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Biotechnology of Okpeye: A Nigerian Traditional Fermented Food Condiment

Advances in Microbiology 2023年第8期13卷 373-385页

作者： Uchenna K. Akpi nurul aqilah mohd zaini Chukwudi Innocent Nnamchi Jerry Obetta Ugwuanyi Wan Abd Al Qadr Imad Wan-Mohtar Wan Syaidatul Aqma Wan mohd Noor Department of Microbiology University of Nigeria Nsukka Nigeria Department of Food Sciences Faculty of Science and Technology National University of Malaysia Bangi Malaysia Functional Omics and Bioprocess Development Laboratory Biotechnology Program Institute of Biological Sciences Faculty of Science University of Malaya Kuala Lumpur Malaysia Department of Biological Sciences & Biotechnology Faculty of Science and Technology National University of Malaysia Bangi Malaysia

Most legumes and oil bean seeds used in condiment manufacture in Africa are inedible by nature. They contain antinutritional elements such indigestible oligosaccharides and phytate. Fermentation affects desired alterations by lowering anti-nutritional components and enhancing digestibility. Okpeye is a traditional West African seasoning prepared from Prosopis africana seed solid substrate fermentation. Many homes consider it as a family business because the preparation follows a passed-down habit from previous generations as an inexpensive source of plant protein. However, natural nature of the fermentation process raises concerns about the consistency, quality, and safety of the finished product. Because the seasoning is created on a small scale with less sophisticated equipment and manufacturing procedures, there are concerns about microbial safety. Thus, fermentation process and the range of microbial composition involved in Prosopis africana okpeye production were evaluated in this review. Potential spoilage agents, as well as biochemical and nutritional changes occurring during production of okpeye are gaining interest among researcher. This review highlights information that can help in developing starter cultures in a controlled fermentation process that ensures quality, longer shelf life, and microbiological safety.

关键词： Okpeye Prosopis africana Fermentation Legumes Condiment

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Stochastic Computing Convolutional Neural Network Architecture Reinvented for Highly Efficient Artificial Intelligence Workload on Field-Programmable Gate Array

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Research 2024年第2期2024卷 55-79页

作者： Yang Yang Lee zaini Abdul Halim mohd Nadhir Ab Wahab Tarik Adnan Almohamad School of Electrical and Electronic Engineering Universiti Sains MalaysiaNibong Tebal 14300 Penang Malaysia School of Computer Sciences Universiti Sains MalaysiaGelugor11800 PenangMalaysia Electrical-Electronics Engineering Department Faculty of EngineeringKarabuk University78050 KarabukTurkiye

Stochastic computing(SC)has a substantial amount of study on application-specific integrated circuit(ASIC)design for artificial intelligence(AI)edge computing,especially the convolutional neural network(CNN)***,SC has little to no optimization on field-programmable gate array(FPGA).Scaling up the ASIC logic without FPGA-oriented designs is inefficient,while aggregating thousands of bitstreams is still challenging in the conventional *** research has reinvented several FPGA-efficient 8-bit SC CNN computing architectures,i.e.,SC multiplexer multiply-accumulate,multiply-accumulate function generator,and binary rectified linear unit,and successfully scaled and implemented a fully parallel CNN model on Kintex7 *** proposed SC hardware only compromises 0.14%accuracy compared to binary computing on the handwriting Modified National Institute of Standards and Technology classification task and achieved at least 99.72%energy saving per image feedforward and 31?more data throughput than modern *** to SC,early decision termination pushed the performance baseline exponentially with minimum accuracy loss,making SC CNN extremely lucrative for AI edge computing but limited to classification *** SC's inherent noise heavily penalizes CNN regression performance,rendering SC unsuitable for regression tasks.

关键词： hardware Highly rendering

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Occurrence of K1 and K2 serotypes and genotypic characteristics of extended spectrumβ-lactamases-producing Klebsiella pneumoniae isolated from selected hospitals in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 30-38页

作者： nurul Syazrah Anuar Hazmin Hazman Sharven Raj Jeyakumar mohd Nasir mohd Desa Hasni Idayu Saidi Siti Norbaya Masri Nur Afiza Aziz Nurshahira Sulaiman Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia Microbiology Unit Department of PathologyHospital Sultanah AminahJalan Persiaran Sultan Abu Bakar80100 Johor BahruJohorMalaysia

Objective:To determine the distribution,phenotypic and genetic background of extended spectrumβ-lactamases(ESBL)-producing Klebsiella(K.)pneumoniae clinical isolates associated with K1 and K2 serotypes in two selected hospitals in ***:A total of 192 *** isolates were collected and subjected to antibiotic susceptibility,hypermucoviscosity test and multiplex PCR to detect the presence of K1-and K2-serotype associated *** sequence typing(MLST)was performed on ESBL-producing *** isolates presented with K1 and K2 serotypes,followed by phylogenetic ***:A total of 87 out of 192(45.3%)of the *** isolates collected were ESBL ***,only 8.3%(16/192)and 10.9%(21/192)of the total isolates were detected to carry K1-and K2-serotype associated genes,*** analysis showed that K1 and K2 capsular serotypes were not significantly associated with ESBL phenotype(P=0.196).However,they were significantly associated with hypervirulent,as demonstrated by the positive string test(P<0.001).MLST analysis revealed that ST23 as the predominant sequence type(ST)in the K1 serotype,while the ST in the K2 serotype is more ***:Although the occurrence of ESBL-producing isolates among the hypervirulent strains was low,their coexistence warrants the need for continuous *** showed that these isolates were genetically heterogeneous.

关键词： Extended spectrumβ-lactamases Klebsiella pneumoniae Capsular serotypes Genotypic

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A review of salivary composition changes induced by fasting and its impact on health

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Food Science and Human Wellness 2024年第1期13卷 50-64页

作者： nurul Fadhilah Kamalul Aripin NIdayu Zahid mohd Aizat Abdul Rahim Hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah Hashim School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of ChemistryFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Oral and Craniofacial Sciences Faculty of DentistryUniversiti MalayaKuala Lumpur 50603Malaysia UMSC Dental Specialist Clinic UM Dentistry TowerUniversiti MalayaMedical CentreKuala Lumpur 50603Malaysia Leicester School of Allied Health Sciences De Montfort UniversityLeicester LE19BHUnited Kingdom Chancellery(Research and Innovation) Universiti MalayaKuala Lumpur 50603Malaysia

Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and *** diagnostic has gained popularity due to its non-invasive sampling ***(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are *** metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding *** example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many *** timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is *** review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting.

关键词： Saliva Fasting Nitrate Nitrite Nitric oxide

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Nutritional and therapeutic benefits of coconut milk and its potential as a plant-based functional yogurt alternative: a review

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Food Science and Human Wellness 2024年

作者： Gengghatarani Gengan nurul Solehah mohd zaini Nazamid Saari Anis Shobirin Meor Hussin Ahmad Haniff Jaafar Hanan Hasan Elicia Jitming Lim Wan Abd Al Qadr Imad Wan-Mohtar Muhamad Hafiz Abd Rahim Functional Omics and Bioprocess Development Laboratory， Institute of Biological Sciences， Faculty of Science， Universiti Malaya Faculty of Food Science and Technology， Universiti Putra Malaysia School of Life and Environmental Sciences， The University of Sydney

Plant-based milks are on the rise due to an increased awareness of their sustainability and health benefits. Currently， dairy milk is the most nutritionally complete beverage， but it suffers from the presence of indigestible lactose and allergenic proteins. Coconut milk has been around for a long time， but its application is limited due to a perceived lack of specific nutrients， high saturated fat levels， and low acceptability. Recent evidence indicates， however， that the saturated fat and other plant-based components found in coconut milk are good for metabolic outcomes and brain health. The conversion of coconut milk to yoghurt will further improve its functionality by boosting its existing nutritional qualities. In this article， the nutritional value of coconut milk， as well as its potential downsides， its application as yoghurt， and suggestions for enhancing its nutritional functionality will be examined.

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A Comprehensive Classification and Analysis of Geomagnetic Storms Over Solar Cycle 24

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Research in Astronomy and Astrophysics 2024年第8期24卷 75-84页

作者： Raja Adibah Raja Halim Shah nurul Shazana Abdul Hamid Mardina Abdullah Adlyka Annuar Idahwati Sarudin Zahira mohd Radzi Akimasa Yoshikawa Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiMalaysia Space Science Centre(ANGKASA) Institute of Climate ChangeUniversiti Kebangsaan Malaysia43600 BangiMalaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiMalaysia School of Physics Universiti Sains Malaysia11800 USMPulau PinangMalaysia Malaysian Space Agency(MYSA) Kuala Lumpur50480Malaysia International Research Center for Space and Planetary Environmental Science(i-SPES) Kyushu University819-0395 FukuokaJapan

A geomagnetic storm is a global disturbance of Earth?s magnetosphere,occurring as a result of the interaction with magnetic plasma ejected from the *** considerable research,a comprehensive classification of storms for a complete solar cycle has not yet been fully developed,as most previous studies have been limited to specific storm *** study,therefore,attempted to present complete statistics for solar cycle 24,detailing the occurrence of geomagnetic storm events and classifying them by type of intensity(moderate,intense,and severe),type of complete interval(normal or complex),duration of the recovery phase(rapid or long),and the number of steps in the storm?s *** analysis was applied to data from ground-based magnetometers,which measured the Dst index as provided by the World Data Center for Geomagnetism,Kyoto,*** study identified 211 storm events,comprising moderate(177 events),intense(33 events),and severe(1 event)*** 36%of ICMEs and 23%of CIRs are found to be geoeffective,which caused geomagnetic *** to four-step development of geomagnetic storms was exhibited during the main phase for this solar *** showed the geomagnetic storms developed one or more steps in the main phase,which were probably related to the driver that triggered the geomagnetic storms.A case study was additionally conducted to observe the variations of the ionospheric disturbance dynamo(Ddyn)phenomenon that resulted from the geomagnetic storm event of 2015July *** attenuation of the Ddyn in the equatorial region was analyzed using the H component of geomagnetic field data from stations in the Asian sector(Malaysia and India).The variations in the Ddyn signatures were observed at both stations,with the TIR station(India)showing higher intensity than the LKW station(Malaysia).

关键词： (Sun)sunspots-Sun activity-(Sun)solar-terrestrial relations-Sun coronal mass ejections(CMEs)

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Biotechnology of Okpeye: A Nigerian Traditional Fermented Food Condiment

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Advances in Microbiology（微生物学） 2023年第8期

作者： Uchenna K.Akpi nurul aqilah mohd zaini Chukwudi Innocent Nnamchi Jerry Obetta Ugwuanyi Wan Abd Al Qadr Imad Wan-Mohtar Wan Syaidatul Aqma Wan mohd Noor

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Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats

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Journal of Integrative Medicine 2020年第1期18卷 46-58页

作者： Nadiah Razali Aidiahmad Dewa mohd zaini Asmawi Nornisah Mohamed nurul Maizan Manshor Department of Physiology School of Pharmaceutical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Department of Pharmacology School of Pharmaceutical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Department of Chemistry School of Pharmaceutical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia

Objective: To evaluate vasorelaxant and vasoconstriction effects of Zingiber officinale var. rubrum(ZOVR)on live rats and isolated aortic rings of spontaneously hypertensive rats(SHRs).Methods: Extracts of ZOVR were subjected to in-vivo antihypertensive screening using noninvasive blood pressures in SHRs. The most potent extract, ZOVR petroleum ether extract(ZOP) was then fractionated using n-hexane, chloroform and water. Isolated thoracic aortic rings were harvested and subjected to vascular relaxation studies of n-hexane fraction of ZOP(HFZOP) with incubation of different antagonists such as Nω-nitro-L-arginine methyl ester(L-NAME, 10 μmol/L), indomethacin(10 μmol/L), methylene blue(10 μmol/L), atropine(1 μmol/L), glibenclamide(10 μmol/L), prazosin(0.01 μmol/L), and propranolol(1 μmol/L).Results: During the screening of various ZOVR extracts, ZOP produced the most reduction in blood pressures of SHRs and so did HFZOP. HFZOP significantly decreased phenylephrine-induced contraction and enhanced acetylcholine-induced relaxation. L-NAME, indomethacin, methylene blue, atropine, and glibenclamide significantly potentiated the vasorelaxant effects of HFZOP. Propranolol and prazosin did not alter the vasorelaxant effects of HFZOP. HFZOP significantly suppressed the Ca2+-dependent contraction and influenced the ratio of the responses to phenylephrine in Ca2+-free ***: This study demonstrates that ZOP may exert an antihypertensive effect in the SHR model. Its possible vascular relaxation mechanisms involve nitric oxide and prostacyclin release, activation of cGMP-KATP channels, stimulation of muscarinic receptors, and transmembrane calcium channel or Ca2+release from intracellular stores. Possible active compounds that contribute to the vasorelaxant effects are 6-gingerol, 8-gingerol and 6-shogaol.

关键词： Zingiber officinale var.rubrum Vasorelaxation Vasoconstriction Aortic rings Herbal medicine

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Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum *** extract in normal and streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1029-1036页

作者： Leila Mousavi Rabeta mohd Salleh Vikneswaran Murugaiyah mohd zaini Asmawi Food Technology Division School of Industrial TechnologyUniversiti Sains Malaysia Discipline of Pharmacology School of Pharmaceutical SciencesUniversiti Sains Malaysia

Objective:To investigate the antidiabetic activity of Ocimum tenuiflorum L.(***) leaves used in the traditional medicine management of diabetes in ***:*** leaves were extracted sequentially with hexane,chloroform,ethyl acetate,methanol,and *** extracts were evaluated in terms of antidiabetic activity by using acute,subcutaneous glucose tolerance,and sub-chronic tests in streptozotocininduced diabetic *** extracts were also subjected to phytochemical ***:With an acute dose(1 g/kg),the methanol extracts showed significant reduction(31%) in fasting blood glucose(FBG) of the streptozotocin-induced diabetic *** FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts;the decreasing rates were 20%after 2 h,21%after 3 h,and 8%after 5 and 7 *** 7 h(31%),the effect of methanol extract on FBG was significantly lower than that of *** the subcutaneous glucose tolerance test,only methanol and hexane extracts showed the similarity of metformin in diabetic *** 14 days,the effects of these extracts were similar to those of metformin(63.33%).The total flavonoid and phenolic contents of extracts decreased as the polarity of the extraction solvent ***:The results obtained provide support for a possible use of *** leaves in managing hyperglycemia and preventing the complications associated with it in type 2 diabetic.

关键词： Ocimum tenuiflorum L. Streptozotocin-induced diabetes Antidiabetic Fasting blood glucose Subcutaneous glucose tolerance test Phytochemical analysis

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Adsorption Isotherm and Kinetic Study of Methane on Palm Kernel Shell-Derived Activated Carbon

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Journal of Bioresources and Bioproducts 2023年第1期8卷 66-77页

作者： mohd Saufi Md zaini Muhammad Arshad Syed Shatir A.Syed-Hassan School of Chemical Engineering College of EngineeringUniversiti Teknologi MARA Cawangan TerengganuKampus Bukit BesiDungun 23200Malaysia Department of Basic Science Jhang-Campus University of Veterinary and Animal ScienceLahore 35200Pakistan School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia

Activated carbon(AC)was synthesized from palm kernel shell(PKS)using different activating agents,i.e.,steam,carbon dioxide(CO 2),and CO 2-steam,in order to analyze the impact of acti-vating agents on the pore opening of *** this study,AC produced from PKS was found to have great potential as an adsorbent for methane *** different molecular diffusivity and reac-tivity of the combination of CO 2 and steam succeeded in producing AC with the highest burn-offof 78.57%,a surface area of 869.82 m 2/g,a total pore volume of 0.47 cm 3/g,and leading to maximum methane gas adsorption capacity of 4.500 mol/*** types of ACs exhibited the best fit with the Freundlich isotherm model,with the correlation coefficient(R 2)ranging from 0.997 to 0.999,indicating the formation of multilayer *** addition,the adsorption kinetic data for all ACs followed the pseudo-first-order model showing that the rate of adsorption was dependent on both the adsorbent and the adsorbate and was governed primarily by physical ad-sorption between the pore surface and methane *** results of intraparticle diffusion model indicated that the adsorption of methane was affected by both pore diffusion and exterior layer diffusion due to the different adsorption rates.

关键词： Palm kernel shell Activated carbon Methane adsorption Kinetic model Isotherm model

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