Metabolic phenotyping of mouse mutants in the German Mouse Clinic

作     者：Ralf ELVERT Nicole EHRHARDT Martin TAUBE Martin KLINGENSPOR Valerie GAILUSDURNER Helmut FUCHS Martin Hrabe DE ANGELIS Veronique BLANQUET Gerhard HELDMAIER 

作者机构：Institute of Experimental GeneticsGerman Mouse ClinicNeuherbergMunichGermany Department of BiologyPhilipps University of MarburgMarburgGermany Laboratory of Molecular Experimental GeneticsInstitute of TransgenoseOrleansFrance 

出 版 物：《Integrative Zoology》 (整合动物学（英文版）)

年 卷 期：2006年第1卷第3期

页      面：122-125页

核心收录：

学科分类：0401[教育学-教育学] 04[教育学] 

主　　题：calorimetry energy metabolism metabolic phenotyping mouse mutant telemetry 

摘      要：The German Mouse Clinic was established as a phenotyping center to provide the scientific community with systematic standardized phenotyping of mouse models from various genetic *** found metabolic phenotypes in nine out of 20 mutant lines screened in a primary *** on these findings,the mutants were analyzed in secondary and tertiary *** of a sample mutant line,isolated from the ENU-screen at the National Research Center for Environment and Health in Munich,were found to have lower body weight,consume less food,but have higher ratios of metabolized energy per unit body weight compared with their wild-type *** metabolic rate and heat production were simultaneously increased by 16–18%,whereas body fat content was reduced by 11–16%.The combination of various parameters of energy consumption,expenditure and energy storage illustrate the metabolic demands of the sample mutant mouse line and demonstrate the utility of the powerful phenotyping tool used at the German Mouse Clinic.