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Mental health research in the Arab region in response to the COVID-19 pandemic:a scoping review

General Psychiatry 2022年第2期35卷 85-91页

作者： Mohamed Hussein Mahmoud Osman Hassan Ibrahim Hamdy Ezzat Abdelhafez Sami Ouanes Eiman Al-Janahi Yuri Zoghbi ovais wadoo Mental Health Services Hamad Medical CorporationDohaAd DawhahQatar Department of Neurosurgery Hamad Medical CorporationDohaAd DawhahQatar College of Medicine Qatar UniversityDohaAd DawhahQatar Department of Psychiatry College of MedicineQatar UniversityDohaAd DawhahQatar

Background The ongoing pandemic has led to a global surge in coronavius disease 2019(COVID-19)-related mental health ***,most related publications come from Western countries or China,and their findings cannot alwrays be extrapolated to Arabl *** This study provides a quantitative and qualitative analysis of mental health research pertaining to Arab countries'response to the COVID-19 *** A scoping review of the World Health Organzation(WHO)C0VID-19 database for publications on mental health was conducted by authors afllated *** istutions,including artides from inception to 24 October *** indluded publications were evaluated for their national distribution,international cllaboration,publication type,and main research *** quality analysis of the incuded research studies was performed using the original and mdified versions of the Newcastle Ottawa *** In total,102 articles were included in this study,averaging 4.6 articles per Arab *** of the articles emerged from the Kingdom of Saudi Arabia,Jordan,and Egypt.A majority of publications demonstrated intermational *** of the publications were original research studies and cross sectional in *** predominant research theme was examining the pandemic s mental health effects on the general population and healthcare workers.0nly 28.0% of the studies were of high methodologial quality,where as 41.5% were moderate and 30.5% were low in *** Mental health research in response to the COVID-19 pandemic in the Arab region has quantitative and qualitative *** institutions need torespond to the pandemic prompty in order to address the delineated research gap and to generate higher-quality research output.

关键词： qualitative prompt publications

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Mental health during COVID-19 in Qatar

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General Psychiatry 2020年第6期33卷 432-436页

作者： ovais wadoo Javed Latoo Shuja Mohd Reagu Raed Ahmad Assi Amro Naseer Ahmad Masoodi Majid Alabdulla Department of Psychiatry Mental Health ServicesDohaQatar Ambulatory General Internal Medicine Hamad Medical CorporationDohaQatar Department of Psychiatry Qatar University College of MedicineDohaAd DawhahQatar

INTRODUCTION The COVID-19 pandemic has posed unprecedented health and social *** has been working to promote the integration of mental health and psychosocial support into the COVID-19 response effort.1 It is vital that targeted measures are initiated to mitigate the potential mental health consequences of the COVID-19 pandemic and psychiatric patients continue to receive a range of psychiatric *** need to adapt strategies identified by WHO to strengthen mental healthcare delivery.

关键词： consequences initiated COV

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Mental health stigma:the role of dualism,uncertainty,causation and treatability

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General Psychiatry 2021年第4期34卷 74-77页

作者： Javed Latoo Minal Mistry Majid Alabdulla ovais wadoo Farida Jan Tariq Munshi Yousaf Iqbal Peter Haddad Mental Health Services Hamad Medical CorporationDohaQatar College of Medicine Qatar UniversityDohaQatar Fredericton Addiction and Mental Health Services FrederictonNew BrunswickCanada Department of Psychiatry Northamptonshire Healthcare NHS Foundation TrustNorthamptonUK Department of Psychiatry University of TorontoTorontoOntarioCanada

INTRODUCTION Public stigma on mental health has been defined as‘the set of negative attitudes and beliefs that motivate individuals to fear,reject,avoid and discriminate against people with mental illness’.1 Stigma causes immense suffering to people with mental disorders across the *** to a recent Human Rights Watch report,people with mental health conditions are still shackled in 60 countries.2 Nearly nine out of 10 mental health service users in England have experi-enced discrimination.3 Stigma can be perpet-uated by people in all walks of life,including the family and friends of those with mental disorders,and healthcare professionals,including those working in mental *** adverse consequences of stigma include shame,self-blame,isolation and discrimi-nation.

关键词： consequences uncertainty suffering

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Students' sustainability consciousness with the three dimensions of sustainability:Does the locus of control play a role?

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Regional Sustainability 2023年第1期4卷 13-27页

作者： Durdana ovais Department of economics The Bhopal School of Social SciencesBhopalMadhya Pradesh462001India

The persistent environmental problems and the growing difficulty to achieve sustainable development require a re-evaluation of person’ sustainable knowledge, attitude, and behaviour. To go to where we want to go, we must first assess where we are now. The study investigated the level of sustainability consciousness of students in India, and sustainability consciousness was expressed in sustainability knowledge, attitude, and behaviour. Sustainability consciousness was further examined using the three dimensions, such as environment, society, and economy. By drawing the perception map of students and studying the role of the locus of control, the reasons why sustainability knowledge does not appear in sustainability behaviour were analyzed. Quantitative analysis was conducted for a sample of 205 students from higher educational institutions across central India(Madhya Pradesh) from January to March in 2022. The data were analyzed using the SPSS 26 and Smart Partial Least Square(PLS) 3.0. The research revealed that sustainability attitude impacts sustainability behaviour more than sustainability knowledge. The results showed that respondents’ sustainability knowledge is higher than their sustainability attitude and behaviour. Moreover, it was discovered that economic concerns can lead to sustainability behaviour. In order to study respondents’ behaviour regarding sustainability consciousness, the study divided respondents into two groups according to the locus of control: the internal and external locus of control. It was found that most respondents thought whatever happened around them was beyond their control. Further, the locus of control influenced sustainability behaviour in groups with the internal locus of control. The study helps to explain why sustainability knowledge and attitude cannot translate into sustainability behaviour and provides a basis for achieving sustainable development. The conclusions of this study are crucial for governments, educational ins

关键词： Sustainability Consciousness Sustainability knowledge Sustainability attitude Sustainability behaviour Locus of control Higher education

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Mutagenic and cytotoxic potential of Endosulfan and Lambda-cyhalothrin—In vitro study describing individual and combined effects of pesticides

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Journal of Environmental Sciences 2014年第7期26卷 1471-1479页

作者： Umber Saleem Sohail Ejaz Muhammad Ashraf Muhammad ovais Omer Imran Iltaf Zainab Batool Riffat Fatima Msbah Afzal Department of Pharmacology & Toxicology University of Veterinary and Animal Sciences Lahore 54000 Pakistan Department of Clinical Neurosciences Neurology Unit Addenbrooke's Hospital University of Cambridge Cambridge UK Microbiology Section Quality Operations Laboratory University of Veterinary and Animal Sciences Lahore Pakistan

Excessive use of pesticides poses increased risks to non target species including humans. In the developing countries, lack of proper awareness about the toxic potential of pesticides makes the farmer more vulnerable to pesticide linked toxicities, which could lead to diverse pathological conditions. The toxic potential of a pesticide could be determined by their ability to induce genetic mutations and cytotoxicity. Hence, determination of genetic mutation and cytotoxicity of each pesticide is unavoidable to legislate health and safety appraisal about pesticides. The objective of current investigation was to determine the genotoxic and cytotoxic potential of Endosulfan（EN） and Lambda-cyhalothrin（LC）; individually and in combination. 3-（4,5-Dimethylthiazol-2-yl）-2,5-Diphenyltetrazolium Bromide（MTT） assay was utilized to determine cytotoxicity, while two mutant histidine dependent Salmonella strains（TA98, TA100） were used to determine the mutagenicity of EN and ***, mutagenicity assay was conducted with and without S9 to evaluate the effects of metabolic activation on mutagenicity. Even though a dose dependent increase in the number of revertant colonies was detected with EN against both bacterial strains, a highly significant（p 〈 0.05） increase in the mutagenicity was detected in TA98 with S9. In comparison, data obtained from LC revealed less mutagenic potential than EN. Surprisingly,the non-mutagenic individual-concentrations of EN and LC showed dose dependent mutagenicity when combined. Combination of EN and LC synergistically induced mutagenicity both in TA98 and TA100. MTT assay spotlighted comparable dose dependent cytotoxicity effects of both pesticides. Interestingly, the combination of EN and LC produced increased reversion and cytotoxicity at lower doses as compared to each pesticide, concluding that pesticide exposure even at sub-lethal doses can produce cytotoxicity and genetic mutations, which could lead to carcinogenicity.

关键词： Endosulfan Lambda-cyhalothrin Mutagenicity Cytotoxicity

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噬菌体衣壳纳米颗粒作为病毒感染的多价抑制剂

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Science Bulletin 2020年第24期65卷 2050-2052,M0004页

作者： Manzar Abbas Muhammad ovais 陈春英 Institute for Molecules and Materials Radboud UniversityNijmegen 6525 AJthe Netherlands CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700China

In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19 [2]. Coronavirus has a spike protein, which tends to bind with receptors present in the lung tissues, and that helps in its entry to the cells and replication inside [3]. Therefore, we are in need to design the multivalent nanomaterials, which can act as receptors to bind with spike protein of virus and stop its replication(Fig. 1).

关键词：病毒感染衣壳 lung

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Progressive multifocal leukoencephalitis in a patient with sarcoidosis on hydroxychloroquine with negative cerebrospinal fluid testing for the John Cunningham virus

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Neuroimmunology and Neuroinflammation 2018年第1期5卷 18-24页

作者： ovais Inamullah Casey Farin Linh Tran Roger McLendon Mark Skeen Joel Morgenlander Neurology Department Duke University HospitalDurhamNC27705USA Child Neurology Department Duke University HospitalDurhamNC27705USA Pathology Department Duke University HospitalDurhamNC27705USA

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus typically seen in immuno-compromised patients. Several drugs that suppress that immune system have already been known to cause PML such as natalizumab and rituximab. We present a patient with sarcoidosis who develops PML in the rare setting of minimal immunosuppression with only hydroxychloroquine. There was significant delay in the diagnosis due to negative cerebrospinal fluid testing for JC virus and concern for neuro-sarcoidosis, but eventually a diagnosis of PML was made via brain biopsy.

关键词： Progressive multifocal leukoencephalopathy sarcoidosis hydroxychloroquine neuroimmunology

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Precise nanomedicine for intelligent therapy of cancer

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Science China Chemistry 2018年第12期61卷 1503-1552页

作者： Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao State Key Laboratoiy of Radiation Medicine and Protection Jiangsu Key Laboratoiy of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Key Laboratoiy of Biomedical Polymers of Ministry of Education Department of Chemistiy Wuhan University Wuhan 430072 China Laboratoiy of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Molecular Science and Biomedicine Laboratoiy State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistiy and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China Jiangsu Key Laboratoiy for Carbon-Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Soochow University Suzhou 215123 China Department of Polymer Science and Engineering College cf Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Department of Chemistiy Tsinghua University Beijing 100084 China National Engineering Research Center for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Chemistiy and Department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Health Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China CAS Key Laboratoiy for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Key Labo

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

关键词： nanomedicine nanoparticles cancer therapy cancer imaging intelligent therapy

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