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Hamstring autograft utilization in reconstructing anterior cruciate ligament:Review of harvesting techniques,graft preparation,and different fixation methods

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World Journal of Orthopedics 2022年第10期13卷 876-890页

作者： Waleed Albishi Baraa Baltow nora Albusayes Ameer A Sayed Hamza M Alrabai Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia Department of Orthopedic Surgery AlHada Armed Forces HospitalMinistry of DefenseAlHada 26792Saudi Arabia Department of Orthopedic Surgery King Fahad Armed Forces HospitalMinistry of DefenseJeddah 23311Saudi Arabia

Rupture of the anterior cruciate ligament(ACL)is a common orthopedic *** graft options are available for the reconstruction of ruptured *** the hamstring muscle as an autograft was first described in 1934,and it remains a commonly harvested graft for ACL *** autografts can be harvested using the traditional anteromedial approach or the newer posteromedial *** isolated semitendinosus tendon can be used or combined with the gracilis *** are numerous methods for graft fixation,such as intra-tunnel or extra-tunnel *** comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation *** provides a comprehensive overview for choosing the optimal surgical technique when treating patients.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Graft fixation Hamstring autograft Infrapatellar nerve injury Patient reported outcomes

Ketamine use disorder:preclinical,clinical,and neuroimaging evidence to support proposed mechanisms of actions

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Intelligent Medicine 2022年第2期2卷 61-68页

作者： Leah Vines Diana Sotelo Allison Johnson Evan Dennis Peter Manza nora D.Volkow Gene-Jack Wang Laboratory of Neuroimaging National Institute on Alcohol Abuse and AlcoholismNational Institutes of Health10 Center DrRm B2L124BethesdaMarylandUnited States

Ketamine,a noncompetitive N-methyl-D-aspartate(NMDA)receptor antagonist,has been exclusively used as an anesthetic in medicine and has led to new insights into the pathophysiology of neuropsychiatric *** studies have shown that low subanesthetic doses of ketamine produce antidepressant effects for individuals with ***,its use as a treatment for psychiatric disorders has been limited due to its reinforcing effects and high potential for diversion and *** studies have focused on understanding the molecular mechanisms underlying ketamine’s antidepressant effects,but a precise mechanism had yet to be *** we review different hypotheses for ketamine’s mechanism of action including the direct inhibition and disinhibition of NMDA receptors,aminomethylphosphonic acid receptors(AMPAR)activation,and heightened activation of monoaminergic *** proposed mechanisms are not mutually exclusive,and their combined influence may exert the observed structural and functional neural *** term use of ketamine induces brain structural,functional impairments,and neurodevelopmental effects in both rodents and *** misuse has increased rapidly in the past 20 years and is one of the most common addictive drugs used in *** proposed mechanisms of action and supporting neuroimaging data allow for the development of tools to identify‘biotypes’of ketamine use disorder(KUD)using machine learning approaches,which could inform intervention and treatment.

关键词： Ketamine Neuroimaging N-methyl-D-aspartate Dopamine Serotonin Glutamatergic Gamma-aminobutyric acid

Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats

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Food Science and Human Wellness 2023年第6期12卷 1981-1990页

作者： Ali Y.Naoom Wenyi Kang nora F.Ghanem Mohamed M.Abdel-Daim Fatma M.El-Demerdash Department of Medical Laboratory Techniques Imam Ja'afar Al-Sadiq UniversityAl-Muthanna 66002Iraq National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Department of Zoology Faculty of ScienceKafr ElSheikh UniversityKafr El Sheikh 33516Egypt Department of Pharmaceutical Sciences Pharmacy ProgramBatterjee Medical CollegeJeddah 21442Saudi Arabia Pharmacology Department Faculty of Veterinary MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Environmental Studies Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria 21526Egypt

This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa(kiwifruits)aqueous extract in streptozotocin-treated *** were distributed into;control,*** aqueous extract(ADAE;1 g/kg orally),streptozotocin(STZ;50 mg/kg,i.p,single dose),and STZ plus ADAE,*** showed that ADAE had high antioxidant and radical scavenging *** in blood sugar level,lipid peroxidation(LPO),kidney function biomarkers,and perturbations in hematological parameters were observed in diabetic ***,enzymatic and non-enzymatic antioxidants,protein content,and alkaline phosphatase(ALP)activity ***,histological,immunohistochemical alpha-smooth muscle actin immunoreactivity(α-SMA-ir)and histochemical(collagen,total protein,DNA,and RNA)alterations were observed in rat ***,STZ produced upregulation of inflammatory associated genes(tumor necrosis factor-alpha;TNF-αand transforming growth factorβ1;TGF-β1)and triggered apoptosis by upregulating apoptotic related gene[Bcl2-associated X protein(Bax)]and downregulating anti-apoptotic related gene B-cell lymphoma-2(Bcl-2)based on real-time PCR ***,diabetic rats administered with ADAE showed significant restoration in LPO,antioxidant status,and biochemical indices besides tissue architecture,and genes improvement regarding STZ ***,*** has a valuable ameliorative infl uence and can restore glucose levels and improve kidney dysfunction in diabetic rats.

关键词： Diabetes mellitus Actinidia deliciosa Inflammation Apoptosis Oxidative stress Nephropathy

Petrography and tectonic provenance of the Permian Tunas Formation:Implications on the paleotectonic setting during the ClaromecóForeland Basin evolution,southwestern Gondwana margin,Argentina

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Journal of Palaeogeography 2022年第3期11卷 427-447页

作者： María Belén Febbo Renata N.Tomezzoli nora N.Cesaretti Giselle Choque Natalia B.Fortunatti Guadalupe Arzadún Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Argentina Dpto.de Geología Universidad Nacional del SurAvenida Alem 1253B8000ICPBahía BlancaArgentina Centro de Geología Aplicada y Medio Ambiente(CGAMA CIC–UNS)Dpto.de GeologíaUniversidad Nacional del SurBahía BlancaArgentina Laboratorio de Paleomagnetismo“Daniel A.Valencio” Instituto de Geociencias BásicasAplicadas y Ambientales de Buenos Aires(IGEBA)Departamento de Ciencias GeológicasFacultad de Ciencias Exactas y Naturales(FCEyN)Universidad de Buenos Aires(UBA)Pabellón II(1428)CABAArgentina Laboratorio de Termocronología(La.Te Andes–CONICET) Las Moreras 310A4401XBAVaquerosSaltaArgentina

The Claromec o Basin is located at the south-western sector of the Buenos Aires province,*** basin is considered a foreland basin closely related to the evolution of the southwestern Gondwana *** contribution focuses on the provenance analysis of the Tunas Formation(Permian,Pillahuinc o Group),which represents the last filling stage for the Claromec o Foreland *** and tectonic provenance analyses were performed in sandstones recovered from subsurface(PANG 0001 and PANG0003 exploration wells)and outcrops located close to the basin center(Gonzales Chaves locality).In the subsurface,the analyzed succession is composed of medium-to fine-grained sandstones interbedded with tuffs,mudrocks,carbonaceous mudrocks and coal *** outcrops,the succession is dominated by mediumto fine-grained sandstones interbedded with *** composition patterns are distributed into the recycled orogen and transitionally recycled to mixed *** analyses,in addition to provenance and sedimentological studies,confirm that sedimentary material was derived from a mixed source,which largely comes from the Sierras Australes fold and thrust belt,located towards the W-SW,where the sedimentary succession is interbedded with volcanic *** Tunas Formation shows clear differences in its modal composition,paleocurrent direction and paleoenvironmental conditions with respect to the underlying units of the Pillahuinc o Group(Sauce Grande,Piedra Azul and Bonete formations).Source areas changed from cratonic to mixed fold belt/arc-derived material,suggesting variations in the Claromec o Basin configuration during the Late *** in the paleotectonic scenario during the deposition of the Tunas Formation have been interpreted as a consequence of a compressive post-collisional deformation event,the product of adjustment,accommodation and translation of terrains towards the equator during the Permian-Triassic to form Pangea.

关键词： Provenance area Petrography Tunas Formation ClaromecóForeland Basin Southwestern Gondwana margin Permian Upper Paleozoic

Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients

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World Journal of Hepatology 2023年第2期15卷 225-236页

作者： Michael K Zijlstra Anuhya Gampa nora Joseph Amnon Sonnenberg Claus J Fimmel Department of Internal Medicine NorthShore University Health SystemEvanstonIL 60201United States Division of Gastroenterology and Hepatology University of Chicago Pritzker School of MedicineChicagoIL 60637United States Department of Pathology NorthShore University Health SystemEvanstonIL 60201United States Portland VA Medical Center PortlandOR 97239United States Department of Gastroenterology Oregon Health Sciences UniversityPortlandOR 97201United States Division of Gastroenterology Department of Internal MedicineNorthShore University Health SystemEvanstonIL 60201United States

BACKGROUND Cirrhosis and its complications develop in a subgroup of patients with nonalcoholic fatty liver disease(NASH).Early detection of liver fibrosis represents an important goal of clinical *** To test the hypothesis that the development of cirrhosis in nonalcoholic fatty liver disease patients is preceded by the long-term trends of platelet counts and Fib-4 *** We identified all patients in our healthcare system who had undergone fibrosis staging by liver biopsy or magnetic resonance elastography(MRE)for nonalcoholic fatty liver disease during the past decade(n=310).Platelet counts,serum glutamic-pyruvic transaminase and serum glutamic oxalacetic transaminase values preceding the staging tests were extracted from the electronic medical record system,and Fib-4 scores were *** predictors of advanced fibrosis were evaluated using multivariate regression *** Significant decreases in platelet counts and increases in Fib-4 scores were observed in all fibrosis stages,particularly in patients with *** the liver biopsy group,the presence of cirrhosis was best predicted by the combination of the Fib-4 score at the time closest to staging(P<0.0001),the presence of diabetes(P=0.0001),and the correlation coefficient of the preceding timedependent drop in platelet count(P=0.044).In the MRE group,Fib4 score(P=0.0025)and platelet drop(P=0.0373)were significant *** comparison,the time-dependent rise of the Fib-4 score did not contribute in a statistically significant *** Time-dependent changes in platelet counts and Fib-4 scores contribute to the prediction of cirrhosis in NASH patients with biopsy-or MRE-staged *** incorporation into predictive algorithms may assist in the earlier identification of high-risk patients.

关键词： Non-alcoholic fatty liver disease Liver fibrosis cirrhosis Prediction Liver biopsy Magnetic resonance elastography

An insight into aggregation kinetics of polystyrene nanoplastics interaction with metal cations

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Chinese Chemical Letters 2022年第12期33卷 5213-5217页

作者： Yucheng Zhang Xiaotong Su nora FYTam Xiaolan Lao Meiling Zhong Qihang Wu Huifang Lei Zihui Chen Zhang Li Jie Fu Key Laboratory for Water Quality and Conservation of the Pearl Stream Delta Ministry of EducationSchool of Environmental Science and EngineeringGuangzhou UniversityGuangzhou 510006China State Key Laboratory of Marine Pollution and Department of Chemistry City University of Hong KongHong KongChina School of Science and Technology Open University of Hong KongHong KongChina School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Once inevitably released into the aquatic environment,polystyrene nanoplastics(PS-NPs)will present complicated environmental behaviors,of which the aggregation is a key process determining their environmental fate and *** this study,the aggregation kinetics of different sizes(30 nm and 100 nm)of PS-NPs with metal cations(Na^(+),K^(+),Ca^(2+),Mg^(2+)and Pb^(2+))at different solution pH(3,6 and 8)were *** results showed that the aggregation of PS-NPs increased with cation *** Pb^(2+)as an example,the adsorption behavior of cations onto PS-NPs was determined by transmission electron microscopy(TEM)and energy dispersive X-ray(EDX)spectroscopy,which demonstrated Pb^(2+)could be adhered onto the surface of PS-NPs with the effect of charge *** critical coagulation concentrations(CCC)of smaller PS-NPs were higher than that of larger PS-NPs for monovalent cations,whereas a different pattern is observed for divalent *** was suggested that there were other factors that DLVO theory does not consider affect the stability of NPs with different particle *** addition,it should be noted that PS-NPs had the capacity of adsorbing large amounts of heavy metal cations and carried them transport to a long distance,and the corresponding ecological risks need to further elucidate.

关键词： Polystyrene nanoplastics Lead cation Aggregation kinetics Critical coagulation concentration Size effect

Association of COVID- 19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study

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Family Medicine and Community Health 2023年第4期11卷 45-55页

作者： Lindsey Wang Pamela B Davis Nathan Berger David C Kaelber nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for AI in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus(RSV)infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the *** This is a retrospective population-based cohort *** outcomes were examined,including overall RSV infection,positive lab test-confirmed RSV infection,clinically diagnosed RSV diseases,RSV-associated bronchiolitis and unspecified *** ratio(RR)and 95%CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched *** Nationwide multicentre database of electronic health records(EHRs)of 61.4million patients in the USA including 1.7million children 0–5 years of age,which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals,primary care and specialty treatment *** The study population consisted of 228940 children of 0–5 years with no prior RSV infection who had medical encounters in October *** were replicated in a separate study population of 370919 children of 0–5 years with no prior RSV infection who had medical encounters in July 2021–August 2021 during a non-overlapping time *** For the 2022 study population(average age 2.4 years,46.8%girls,61%white,16%black),the risk for incident RSV infection during October 2022–December 2022 was 6.40%for children with prior COVID-19 infection,higher than 4.30%for the matched children without COVID-19(RR 1.40,95%CI 1.27 to 1.55);and among children aged 0–1year,the overall risk was 7.90%for those with prior COVID-19 infection,higher than 5.64%for matched children without(RR 1.40,95%CI 1.21 to 1.62).For the 2021 study population(average age 2.2 years,46%girls,57%white,20%black),the risk for incident RSV infection during July 2021–December 2021 was 4.85%for childre

关键词： infections matched centre

Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023

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Family Medicine and Community Health 2023年第4期11卷 36-44页

作者： Lindsey Wang Nathan Berger Pamela B Davis David C Kaelber nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for Artificial Intelligence in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective The long-term time trend and seasonality variations of first-time medically attended respiratory syncytial virus(RSV)infections among young children are *** aim to examine the time trend of medically attended first-time RSV infections among young children in the USA from January 2010 through January *** This is a population-based cohort study using electronic health records(EHRs).Monthly incidence rate of medically attended first-time RSV infection(cases per 10000000 person-days).A time-series regression model was used to model and predict time trends and *** Multicenter and nationwide TriNetX Network in the *** The study population comprised children aged 0–5 years who had medical visits during the period of January 2010 to January *** The data included 29013937 medical visits for children aged 0–5 years(46.5%girls and 53.5%boys)from January 2010 through January *** 2010 through 2019,the monthly incidence rate of first-time medically attended RSV infection in children aged 0–5 years followed a consistent seasonal *** patterns of medically attended RSV infections were significantly disrupted during the COVID-19 *** 2020,the seasonal variation disappeared with a peak incidence rate of 20 cases per 1000000 person-days,a decrease of 97.4%from the expected peak rate(rate ratio or RR:0.026,95%CI 0.017 to 0.040).In 2021,the seasonality returned but started 4 months earlier,lasted for 9 months,and peaked in August at a rate of 753 cases per 1000000 person-days,a decrease of 9.6%from the expected peak rate(RR:0.90,95%CI 0.82 to 0.99).In 2022,the seasonal pattern is similar to prepandemic years but reached a historically high rate of 2182 cases per 10000000 person-days in November,an increase of 143%from the expected peak rate(RR:2.43,95%CI 2.25 to 2.63).The time trend and seasonality of the EHR-based medically attended RSV infections are consistent with those of RSV-associated hospital

关键词： infections trend attended

Using immune cell-based bioactivity assays to compare the inflammatory activities of oil sands process-affected waters from a pilot scale demonstration pit lake

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Journal of Environmental Sciences 2023年第6期128卷 55-70页

作者： Dustin M.E.Lillico nora A.S.Hussain Yemaya Y.Choo-Yin Rui Qin Zuo Tong How Mohamed Gamal El-Din James L.Stafford Department of Biological Sciences University of AlbertaAlberta T6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaAlberta T6G 2E9Canada

In this study,we provide evidence that oil sands process-affected waters(OSPW)contain factors that activate the antimicrobial and proinflammatory responses of immune ***,using the murine macrophage RAW 264.7 cell line,we establish the bioactivity of two different OSPW samples and their isolated ***,we directly compared the bioactivity of two pilot scale demonstration pit lake(DPL)water samples,which included expressed water from treated tailings(termed the before water capping sample;BWC)as well as an after water capping(AWC)sample consisting of a mixture of expressed water,precipitation,upland runoff,coagulated OSPW and added *** inflammatory(*** activating)bioactivity was associated with the AWC sample and its organic fraction(OF),whereas the BWC sample had reduced bioactivity that was primarily associated with its inorganic fraction(IF).Overall,these results indicate that at non-toxic exposure doses,the RAW 264.7 cell line serves as an acute,sensitive and reliable biosensor for the screening of inflammatory constituents within and among discrete OSPW samples.

关键词： OSPW Oil sands Tailings ponds Remediation Macrophages Bioactivity Bioindicator Immunoecotoxicology