Frequency of Juvenile Myoclonic Epilepsy Clinical Phenotypes in Siberia
Frequency of Juvenile Myoclonic Epilepsy Clinical Phenotypes in Siberia作者机构：The Voyno-Yasenetsky Krasnoyarsk State Medical University of the Health Ministry of Russia Krasnoyarsk Russia The Chita State Medical Academy of the Health Ministry of Russia Chita Russia
出 版 物：《World Journal of Neuroscience》 (神经科学国际期刊（英文）)
年 卷 期：2016年第6卷第1期
页 面：32-36页
主 题：Idiopathic Generalised Epilepsy Juvenile Myoclonic Epilepsy JME Janz Syndrome Clinic Phenotype Phenotyping Diagnosis Prognosis
摘 要：Juvenile myoclonic epilepsy (JME) is characterised by myoclonia during awakening, generalised tonic-clonic seizures, typical absences and usually presents for the first time at the age of 12 to 18 years old. This article describes the results of a clinical study into JME phenotypes in patients living in the Siberian Federal District. We have shown that the incidence of JME among males was lower than among females (1:1.9) and JME debut age for males was higher than in those women. Classical phenotype of JME (Type I) was dominant and more common in males compared to females—70.4% vs. 58.5%, respectively. The JME phenotype with worse prognosis in terms of achieving stable clinical remission (Type II) occurred 3.5 times more frequently among female patients compared to male (13.2% vs. 3.7% respectively). The findings resulting from this study give a deeper insight into the diagnosis and prognosis of this form of idiopathic generalised epilepsy in predisposed families.
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