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Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias,Northern Spain

World Journal of Pediatrics 2022年第12期18卷 835-844页

作者： Elisa garcía-garcía Mercedes Rodríguez-Pérez David Pérez-Solís Carlos Pérez-Méndez Cristina Molinos-Norniella Ángeles Cobo-Ruisánchez Eva María Fernández Fernández noelia garcía gonzález Laura Calle-Miguel Pediatrics Department Centro de Salud LaviadaCalle Juanín de Mieres833207GijónSpain Microbiology Department Hospital Universitario Central de AsturiasOviedoSpain Pediatrics Department Hospital Universitario San AgustínAvilésSpain Pediatrics Department Hospital Universitario de CabueñesGijónSpain Pediatrics Department Hospital Carmen y Severo Ochoa.Cangas del NarceaSpain Pediatrics Department Centro de Salud TeatinosOviedoSpain Pediatrics Department Hospital Universitario Central de AsturiasOviedoSpain

Background Updated seroprevalence estimates are important to describe the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)landscape and to guide public health *** aims are to describe longitudinal changes in seroprevalence in children in a region in Northern Spain and to analyze factors associated with SARS-CoV-2 *** Prospective multicenter longitudinal study with subjects recruited from July to September ***(up to 14 years old)were included and followed up until September *** blood samples were collected every six months during three testing rounds and were analyzed for SARS-CoV-2 *** data regarding epidemiological features,contact tracing,symptoms,and virological tests were *** evolution of SARS-CoV-2 seroprevalence during the study and the differences between children with positive and negative SARS-CoV-2 antibody tests were *** Two hundred children were recruited(50.5%girls,median age 9.7 years).The overall seroprevalence increased from round 1[1.5%,95%confidence interval(CI)0.3%–4.3%]to round 2(9.1%,95%CI 4.6%–12.7%)and round 3(16.6%,95%CI 9.5%–19.6%)(P<0.001).Main changes occurred in children aged zero to four years(P=0.001)who lived in urban areas(P<0.001).None of the children who were previously positive became *** multivariable analysis,three variables independently associated with SARS-CoV-2 seropositivity were identified:close contact with coronavirus disease 2019(COVID-19)confirmed or suspected cases[odds ratio(OR)=3.9,95%CI 1.2–12.5],previous positive virological test(OR=17.1,95%CI 3.7–78.3)and fatigue(OR=18.1,95%CI 1.7–193.4).Conclusions SARS-CoV-2 seroprevalence in children has remarkably increased during the time of our *** was the only COVID-19-compatible symptom that was more frequent in seropositive than in seronegative children.

关键词： Antibodies Child COVID-19 Seroepidemiologic studies

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The immune system:uncharted pathways between senses and the brain

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Neural Regeneration Research 2024年第6期19卷 1173-1174页

作者： noelia Casares Mar Cuadrado-Tejedor Ana garcía-Osta Juan JoséLasarte Immunology and Immunotherapy Program Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Division of Gene Therapy for Neurological Disorders Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Pathology Anatomy and Physiology DepartmentSchool of MedicineUniversity of NavarraIDISNAPamplonaSpain

Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth *** perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological *** addition to the direct effects of sense-induced mediators in the brain.

关键词： prompt system transmitting

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Stable Matchings in the Marriage Model with Indifferences

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Journal of the Operations Research Society of China 2021年第3期9卷 593-617页

作者： noelia Juarez Jorge Oviedo Instituto de Matemática Aplicada San Luis IMASLUniversidad Nacional de San Luis and CONICETEjército de los Andes 950D5700HHW San LuisArgentina

For the marriage model with indifferences,we define an equivalence relation over the stable matching *** identify a sufficient condition,the closing property,under which we can extend results of the classical model(without indifferences)to the equivalence classes of the stable matching *** condition allows us to extend the lattice structure over classes of equivalences and the rural hospital theorem.

关键词： Stability Indifferences Lattice structure

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Marriage Market with Indifferences: A Linear Programming Approach

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Journal of the Operations Research Society of China 2023年第1期11卷 219-242页

作者： noelia Juarez Pablo A.Neme Jorge Oviedo Instituto de Matemática Aplicada San Luis IMASLRedNIEUniversidad Nacional de San Luis and CONICETD5700HHWSan LuisRepublica Argentina

We study stable and strongly stable matchings in the marriage market with indifference in their *** characterize the stable matchings as integer extreme points of a convex *** give an alternative proof for the integrity of the strongly stable matching ***,we compute men-optimal(women-optimal)stable and strongly stable matchings using linear *** preferences are strict,we find the men-optimal(women-optimal)stable matching.

关键词： Matching markets The marriage market with indifferences Optimal stable matchings Linear programming

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Long noncoding RNA in cardiac aging and disease

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Journal of Molecular Cell Biology 2019年第10期11卷 860-867页

作者： noelia Lozano-Vidal Diewertje IBink Reinier A.Boon Department of Physiology Amsterdam Cardiovascular SciencesAmsterdam Universitair Medische CentraVrije Universiteit Amsterdam1081 HZAmsterdamthe Netherlands Institute of Cardiovascular Regeneration Goethe UniversityFrankfurt am MainGermany German Center for Cardiovascular Research(DZHK) Partner Site Rhein-MainBerlinGermany

Cardiovascular diseases(CVDs)are the main cause of morbidity and mortality in Western society and present an important agerelated *** the constant rise in life expectancy,prevalence ofCVD in the population will likely increase *** therapies,especially in the elderly,are needed to combat *** review is focused on the role of long noncoding RNA(IncRNA)in *** sequencing experiments in the past decade showed that most RNA does not code for protein,but many RNAs function as ***,we summarize the recent findings of IncRNA regulation in the diseased *** potential use of these RNAs as biomarkers of cardiac disease prediction is also discussed.

关键词： long non coding RNA aging cardiovascular disease

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ADAM17/TACE:a key molecule in brain injury regeneration

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Neural Regeneration Research 2019年第8期14卷 1378-1379页

作者： Samuel Dominguez-garcia Carmen Castro noelia Geribaldi-Doldan Area de Fisiologia Facultad de Medicina Universidad de Cadiz Cadiz Spain Instituto de Investigacion e Innovacion Biomedica de Cadiz (INIBICA) Universidad de Cadiz Cadiz Spain

It has been many years since "the tumor necrosis factor-a-converting enzyme”,also known as ADAM17/TACE, was described as "the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.

关键词： ADAM17/TACE key molecule injury regeneration

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Role of capsule endoscopy in suspected celiac disease: A European multi-centre study

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World Journal of Gastroenterology 2017年第4期23卷 703-711页

作者： Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier garcia-Lledo José-Francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-garcía Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio López-Higueras noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos Bruno Rosa Santiago gonzález-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona gonzález-Suárez Sofía Xavier Federico Argüelles-Arias Juan-Manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-garcía-Argüelles Digestive Diseases Unit General University Hospital of Valencia Small Bowel Unit Hospital Morales Meseguer Digestive Diseases Unit General University Gregorio Maranón Unit of Gastroenterology and Endoscopy Complejo Hospitalario de Navarra Center for prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterology and Endoscopy University Hospital Virgen Macarena Gastroenterology department Hospital Virgen de la Arrixaca Department of Gastroenterology Complejo Hospitalario de Toledo Department of Gastroenterology University of Navarra Clinic1 Endoscopy Digestive Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestive Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestive Diseases Unit Clinical Hospital San Carlos1 Digestive Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestive Unit Hospital Clinic de Barcelona

AIMTo analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE).METHODSThis is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were *** overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated *** has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.

关键词： Capsule endoscopy Celiac disease Anti-transglutaminase antibodies Gluten-free diet Non-celiac gluten sensitivity

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Non-guided self-learning program for high-proficiency optical diagnosis of diminutive and small colorectal lesions: A single-endoscopist pilot study

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World Journal of Gastroenterology 2019年第10期25卷 1278-1287页

作者： Marco Bustamante-Balén Carla Satorres Lorena Puchades Belén Navarro Natalia garcía-Morales noelia Alonso Marta Ponce Lidia Argüello Vicente Pons-Beltrán Gastrointestinal Endoscopy Research Group Gastrointestinal Endoscopy UnitDigestive Diseases DepartmentLa Fe Polytechnic University Hospital Digestive Diseases Department La Fe Polytechnic University Hospital Gastrointestinal Endoscopy Unit Digestive Diseases DepartmentLa Fe Polytechnic University Hospital

BACKGROUND The implementation of optical diagnosis(OD) of diminutive colorectal lesions in clinical practice has been hampered by differences in performance between community and academic settings. One possible cause is the lack of a standardized learning tool. Since the factors related to better learning are not well described, strong evidence upon which a consistent learning tool could be designed is lacking. We hypothesized that a self-designed learning program may be enough to achieve competency in OD of diminutive lesions of the *** To assess the accuracy of OD of diminutive lesions in real colonoscopies after application of a self-administered learning *** This was a single-endoscopist prospective pilot study, in which an experienced endoscopist followed a self-designed, self-administered learning program in OD of colorectal lesions. An assessment phase divided in two halves with a 6-mo period in between without performance of OD was developed in a populationbased colorectal cancer screening program. The accomplishment of the Preservation and Incorporation of Valuable Endoscopic Innovations criteria and performance measures were calculated overall and in the two halves of the assessment phase, assessing their response to the 6-mo stopping period. The evolution of performance through blocks of 50 lesions was also *** Overall, 152 patients and 522 lesions(≤ 5 mm: 399, and 6-9 mm: 123) were included. The negative predictive value for the OD of adenoma in rectosigmoid lesions diagnosed with high confidence was 91.7% [95% confidence interval(CI):87.3-96.6]. The proportion of agreement on surveillance interval between OD and pathological diagnosis was higher than 95%. Overall accuracy for diminutive lesions diagnosed with high confidence was 89.5%(95%CI: 86.3-92.7). The overall accuracy of OD was similar in the two halves of the assessment phase [90.1(95%CI: 85.6-94.7) vs 88.2(95%CI: 87.9-95.9)]. All the other performance parameters we

关键词： Optical diagnosis Accuracy Learning Polyp Colonoscopy Education

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NUMERICAL ANALYSIS OF A PROBLEM INVOLVING A VISCOELASTIC BODY WITH DOUBLE POROSITY

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Journal of Computational Mathematics 2022年第3期40卷 415-436页

作者： noelia Bazarra Jose R.Fernandez MariCarme Leseduarte Antonio Magana Ramon Quintanilla Departamento de Matematica Aplicada I Universidade de VigoETSI TelecomunicacionCampus As Lagoas Marcosende s/n36310 VigoSpain Departamento de Matematicas E.S.E.I.A.A.T.-U.P.C.Colom 1108222 TerrassaBarcelonaSpain

We study from a numerical point of view a multidimensional problem involving a viscoelastic body with two porous *** mechanical problem leads to a linear system of three coupled hyperbolic partial differential *** corresponding variational formulation gives rise to three coupled parabolic linear *** existence and uniqueness result,and an energy decay property,are ***,fully discrete approximations are introduced using the finite element method and the implicit Euler scheme.A discrete stability property and a priori error estimates are proved,from which the linear convergence of the algorithm is derived under suitable additional regularity ***,some numerical simulations are performed in one and two dimensions to show the accuracy of the approximation and the behaviour of the solution.

关键词： Viscoelasticity with double porosity Finite elements A priori estimates Numerical simulations

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A commentary on the interplay of biomaterials and cell adhesion:new insights in bone tissue regeneration

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BIOCELL 2024年第11期48卷 1517-1520页

作者： A.NOEL GRAVINA noelia D´ELÍA LUCIANO A.BENEDINI PAULA MESSINA DepartamentodeQuímica UniversidadNacionaldelSur(UNS)BahíaBlanca8000Argentina INQUISUR-CONICET UniversidadNacionaldelSur(UNS)BahíaBlanca8000Argentina DepartamentodeBiología BioquímicayFarmaciaUniversidadNacionaldelSur(UNS)BahíaBlanca8000Argentina

This article navigates the relationship between biomaterials and osteogenic cell adhesion,highlighting the importance of mimicking the physiological response for bone tissue *** this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix,explaining the leading role of integrins and cadherins in cell adhesion,and the intracellular signaling pathways ***,there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment,taking advantage of these known speciﬁc signaling ***ﬁnal remarks lay on the need for careful consideration of in-vitro and in-vivo complexities in biomaterial development.

关键词： Osteogenesis Cadherins Integrins Extracellular cell matrix

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