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An Energy-Efficient Protocol for Internet of Things Based Wireless Sensor Networks

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Computers, Materials & Continua 2023年第5期75卷 2397-2412页

作者： Mohammed Mubarak Mustafa Ahmed Abelmonem Khalifa Korhan Cengiz nikola Ivkovic Department of Information Technology Sri Krishna College of Engineering&TechnologyCoimbatoreIndia Department of Networking and Security College of Information TechnologyUniversity of FujairahFujairahUAE Switching and Traffic Department National Telecommunication InstituteCairoEgypt Department of Computer Engineering Istinye UniversityZeytinburnuIstanbulTurkey Faculty of Organization and Informatics University of ZagrebVarazdinCroatia

The performance of Wireless Sensor Networks(WSNs)is an important fragment of the Internet of Things(IoT),where the current WSNbuilt IoT network’s sensor hubs are enticing due to their critical *** grouping hubs,a clustering convention offers a useful solution for ensuring energy-saving of hubs andHybridMedia Access Control(HMAC)during the course of the ***,current grouping standards suffer from issues with the grouping structure that impacts the exhibition of these conventions *** this investigation,we recommend an Improved Energy-Proficient Algorithm(IEPA)for HMAC throughout the lifetime of the WSN-based *** consecutive segments are *** the covering of adjusted clusters,an ideal number of clusters is determined ***,fair static clusters are shaped,based on an updated calculation for fluffy cluster heads,to reduce and adapt the energy use of the sensor *** heads(CHs)are,ultimately,selected in optimal locations,with the pivot of the cluster heads working among cluster ***,the proposed convention diminishes and balances the energy utilization of hubs by improving the grouping structure,where the IEPAis reasonable for systems that need a long *** assessment results demonstrate that the IEPA performs better than existing conventions.

关键词： Energy consumption improved energy-proficient algorithm internet of things wireless sensor network

Dual biologic therapy with ocrelizumab for multiple sclerosis and vedolizumab for Crohn's disease:A case report and review of literature

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World Journal of Clinical Cases 2022年第8期10卷 2569-2576页

作者： Michael Au nikola Mitrev Rupert W Leong Viraj Kariyawasam Department of Gastroenterology and Hepatology Blacktown and Mt Druitt HospitalsWestern Sydney Local Health DistrictSydney 2148New South WalesAustralia Blacktown Clinical School Western Sydney UniversityBlacktown 2148New South WalesAustralia Department of Gastroenterology and Hepatology Blacktown HospitalWestern Sydney Local Health DistrictBlacktown 2148New South WalesAustralia Endoscopy Department and Inflammatory Bowel Disease Service Concord HospitalSydney 2137New South WalesAustralia Concord Clinical School University of SydneySydney 2137New South WalesAustralia Inflammatory Bowel Disease Service Blacktown HospitalWestern Sydney Local Health DistrictBlacktown 2148New South WalesAustria

BACKGROUND Little is known about the safety and efficacy of using two or more biologics for the treatment of immune-mediated diseases,including Crohn’s disease(CD).CASE SUMMARY This case report and narrative review demonstrate the potential safety of dual biologic therapy(DBT)in a 45-year-old female with two separate immunemediated *** had a history of multiple sclerosis for which she was receiving treatment with ocrelizumab,and she had been recently diagnosed with CD after presenting with *** CD diagnosis was confirmed radiologically,endoscopically,histologically,and *** patient received treatment with vedolizumab,a gut-specific inhibitor of theα4β7 integrin on *** adverse reactions were observed for the duration of *** safety of ocrelizumab and vedolizumab for the treatment of different immune-mediated diseases was *** DBT may be a safe and effective option for the treatment of refractory disease or multiple immunemediated *** biologics,which have improved safety profiles and gut specificity,may provide promising avenues for ***,caution must be exercised in the appropriate selection of biologics given their inherent immunosuppressive properties,side effects,and efficacy *** evidence suggests that biologic therapy is not associated with a worse prognosis in patients with coronavirus disease 2019,but treatment decisions should be made in a multidisciplinary *** research from controlled trials is needed to better understand the safety profile of DBT in *** immunopathological mechanisms underlying DBT also remain to be clarified.

关键词： Dual biologic therapy Combination Immunosuppression Safety Autoimmune Case report

Research of Mechanical and Thermal Properties of Composite Material Based on Gypsum and Straw

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Journal of Renewable Materials 2022年第7期10卷 1859-1873页

作者： nikola Vavřínová Kateřina Stejskalová JiříTeslík Kateřina Kubenková JiříMajer Faculty of Civil Engineering VSB-Technical University of OstravaOstrava70800Czech Republic

This article is focused on the investigation of the mechanical and thermal properties of composite material that could be used for the production of plaster or *** composite material is made of gypsum and reinforcing natural *** article verifies whether this natural reinforcement can improve the investigated properties compared to conventional plasters and gypsum plasterboards made of pure *** this composite material,high-strength plasterboards could then be produced,which meet the higher demands of users than conventional gypsum *** their production,natural waste materials would be used *** part of the development of new building materials,it is necessary to specify essential characteristics for their later use in civil *** wheat straw and three gypsum classes with strengths G2(2 MPa)—gypsum Class I.,G5(5 MPa)—gypsum Class *** G16(16 MPa)—gypsum Class *** used to create the test *** were made with different ratios of the two ingredients,with the percentages of straw being 0%,2.5%,and 5%for each gypsum *** first part of the article describes how the increasing proportion of straw affects the composite’s mechanical properties(flexural strength and compressive strength).The second part of the article focuses on the change of thermal properties(thermal conductivity and specific heat capacity).The last part of the article mentions the verification of the fire properties(single-flame source fire test and gross heat of combustion)of this composite *** research has shown that the increasing proportion of straw reinforcement caused a deterioration in the flexural strength(up to 56.49%in the *** of gypsum Class II.)and compressive strength(up to 80.27%in the *** of gypsum Class III.)and an improvement in the specific heat capacity and thermal conductivity(up to 31.40%in the ***).This composite material is thus not suitable for the production of high-streng

关键词： Composite material gypsum plasterboard crushed straw flexural strength compressive strength thermal conductivity specific heat capacity ignitability gross heat of combustion

Treatment options in stage I seminoma

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Oncology Research 2022年第3期30卷 117-128页

作者： UROS BUMBASIREVIC MARKO ZIVKOVIC MILOS PETROVIC VESNA CORIC nikola LISICIC NEBOJSA BOJANIC Clinic of Urology University Clinical Center of SerbiaBelgrade11000Serbia Faculty of Medicine University of BelgradeBelgrade11000Serbia Institute of Medical and Clinical Biochemistry Faculty of MedicineUniversity of BelgradeBelgrade11000Serbia

Seminomas are most commonly diagnosed in clinical stage I(CSI).After orchiectomy,approximately 15%of patients in this stage have subclinical *** radiotherapy(ART)delivered to the retroperitoneum and ipsilateral pelvic lymph nodes has been the mainstay of treatment for many *** highly efﬁcient,with long-term cancer-speciﬁc survival(CSS)rates approaching almost 100%,ART is associated with considerable long-term consequences,particularly cardiovascular toxicity and increased risk of secondary malignancies(SMN).Therefore,active surveillance(AS)and adjuvant chemotherapy(ACT)were developed as alternative treatment *** AS prevents patient overtreatment,it is associated with strict follow-up regimens and increased radiation exposure due to repeated *** to equivalent CSS rates to ART,and lower toxicity,one course of adjuvant carboplatin presents the cornerstone of chemotherapy for CSI *** is almost 100%for patients with CSI seminoma,regardless of the chosen treatment ***,a personalized approach in treatment selection is ***,routine radiotherapy for CSI seminoma patients is no longer ***,it should be reserved for patients who are unﬁt or unwilling for AS or ***ﬁcation of prognostic factors for disease relapse allowed for the development of risk-adapted treatment strategy and stratiﬁcation of patients in low-risk and high-risk *** risk-adapted policy needs further validation,surveillance is currently recommended in low-risk patients,while ACT is reserved for patients with a higher risk of relapse.

关键词： Chemotherapy Radiotherapy Risk-adapted strategy Seminoma Surveillance

Classical behaviour of various variables in an open Bose-Hubbard system

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Chinese Physics B 2011年第12期20卷 63-71页

作者： nikola Buri Institute of Physics University of BelgradeP O BOX 6811000 BelgradeSerbia

Quantum dispersions of various sets of dynamical variables of an open Bose-Hubbard system in a classical limit are studied. To this end, an open system is described in terms of stochastic evolution of its quantum pure states. It is shown that the class of variables that display classical behaviour crucially depends on the type of noise. This is relevant in the mean-field approximation of open Bose-Hubbard dynamics.

关键词： quantum trajectories decoherence classical limit

Glial cells in intracerebral transplantation for Parkinson’s disease

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Neural Regeneration Research 2020年第7期15卷 1173-1178页

作者： nikola Tomov Institute of Anatomy University of Bern

In the last few decades,intracerebral transplantation has grown from a dubious neuroscientific topic to a plausible modality for treatment of neurological *** possibility for cell replacement opens a new field of perspectives in the therapy of neurodegenerative disorders,ischemia,and neurotrauma,with the most lessons learned from intracerebral transplantation in Parkinson's *** animal studies and a few small-scale clinical trials have proven the concept of intracerebral grafting,but still have to provide a uniform and highly efficient approach to the procedure,suitable for clinical *** success of intracerebral transplantation is highly dependent on the integration of the grafted cells with the host *** this process,glial cells are clearly more than passive *** provide transplanted cells with mechanical support,trophics,mediate synapse formation,and participate in graft *** the same time,glial cells mediate scarring,graft rejection,and neuroinflammation,which can be *** can use this information to try to understand the mechanisms behind the glial reaction to intracerebral *** and utilizing glial reactivity can move translational research forward and provide an insight not only to post-transplantation events but also to mechanisms of neuronal death and *** about glial reactivity to transplanted cells could also be a key for optimization of transplantation protocols,which ultimately should contribute to greater patient benefit.

关键词： astroglia dopaminergic glial scarring microglia neuroinflammation Parkinson's disease transplantation

A comparison of power measurement techniques and electrical characterization of an atmospheric pressure plasma jet

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Plasma Science and Technology 2022年第10期24卷 74-85页

作者： Olivera JOVANOVIĆ Nevena PUAČ nikolaŠKORO Institute of Physics University of BelgradePregrevica 118Belgrade 11080Serbia

In the last two decades a growing interest has been shown in the investigation of atmospheric pressure plasma jets(APPJs)that operate in contact with liquid *** order to form a complete picture about such experimental systems,it is necessary to perform detailed diagnostics of plasma jets,as one step that will enable the adjustment of system properties for applications in different *** this work,we conducted a detailed electrical characterisation of a plasma system configuration used for water treatment.A helium plasma jet,with a pin electrode powered by a continuous sine wave at a frequency of 330 k Hz,formed a streamer that was in contact with a distilled water *** electrical circuit allowed the monitoring of electrical signals supplied to the jet and also to the plasma *** electrical characterisation together with power consumption measurements was obtained by using two different *** first method was based on the direct measurements of voltage and current signals,while in the second method we used'Lissajous figures'.We compared these two methods when used for discharge power estimation and addressed their advantages and *** results showed that both of these methods could be used to successfully determine power consumed by a discharge in contact with water,but only when taking into account power dissipation without plasma.

关键词： APPJ electrical characterization discharge power Lissajous figure

Measures of intracranial compartments in acute intracerebral haemorrhage:data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial(RIGHT-2)

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Stroke & Vascular Neurology 2023年第2期8卷 151-160页

作者： Kailash Krishnan Zhe Kang Law Lisa J Woodhouse Rob A Dineen nikola Sprigg Joanna M Wardlaw Philip M Bath Stroke Department of Acute MedicineNottingham University Hospitals NHS TrustNottinghamUK Stroke Trials Unit University of NottinghamNottinghamUK Department of Medicine National University of Malaysia Faculty of MedicineKuala LumpurMalaysia Radiological Sciences Research Group University of NottinghamNottinghamUK National Institute of Health Research Nottingham Biomedical Research Centre University of NottinghamNottinghamUK Centre for Clinical Brain Sciences UK Dementia Research InstituteChancellor's BuildingUniversity of EdinburghEdinburghUK

Background and purpose Intracerebral haemorrhage volume(ICHV)is prognostically important but does not account for intracranial volume(ICV)and cerebral parenchymal volume(CPV).We assessed measures of intracranial compartments in acute ICH using computerised tomography scans and whether ICHV/ICV and ICHV/CPV predict functional *** also assessed if cistern effacement,midline shift,old infarcts,leukoaraiosis and brain atrophy were associated with *** Data from 133 participants from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial trial were *** included ICHV(using ABC/2)and ICV(XYZ/2)(by independent observers);ICHV,ICV and CPV(semiautomated segmentation,SAS);atrophy(intercaudate distance,ICD,Sylvian fissure ratio,SFR);midline shift;leukoaraiosis and cistern effacement(visual assessment).The effects of these measures on death at day 4 and poor functional outcome at day 90(modified Rankin scale,mRS of>3)was *** ICV was significantly different between XYZ and SAS:mean(SD)of 1357(219)vs 1420(196),mean difference(MD)62 mL(p<0.001).There was no significant difference in ICHV between ABC/2 and *** was very good agreement for ICV measured by SAS,CPV,ICD,SFR,leukoaraiosis and cistern score(all interclass correlations,n=10:interobserver 0.72-0.99,intraobserver 0.73-1.00).ICHV/ICV and ICHV/CPV were significantly associated with mRS at day 90,death at day 4 and acute neurological deterioration(all p<0.05),similar to *** shift and cistern effacement at baseline were associated with poor functional outcome but old infarcts,leukoaraiosis and brain atrophy were *** Intracranial compartment measures and visual estimates are *** adjusted for ICH and CPV could be useful to prognosticate in acute *** presence of midline shift and cistern effacement may predict outcome but the mechanisms need validation in larger studies.

关键词： measures Tri nitrate

Using antifibrinolytics to tackle neuroinflammation

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Neural Regeneration Research 2020年第12期15卷 2203-2206页

作者： Stanimir Atsev nikola Tomov Faculty of Medicine Trakia UniversityStara ZagoraBulgaria Institute of Anatomy University of BernBernSwitzerland

Plasmin is generally known as a promotor of *** advancement suggests that it has a complex role as immunity *** inhibition of plasmin production and activity has been proven to improve neurological outcomes in traumatic brain injury and subarachnoid hemorrhage,most probably by preventing *** immune-modulatory properties of antifibrinolytics,however,suggest that they probably have effects unrelated to fibrinolysis inhibition,which are currently not adequately *** present work aims to give an account of the existing data regarding antifibrinolytics as agents influencing *** and clinical studies on the possible influence of antifibrinolytics on neuroinflammation are ***,the emerging evidence suggests that inhibition of plasmin(ogen)activity can ameliorate neuroinflammation to some *** data demonstrate that plasmin(ogen)is not exclusively involved in fibrinolysis,but also has other substrates and can precipitate in inflammatory *** on the role of plasmin as the factor for the development of neuroinflammation shows the significant potential of antifibrinolytics as pharmacotherapy of neuroinflammationm,which is worthy of further exploration.

关键词： antifibrionolytics fibrin fibrinogen neuroinflammation plasmin plasminogen tranexamic acid