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Polyherbal formula SC-E3 inhibits rheumatoid arthritis activity in a mouse model of type-Ⅱcollagen-induced arthritis

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Journal of Integrative Medicine 2021年第3期19卷 265-273页

作者： Ju-Yeon Park Young-Won Kwon Sun-Ah kim Sun-Dong Park Chang-Hyun kim Jin-hee kim Ju-hee Lee College of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Biomedical Laboratory Science College of Health ScienceCheongju UniversityCheongju 28503Republic of Korea

Objective:SC-E3 is a polyherbal formula that contains five medicinal herbs used frequently in traditional herbal *** our previous study,we demonstrated the antioxidant and anti-inflammatory effects of *** present study examined the effects of SC-E3 in a mouse model of type-II collagen-induced arthritis(CIA).Methods:In vivo,male DBA/1 J mice were immunized by intradermal injection of bovine type-II collagen and complete or incomplete Freund’s adjuvant,to induce ***-E3 was orally administered daily for 23 *** vitro,bone marrow-derived macrophages(BMMs)were treated with macrophage colony-stimulating factor(M-CSF)and receptor activator of nuclear factor-j B ligand(RANKL)in the absence or presence of ***:Administrations of SC-E3 were found to have anti-arthritic effects in the joints of CIA mice,as evidenced by reduced paw swelling,bone erosion and deformation,inflammatory cell infiltration,and inflammation in synovial ***-E3 also reduced serum levels of tumor necrosis factor-a,interleukin-1 b,aspartate aminotransferase and alanine ***,tartrateresistant acid phosphatase-positive osteoclast numbers in the joints were significantly lower in SC-E3-treated CIA mice than in CIA *** addition,the differentiations of BMMs to multinucleated osteoclasts induced by M-CSF and RANKL stimulation were dose-dependently reduced by ***:These results suggest that SC-E3 possesses substantial anti-arthritic activity because it inhibits pro-inflammatory cytokines and osteoclastogenesis,and that SC-E3 has potential therapeutic use for the treatment of rheumatoid arthritis.

关键词： Herbal formula Anti-inflammatory Rheumatoid arthritis Collagen-induced arthritis Osteoclastogenesis

Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1113-1116页

作者： Joonku Hahn Hwi kim Yongjun Lim Eun-hee kim Byoungho Lee School of Electrical Engineering Seoul National University

We propose a novel spatial phase-shifting interferometry that exploits a genetic algorithm to compensate for geometric errors. Spatial phase-shifting interferometry is more suitable for measuring objects with properties that change rapidly in time than the temporal phase-shifting interferometry. However, it is more susceptible to the geometric errors since the positions at which interferograms are collected are different. In this letter, we propose a spatial phase-shifting interferometry with separate paths for object and reference waves. Also, the object wave estimate is parameterized in terms of geometric errors, and the error is compensated by using a genetic algorithm.

关键词： Spatial phase-shifting interferometry with compensation of geometric errors based on genetic algorithm

Cloud Radiative Effects and Changes Simulated by the Coupled Model Intercomparison Project Phase 5 Models

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Advances in Atmospheric Sciences 2017年第7期34卷 859-876页

作者： Sun-hee SHIN Ok-Yeon kim Dongmin kim Myong-In LEE Climate Research Department APEC Climate Center Busan 48058 Republic of Korea School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Republic of Korea

Using 32 CMIP5（Coupled Model Intercomparison Project Phase 5） models, this study examines the veracity in the simulation of cloud amount and their radiative effects（CREs） in the historical run driven by observed external radiative forcing for 1850-2005, and their future changes in the RCP（Representative Concentration Pathway） 4.5 scenario runs for2006-2100. Validation metrics for the historical run are designed to examine the accuracy in the representation of spatial patterns for climatological mean, and annual and interannual variations of clouds and CREs. The models show large spread in the simulation of cloud amounts, specifically in the low cloud amount. The observed relationship between cloud amount and the controlling large-scale environment are also reproduced diversely by various models. Based on the validation metrics,four models-ACCESS1.0, ACCESS1.3, Had GEM2-CC, and Had GEM2-ES-are selected as best models, and the average of the four models performs more skillfully than the multimodel ensemble *** models project global-mean SST warming at the increase of the greenhouse gases, but the magnitude varies across the simulations between 1 and 2 K, which is largely attributable to the difference in the change of cloud amount and distribution. The models that simulate more SST warming show a greater increase in the net CRE due to reduced low cloud and increased incoming shortwave radiation, particularly over the regions of marine boundary layer in the subtropics. Selected best-performing models project a significant reduction in global-mean cloud amount of about-0.99% K^-1and net radiative warming of 0.46 W m^-2K^-1, suggesting a role of positive feedback to global warming.

关键词： warming cloud radiative historical CMIP interannual greenhouse ACCESS oceans seasonal

Development of polyimide films reinforced with boron nitride and boron nitride nanosheets for transparent flexible device applications

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Nano Research 2018年第5期11卷 2366-2378页

作者： You Jin Min Kyeong-hee Kang Dae-Eun kim Department of Mechanical Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea

The benefits of reinforcing polyimide （PI） films with boron nitride （BN） particles and boron nitride nanosheets （BNNSs） were assessed with the aim of enhancing their thermal, optical, and mechanical properties for flexible device applications. BNNSs were prepared from BN particles using a liquid-phase exfoliation method assisted by an ultrasonic probe-type sonicator and centrifugator. PI-based composite films blended with BNNSs and BN particles were fabricated at various concentrations via mechanical stirring and spin coating. The transparency of the PI/BNNS composite films remained almost the same as that of pure PI films up to 3 wt.% whereas the transparency of the PI/BN composite films decreased with increasing concentration of the BN fillers at 550 nm. The thermal stability improved significantly with increasing concentrations of both BN and BNNS relative to that of pure PI films. The temperature for 5% weight loss of the PI/BNNS composite film was higher than that of the PI/BN composite film at the same filler concentration. The composite films with 2 wt.% BN or BNNS showed the lowest wear rate, and the PI/BNNS composite films showed more stable frictional behavior compared to the PI/BN composite films. In addition, bending tests showed that the PI/BNNS composite films exhibited excellent flexibility compared to the PI/BN composite films. Overall, the results indicate that the BNNS can be effectively used as a filler that can enhance the thermal and mechanical properties of polymer materials for flexible device applications.

关键词： polyimide (PI) boron nitride (BN) transparency thermal properties flexibility tribology

Facile synthesis of graphitic carbon-nitride supported antimony-doped tin oxide nanocomposite and its application for the adsorption of volatile organic compounds

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Journal of Environmental Sciences 2019年第5期31卷 35-42页

作者： Devi Prashad Ojha Jun hee Song Han Joo kim Department of Convergence Technology Engineering Chonbuk National University Eco-friendly Machine Parts Design Center Chonbuk National University

Antimony-doped tin oxide(ATO) nanoparticles with an average size of ～ 6 nm were prepared by co-precipitation and subsequent heat treatment. Graphitic carbon nitride(g-CN)/ATO hybrid nanocomposite was designed by the combination of thermally synthesized g-CN and ATO nanoparticles by ultrasonication. The materials were characterized using N2 adsorption/desorption(BET), X-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), transmission electron microscopy(TEM) and Fourier transform infrared spectroscopy(FTIR). A mixture of five volatile organic compounds(VOCs, chloroform, benzene, toluene, xylene and styrene) was used to compare the adsorption capacity of the samples. The adsorption capacity of ATO nanoparticles was improved by the addition of g-CN. Experimental data showed that, among the five VOCs,chloroform was the least adsorbed, regardless of the samples. The g-CN/ATO showed nearly three times greater adsorption capacity for the VOC mixture than pure ATO. The unchanged efficiency of VOC adsorption during cyclic use demonstrated the completely reversible adsorption and desorption behavior of the nanocomposite at room conditions. This economically and environmentally friendly material can be a practical solution for outdoor and indoor VOC removal.

关键词： Antimony-doped tin oxide(ATO) Graphitic carbon nitride(g-CN) Volatile organic compounds(VOC) Adsorption

Korean red ginseng promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2020年第5期15卷 887-893页

作者： Sun Ryu Hyongjun Jeon hee-Young kim Sungtae Koo Seungtae kim Korean Medicine Research Center for Healthy Aging Pusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea

Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and *** red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still ***,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the ***-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 ***,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral *** in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then ***-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated *** Morris water maze test showed that KRG administration enhanced the learning and memory abilities *** also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to *** of KRG promotes learning and memory abilities,possibly by enhancing hippocampal *** study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval ***-2016-1071) on January 19,2016.

关键词： bromodeoxyuridine cerebral dopamine neurotrophic factor ciliary neurotrophic factor doublecortin ginseng hippocampus Korean red ginseng learning memory neurogenesis proliferating cell nuclear antigen red ginseng

Mechanical characteristics of fused cast basalt tube encased in steel pipe for protecting steel surface

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中国有色金属学会会刊：英文版 2009年第4期19卷 935-940页

作者： Jee-Seok WANG Jong-Do kim hee-Jong YOON Division of Mechanical and Information Engineering Korea Maritime University Division of Marine System Engineering Korea Maritime University Department of Research and Development Dongdo Basalt Industry Co.Ltd

Because of the various excellent characteristics of cast basalt materials,such as,anti-corrosion,anti-wearing,good hardness,high chemical stability,of which steel may not possess,the steel-basalt composite pipes are used in severe environments for compensating the defects of *** limit of bending moment with which steel-basalt composite pipe may safely endure was calculated and the limit curvature of the composite pipe in the safe range was *** application temperature of steel-basalt pipe was examined due to a different coefficient among basalt,mortar and mild steel.

关键词：玄武岩钢管表面保护机械特性包裹熔铸化学稳定性复合管

Repetitive response to gemcitabine that led to curative resection in cholangiocarcinoma

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World Journal of Gastroenterology 2009年第36期15卷 4593-4595页

作者： Seong Hun kim In hee kim Sang Wook kim Seung-Ok Lee Division of Gastroenterology and Hepatology Department of Internal MedicineChonbuk National University Medical SchoolJeonju 561-712South Korea

This study reports a case of unresectable intrahepatic mass-forming cholangiocarcinoma which showed a dramatic response to gemcitabine that led to curative resection and a long-term survival of more than five *** and five cycles of gemcitabine monotherapy were administered separately over a three-year period and a radical excision was performed at 4.5 years after *** case indicates the role of gemcitabine as a neoadjuvant chemotherapeutic agent for cholangiocarcinoma and guarantees a randomized controlled prospective study.

关键词： Cholangiocarcinoma Gemcitabine Neoadjuvant chemotherapy

K2Ti6O13 Nanoparticle-Loaded Porous rGO Crumples for Supercapacitors

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Nano-Micro Letters 2020年第1期12卷 115-123页

作者： Chongmin Lee Sun Kyung kim Hankwon Chang hee Dong Jang Department of Nanomaterials Science and Engineering University of Science and TechnologyYuseong‑guDaejeon 34113Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesYuseong‑guDaejeon 34132Republic of Korea

One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface *** those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for *** hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ***,we present porous rGO crumples(PGC)decorated with KTO nanoparticles(NPs)for application to *** KTO NP/PGC composites were synthesized by aerosol spray pyrolysis and post-heat *** NPs less than 10 nm in diameter were loaded onto PGCs ranging from 3 to 5μ*** porous structure of the composites was obtained by the activation of rGO by adding an excessive amount of KOH to the *** KTO NP/PGC composite electrodes fabricated at the GO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1.

关键词： Potassium hexa-titanate Porous graphene crumples Supercapacitors