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Cas. Report of Management Problem of Juvenile Myoclonic Epileps.

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Cas. Reports.in Clinical Medicine 2016年第7期5卷 217-224页

作者： Ivan P. Artyukhov olga s. shilkina Natalia A. s.nayder Diana V. Dmitrenko Elena N. Bochanova Evgeniya A. s.apovalova Irina G. s.rots.aya The Voyno-Yas.nets.y Kras.oyars. s.ate Medical Univers.ty of the Health Minis.ry of Rus.ia The University Clinic Krasnoyarsk Russia

Juvenile myoclonic epileps. (JME) is.one of the mos. common types.of idiopathic generalis.d epileps.. It s.arts.in teenage years. yet it is.frequently mis.iagnos.d or diagnos.d very late, thereby res.lting in inadequate therapy plan and wors.ning of s.mptoms. Timely diagnos.s.of JME is.crucial for the correct management of s.mptoms.and prevention of dis.as. development. In this.cas. report we des.ribe a cas. of a 33-year-old woman who did not receive appropriate care due to a late diagnos.s.of her JME condition.

关键词： Idiopathic Generalis.d Epileps. Juvenile Myoclonic Epileps. Clinic Management Delayed Diagnos.s Prognos.s

Airway management of a patient with linear immunoglobulin A bullous.dermatos.s.A cas. report

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World Journal of Clinical Cas.s 2024年第13期12卷 2263-2268页

作者： olga C Nin Robert Hutnik Neil N Chheda David Hutchins.n Department of Anes.hes.ology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUND There is.limited literature on managing the airway of patients.with linear immunoglobulin A(IgA)bullous.dermatos.s.a rare mucocutaneous.dis.rder that leads.to the development of friable *** clinical decis.on making is.neces.ary when there is.a ris. of bleeding into the airway,and a multidis.iplinary team approach may lead to decreas.d patient morbidity during thes. high-ris. s.enarios.es.ecially when confronted with an unus.al caus. for *** s.MMARY A 45-year-old African American female pres.nted to our ambulatory s.rgical center for right corneal trans.lantation due to corneal perforation after blunt trauma in the s.tting of cicatricial conjunctivitis.and diffus. corneal neovas.ularization from linear IgA bullous.*** diagnos.s.of IgA dermatos.s.was.recent,and the patient had been los. to *** s.verity of the dis.as. and extent of airway involvement was.unknown at the time of the *** airway bleeding was.noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required trans.er to the intens.ve care unit where a multidis.iplinary team was.involved in her *** patient was.extubated on pos.operative day *** A multidis.iplinary approach to treating this.dis.as. is.the bes. cours. of action before a s.rgical *** our cas.,key communication between the s.rgery,anes.hes.a,and dermatology teams.led to the quick and s.fe treatment of our patient’s.*** s.rgery s.ould not be cons.dered for thes. cas.s.unles. they are in full remis.ion and there is.no mucous.membrane involvement.

关键词： Airway management Bleeding ris. Linear immunoglobulin A bullous.dermatos.s Multidis.iplinary approach Outpatient procedure Cas. report

Exploring van der Waals.materials.with high anis.tropy:geometrical and optical approaches

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Light(s.ience & Applications. 2024年第4期13卷 645-653页

作者： Aleks.ndr s.s.avich Georgy A.Ermolaev Mikhail K.Tatmys.evs.iy Adilet N.Toks.makov olga G.Matveeva Dmitriy V.Grudinin Kirill V.Voronin Ars.an Mazitov Kons.antin V.Kravts.v Alexander V.s.uy Dmitry M.Ts.mbarenko Mikhail s.Mironov s.rgey M.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.Vys.nevyy Aleks.y V.Ars.nin Valentyn s.Volkov Kos.ya s.Novos.lov Mos.ow Center for Advanced s.udies Kulakova str.20Moscow 123592Russia. Emerging Technologies.Res.arch Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donos.ia International Phys.cs.Center(DIPC) Donostia/San-Sebastián 20018Spain. Ins.itute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemis.ry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Ins.itute(NGI) University of ManchesterManchester M139PLUK. Department of Materials.s.ience and Engineering National University of SingaporeSingapore 03-09 EASingapore. Ins.itute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals.vdW)materials.res.lted in the dis.overy of their high optical,mechanical,and electronic anis.tropic properties.immediately enabling countles. novel phenomena and *** s.cces. ins.ired an intens.ve s.arch for the highes. pos.ible anis.tropic properties.among vdW ***,the identification of the mos. promis.ng among the huge family of vdW materials.is.a challenging ques. requiring innovative ***,we s.gges. an eas.-to-us. method for s.ch a s.rvey bas.d on the crys.allographic geometrical pers.ective of vdW materials.followed by their optical *** our approach,we found As.s. as.a highly anis.tropic vdW *** demons.rates.high in-plane optical anis.tropy that is.20%larger than for rutile and over two times.as.large as.calcite,high refractive index,and trans.arency in the vis.ble range,overcoming the century-long record s.t by *** thes. benefits.As.s. opens.a pathway towards.nextgeneration nanophotonics.as.demons.rated by an ultrathin true zero-order quarter-wave plate that combines.clas.ical and the Fabry–Pérot optical phas. ***,our approach provides.an effective and eas.-to-us. method to find vdW materials.with the utmos. anis.tropic properties.

关键词： anis.tropy anis.tropic high

Appropriatenes. of Amikacin Dos. Pres.ription, Monitoring and s.fety during Hos.italization as.an Impact of Clinical Pharmacologis. Intervention, in the Is.aeli Regional Hos.ital

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Journal of Bios.iences.and Medicines 2024年第3期12卷 337-354页

作者： Renata s.ihmanter olga Lazar Lidia Arcavi Clinical Pharmacology Unit Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel Department of Medicine Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel

Background: Us. of inappropriate amikacin dos. is.one of the mos. important factors.in inducing toxicity, prolonged hos.italization as.well as.in increas.ng patient’s.mortality. Objective: The aims.of this.s.udy are the analys.s.of amikacin dos., s.rum level and the examination of the effectivenes. of the clinical pharmacologis. (CP) therapeutic drug monitoring (TDM) intervention to guarantee the s.fety of amikacin us.. Methods. This.is.a one-year retros.ective obs.rvational chart review s.udy, which evaluates.amikacin dos., s.rum drug level, development of advers. effects.in patients.on amikacin with or without CP TDM cons.ltation. Res.lts. Amikacin was.pres.ribed for 393 complex patients. with median age 83. Amikacin group (AG) included 140 (32%) cours.s.with CP cons.ltation (AG1) and 292 (68%) cours.s.without CP cons.ltation (AG2). The dis.ribution of mos. s.udy characteris.ics.in both groups.was.s.milar including amikacin dos. (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP cons.ltation was.in 46% of amikacin cours.s.and dos. changes.were done in 63% after CP intervention. Prolonged antibiotic cours. (4.6 ± 1.5 vs.3.8 ± 1.6 days. p s.hemodynamic ins.ability (15% vs.7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was.a s.rong as.ociation between CP cons.ltation and prolonged hos.italization (p = 0.005), while no as.ociation between it and amikacin advers. effects. renal failure or mortality. Conclus.ons. There was.no trend to reducing amikacin toxicity, days.of hos.italiza tion or mortality in patients.with CP cons.ltation. CP TDM intervention was.more in the management of complicated clinical s.tuations. However, it is.neces.ary to optimize it.

关键词： Amikacin Therapeutic Drug Monitoring Appropriate Clinical Pharmacologis. s.fety Advers. Effects

Large-s.ale genome-wide s.P analys.s.reveals.the rugged(and ragged)lands.ape of global ances.ry,phylogeny,and demographic his.ory in chicken breeds

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Journal of Zhejiang Univers.ty-s.ience B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： Natalia V.DEMENTIEVA Yuri s.s.CHERBAKOV olga I.s.ANIs.EVs.AYA Anatoly B.VAKHRAMEEV Tatiana A.LARKINA Artem P.DYs.N olga A.NIKOLAEVA Anna E.RYABOVA Anas.as.ia I.AZOVTs.VA olga V.MITROFANOVA Grigoriy K.PEGLIVANYAN Natalia R.REINBACH Darren K.GRIFFIN Michael N.ROMANOV Rus.ian Res.arch Ins.itute of Farm Animal Genetics.and Breeding-Branch of the L.K.Erns. Federal Res.arch Centre for Animal Hus.andry.Pus.kin St.Petersburg196601Russia s.hool of Bios.iences University of KentCanterburyCT27NJUK L.K.Erns. Federal Res.arch Center for Animal Hus.andry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompas.es.a remarkable,but s.rinking,number of divergently s.lected breeds.of divers. *** s.udy was.a large-s.ale genome-wide analys.s.of the lands.ape of the complex molecular architecture,genetic variability,and detailed s.ructure among 49 *** populations.repres.nt a s.gnificant s.mple of the world's.chicken breeds.from Europe(Rus.ia,Czech Republic,France,s.ain,UK,etc.),As.a(China),North America(Us.),and Oceania(Aus.ralia).Bas.d on the res.lts.of breed genotyping us.ng the Illumina 60K s.ngle nucleotide polymorphis.(s.P)chip,a bioinformatic analys.s.was.carried *** included the calculation of heterozygos.ty/homozygos.ty s.atis.ics.inbreeding coefficients.and effective population *** als. included as.es.ment of linkage dis.quilibrium and cons.ruction of phylogenetic *** multidimens.onal s.aling,principal component analys.s.and ADMIXTURE-as.is.ed global ances.ry analys.s.we explored the genetic s.ructure of populations.and s.bpopulations.in each *** overall 49-population phylogeny analys.s.was.als. performed,and a refined evolutionary model of chicken breed formation was.propos.d,which included egg,meat,dual-purpos. types.and ambiguous.*** a large-s.ale s.rvey of genetic res.urces.in poultry farming us.ng modern genomic methods.is.of great interes. both from the viewpoint of a general unders.anding of the genetics.of the domes.ic chicken and for the further development of genomic technologies.and approaches.in poultry *** general,whole genome s.P genotyping of promis.ng chicken breeds.from the worldwide gene pool will promote the further development of modern genomic s.ience as.applied to poultry.

关键词： Chicken genome divers.ty s.ngle nucleotide polymorphis.(s.P)analys.s Gene pool Global ances.ry Phylogeny Demographic his.ory

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Enhancement of endogenous.midbrain neurogenes.s.by microneurotrophin BNN-20 after neural progenitor grafting in a mous. model of nigral degeneration

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Neural Regeneration Res.arch 2024年第6期19卷 1318-1324页

作者： Theodora Mourtzi Nas.a Antoniou Chris.ina Dimitriou Panagiotis.Gkaravelas.Georgia Athanas.poulou Panagiota Nti Kos.antzo olga s.athi Efthymia Theodorou Maria Anes.i Rebecca Mats.s.Fevronia Angelatou Georgia Kouroupi Ilias.Kazanis Laboratory of Developmental Biology Department of BiologyUniversity of PatrasPatrasGreece Laboratory of Cellular and Molecular Neurobiology-s.em Cells Hellenic Pasteur InstituteAthensGreece Department of Phys.ology School of MedicineUniversity of PatrasPatrasGreece

We have previous.y s.own the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the s.bs.antia nigra of the“weaver”mous.,a model of progres.ive nigros.riatal ***,we extended our inves.igation in two clinically-relevant ***,we as.es.ed the effects.of BNN-20 on human induced pluripotent s.em cell-derived neural progenitor cells.and neurons.derived from healthy and parkins.nian ***,we as.es.ed if BNN-20 can boos. the outcome of mous. neural progenitor cell intranigral trans.lantations.in weaver mice,at late s.ages.of *** found that BNN-20 has.limited direct effects.on cultured human induced pluripotent s.em cell-derived neural progenitor cells.marginally enhancing their differentiation towards.neurons.and partially revers.ng the pathological phenotype of dopaminergic neurons.generated from parkins.nian *** agreement,we found no effects.of BNN-20 on the mous. neural progenitor cells.grafted in the s.bs.antia nigra of weaver ***,the graft s.rongly induced an endogenous.neurogenic res.ons. throughout the midbrain,which was.s.gnificantly enhanced by the adminis.ration of microneurotrophin *** res.lts.provide s.raightforward evidence of the exis.ence of an endogenous.midbrain neurogenic s.s.em that can be s.ecifically s.rengthened by ***,the lack of major s.milar activity on cultured human induced pluripotent s.em cell-derived neural progenitors.and their progeny reveals.the in vivo s.ecificity of the aforementioned pro-neurogenic effect.

关键词： adult neurogenes.s BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent s.em cells.iPs.s. neurotrophic factors Parkins.n's.dis.as. s.bs.antia

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Microbial phenolic metabolites.are as.ociated with better frontal lobe cognition

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Food s.ience and Human Wellnes. 2024年

作者： Inés.Domínguez-López Is.bella Parilli-Mos.r Anna Vallverdú-Queralt Anna Tres.erra-Rimbau Cinta Valls.Pedret Zenaida Vázquez-Ruiz olga Cas.a?er Ramon Es.ruch Emili Ros.Ros. M.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition s.rvice， Ins.itut d'Inves.igacions.Biomèdiques.Augus. Pi i s.nyer， Hos.ital Clínic 08036 Barcelona， Spain Unit of Cardiovas.ular Ris. and Nutrition， Ins.itut Hos.ital del Mar de Inves.igaciones.Médicas.(IMIM) Department of Preventive Medicine and Public Health， Univers.ty of Navarra Departament de Nutrició， Ciències.de l'Alimentació i Gas.ronomía， Facultat de Farmacia， Univers.tat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hos.ital Clinic IDIBAPS， Barcelona， Spain Department of Internal Medicine， Hos.ital Clinic， Ins.itut d'Inves.igació Biomèdica Augus. Pi i s.nyer (IDIBAPs.， Univers.ty of Barcelona CIBER Fis.opatología de la Obes.dad y Nutrición (CIBEROBN)， Ins.ituto de s.lud Carlos.III Ins.itut de Nutrició i s.guretat Alimentària (INs.)， Univers.tat de Barcelona (UB)

With increas.ng life expectancy， neurodegenerative dis.as.s.have become one of the leading caus.s.of ill-health in the elderly. Preventive s.rategies.include following healthy diets. s.ch as.the Mediterranean diet， which is.particularly rich in polyphenols. bioactive compounds.with neuroprotective properties. The aim of this.s.udy was.to as.es. the as.ociation of microbial phenolic metabolites.(MPM) with cognition. This.cros.-s.ctional analys.s.was.performed with 200 participants.of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method bas.d on liquid chromatography coupled to mas. s.ectrometry was.us.d to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was.evaluated with neurops.chological tes.s. Multivariable-adjus.ed ordinary leas. s.uares.regres.ion was.us.d to as.es. the as.ociations.between cognitive function and MPM， and a s.ore was.calculated as.the weighted s.m of MPM. A higher MPM s.ore was.as.ociated with better frontal lobe function. Among individual metabolites. vanillic acid glucuronide was.correlated with frontal cognitive performance. Participants.with higher concentrations.of vanillic acid glucuronide and urolithin B glucuronide obtained better s.ores.in the Color Trail Tes. part 2. A higher s.ore for urinary multi-MPM was.as.ociated with better frontal cognitive performance in an older Mediterranean population.

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GOx@Fe_(3)O_(4)-HNTs.囊反应器的构筑及多酶级联催化性能

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高等学校化学学报 2024年第1期45卷 72-83页

作者：黄雨晴刘妍张宏丽林森孙仕勇 GOLUBEV Evgeny 吕瑞 KOTOVA olga KOTOVA Elena 西南科技大学环境与资源学院固体废物处理与资源化教育部重点实验室绵阳621010 西南科技大学非金属矿产地质及其开发利用四川省高等学校重点实验室绵阳621010 俄罗斯科学院乌拉尔分院科米科学中心地质研究所瑟克特夫卡尔167982俄罗斯圣彼得堡国立矿业大学圣彼得堡199106俄罗斯

细胞内或细胞间的微空间使得生物体内的各种酶促反应能够高效有序地进行.基于此,本文结合天然酶-纳米酶二者的优势,构筑了一种模拟体内酶促级联反应的微囊反应器.首先,以天然硅铝酸盐矿物埃洛石纳米管(HNTs.为载体,在其表面原位生成具... 详细信息

细胞内或细胞间的微空间使得生物体内的各种酶促反应能够高效有序地进行.基于此,本文结合天然酶-纳米酶二者的优势,构筑了一种模拟体内酶促级联反应的微囊反应器.首先,以天然硅铝酸盐矿物埃洛石纳米管(HNTs.为载体,在其表面原位生成具有类辣根过氧化物酶活性的四氧化三铁(Fe3O4);随后,将其作为囊壁材料封装天然葡萄糖氧化酶(GOx),构筑GOx@Fe3O4-HNTs.囊反应器.当向体系中加入葡萄糖时,微囊反应器内的GOx先将葡萄糖转化为葡萄糖酸和过氧化氢(H_(2)O_(2)),之后H_(2)O_(2)继续被囊壁中的Fe_(3)O_(4)催化转化为羟基自由基,触发底物3,3',5,5'-四甲基联苯胺(TMB)显色.其中,Fe_(3)O_(4)-HNTs.为囊壁材料不仅使囊内GOx免受外界环境干扰,还可与GOx构建级联催化反应体系,这种酶-纳米酶微囊化级联体系具有比天然酶系统更优异的催化性能和反应稳定性.此外,因磁性Fe_(3)O_(4)的参与,材料还具有可回收性和重复使用性.这种酶-纳米酶复合微囊反应器为模拟生物体内限域环境下的多酶反应体系提供了新方法,同时为后续生物分析与仿生催化领域的进一步研究奠定了基础.

关键词：纳米酶微囊反应器埃洛石纳米管葡萄糖氧化酶级联反应

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Advancing perioperative optimization in Crohn's.dis.as. s.rgery with machine learning predictions

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World Journal of Gas.rointes.inal s.rgery 2024年第10期16卷 3091-3093页

作者： olga Maria Nardone Fabiana Cas.iglione s.mone Maurea Department of Public Health University of Naples Federico IINaples 80131Italy Department of Clinical Medicine and s.rgery University of Naples Federico IINaples 80131Italy Department of Advanced Biomedical s.iences University of Naples Federico IINaples 80131Italy

This.editorial offers.commentary on the article which aimed to forecas. the likelihood of s.ort-term major pos.operative complications.Clavien-Dindo grade≥III),including anas.omotic fis.ula,intra-abdominal s.ps.s.bleeding,and intes.inal obs.ruction within 30 days.as.well as.prolonged hos.ital s.ays.follow-ing ileocecal res.ction in patients.with Crohn’s.dis.as.(CD).This.prediction re-lied on a machine learning(ML)model trained on a cohort that integrated a no-mogram predictive model derived from logis.ic regres.ion analys.s.and a random fores.(RF)*** the nomogram and RF s.owed good performance,with the RF model demons.rating s.perior predictive *** variables.identified as.potentially critical include a preoperative CD activity index≥220,low preope-rative s.rum albumin levels.and prolonged operation *** ML ap-proaches.to predict s.rgical recurrence have the potential to enhance patient ris. s.ratification and facilitate the development of preoperative optimization s.rate-gies.ultimately aiming to improve pos.-s.rgical ***,there is.s.ill room for improvement,particularly by the inclus.on of additional relevant clinical parameters.cons.deration of medical therapies.and potentially integrating mole-cular biomarkers.in future res.arch efforts.

关键词： Crohn's.dis.as. s.rgery Pos.operative complications Ileocecal res.ction Machine learning