 2007年第5期22卷 681-694页

作者： ozgur Sinanoglu Mathematics and Computer Science Department Kuwait University SafatKuwait

Scan-based testing methodologies remedy the testability problem of sequential circuits; yet they suffer from prolonged test time and excessive test power due to numerous shift operations. The correlation among test data along with the high density of the unspecified bits in test data enables the utilization of the existing test data in the scan chain for the generation of the subsequent test stimulus, thus reducing both test time and test data volume. We propose a pair of scan approaches in this paper; in the first approach, a test stimulus partially consists of the preceding stimulus, while in the second approach, a test stimulus partially consists of the preceding test response bits. Both proposed scan-based test schemes access only a subset of scan cells for loading the subsequent test stimulus while freezing the remaining scan cells with the preceding test data, thus decreasing scan chain transitions during shift operations. The proposed scan architecture is coupled with test data manipulation techniques which include test stimuli ordering and partitioning algorithms, boosting test time reductions. The experimental results confirm that test time reductions exceeding 97%, and test power reductions exceeding 99% can be achieved by the proposed scan-based testing methodologies on larger ISCAS89 benchmark circuits.

关键词： scan-based testing test data compression test correlation scan architecture design

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INTEGRATING COMPLEX SYSTEM DYNAMICS OF PANDEMIC INFLUENZA WITH A MULTI-CRITERIA DECISION MAKING MODEL FOR EVALUATING PUBLIC HEALTH STRATEGIES

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Journal of Systems Science and Systems Engineering 2013年第3期22卷 319-339页

作者： ozgur M ARAZ College of Public Health University of Nebraska Medical CenterUSA

Recent developments in computational sciences and computer modeling have allowed emergency preparedness exercises to include simulation models as supporting tools. These simulation models are generally built for predicting temporal and geographic patterns of disease spread. However sole use of simulation models in exercise design falls short in terms of incorporating policy decision makers＇ preferences into decision-making processes. In this paper, a general framework for exercising public health preparedness plans with a decision support system is presented to integrate estimation of key epidemiological parameters with a system dynamics model of an outbreak. A multi-criteria decision making framework, an Analytical Hierarchy Process model, is then developed and integrated with the simulation model to help public health policy makers prioritize their response goals and evaluate mitigation strategies in a table-top exercise environment.

关键词： Multi-criteria decision making analytical hierarchy process public health preparedness exercises pandemic influenza modeling complex systems

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Current status of diagnosis and treatment of hepatic echinococcosis

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World Journal of Hepatology 2016年第28期8卷 1169-1181页

作者： Memmet Mihmanli Ufuk Oguz Idiz Cemal Kaya Uygar Demir ozgur Bostanci Sinan Omeroglu emre Bozkurt Department of General Surgery Sisli Hamidiye Etfal Training and Research Hospital

Echinococcus granulosus(***) and Echinococcus multilocularis(***) infections are the most common parasitic diseases that affect the *** disease course is typically slow and the patients tend to remain asymptomatic for many *** the diagnosis is *** upper quadrant abdominal pain,hepatitis,cholangitis,and anaphylaxis due to dissemination of the cyst are the main presenting *** is important in *** World Health Organization classification,based on ultrasonographic findings,is used for staging of the disease and treatment *** addition to the imaging methods,immunological investigations are used to support the *** available treatment options for *** infection include open surgery,percutaneous interventions,and *** surgery is the first-choice treatment for *** infection,while pharmacotherapy is used as an adjunct to *** to a paucity of clinical studies,empirical evidence on the treatment of *** and *** infections is largely lacking;there are no prominent and widely accepted clinical algorithms *** this article,we review the diagnosis and treatment of *** and *** infections in the light of recent evidence.

关键词： Echinococcus granulosus Echinococcus multilocularis Liver Ultrasonography Albendazole

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THE PICARD THEOREM ON S-METRIC SPACES

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Acta Mathematica Scientia 2018年第4期38卷 1245-1258页

作者： Nihal Yihnaz ozgur Nihal TAS Department of Mathematics Balikesir University 10145 Balikesir Turkey

Recently, the notion of an S-metric space is defined and extensively studied as a generalization of a metric space. In this paper, we define the notion of the S∞-space and prove its completeness. We obtain a new gene... 详细信息

关键词： S∞-space completeness Picard Theorem initial value problem

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An Efficient Parallel Solution Framework for the Linear Solution of Large Systems on PC Clusters

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Tsinghua Science and Technology 2008年第S1期13卷 65-70页

作者： ozgur Kurc Semih Ozmen Structural Mechanics Laboratory Department of Civil Engineering Middle East Technical University

In this paper, a parallel solution framework for the linear static analysis of large structures on PC clusters is presented. The framework consists of two main steps: data preparation and parallel solution. The parallel solution is performed by a substructure based method with direct solvers. The aim of the data preparation step is to create the best possible substructures so that the parallel solution time is minimized. An actual structural model was solved utilizing both homogeneous and heterogeneous PC clusters to illustrate the performance and applicability of the presented framework.

关键词： substructure parallel solution heterogeneous clusters homogeneous clusters workload bal-ancing partitioning repartitioning

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Anatomic and functional results of idiopathic macular epiretinal membrane surgery

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 614-619页

作者： Mehmet ozgur Cubuk Erkan Unsal Department of Ophthalmology Istanbul Research and Education HospitalIstanbul 34025Turkey

AIM: To assess the impact of macular surgery on the functional and anatomic outcomes in patients with grade 2 epiretinal membrane(ERM), and the effect of internal limiting membrane(ILM) peeling on visual acuity and to analyze the long-term effect of pars plana vitrectomy(PPV) on intraocular pressure(IOP).METHODS: Pseudophakic eyes(62 eyes) diagnosed as idiopathic grade 2 ERM with at least 6 mo postoperative follow-up were included in this retrospective study. The fellow eye was nonvitrectomized. Patients were divided into two groups: group 1(29 eyes) treated with ERM and ILM peeling and group 2(33 eyes) with only ERM peeling. Preoperative and postoperative best corrected visual acuity(BCVA), slit-lamp, and a dilated fundus examination was performed. IOP was measured with Goldman applanation tonometer before, day 1 and first week and each visit after surgery. The incidence of significant IOP elevation was compared between vitrectomized eyes and nonvitrectomized fellow ***: Visual improvement was statistically significant and similar in both groups(P=0.008 in group 1, P=0.002 in group 2, P=0.09 inter-group). The amount of decrease in central macular thickness was statistically significant and similar in both groups(P=0.005 group 1, P=0.008 group 2, P=0.37 intergroup). At the final follow-up(14.1±9.6 mo) the incidence of significant IOP elevation was 4% in vitrectomized eyes(three eyes) and 3%(two eyes) in the nonvitrectomized fellow eyes(P=0.12). Four eyes(12.1%) had recurrent ERM after a mean follow-up of 8.6±1.1 mo in group 2, there was no recurrence in group 1(P=0.01).CONCLUSION: Recurrence of ERM may be decreased by ILM peeling during ERM surgery. However, it seems that ILM peeling do not affect the functional outcome and 23-gauge PPV alone do not have a significant effect on IOP.

关键词： epiretinal membrane internal limiting membrane peeling pars plana vitrectomy intraocular pressure

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Scour and liquefaction issues for anchors and other subsea structures in floating offshore wind farms: A review

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Water Science and Engineering 2022年第1期15卷 3-14页

作者： B.Mutlu Sumer Veysel Sadan ozgur Kirca BM SUMER Consultancy&Research ITU ARI Teknokent 1Nol5Istanbul 34467Turkey Department of Civil Engineering Istanbul Technical UniversityMaslak 34467Turkey

This article reviews scouring and liquefaction issues for anchor foundations of floating offshore wind *** review is organized in two sections:(1)the scouring issues for drag-embedment anchors(DEAs)and other subsea structures associated with DEAs such as tensioners,clump weights,and chains in floating offshore wind farms;and(2)the liquefaction issues for the same types of structures,particularly for *** scouring processes are described in detail,and the formulae and design guidelines for engineering predictions are included for quantities like scour depth,time scale,and sinking due to general shear failure of the bed soil caused by scoui\The latter is furnished with numerical ***,in the second section,the liquefaction processes are described with special reference to residual liquefaction where pore-water pressure builds up in undrained soils(such as fine sand and silt)under waves,leading to liquefaction of the bed soil and precipitating failure of DEAs and their associated subsea *** integrated mathematical model to deal with liquefaction around and the resulted sinking failure of DEAs,introduced in a recent study,has been *** of the model is illustrated with a numerical *** is believed that the present review and the existing literatures from the"neighboring"fields form a complementary source of information on scour and liquefaction around foundations of floating offshore wind farms.

关键词： Floating structures Liquefaction Offshore structures Offshore wind energy Renewable energy Scouring

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Carrier Density and Electric Field Dependent Nonlinear Transport of Chemical Vapor Deposition Graphene

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Chinese Physics Letters 2013年第3期30卷 127-130页

作者： KHALIL Hafiz M.W. KELEKCI ozgur NOH Hwayong Department of Physics and Graphene Research Institute Sejong UniversitySeoul 143-747Korea

We report on the measurements of nonlinear current-voltage characteristics of graphene fabricated by chemical vapor *** current-voltage characteristic is described by a power law with a superlinear dependence of the current on the voltage,and the nonlinearity depends on the carrier density and the excitation *** nonlinearity is strongest at the Dirac point and becomes weaker as the carrier density *** the Dirac point,we also observe a crossover to a much stronger nonlinear transport when the electric field increases above 104 V/m.

关键词： deposition. nonlinearity nonlinear

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Scan Cell Positioning for Boosting the Compression of Fan-Out Networks

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Journal of Computer Science & Technology 2009年第5期24卷 939-948页

作者： ozgur Sinanoglu Mohammed Al-Mulla Noora A.Shunaiber Alex Orailoglu Math and Computer Science Department Kuwait University Computer Science and Engineering Department University of CaliforniaSan DiegoLa JollaCA92093 U.S.A.

Ensuring a high manufacturing test quality of an integrated electronic circuit mandates the application of a large volume test set. Even if the test data can be fit into the memory of an external tester, the consequent increase in test application time reflects into elevated production costs. Test data compression solutions have been proposed to address the test time and data volume problem by storing and delivering the test data in a compressed format, and subsequently by expanding the data on-chip. In this paper, we propose a scan cell positioning methodology that accompanies a compression technique in order to boost the compression ratio, and squash the test data even further. While we present the application of the proposed approach in conjunction with the fan-out based decompression architecture, this approach can be extended for application along with other compression solutions as well. The experimental results also confirm the compression enhancement of the proposed methodology.

关键词： scan-based testing test data compression scan cell reordering scan architecture design

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