Manipulation of the intestinal microbiome-a slow journey to primetime

作     者：Ofra Kriger-Sharabi Stephen D H Malnick David Fisher 

作者机构：Institute of GastroenterologyAssuta Medical CenterAshdod 7747629Israel Department of Internal MedicineKaplan Medical CenterRehovot 76100Israel Department of EndocrinologySoroka Medical CenterBeer Sheva POB 151Israel 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第21期

页      面：4975-4988页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gut microbiota Fecal microbiota transplantation Clostridoides difficile Metabolic associated fatty liver disease Irritable bowel syndrome Inflammatory bowel disease 

摘      要：The gut microbiota has important functions in the regulation of normal body *** of the microbiota are being increasingly linked to various disease *** microbiome has been manipulated via the administration of stool from animals or humans,for more than 1000 ***,fecal microbiota transplantation can be performed via endoscopic administration of fecal matter to the duodenum or colon or via capsules of lyophilized *** recently fecal microbial transplantation has been shown to be very effective for recurrent Clostridoides difficile infection(CDI).In addition there is some evidence of efficacy in the metabolic syndrome and its hepatic manifestation,metabolic associated fatty liver disease(MAFLD),irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).We review the current literature regarding the microbiome and the pathogenesis and treatment of CDI,MAFLD,IBS and IBD.