Serum cytokines profiles in Nigerian children with Ascaris lumbricoides infection

作     者：Nmorsi Onyebiguwa Patrick Goddey Irior Dominic Osagie Abu Maliki 

作者机构：Tropical Diseases Research UnitDepartment of ZoologyAmbrose Alli UniversityEkpomaNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2010年第3卷第4期

页      面：288-291页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：IL-4 IL-5 IL-10 TNF-α Ascaris lumbricoides Children Nigeria 

摘      要：Objective:To investigate the cytokines pr of ile in the serum of some Nigerian children with Ascaris lumbricoides(***) infection and relations between the intensity of infection, age and the concentration of these ***:Feacal samples from consenting children were examined using formol ether concentration techniques and Kato-Katz thick smear *** of 96 children comprising 76 *** infection and 20 controls were subjected to enzymes-linked immunosorbent ***:The mean sera concentration of tumor necrosis factor alpha(TNF-α),interleukin-4(IL-4),interleukin-5(IL-5),interleukin- 10(IL-10) were(16.7±7.6) pg/mL,(4.6±0.8)pg/mL,(391.6±52.0) pg/mL and(181.2±30.4) pg/mL,*** control subjects had the following mean serum cytokines:TNF-α(2.9±1.8) pg/m,IL-4(4.0±0.1) pg/mL,IL-5(125.1±50.1) pg/mL,IL-10(74.5±54.2) pg/ mL,*** difference between the sera cytokines concentration of the *** infected children and their controls were statistically significant for TNF-α,IL- 5 and IL-10(χ~2= 9.99,P 0.05;χ~2 = 137.24,P 0.05;χ~2 = 44.30,P 0.05,respectively). The intensity of infection correlated positively with TNF-α,and IL-5(r = 0.93 and 0.98, respectively) while IL-4 and IL- 10 correlated negatively with the intensity of infection(r = -0.62 and 0.99,respectively).TNF-α,IL-4 and IL-5 correlated positively with age(r = 0.19,0.33 and 0.66,respectively).The mean cytokines between those with mild and moderate infections were statistically significant for TNF-α,IL-5 and IL-10(χ~2 = 3.60,4.52 and 5.30, respectively).The ratio of TNF-α:IL-10 was ***:Elevated IL-5,IL-10 and TNF-αfound in the sera of the volunteers with Ascariasis implicates these cytokines as key mediators in the host responses to *** infection in our studied area.