Schistosoma haematobium and Plasmodium falciparum coinfection with protection against Plasmodium falciparum malaria in Nigerian children

作     者：Nmorsi OPG Isaac C Ukwandu NCD Ekundayo AO Ekozien MI 

作者机构：Tropical Diseases Research UnitDepartment of ZoologyAmbrose Alli UniversityEkpomaNigeria Department of Medical MicrobiologyAmbrose Alli UniversityEkpomaNigeria Department of MicrobiologyAmbrose Alli UniversityEkpomaNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2009年第2卷第2期

页      面：16-20页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Schistosoma haematobium Plasmodium falciparum Malaria 

摘      要：Objective:Malaria remains the single leading killer of children in sub - Sahara Africa and Schistosomiasis is considered to be second to malaria in global *** - infection of malaria and urinary schistosomiasis has been reported to exacerbate disease morbidity such as *** different part of the globe,the co - infection between malaria and schistosomiasis provides some protections on the infected *** protective effect of this co - infection elucidated immunologically using cytokines is lacking in our ***:Urine and blood samples obtained from the 160 volunteers were subjected to standard parasitological techniques for diagnosis of urinary schistosomiasis and malaria *** samples collected from these volunteers comprising 80 children with schistosomiasis and malaria and the 80 children who had malaria only were subjected to cytokines concentration determination using commercial standard enzyme linked immunosorbent assay kits(Abeam,UK).Results:Eighty participants with co - infection had a mean malarial parasitaemia of 662±201.1μL while the 80 participants with only *** malaria had a mean malarial parasiteamia of 5943±3270.7μ*** the volunteers had mean haemoglobin of 11.2 g/dL for co - infected individuals and 5.7 g/dL for participants with single infection of *** serum cytokine levels of the children with S. haematobium and *** and only *** infection are as follows;interleukin - 4(16.6 pg/ mL versus 5.2 pg/mL),IL - 5(501.3 pg/mL versus 357.5 pg/mL);IL -8(2 550 pg/mL versus 309 pg/mL),IL - 10(273 pg/mL versus 290 pg/mL),TNF -α(25 pg/mL versus 290 pg/mL) and IFN -γ(21.9 pg/mL versus 2.5 pg/mL).The TNF -α/IL - 10 ratio is 7 for the children with co - infection while those with only *** malaria infection had a TNF -α/IL - 10 ratio of ***:We conclude that the elevated IL - 4,IL - 5,IL - 8 and IFN -γconcentration induced by schistosomiasis altered the Th1/Th 2 profile a