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Pro-and anti-inflammatory cytokines profiles among Nigerian children infected with Plasmodium falciparum malaria

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 41-44页

作者： nmorsi opg Isaac C Ukwandu NCD Ohaneme BA Tropical Disease Reseach Unit Department of ZoologyAmbrose Aui Univeosity Department of Medical Microbiology Ambrose Alli University

Objective:To examine array of some pro- and anti-inflammatory cytokines,namely, interleukin-4(IL-4),interleukin-10(IL-10),interferon-γ(IFN-γ),interleukin-5(IL-5), interleukin-6(IL-6),interleukin-12(IL-12) and tumor necrosis factor-α(TNF-α) concentrations in some Nigerians with falciparum ***:Sera were obtained from the blood samples of 96 Nigerian children with Plasmodium falciparum *** sera were subjected to cytokine evaluation using commercial standard enzyme linked immunosorbent assay kits(Abcam,UK).Results:Mean pro-inflammatory cytokines in serum of children with uncomplicated and complicated malaria were IL-5 482.2 pg/mL versus 526.7 pg/mL,IL-6 98.8 pg/mL versus 82.6 pg/mL,IL-12 24.1 pg/mL versus 15.9 pg/mL,TNF-α107 pg/mL versus 511.7 pg/mL and IFN- 7 2.1 pg/mL versus 2.5 pg/*** anti-inflammatory cytokines status of IL-4 were 4.7 pg/mL versus 20.3 pg/mL,and IL-10 were 216 pg/mL versus 143.8 pg/mL in uncomplicated versus complicated/severe malaria *** with uncomplicated malaria had mean parasitaemia level of 3 158.9 parasites/μL while mean parasitaemia level for participants with complicated malaria was 12 550.5 parasite/μL and this difference was statistically significant(χ~2 =5 614.6,P<0.05).The difference between mean haemoglobin level for uncomplicated malaria(9.6 g/dL) and severe malaria(3.9 g/dL) was statistically significant (χ~2 = 2.3,P<0.05).The relationship between serum level of IL-6,IL-12,IFN-γ,IL-10 and IL-4 and ages showed positive correlation at r=0.92,0.99,0.86,0.95 and 0.85,respectively;while IL-5 and TNF-αhad negative correlation at r=-0.99 and -0.99,***: IL-4,IL-5,IL-6,IL-10,IL-12,TNF-αand IFN-γare involved in the immunopathology and immunoregulation of uncomplicated and complicated malaria ***-6,IL-12,IFN-γand IL-10 depressed in complicated/severe malaria may not provide any protective immunity and may be indicators of poor prognosis in Plasmodium falciparum infected

关键词： Plasmodium falciparum Pro-and anti-inflammatory cytokines Children Anaemia Nigeria

Relationship between pro-and anti-inflammatory cytokines profiles and some haematological parameters in some Cameroonians infected with Onchocerca volvulus

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 713-717页

作者： nmorsi opg Nkot BP Isaac C Che J Tropical Disease Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria

Objective:To investigate the relationship between white blood cells,lymphocytes,monocytes, and Interleukin(IL)-1α,***-10 and IL-13 production in Cameroonians with Onchocerca volvulus(***) ***:A lolal of 357 individuals from five sites at Upper *** and Sanaga Maritime divisions and located along Sanaga valley of Sanaga River in South Cameroon were screened for the presence of *** using the skin *** levels of the interleukins(IL-) namely IL-1α,IL-6,IL-10 and IL-13 were evaluated using enzyme linked immunoabsorbent assay *** parameters were evaluated using standard laboratory automated ***:*** microfilariae were found in skin tissues of 85(23.81%) *** mean interleukin(IL-) levels in the 0,volvulus control and infected individuals were IL-1αin(1.65±0.79 and 2.31±0.5) pg/ml.:IL-6 in(278.36±55.34 and 20l.74±34.56) pg/ml.:IL-10 in(436.03±208.64 and 418.49±I47.88) pg/*** IL-13 in(8.98±7.28 and 3S.06±11.92) pg/*** was a negative correlation between monocyte counts and IL-10 concentration in positive individuals.A negative correlation of IL-6 with while blood cell and lymphocyte counts was observed(P<0.05).The level of IL-13 was positively associated with microfilaria]load(P<0.05).Conclusions:We observed depressed IL-6 and raised IL-13 concentrations in the sera of individuals with onchocerciasis which implicate these interleukins in the immunological responses of the ***,these IL-6 and IL-13 are associated with *** infection among Cameroonians.

关键词： Pro inflammatory cytokines Anti inflammatory cytokines Haematological parameters Onchocerca volvulus Cameroonians Microfilarial load

Schistosoma haematobium and Plasmodium falciparum coinfection with protection against Plasmodium falciparum malaria in Nigerian children

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 16-20页

作者： nmorsi opg Isaac C Ukwandu NCD Ekundayo AO Ekozien MI Tropical Diseases Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria Department of Medical Microbiology Ambrose Alli UniversityEkpomaNigeria Department of Microbiology Ambrose Alli UniversityEkpomaNigeria

Objective:Malaria remains the single leading killer of children in sub - Sahara Africa and Schistosomiasis is considered to be second to malaria in global *** - infection of malaria and urinary schistosomiasis has been reported to exacerbate disease morbidity such as *** different part of the globe,the co - infection between malaria and schistosomiasis provides some protections on the infected *** protective effect of this co - infection elucidated immunologically using cytokines is lacking in our ***:Urine and blood samples obtained from the 160 volunteers were subjected to standard parasitological techniques for diagnosis of urinary schistosomiasis and malaria *** samples collected from these volunteers comprising 80 children with schistosomiasis and malaria and the 80 children who had malaria only were subjected to cytokines concentration determination using commercial standard enzyme linked immunosorbent assay kits(Abeam,UK).Results:Eighty participants with co - infection had a mean malarial parasitaemia of 662±201.1μL while the 80 participants with only *** malaria had a mean malarial parasiteamia of 5943±3270.7μ*** the volunteers had mean haemoglobin of 11.2 g/dL for co - infected individuals and 5.7 g/dL for participants with single infection of *** serum cytokine levels of the children with S. haematobium and *** and only *** infection are as follows;interleukin - 4(16.6 pg/ mL versus 5.2 pg/mL),IL - 5(501.3 pg/mL versus 357.5 pg/mL);IL -8(2 550 pg/mL versus 309 pg/mL),IL - 10(273 pg/mL versus 290 pg/mL),TNF -α(25 pg/mL versus 290 pg/mL) and IFN -γ(21.9 pg/mL versus 2.5 pg/mL).The TNF -α/IL - 10 ratio is 7 for the children with co - infection while those with only *** malaria infection had a TNF -α/IL - 10 ratio of ***:We conclude that the elevated IL - 4,IL - 5,IL - 8 and IFN -γconcentration induced by schistosomiasis altered the Th1/Th 2 profile a

关键词： Schistosoma haematobium Plasmodium falciparum Malaria

Serum cytokines profiles in Nigerian children with Ascaris lumbricoides infection

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 288-291页

作者： nmorsi Onyebiguwa Patrick Goddey Irior Dominic Osagie Abu Maliki Tropical Diseases Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria

Objective:To investigate the cytokines pr of ile in the serum of some Nigerian children with Ascaris lumbricoides(***) infection and relations between the intensity of infection, age and the concentration of these ***:Feacal samples from consenting children were examined using formol ether concentration techniques and Kato-Katz thick smear *** of 96 children comprising 76 *** infection and 20 controls were subjected to enzymes-linked immunosorbent ***:The mean sera concentration of tumor necrosis factor alpha(TNF-α),interleukin-4(IL-4),interleukin-5(IL-5),interleukin- 10(IL-10) were(16.7±7.6) pg/mL,(4.6±0.8)pg/mL,(391.6±52.0) pg/mL and(181.2±30.4) pg/mL,*** control subjects had the following mean serum cytokines:TNF-α(2.9±1.8) pg/m,IL-4(4.0±0.1) pg/mL,IL-5(125.1±50.1) pg/mL,IL-10(74.5±54.2) pg/ mL,*** difference between the sera cytokines concentration of the *** infected children and their controls were statistically significant for TNF-α,IL- 5 and IL-10(χ~2= 9.99,P< 0.05;χ~2 = 137.24,P < 0.05;χ~2 = 44.30,P < 0.05,respectively). The intensity of infection correlated positively with TNF-α,and IL-5(r = 0.93 and 0.98, respectively) while IL-4 and IL- 10 correlated negatively with the intensity of infection(r = -0.62 and 0.99,respectively).TNF-α,IL-4 and IL-5 correlated positively with age(r = 0.19,0.33 and 0.66,respectively).The mean cytokines between those with mild and moderate infections were statistically significant for TNF-α,IL-5 and IL-10(χ~2 = 3.60,4.52 and 5.30, respectively).The ratio of TNF-α:IL-10 was ***:Elevated IL-5,IL-10 and TNF-αfound in the sera of the volunteers with Ascariasis implicates these cytokines as key mediators in the host responses to *** infection in our studied area.

关键词： IL-4 IL-5 IL-10 TNF-α Ascaris lumbricoides Children Nigeria

Human African trypanosomiasis in endemic focus of Abraka,Nigeria

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 448-450页

作者： Onyebiguwa Patrick Goddey nmorsi Clement Isaac Igho Benjamin Igbinosa Duncan Ogheneocovo Umukoro Dafe Palmer Aitaikuru Tropical Disease Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria Family Medicine Department Delta State UniversityAbraka Department of Science Laboratory Technology Delta State PolytechnicOtefeOghara

Objective:To investigated the prevalence of human African trypanosomiasis(HAT),a neglected tropical disease caused by Trypanosoma brucei gambiens in an endemic focus of Nigeria,as it relates to age,sex and occupational ***:A total of 474 human subjects were screened using card agglutination test for trypanosomiasis *** samples were further investigated for parasite positivity in blood/serum and cerebrospinal fluid(CSF).Results:Of the 474 screened,44(9.3%) were seropositive with seroprevalence of 22(9.6%) in Urhouka,14(9.5%) in Umeghe and 8(7.9%) for *** number of seropositives,observed for weakly,moderately and strongly positives for the three communities were 4,7 and 11 in Urhouka,4,5 and 5 in Umeghe and 3,2 and 3 in Ugonu *** the 16 volunteers with detected parasite in their blood,4 of them were weakly positive,5 of them were moderately positive and 7 of them strongly positive.4 volunteers from Urhouka community were found parasites in their CSF and they were all strongly *** difference between the seroprevalence of males and females was not statistically significant(OR=1.14,95%CI=0.37-3.4,P>0.05).The prevalence difference between age group 21-30 years old and the youngest and oldest age groups was statistically significant(OR=3.5,95%CI= 1.08-12.57,P0.05),It was observed that farmers had significantly higher prevalence of HAT infection as well as greater risk of Trypanosoma brucei gambiense infection than inhabitants with other occupations (OR=3.25,95%CI=0.99-11.79,P<0.05).Conclusions:Human activities such as farming and visits to the river have been identified as major risk factors to *** the breakdown of HAT control program has been advanced for the rise in HAT in Abraka,an endemic focus in Nigeria.

关键词： Human African trypanosomiasis Trypanosoma brucei gambiense Seropositivity Risk factors Nigeria