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Sniffing Bacteria with a Carbon-Dot Artificial Nose

Nano-Micro Letters 2021年第7期13卷 138-152页

作者： Nitzan Shauloff Ahiud Morag Karin Yaniv Seema Singh Ravit Malishev ofra paz-tal Lior Rokach Raz Jelinek Department of Chemistry Ben Gurion University of the Negev84105 Beer ShevaIsrael Department of Biotechnology Engineering Ben Gurion University of the Negev84105 Beer ShevaIsrael Chemistry Department Nuclear Research CenterNegevP.O.Box 900184190 Beer ShevaIsrael Department of Software and Information System Engineering Ben-Gurion University of the NegevBeer ShevaIsrael Ilse Katz Institute for Nanotechnology Ben Gurion University of the Negev84105 Beer ShevaIsrael

Continuous,real-time monitoring and identification of bacteria through detection of microbially emitted volatile molecules are highly sought albeit elusive *** introduce an artificial nose for sensing and distinguishing vapor molecules,based upon recording the capacitance of interdigitated electrodes(IDEs)coated with carbon dots(C-dots)exhibiting different *** of the C-dot-IDEs to volatile molecules induced rapid capacitance changes that were intimately dependent upon the polarities of both gas molecules and the electrode-deposited *** deciphered the mechanism of capacitance transformations,specifically substitution of electrode-adsorbed water by gas molecules,with concomitant changes in capacitance related to both the polarity and dielectric constants of the vapor molecules *** C-dot-IDE gas sensor exhibited excellent selectivity,aided by application of machine learning *** capacitive C-dot-IDE sensor was employed to continuously monitor microbial proliferation,discriminating among bacteria through detection of distinctive“volatile compound fingerprint”for each bacterial *** C-dot-IDE platform is robust,reusable,readily assembled from inexpensive building blocks and constitutes a versatile and powerful vehicle for gas sensing in general,bacterial monitoring in particular.

关键词： Carbon dots Bacterial detection Bacterially emitted volatile molecules Capacitive gas sensors Gas polarity

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Geometric phase opens new frontiers in nonlinear frequency conversion of light

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Frontiers of physics 2022年第1期17卷 1-5页

作者： Mai tal Danielle Ben Haim tal Ellenbogen Department of Physical Electronics Faculty of EngineeringTel-Aviv UniversityTel-Aviv6779801Israel Raymond and Beverly Sackler School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv6779801Israel Center for Light-Matter Interaction Tel-Aviv UniversityTel-Aviv6779801Israel

Nonlinear frequency conversion of light involves in-teraction of photons through the nonlinear dielec-tric response of mat erials to genera te light at new *** first demonstration of nonlinear optical frequency conver... 详细信息

关键词： nonlinear light frontier

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Manipulation of the intestinal microbiome-a slow journey to primetime

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World Journal of Clinical Cases 2023年第21期11卷 4975-4988页

作者： ofra Kriger-Sharabi Stephen D H Malnick David Fisher Institute of Gastroenterology Assuta Medical CenterAshdod 7747629Israel Department of Internal Medicine Kaplan Medical CenterRehovot 76100Israel Department of Endocrinology Soroka Medical CenterBeer Sheva POB 151Israel

The gut microbiota has important functions in the regulation of normal body *** of the microbiota are being increasingly linked to various disease *** microbiome has been manipulated via the administration of stool from animals or humans,for more than 1000 ***,fecal microbiota transplantation can be performed via endoscopic administration of fecal matter to the duodenum or colon or via capsules of lyophilized *** recently fecal microbial transplantation has been shown to be very effective for recurrent Clostridoides difficile infection(CDI).In addition there is some evidence of efficacy in the metabolic syndrome and its hepatic manifestation,metabolic associated fatty liver disease(MAFLD),irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).We review the current literature regarding the microbiome and the pathogenesis and treatment of CDI,MAFLD,IBS and IBD.

关键词： Gut microbiota Fecal microbiota transplantation Clostridoides difficile Metabolic associated fatty liver disease Irritable bowel syndrome Inflammatory bowel disease

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Cost effectiveness of routine duodenal biopsies in iron deficiency anemia

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World Journal of Gastroenterology 2016年第34期22卷 7813-7823页

作者： Efrat Broide Shay Matalon ofra Kriger-Sharabi Vered Richter Haim Shirin Moshe Leshno The Kamila Gonczarowski Institute of Gastroenterology Assaf Harofeh Medical Center Faculty of Business Administration Tel-Aviv University

AIM To investigate the cost effectiveness of routine small bowel biopsies(SBBs) in patients with iron deficiency anemia(IDA) independent of their celiac disease(CD) serology test *** We used a state transition Markov model. Two strategies were compared: routine SBBs during esophagogastroduodenoscopy(EGD) in all patients with IDA regardless their celiac serology status(strategy A) vs SBBs only in IDA patients with positive serology(strategy B). The main outcomes were quality adjusted life years(QALY),average cost and the incremental cost effectiveness ratio(ICER). One way sensitivity analysis was performed on all variables and two way sensitivity analysis on selected variables were done. In order to validate the results,a Monte Carlo simulation of 100 sample trials with 10,and an acceptability curve were *** Strategy A of routine SBBs yielded 19.888 QALYs with a cost of $218.10 compared to 19.887 QALYs and $234.17 in strategy B. In terms of cost-effectiveness,strategy A was the dominant strategy,as long as the cost of SBBs stayed less than $67. In addition,the ICER of strategy A was preferable,providing the cost of biopsy stays under $77. Monte Carlo simulation demonstrated that strategy A yielded the same QALY but with lower costs than strategy B. CONCLUSION Our model suggests that EGD with routine SBBs is a cost-effective approach with improved QALYs in patients with IDA when the prevalence of CD is 5% or greater. SBBs should be a routine screening tool for CD among patients with IDA,regardless of their celiac antibody status.

关键词： Celiac disease Iron deficiency anemia Cost-effectiveness Esophagogastroduodenoscopy Markov model

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Cattle change plant reproductive phenology,promoting community changes in a post-fire Nothofagus forest in northern Patagonia,Argentina

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Journal of Plant Ecology 2013年第6期6卷 459-467页

作者： Manuel de paz Estela Raffaele Laboratorio Ecotono INIBIOMACONICET-Universidad Nacional del ComahueQuintral 1250San Carlos de BarilocheRio Negro 8400Argentina

Aims Variations in rates and length of flowering and fruiting not only affect the reproduction of a given plant species but also the behavior and reproduction of associated *** and fruiting variations may be influenced by herbivory,especially by large *** aim of this study was to determine the effects of cattle browsing on the reproductive phenology of understory species in a subalpine post-fire Nothofagus forest in *** The effects of herbivory on plant reproductive phenology were studied in a set of experimental exclosures(fenced plots)installed since 2001 in a post-fire *** forest,located in Nahuel Huapi National Park(NHNP),*** monitored the beginning and duration of each reproductive phenological stage:floral bud,open flower,immature fruit and mature *** also counted the number of flowers,fruits,seeds and viable seeds of the dominant plants to assess whether browsing modifies temporal patterns of the flowering and fruiting *** Findings Cattle reduced the total number of species flowering and fruiting and changed the reproductive phenology of some *** found that palatable species seem to be negatively affected by browsing in terms of reduced fitness due to changes in flowering and fruiting *** contrast,cattle benefitted the reproduction of non-palatable species and could promote the invasion of shade-intolerant exotic forbs such as Cirsium *** effects of livestock reported in this study are important to understanding how browsing could alter native species establishment and possibly alter successional trajectories during recolonization after fire.

关键词： plant fitness livestock browsing flowering fruiting

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Accurate and efficient band-gap predictions for metal halide perovskites at finite temperature

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npj Computational Materials 2022年第1期8卷 2267-2279页

作者： Haiyuan Wang Alexey tal Thomas Bischoff Patrick Gono Alfredo Pasquarello Chaire de Simulationàl’Echelle Atomique(CSEA) Ecole Polytechnique Fédérale de Lausanne(EPFL)LausanneCH-1015Switzerland

We develop a computationally efficient scheme to accurately determine finite-temperature band gaps for metal halide perovskites belonging to the class ABX_(3)(A=Rb,Cs;B=Ge,Sn,Pb;and X=F,Cl,Br,I).First,an initial estimate of the band gap is provided for the ideal crystalline structure through the use of a range-separated hybrid functional,in which the parameters are determined non-empirically from the electron density and the high-frequency dielectric ***,we consider two kinds of band-gap corrections to account for spin-orbit coupling and thermal vibrations including zero-point *** particular,the latter effect is accounted for through the special displacement method,which consists in using a single distorted configuration obtained from the vibrational frequencies and eigenmodes,thereby avoiding lengthy molecular *** sequential consideration of both corrections systematically improves the band gaps,reaching a mean absolute error of 0.17 eV with respect to experimental *** computational efficiency of our scheme stems from the fact that only a single calculation at the hybrid-functional level is required and that it is sufficient to evaluate the corrections at the semilocal level of *** scheme is thus convenient for the screening of large databases of metal halide perovskites,including large-size systems.

关键词： theory. perovskite halide

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Gender medicine:Lessons from COVID-19 and other medical conditions for designing health policy

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World Journal of Clinical Cases 2020年第17期8卷 3645-3668页

作者： Yossy Machluf Yoram Chaiter Orna tal Shamir Research Institute University of HaifaKazerin 1290000Israel The Israeli Center for Emerging Technologies in Hospitals and Hospital-based Health Technology Assessment Shamir(Assaf Harofeh)Medical CenterZerifin 7030100Israel Shamir(Assaf Harofeh)Medical Center Affiliated to the Sackler Faculty of MedicineTel Aviv UniversityZerifin 7030100Israel Department of Management Program of Public Health and Health System AdministrationBar Ilan UniversityRamat Gan 5290002Israel

Gender-specific differences in the prevalence,incidence,comorbidities,prognosis,severity,risk factors,drug-related aspects and outcomes of various medical conditions are well *** present a literature review on the extent to which research in this field has developed over the years,and reveal gaps in gender-sensitive awareness between the clinical portrayal and the translation into gender-specific treatment regimens,guidelines and into gender-oriented preventive strategies and health ***,through the lens of gender,we describe these domains in detail for four selected medical conditions:Asthma,obesity and overweight,chronic kidney disease and coronavirus disease *** some of the key gender differences become more apparent during adolescence,we focus on this developmental ***,we propose a model which is based on three influential issues:(1)Investigating gender-specific medical profiles of related health conditions,rather than a single disease;(2)The dynamics of gender disparities across developmental stages;and(3)An integrative approach which takes into account additional risk factors(ethnicity,socio-demographic variables,minorities,lifestyle habits etc.).Increasing the awareness of gender-specific medicine in daily practice and in tailored guidelines,already among adolescents,may reduce inequities,facilitate the prediction of future trends and properly address the characteristics and needs of certain subpopulations within each gender.

关键词： Gender medicine Adolescent health Model Risk factors Guidelines and policy Asthma COVID-19 Obesity Chronic kidney disease

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Unilateral mimicking bilateral BPPV- a forgotten entity? Characteristics of a largecohort of patients, comparison with posterior canal BPPV and clinical implications

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Journal of Otology 2021年第4期16卷 252-257页

作者： Lea Pollak Ronit Gilad tal Michael Neurology and Dizziness Clinic Kupat Cholim Macabi and the Ben GurionUniversity of the NegevBeer ShevaIsrael Neurology Department Kaplan Medical CenterRechovotAffiliated to the HebrewUniversityJerusalemIsrael The Faculty of Health Public Ben Gurion University of the NegevBeerShevaIsrael

Objective: Unilateral mimicking bilateral benign paroxysmal positional vertigo (umb-BPPV) was attributed to inappropriate head positioning during testing of the posterior canal. Despite its inclusion in theDiagnostic criteria for the classification of vestibular disorders of the Barany Society, the clinical characteristics and treatment responsiveness of this BPPV subtype have not been intensively ***: Records of patients with BPPV seen at a single outpatient dizziness clinic during the years 2000e2020 were reviewed. Eighty seven patients with umb-BPPV and 86 random patients with posteriorcanal BPPV (p-BPPV) were retrieved. Their demographics and BPPV characteristics were ***: Patients' and BPPV characteristics were similar in umb- and p-BPPV except for the prevalence ofmales in the umb-BPPV group. No differences were found between treatment responsiveness and recurrences in both groups. The recurrence rate of umb-BPPV was not influenced by age, gender, BPPV side,duration of symptoms or treatment responsiveness during the first ***: In accordance with our hypothesis about mixed canalo- and cupulolithiasis as the underlying mechanism of umb-BPPV, patients did not differ in characteristics and treatment responsivenessfrom p-BPPV patients. Recognition of umb-BPPV is important since inappropriate treatment can cause anunnecessary delay in therapy success.

关键词： Benign paroxysmal positional vertigo Canalo-and cupulolithiasis

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Nurses’ Job Satisfaction and Motivation: Patients’ and Nurses’ Perceptions

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Journal of Biosciences and Medicines 2022年第6期10卷 121-131页

作者： Asnat Dor ofra Halperin Department of Health Systems Management Max Stern Academic College of Emek Yezreel Emek-Yezreel Israel Department of Nursing Max Stern Academic College of Emek Yezreel Emek-Yezreel Israel

Background: High quality care is the main concern of healthcare administrators and it was found to be related to nurses’ job satisfaction and motivation. Purpose: The study aimed to compare patients’ and nurses’ perceptions of nurses’ job satisfaction and motivation. Method: In this cross-sectional study the participants were 315 released patients and 329 nurses from eight hospitals in northern Israel. The participants completed three questionnaires: demographics, nursing job satisfaction, and nursing job motivation. Results: Nurses perceived both job satisfaction and motivation higher than the patients. Duration of hospitalization and being accompanied by family, were positively correlated to patients’ perceptions of these variables. Conclusion/Implications for Practice: To optimize care quality, it is important to assess both patients’ and nurses’ perceptions of nurses’ job satisfaction and motivation. Such an assessment may shed light on the nursing experience and on the way that it is reflected in the patients’ experience. A system-wide process is needed to set a national standard for service quality while emphasizing strategies that promote recognition of nurses’ work, for example, compliments and acknowledgment. This could enhance nurses’ sense of work engagement, which, in turn, may increase the patients’ perception of nurses’ job satisfaction and motivation.

关键词： Job Satisfaction Work Motivation Nurses Patients Hospitalization

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