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Antidiabetic and antioxidant activities of Nypa fruticans Wurmb. vinegar sample from Malaysia

Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 589-597页

作者： Nor Adlin Yusoff Mun Fei Yam Hooi Kheng Beh Khairul Niza Abdul Razak Tri Widyawati Roziahanim Mahmud Mariam Ahmad mohd zaini Asmawi School of Pharmaceutical Sciences Universiti Sains Malaysia Integrative Medicine Cluster Advanced Medical and Dental InstituteUniversiti Sains Malaysia Pharmacology Department Medical FacultyUniversity of Sumatera Utara

Objective: To study the antidiabetic and antioxidant activities of nipa palm vinegar(NPV) used in traditional Malay medicine for treating diabetes. Methods: NPV was extracted using liquid-liquid extraction method and the obtained samples were subjected to antidiabetic studies using normal and streptozotocin-induced diabetic rat models whereas antidoxidant activities were investigated via in vitro antioxidant tests namely 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radicals scavenging activities and the reducing power assay. Results: Single administration of NPV and its extracts were not effective in both normal and diabetic rats. In intraperitoneal glucose tolerance test, NPV and its aqueous extract showed significant blood glucose lowering effect. In the sub-acute study, compared with the diabetic control, aqueous extract of NPV showed the most notable blood glucose lowering effect(56.6%) and a significant improvement in serum insulin levels(79.8%, P<0.05). To assess NPV's antioxidant activity, three in vitro antioxidant tests were employed: 2,2-diphenyl-1-picryhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radical-scavenging assays, and the reducing power assay. Ethyl acetate extract had the greatest antioxidant potential and content of phenolic and flavonoid compounds. A linear positive correlation between the antioxidant parameters was observed. Chemical profiling analysis of aqueous extract of NPV revealed the presence of acetic acid(35.25%), the main active constituent which significantly contributed to the observed antidiabetic activity. Conclusions: Aqueous extract of NPV possesses antihyperglycaemic activities comparable to the metformin, while the ethyl acetate extract precipitated significant antioxidant effects attributable to its high phenolic content. These findings suggest that antioxidant compounds of NPV do not contribute much towards the overall observed antidiabetic effect.

关键词： Nypa fruticans Wurmb. Vinegar Antidiabetic Streptozotocin-induced diabetes Antioxidant Phenolics

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Depression,Anxiety,and Behavioural Changes during the COVID-19 Pandemic among Medical and Nursing Students

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International Journal of Mental Health Promotion 2022年第5期24卷 749-757页

作者： Siti Roshaidai mohd Arifin Siti Mardhiah Saiful Azmi Khadijah Hasanah Abang Abdullah nurul Ain Hidayah Abas Rohayah Husain Edre MAidid Karimah Hanim Abd Aziz Ramli Musa Fathima Begum Syed Mohideen Asma Perveen Khairi Che Mat Izazol Idris Department of Special Care Nursing Kulliyyah of NursingInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Thomson Hospital Kota Damansara Petaling Jaya47810Malaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaBandar Baru Nilai71800Malaysia Department of Psychology and Counselling Faculty of Human DevelopmentUniversiti Pendidikan Sultan IdrisTanjong Malim35900Malaysia Psychological Medicine Unit Faculty of MedicineUniversiti Sultan Zainal AbidinKuala Terengganu21300Malaysia Department of Community Medicine Kulliyyah of MedicineInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Department of Psychiatry Kulliyyah of MedicineInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Department of Educational Studies Faculty of Human DevelopmentUniversiti Pendidikan Sultan IdrisTanjong Malim35900Malaysia

During the COVID-19 pandemic,medical and nursing students are faced with various challenges such as the need to attend online classes and juggling clinical postings under the new *** study aimed to assess the asso-ciation between depression,anxiety,and behavioural changes among medical and nursing students during the COVID-19 *** online self-administered questionnaire was distributed between March 2021 and July 2021 to 292 undergraduates medical and nursing students in a higher education institute on the East Coast of *** questionnaires consisted of four parts:sociodemographic data,the Generalised Anxiety Disor-der-7,the Patient Health Questionnaire-9,and questions related to behaviours during the COVID-19 *** study found that 23.6%and 33.6%of the students experienced anxiety and depression respectively,possibly caused by the COVID-19 *** was associated with a high level of behavioural changes during the pandemic with a total of 87%of the students showing behavioural *** interventions such as online counselling and consultation should be implemented by the university to reduce the prevalence of depres-sion and anxiety resulting from the COVID-19 pandemic among medical and nursing students.

关键词： Nursing students medical students depression anxiety behavioural changes pandemic COVID-19

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Hydrodynamic Modelling of Bidong Island Vicinity Waters

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Open Journal of Marine Science 2015年第3期5卷 306-323页

作者： nurul Rabitah Daud mohd Fadzil mohd Akhir Institute of Oceanography and Environment Universiti Malaysia Terengganu Terengganu Malaysia

This paper explores the dynamic of meteorological forcing on current circulation pattern in the vicinity of Bidong using an unstructured flexible mesh hydrodynamic model. The forcings were wind, tides, temperature and salinity. The seasonal wind monsoon, mixed tides with dominant diurnal and tropical monsoon climate is characteristics of Bidong Island. We find that this area has different current circulation patterns in response to monsoon changes. It also experienced a small scale of island wake during NE monsoon. This island wake was generated by a strong northeasterly wind. We performed a series of numerical simulations based on three dominant factors in circulation, and evaluated the model using wind, tides and density. We investigated the wind-driven circulation and residual current. This study contributes to the debates on hydrodynamic of current circulation in vicinity of Bidong Island. Specifically, this study was conducted to understand the changes of currents by seasonal wind (NE monsoon and SW monsoon), temperature and salinity.

关键词： Hydrodynamic Current Circulation Island Modeling Monsoon

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Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 32-45页

作者： Nur Dini Fatini Mohammad Faizal nurul Afina Ramli Nur Najihah Izzati Mat Rani Nur Adania Shaibie Aartid Pattaporn Poonsawas Sunil K.Sharma mohd Cairul Iqbal mohd Amin Centre for Drug Delivery Technology and Vaccine(CENTRIC) Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Pharmacy University Royal College of Medicine Perak(UniKL RCMP)No.3Jalan GreentownIpoh 30450PerakMalaysia Faculty of Pharmacy Thammasat UniversityBangkok 10200Thailand Department of Chemistry University of DelhiDelhi 110007India

The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives,gaining interest worldwide ever since it was first identified in December *** 2023,752 million cumulative cases and 6.8 million deaths were documented ***-19 has been rapidly evolving,affecting virus transmissibility and properties and contributing to increased disease *** Omicron is themost circulating variant of *** success in its treatment has indicated progress in tackling the virus,limitations in delivering the current antiviral agents in battling emerging variants remain *** the latest advancements in nanotechnology for controlling infectious diseases,liposomes have the potential to counteract SARS-CoV-2 because of their ability to employ different targeting strategies,incorporating monoclonal antibodies for the active and passive targeting of infected *** review will present a concise summary of the possible strategies for utilizing immunoliposomes to improve current treatment against the occurrence of SARSCoV-2 and its variants.

关键词： Coronavirus COVID-19 SARS-CoV-2 Liposomes Immunoliposomes

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Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： nurul Azmawati Mohamed mohd Dzulkhairi mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati Ramli Habibah Faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst *** is because of weak immunity and lack of knowledge on proper hand *** quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,*** A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control *** the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based *** numbers of absent days of all the children were recorded for 2 months before the intervention and during the *** In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention *** These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further.

关键词： Absenteeism Hand hygiene Povidone-iodine Pre-school children

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Effect of reduction roasting by using bio-char derived from empty fruit bunch on the magnetic properties of Malaysian iron ore

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 326-330页

作者： nurul A.Yunus mohd H.Ani Hamzah M.Salleh Rusila Z.A.Rashid Tomohiro Akiyama Hadi Purwanto Nur E.F.Othman Faculty of Engineering International Islamic University Malaysia Center for Advanced Research of Energy and Materials Faculty of EngineeringHokkaido University

Beneficiation of Malaysian iron ore is becoming necessary as iron resources are depleting. However, the upgrading process is challenging because of the weak magnetic properties of Malaysian iron ore. In this study, bio-char derived from oil palm empty fruit bunch （EFB） was utilized as an energy source for reduction roasting. Mixtures of Malaysian iron ore and the bio-char were pressed into briquettes and subjected to reduction roasting processes at 873-1173 K. The extent of reduction was estimated on the basis of mass loss, and the mag-netization of samples was measured using a vibrating sample magnetometer （VSM）. When reduced at 873 K, the original goethite-rich ore was converted into hematite. An increase in temperature to 1073 K caused a significant conversion of hematite into magnetite and enhanced the magnetic susceptibility and saturation magnetization of samples. The magnetic properties diminished at 1173 K as the iron ore was par-tially reduced to wustite. This reduction roasting by using the bio-char can assist in upgrading the iron ore by improving its magnetic proper-ties

关键词： iron ores ore reduction ore roasting bio-char magnetic properties

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Molecular Detection of Mutations within the Quinolone Resistance-Determining Regions in Non Typhoidal Salmonella Isolates from Malaysia

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Health 2017年第4期9卷 640-648页

作者： Fadzilah mohd-Nor Noor Aini Abu-Bakar Norzilawati mohd-Isa Zubaidah A. Wahab zaini mohd-Zain Microbiology Discipline Faculty of Medicine UniversitiTeknologi MARA Sg. Buloh Campus Jalan Hospital Sg. Buloh Selangor Malaysia Community of Research (CoRE) of Health & Wellbeing UniversitiTeknologi MARA Shah Alam Selangor Malaysia Microbiology Unit Department of Pathology Hospital Sg. Buloh Sg. Buloh Selangor Malaysia

Introduction: The efficacy of chemotherapy in bacteraemia caused by non-typhoidal Salmonella (NTS) is compromised by antibiotic resistance. Objective: This study was undertaken to describe the mechanism of resistance among clinical NTS isolates. Materials & Methodology: Thirty of NTS were isolated from blood (n = 19), stool (n = 10) and bronchioalveolar lavage (BAL;n = 1) respectively. These isolates were tested for susceptibility testing by disc diffusion method against ampicillin, gentamicin, tetracycline, co-trimoxazole, nalidixic acid, ciprofloxacin and ceftriaxone. Epsilometer tests (E-test) for nalidixic acid and ciprofloxacin were performed for nalidixic acid resistant isolates by disc diffusion method. DNA sequencing was carried out on six of the nalidixic acid resistant Salmonella Enteritidis isolates to identify mutations within quinolones resistance determining regions (QRDR) of gyrA, gyrB, parC and parE genes. Results: Resistance rates of NTS isolates from blood, stool, and BAL were respectively 37%, 20% and 0% for ampicillin, 79%, 40% and 0% for tetracycline, 32%, 40% and 0% for co-trimoxazole, 37%, 10% and 100% for nalidixic acid. Eight isolates were resistant to nalidixic acid and had exhibited reduced susceptibility towards ciprofloxacin by E-test. Mutation within QRDR was detected in gyrA gene (n = 6;Asp 47 → His [3], Asp 51 → Asn [1], Asp 73 → Gly [1], and Gly 48 → Asp [1]) and double mutation was detected in parE gene (n = 3;Gly 48 → Asp [3], Glu 82 → Ser [3]). Out of six isolates, three isolates were found to have both gyrA and parE gene mutations. Conclusions: There was no mutation observed in gyrB and parC gene. Mutation in gyrA gene was sufficient to induce decreased susceptibility to ciprofloxacin. Variation in amino acid sequences are novel, while detection of other gene mutation was uncommon.

关键词： Non-Typhoidal Salmonella Quinolones Resistance-Determining Regions Ciprofloxacin

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Rheological and MECHANICAL Performance of Asphalt Binders and Mixtures Incorporating CaCO3 and LLDPE

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Organic Polymer Material Research 2019年第1期1卷 10-21页

作者： mohd Rosli mohd Hasan Zhanping You mohd Khairul Idham mohd Satar Muhammad Naqiuddin mohd Warid nurul Hidayah mohd Kamaruddin Sharvin Poovaneshvaran School of Civil Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPulau PinangMalaysia Department of Civil and Environmental Engineering Michigan Technological University1400 Townsend Drive HoughtonMI 49931USA Department of Geotechnics and Transportation Faculty of Civil EngineeringUniversiti Teknologi Malaysia81310 Johor BahruJohorMalaysia Faculty of Civil and Environmental Engineering Universiti Tun Hussein Onn Malaysia86400 Parit RajaBatu PahatJohorMalaysia.

This study was conducted to assess the performance of modified asphalt binders and engineering properties of mixtures prepared with incorporation 3 vol%and 6 vol%of calcium carbonate(CaCO3),linear low-density polyethylene(LLDPE),and combinations of CaCO3 and *** rheological properties of control and modified asphalt binders were evaluated using a series of testing such as rotational viscometer(RV),multiple stress creep recovery(MSCR)and bending beam rheometer(BBR)***,four-point beam fatigue test,the dynamic modulus(E*)test and tensile strength ratio(TSR)test were conducted to assess the engineering properties of asphalt *** on the findings,the RV and MSCR test result shows that all modified asphalt binders have improved performance in comparison to the neat asphalt binders in terms of higher viscosity and improved permanent deformation resistance.A higher amount of CaCO3 and LLDPE have led modified asphalt binders to better recovery percentage,except the asphalt binders modified using a combination of CaCO3 and ***,the inclusion of LLDPE into asphalt binder has lowered the thermal cracking *** incorporation of CaCO3 in asphalt mixtures was found beneficial,especially in improving the ability to resist fatigue cracking of asphalt *** contrast,asphalt mixtures show better moisture sensitivity through the addition of *** addition of LLDPE has significantly enhanced the indirect tensile strength values and tensile strength ratio of asphalt mixtures.

关键词： Asphalt modification Binder rheology Mineral filler Mixture performance Plastic

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The evolution of pneumococcal vaccine on children in Malaysia:the efficacy and outcome

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Infectious Diseases Research 2021年第4期2卷 11-21页

作者： Semiat Opeyemi Yusuff Siti Norbaya Masri nurul Diana Dzaraly Niazlin mohd Taib mohd Nasir mohd Desa Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangor43400 UPMSerdangMalaysia Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPMSerdangSelangorMalaysia

With pathogenic bacterium,numerous studies have been conducted in developing new vaccines,and available pneumococcal vaccines have been implemented for the prevention of related ***,Streptococcus pneumoniae is known to have developed resistance to many of the proposed preventive *** a result,contemporary research,including our study,has reviewed how Streptococcus pneumoniae has become resistant to vaccines and to further determine how to prevent the negative effect of the non-vaccine serotype on vaccine serotype *** have been known as one of the bacteria that has highest preventive strength of vaccination provided to humans,where children’s immunity requires the vital of it,based on immunization schedule to boost their immune system against the diseases of high mortality and *** pneumococcal vaccines are derived from its strains called serotypes,and further research is being conducted to determine more potent vaccines from other pneumococcal virulence *** impose and implement the pneumococcal vaccine,the serotype distribution needs to be *** deal with this verification,clinical or carriage samples are required for the determination and differentiation of vaccine serotypes from non-vaccine *** Malaysia,the carriage rates are often limited to the clinical epidemiology of Streptococcus *** samples are more needed in tracking the vaccine efficacy for pre-and post-immunization to prevent and reduce pneumococcal diseases before they manifest into clinical ***,in this review article,we explore the mentioned highlights for sufficient discussion,discovery,and knowledgeable implementation of pneumococcal vaccine.

关键词： Streptococcus pneumoniae Serotype Vaccine Children Carriage Malaysia

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I-PRESENT<sup>TM</sup>: An Involutive Lightweight Block Cipher

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Journal of Information Security 2014年第3期5卷 114-122页

作者： Muhammad Reza Z’aba Norziana Jamil mohd Ezanee Rusli Md. zaini Jamaludin Ahmad Azlan mohd Yasir College of Information Technology Universiti Tenaga Nasional Kajang Malaysia CoRE Expert Systems Sdn. Bhd. Office 1 Level 2 Resource Centre Technology Park Malaysia Kuala Lumpur Malaysia MIMOS Berhad Kuala Lumpur Malaysia

This paper proposes a new involutive light-weight block cipher for resource-constraint environments called I-PRESENTTM. The design is based on the Present block cipher which is included in the ISO/IEC 29192 standard on lightweight cryptography. The advantage of I-PRESENTTM is that the cipher is involutive such that the encryption circuit is identical to decryption. This is an advantage for environments which require the implementation of both circuits. The area requirement of I-PRESENTTM compares reasonably well with other similar ciphers such as PRINCE.

关键词： Block Cipher Lightweight Cryptography PRESENT PRINCE Cryptanalysis

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