Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum *** extract in normal and streptozotocin-induced diabetic rats

作     者：Leila Mousavi Rabeta Mohd Salleh Vikneswaran Murugaiyah Mohd Zaini Asmawi 

作者机构：Food Technology DivisionSchool of Industrial TechnologyUniversiti Sains Malaysia Discipline of PharmacologySchool of Pharmaceutical SciencesUniversiti Sains Malaysia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2016年第6卷第12期

页      面：1029-1036页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Funded by a grant of USM(101/PTEKIND/812176) 

主　　题：Ocimum tenuiflorum L. Streptozotocin-induced diabetes Antidiabetic Fasting blood glucose Subcutaneous glucose tolerance test Phytochemical analysis 

摘      要：Objective:To investigate the antidiabetic activity of Ocimum tenuiflorum L.(***) leaves used in the traditional medicine management of diabetes in ***:*** leaves were extracted sequentially with hexane,chloroform,ethyl acetate,methanol,and *** extracts were evaluated in terms of antidiabetic activity by using acute,subcutaneous glucose tolerance,and sub-chronic tests in streptozotocininduced diabetic *** extracts were also subjected to phytochemical ***:With an acute dose(1 g/kg),the methanol extracts showed significant reduction(31%) in fasting blood glucose(FBG) of the streptozotocin-induced diabetic *** FBG-decreasing effect of ethyl acetate extract was more rapid than that of the other extracts;the decreasing rates were 20%after 2 h,21%after 3 h,and 8%after 5 and 7 *** 7 h(31%),the effect of methanol extract on FBG was significantly lower than that of *** the subcutaneous glucose tolerance test,only methanol and hexane extracts showed the similarity of metformin in diabetic *** 14 days,the effects of these extracts were similar to those of metformin(63.33%).The total flavonoid and phenolic contents of extracts decreased as the polarity of the extraction solvent ***:The results obtained provide support for a possible use of *** leaves in managing hyperglycemia and preventing the complications associated with it in type 2 diabetic.