Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats

作     者：Ali Y.Naoom Wenyi Kang Nora F.Ghanem Mohamed M.Abdel-Daim Fatma M.El-Demerdash Ali Y.Naoom;Wenyi Kang;Nora F.Ghanem;Mohamed M.Abdel-Daim;Fatma M.El-Demerdash

作者机构：Department of Medical Laboratory TechniquesImam Ja'afar Al-Sadiq UniversityAl-Muthanna 66002Iraq National R&D Center for Edible Fungus Processing TechnologyHenan UniversityKaifeng 475004China Department of ZoologyFaculty of ScienceKafr ElSheikh UniversityKafr El Sheikh 33516Egypt Department of Pharmaceutical SciencesPharmacy ProgramBatterjee Medical CollegeJeddah 21442Saudi Arabia Pharmacology DepartmentFaculty of Veterinary MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Environmental StudiesInstitute of Graduate Studies and ResearchAlexandria UniversityAlexandria 21526Egypt 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第6期

页      面：1981-1990页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 083203[工学-农产品加工及贮藏工程] 10[医学] 

基　　金：Institute of Graduate Studies and Research Alexandria University, AU 

主　　题：Diabetes mellitus Actinidia deliciosa Inflammation Apoptosis Oxidative stress Nephropathy 

摘      要：This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa(kiwifruits)aqueous extract in streptozotocin-treated *** were distributed into;control,*** aqueous extract(ADAE;1 g/kg orally),streptozotocin(STZ;50 mg/kg,i.p,single dose),and STZ plus ADAE,*** showed that ADAE had high antioxidant and radical scavenging *** in blood sugar level,lipid peroxidation(LPO),kidney function biomarkers,and perturbations in hematological parameters were observed in diabetic ***,enzymatic and non-enzymatic antioxidants,protein content,and alkaline phosphatase(ALP)activity ***,histological,immunohistochemical alpha-smooth muscle actin immunoreactivity(α-SMA-ir)and histochemical(collagen,total protein,DNA,and RNA)alterations were observed in rat ***,STZ produced upregulation of inflammatory associated genes(tumor necrosis factor-alpha;TNF-αand transforming growth factorβ1;TGF-β1)and triggered apoptosis by upregulating apoptotic related gene[Bcl2-associated X protein(Bax)]and downregulating anti-apoptotic related gene B-cell lymphoma-2(Bcl-2)based on real-time PCR ***,diabetic rats administered with ADAE showed significant restoration in LPO,antioxidant status,and biochemical indices besides tissue architecture,and genes improvement regarding STZ ***,*** has a valuable ameliorative infl uence and can restore glucose levels and improve kidney dysfunction in diabetic rats.