Using antifibrinolytics to tackle neuroinflammation

作     者：Stanimir Atsev Nikola Tomov 

作者机构：Faculty of MedicineTrakia UniversityStara ZagoraBulgaria Institute of AnatomyUniversity of BernBernSwitzerland 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第12期

页      面：2203-2206页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：antifibrionolytics fibrin fibrinogen neuroinflammation plasmin plasminogen tranexamic acid 

摘      要：Plasmin is generally known as a promotor of *** advancement suggests that it has a complex role as immunity *** inhibition of plasmin production and activity has been proven to improve neurological outcomes in traumatic brain injury and subarachnoid hemorrhage,most probably by preventing *** immune-modulatory properties of antifibrinolytics,however,suggest that they probably have effects unrelated to fibrinolysis inhibition,which are currently not adequately *** present work aims to give an account of the existing data regarding antifibrinolytics as agents influencing *** and clinical studies on the possible influence of antifibrinolytics on neuroinflammation are ***,the emerging evidence suggests that inhibition of plasmin(ogen)activity can ameliorate neuroinflammation to some *** data demonstrate that plasmin(ogen)is not exclusively involved in fibrinolysis,but also has other substrates and can precipitate in inflammatory *** on the role of plasmin as the factor for the development of neuroinflammation shows the significant potential of antifibrinolytics as pharmacotherapy of neuroinflammationm,which is worthy of further exploration.