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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf muhammad Bilal Hanif Zuhra Tayyab matej Veis mAKYousaf Shah Naveed mushtaq Dmitry medvedev Yibin Tian Chen Xia martin motola Bin Zhu College of mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules mJanssen Daalen Aurélien Patoz Julien FBally martin Kopp Davide malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Controlling Heat Transfer for the manufacturing of High molecular Weight Polyisobutylene via Formation of micelles

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Chinese Journal of Polymer Science 2019年第9期37卷 898-902页

作者： Szilard Csihony nicole Janssen Klaus mühlbach Advanced materials & Systems

An alternative cationic polymerization method is developed to produce high molecular weight polyisobutylene (Hm-PIB) with molecular weights above 5×10^5g/mol. The method involves micelle formation via functionalized low molecular weight polyisobutylene (Lm-PIB) in non-polar solvent. One end of Lm-PIB is modified with an imidazolium-containing ionic group, which together with the anion (eg. Al2Cl7) works as Lewis acid. While the monomer isobutylene dissolves readily in non-polar solvent, polymerization can occur only within the micelle, which affords stable Hm-PIB particles. Hm-PIB with a molecular weight (mW) close to 1 × 10^6 g/mol was produced successfully with the described method.

关键词： Cationic polymerization High molecular weight polyisobutylene micelle

The role of cellular and molecular neuroimmune crosstalk in gut immunity

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Cellular & molecular Immunology 2023年第11期20卷 1259-1269页

作者： Daping Yang nicole Almanzar Isaac m.Chiu Department of Immunology Harvard Medical SchoolBostonMA02115USA

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关键词： Neuroimmunology Neuroimmune Host defense Gut Sensory

Helper T cell differentiation

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Cellular & molecular Immunology 2019年第7期16卷 634-643页

作者： Jordy Saravia nicole m.Chapman Hongbo Chi Department of Immunology St.Jude Children’s Research HospitalMemphisTNUSA

CD4^(+)T helper cells are key regulators of host health and *** the original model,specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)T-cell ***,we first discuss CD4^(+)T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper *** next describe the mechanisms underlying CD4^(+)T-cell differentiation,including cytokine-induced signaling and transcriptional *** then review current and emerging topics of differentiation,including the plasticity and heterogeneity of T cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate ***,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity.

关键词： T cells Treg differentiation plasticity immunometabolism

metabolic phenotyping of mouse mutants in the German mouse Clinic

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Integrative Zoology 2006年第3期1卷 122-125页

作者： Ralf ELVERT nicole EHRHARDT martin TAUBE martin KLINGENSPOR Valerie GAILUSDURNER Helmut FUCHS martin Hrabe DE ANGELIS Veronique BLANQUET Gerhard HELDmAIER Institute of Experimental Genetics German Mouse ClinicNeuherbergMunichGermany Department of Biology Philipps University of MarburgMarburgGermany Laboratory of molecular Experimental Genetics Institute of TransgenoseOrleansFrance

The German mouse Clinic was established as a phenotyping center to provide the scientific community with systematic standardized phenotyping of mouse models from various genetic *** found metabolic phenotypes in nine out of 20 mutant lines screened in a primary *** on these findings,the mutants were analyzed in secondary and tertiary *** of a sample mutant line,isolated from the ENU-screen at the National Research Center for Environment and Health in munich,were found to have lower body weight,consume less food,but have higher ratios of metabolized energy per unit body weight compared with their wild-type *** metabolic rate and heat production were simultaneously increased by 16–18%,whereas body fat content was reduced by 11–16%.The combination of various parameters of energy consumption,expenditure and energy storage illustrate the metabolic demands of the sample mutant mouse line and demonstrate the utility of the powerful phenotyping tool used at the German mouse Clinic.

关键词： calorimetry energy metabolism metabolic phenotyping mouse mutant telemetry

Ecosystem management in paludified boreal forests:enhancing wood production,biodiversity,and carbon sequestration at the landscape level

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Forest Ecosystems 2018年第4期5卷 376-389页

作者： Benoit Lafleur nicole J.Fenton martin Simard Alain Leduc David Paré Osvaldo Valeria Yves Bergeron NSERC-UQAT-UQAm Industrial Chair in Sustainable Forest management and Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue445boul.de I'UniversiteRouyn-NorandaQC J9X 5E4Canada Department of Geography Laval UniversityQuebecQC GIV 0A6Canada Centre d'etude de la foret Universite du Quebec a Montreal141 Avenue du President-KennedyMontrealQC H2X IY4Canada Ressources Naturelles Canada Service canadien des forets Centre de foresterie des Laurentides1055du P.E P S.P.O.13ox 3800QuebecQC GIV 4C7Canada

Canada’s boreal forest represents an important contributor of the world’s wood supply industry. However,maintaining or increasing productivity of the boreal forest may be challenging in areas dominated by forested peatlands. moreover, sustainable management of these forests must also consider other important aspects of the forest ecosystem such as biodiversity and carbon sequestration. To address these concerns, ecosystem-based management has been implemented in some Canadian jurisdictions, such as in regions where a large portion of the boreal forest is dominated by forested peatlands. The objectives of this paper are(1) to summarize our current understanding of how natural disturbances influence stand dynamics and biodiversity in forested peatlands, and(2) to review the main differences between natural and managed forest stands with respect to soil properties, stand productivity, understory plant communities. We also discuss how even-age management regime succeeds or fails to preserve old forests and how this loss affects both forest structure and habitat diversity at the landscape *** conclude by showing how, in boreal forested peatlands, forest management could contribute to carbon sequestration and mitigate projected climate change.

关键词： Clearcutting Fire Forest dynamics Partial cutting Soil properties Stand productivity Understory plant

Pre-mRNA modifications and their role in nuclear processing

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Frontiers of Electrical and Electronic Engineering in China 2018年第3期6卷 210-227页

作者： nicole m martinez Wendy V Gilbert Department of molecular Biophysics ＆ Biochemistry Yale UniversityNew HavenCT 06520USA

Background： Cellular non-coding RNAs are extensively modified post-transcriptionally, with more than 100 chemically distinct nucleotides identified to date. In the past five years, new sequencing based methods have revealed widespread decoration of eukaryotic messenger RNA with diverse RNA modifications whose functions in mRNA metabolism are only beginning to be known. Results： Since most of the identified mRNA modifying enzymes are present in the nucleus, these modifications have the potential to function in nuclear pre-mRNA processing including alternative splicing. Here we review recent progress towards illuminating the role of pre-mRNA modifications in splicing and highlight key areas for future investigation in this rapidly growing field. Conclusions： Future studies to identify which modifications are added to nascent pre-mRNA and to interrogate the direct effects of individual modifications are likely to reveal new mechanisms by which nuclear pre-mRNA processing is regulated.

关键词： mRNA modification pre-mRNA modification splicing RNA-modifying enzymes