The role of cellular and molecular neuroimmune crosstalk in gut immunity
作者机构：Department of ImmunologyHarvard Medical SchoolBostonMA02115USA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2023年第20卷第11期
页 面：1259-1269页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：The Chiu Lab is supported by NIH grants R01 DK127257 and R01 AI168005 Kenneth Rainin Foundation Burroughs Wellcome Fund Food Allergy Science Initiative Chan-Zuckerberg Initiative Fairbairn Lyme Initiative Drako Family Foundation and Jackson-Wijaya Research Fund
主 题：Neuroimmunology Neuroimmune Host defense Gut Sensory
摘 要：The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.
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