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Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Journal of Cancer Therapy 2013年第6期4卷 1085-1090页

作者： ozgur emre Halit Demir Erkan Dogan Ramazan Esen Tugba Gur Canan Demir Edip Gonullu Nedim Turan Mehmet Fatih Ozbay Division of Biochemistry Department of ChemistryScience FacultyYuzuncu Yil UniversityVanTurkey Department of Medical Oncology Medical FacultyYuzuncu Yil UniversityVanTurkey Department of Hematology Medical FacultyYuzuncu Yil UniversityVanTurkey Division of Biochemistry Health FacultyYuzuncu Yil UniversityVanTurkey Department of Biostatics Faculty of MedicineYuzuncu Yil UniversityVanTurkey Department of Anesthesiology and Reanimation Regional Training and Research Hospital of VanVanTurkey Department of Medical Oncology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Internal Medicine Regional Training and Research Hospital of VanVanTurkey

Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

关键词： Colon Cancer Trace Element Heavy Metal Essential Element

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Current status of diagnosis and treatment of hepatic echinococcosis

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World Journal of Hepatology 2016年第28期8卷 1169-1181页

作者： Memmet Mihmanli Ufuk Oguz Idiz Cemal Kaya Uygar Demir ozgur Bostanci Sinan Omeroglu emre Bozkurt Department of General Surgery Sisli Hamidiye Etfal Training and Research Hospital

Echinococcus granulosus(***) and Echinococcus multilocularis(***) infections are the most common parasitic diseases that affect the *** disease course is typically slow and the patients tend to remain asymptomatic for many *** the diagnosis is *** upper quadrant abdominal pain,hepatitis,cholangitis,and anaphylaxis due to dissemination of the cyst are the main presenting *** is important in *** World Health Organization classification,based on ultrasonographic findings,is used for staging of the disease and treatment *** addition to the imaging methods,immunological investigations are used to support the *** available treatment options for *** infection include open surgery,percutaneous interventions,and *** surgery is the first-choice treatment for *** infection,while pharmacotherapy is used as an adjunct to *** to a paucity of clinical studies,empirical evidence on the treatment of *** and *** infections is largely lacking;there are no prominent and widely accepted clinical algorithms *** this article,we review the diagnosis and treatment of *** and *** infections in the light of recent evidence.

关键词： Echinococcus granulosus Echinococcus multilocularis Liver Ultrasonography Albendazole

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Results of the open surgery after endoscopic basket impaction during ERCP procedure

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World Journal of Gastrointestinal Surgery 2015年第2期7卷 15-20页

作者： Sezgin Yilmaz Ogun Ersen Taner Ozkececi Kadir S Turel Serdar Kokulu emre Kacar Murat Akici Murat Cilekar ozgur Kavak Yuksel Arikan Department of General Surgery Kocatepe University Department of General Surgery State Hospital Department of Anaesthesiology Kocatepe University Department of Radiology Kocatepe University

AIM:To report the results of open surgery for patients with basket impaction during endoscopic retrograde cholangiopancreatography(ERCP) ***: Basket impaction of either classical Dormia basket or mechanical lithotripter basket with an entrapped stone occurred in six *** patients were immediately operated for removal of stone(s) and impacted *** postoperative course,length of hospital stay,diameter of the stone,complication and the surgical procedure of the patients were reported ***: Six patients(M/F,0/6) were operated due to impacted basket during ERCP *** mean age of the patients was 64.33 ± 14.41 *** all cases the surgery was performed immediately after the failed ERCP procedure by making a rightsubcostal *** baskets containing the stone were removed through longitudinal choledochotomy with the *** choledochotomy incisions were closed by primary closure in four patients and T tube placement in two *** patients were also performed cholecystectomy additionally since they had *** patients with T-tube placement it was removed on the 13 th day after a normal T-tube *** patients remained stable at postoperative period and discharged without any complication at median 7 ***: Open surgical procedures can be applied in patients with basket impaction during ERCP procedure in selected cases.

关键词： Biliary stone Endoscopic retrograde cholangiopancreatography Basket Impaction Surgery

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