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Endoscopic hemostasis makes the difference:Angiographic treatment in patients with lower gastrointestinal bleeding

World Journal of Gastrointestinal Endoscopy 2021年第7期13卷 221-232页

作者： David John Werner Till Baar Ralf Kiesslich nicolai wenzel Nael Abusalim Achim Tresch Johannes Wilhelm Rey Radiologie Rhein-Nahe Krankenhaus am St.MarienwörthBad Kreuznach 55543RLPGermany Department of Radiology Helios Dr.Horst-Schmidt-ClinicGermanyWiesbaden 65199HessenGermany Institute for Medical Statistics and Computational Biology Faculty of MedicineUniversity of CologneGermanyCologne 50923NRWGermany Department of Internal Medicine II Helios Dr.Horst-Schmidt-ClinicWiesbadenGermanyWiesbaden 65199HessenGermany Department of Diagnostic and Interventional Radiology Medical Center HanauGermanyHanau 63450HessenGermany CECAD University of CologneGermanyCologne 50923NRWGermany Center for Data and Simulation Science University of CologneGermanyCologne 50923NRWGermany Department of Gastroenterology and Endoscopy Medical Center OsnabrueckGermanyOsnabrueck 49076NiedersachsenGermany

BACKGROUND The large majority of gastrointestinal bleedings subside on their own or after endoscopic ***,a small number of these may pose a challenge in terms of therapy because the patients develop hemodynamic instability,and endoscopy does not achieve adequate *** radiology supplemented with catheter angiography(CA)and transarterial embolization have gained importance in recent *** To evaluate clinical predictors for angiography in patients with lower gastrointestinal bleeding(LGIB).METHODS We compared two groups of patients in a retrospective *** group had been treated for more than 10 years with CA for LGIB(n=41).The control group had undergone non-endoscopic or endoscopic treatment for two years and been registered in a bleeding registry(n=92).The differences between the two groups were analyzed using decision trees with the goal of defining clear rules for optimal *** Patients in the CA group had a higher shock index,a higher Glasgow-Blatchford bleeding score(GBS),lower serum hemoglobin levels,and more rarely achieved hemostasis in primary *** patients needed more transfusions,had longer hospital stays,and had to undergo subsequent surgery more frequently(P<0.001).CONCLUSION Endoscopic hemostasis proved to be the crucial difference between the two patient *** endoscopic hemostasis,along with GBS and the number of transfusions,would permit a stratification of *** prospective confirmation of the present findings,the use of decision trees would permit the identification of patients at risk for subsequent diagnosis and treatment based on interventional radiology.

关键词： Lower gastrointestinal bleeding Endoscopy Angiography Embolization Computed tomography angiography Intervention

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Unmasking lower gastrointestinal bleeding under administration of norepinephrine

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World Journal of Radiology 2022年第12期14卷 375-383页

作者： David John Werner nicolai wenzel Nael Abusalim Ralf Kiesslich Till Baar Achim Tresch Johannes Wilhelm Rey Department of Radiology Helios Dr.Horst-Schmidt-ClinicWiesbaden 65199HessenGermany Radiologie Rhein-Nahe Krankenhaus St.MarienwörthBad Kreuznach 55543Rheinland-PfalzGermany Department of Diagnostic and Interventional Radiology Medical Center HanauHanau 63450HessenGermany Department of Internal Medicine II Helios Dr.Horst-Schmidt-ClinicWiesbaden 65199HessenGermany Institute for Medical Statistics and Computational Biology Faculty of MedicineUniversity of CologneCologne 50923Nordrhein-WestfalenGermany Department of Gastroenterology and Endoscopy Medical Center OsnabrueckOsnabrueck 49076NiedersachsenGermany

BACKGROUND Bleeding in the gastrointestinal tract is common and transarterial embolization enables the clinician to control gastrointestinal *** extravasation is a prerequisite for successful *** angiography is helpful in the detection of elusive *** We performed a retrospective analysis of angiographic treatment in patients with lower gastrointestinal hemorrhage and initially negative angiographies,as well as the role of norepinephrine(NE)in unmasking *** We analyzed 41 patients with lower gastrointestinal bleeding after angiography who had undergone treatment over a period of 10 *** patients had a positive shock index and needed intensive *** In three of four patients,angiography disclosed the site of bleeding when NE was used during the procedure for hemodynamic *** We suggest that angiography performed after the administration of NE in unstable patients with gastrointestinal bleeding and an initially negative angiography has the potential to unmask bleeding sites for successful ***,this statement must be confirmed in prospective studies.

关键词： Lower gastrointestinal bleeding Endoscopy Provocative angiography Norepinephrine Radiology Gastrointestinal bleeding

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Alkaline generation and reactions of CF3CHN2

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Science China Chemistry 2019年第8期62卷 923-924页

作者： nicolai Rosenbaum Christoph Zippe Stefan Brase Institute of Organic Chemistry Karlsruhe Institute of TechnologyFritz-Haber- Weg 676131 KarlsruheGermany Institute of Toxicology and Genetics Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz I 76344 Eggenstein-LeopoldshafenGermany

Fluorinated organic compounds display significant impact in the fields of agrochemicals, pharmaceuticals and materials science. However, very few fluorine-containing compounds are available from nature, and therefore studies of the distinct effect of fluorine substitution mainly depend on the ease of access to fluorinated scaffolds. Among fluorination strategies, the development and application of fluorinated diazo compounds has provided a convenient and effective method for the construction of various fluorinated structural moieties.

关键词： Alkaline generation reactions of CF3CHN2 fluorination strategies

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Forensic Readiness: Emerging Discipline for Creating Reliable and Secure Digital Evidence

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Journal of Harbin Institute of Technology(New Series) 2015年第1期22卷 1-8页

作者： Barbara Endicott-Popovsky nicolai Kuntze Carsten Rudolph Institute of Technology University of Washington Fraunhofer Institute of Technology

Traditional approaches to digital forensics reconstruct events within digital systems that often are not built for the creation of evidence; however,there is an emerging discipline of forensic readiness that examines what it takes to build systems and devices that produce digital data records for which admissibility is a requirement. This paper reviews the motivation behind research in this area,a generic technical solution that uses hardware-based security to bind digital records to a particular state of a device and proposed applications of this solution in concrete,practical scenarios. Research history in this area,the notion of secure digital evidence and a technical solution are discussed. A solution to creating hardware-based security in devices producing digital evidence was proposed in 2012. Additionally,this paper revises the proposal and discusses three distinct scenarios where forensic readiness of devices and secure digital evidence are relevant. It shows,how the different requirements of the three scenarios can be realized using a hardware-based solution. The scenarios are:lawful interception of voice communication,automotive black box,precise farming. These three scenarios come from very distinctive application domains. Nevertheless,they share a common set of security requirements for processes to be documented and data records to be stored.

关键词： digital forensics forensic readiness calibration d

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Development of a procedure for estimating the parameters of mechanistic VOC emission source models from chamber testing data

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Building Simulation 2021年第2期14卷 269-282页

作者： Zhenlei Liu Andreas nicolai Marc Abadie Menghao Qin John Grunewald Jianshun Zhang Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseUSA Dresden University of Technology DresdenGermany University of La Rochelle La RochelleFrance Technical University of Denmark Kongens LyngbyDenmark School of Architecture and Urban Planning Nanjing UniversityNanjingChina

In order to evaluate the impacts of volatile organic compounds(VOCs)emissions from building materials on the indoor air quality beyond the standard chamber test conditions and test period,mechanistic emission source models have been developed in the ***,very limited data are available for the required model parameters including the initial concentration(C_(m0)),in-material diffusion coefficient(D_(m)),partition coefficient(Kma),and convective mass transfer coefficient(k_(m)).In this study,a procedure was developed for estimating the model parameters by using VOC emission data from standard small chamber *** the procedure,initial values of the model parameters were refined by multivariate regression analysis of the measured emission *** verify the procedure and estimate its uncertainty,simulated chamber test data were generated by adding 10% experimental uncertainties on the theoretical curve from the analytical solution to a mechanistic emission *** the procedure was applied to the generated data to estimate the model *** indicated that estimates converged to the original parameter values used for the data generation and the error of estimated parameters D_(m1)C_(m0) and K_(ma) were within±10%,±23%,and±25%of the true values,*** procedure was further demonstrated by applying it to estimate the model parameters from real chamber test *** application of the procedure would result in a database of mechanistic source model parameters for assessing the impact of VOC emissions on indoor pollution load,which are essential input data for evaluating the effectiveness of various indoor air quality(IAQ)design and control strategies as well as the energy required for meeting given IAQ requirements.

关键词： building materials volatile organic compounds(VOCs) emission source model indoor air quality building energy efficiency

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Soil application of Beauveria bassiana GHA against apple sawfly, Hoplocampa testudinea （Hymenoptera： Tenthredinidae）： Field mortality and fungal persistence

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Insect Science 2016年第6期23卷 854-868页

作者： Weronika Swiergiel nicolai V. Meyling Mario Porcel Birgitta Ramert Department of Plant Protection Biology Unit of Integrated Plant Protection Swedish University of Agricultural Sciences (SLU) AlnarpSweden Department of Plant and Environmental Sciences University of Copenhagen Copenhagen Denmark

Low impact alternatives to synthetic insecticides for the control of apple sawfly （Hoplocampa testudinea Klug） are scarce encumbering pest management in organic apple orchards. We investigated the soil persistence and field efficacy of the entomopathogenic fungus Beauveria bassiana （Balsamo） Vuillemin （BotaniGard） against apple sawfly under common organic orchard practices. We also assessed the efficacy of B. bassiana GHA and Metarhiziurn brunneum Petch （indigenous strain） against sawfly in the laboratory. Larvae treated with either fungus in the laboratory died faster than control larvae and displayed 49.4%-68.4% mycosis. In the field, B. bassiana density remained high in the week after application, during larval descent to the soil. Fungal density decreased to 25% at 49 d after application and to 0.4% after 55 weeks. Molecular markers revealed that the majority of fungal isolates recovered comprised the applied B. bassiana strain GHA. Larvae pupating in soil cages in the orchard for 49 d displayed 17% mycosis. The high efficacy under laboratory conditions was not seen in the field. B. bassiana application resulted in densities above the upper natural background level during the growing season, but reversion to background levels occurred within a year. It remains to be investigated whether this has a detrimental effect on nontarget organisms. Additional work is needed to bridge the knowledge gap between laboratory and field efficacy in orchards.

关键词： biological control crop protection entomopathogenic fungi integrated pest management Metarhizium organic orchard

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Survey of feature selection and extraction techniques for stock market prediction

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Financial Innovation 2023年第1期9卷 667-691页

作者： Htet Htet Htun Michael Biehl nicolai Petkov Bernoulli Institute for Mathematics Computer ScienceArtificial IntelligenceUniversity of GroningenGroningenThe Netherlands

In stock market forecasting,the identification of critical features that affect the performance of machine learning(ML)models is crucial to achieve accurate stock price *** review papers in the literature have focused on various ML,statistical,and deep learning-based methods used in stock market ***,no survey study has explored feature selection and extraction techniques for stock market *** survey presents a detailed analysis of 32 research works that use a combination of feature study and ML approaches in various stock market *** conduct a systematic search for articles in the Scopus and Web of Science databases for the years 2011–*** review a variety of feature selection and feature extraction approaches that have been successfully applied in the stock market analyses presented in the *** also describe the combination of feature analysis techniques and ML methods and evaluate their ***,we present other survey articles,stock market input and output data,and analyses based on various *** find that correlation criteria,random forest,principal component analysis,and autoencoder are the most widely used feature selection and extraction techniques with the best prediction accuracy for various stock market applications.

关键词： Feature selection Feature extraction Dimensionality reduction Stock market forecasting Machine learning

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Stability issues of the continuous welded rail track on the concrete sleepers on the curves with radius R ≤ 300 m

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Research in Cold and Arid Regions 2013年第5期5卷 654-658页

作者： Victor Vasylevich Rybkin nicolai Petrovich Nastechik Ruslan Volodymyrovych Marcul V.Lazaryan Dnipropetrovsk National University of Railway Transport

This paper describes the economic and technological benefits of installing continuous welded rail （CWR） track on sharp （radius≤300 m） railway curves. A new form of prestressed concrete sleepers developed by the V. Lazaryan Dniprope- trovsk National University of Railway Transport is shown to improve the lateral shift resistance of CWR track in sharp curves and the use of anchor sleepers on tangents is shown to make it possible to lower the fastening temperature of the CWR track in order to increase the rail lifespan.

关键词： continuous welded rail (CWR) track track configuration stability sharp curves anchor sleepers

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风力机等效载荷的评估

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太阳能学报 2008年第12期29卷 1456-1459页

作者：董礼廖明夫 Manin Kuehn nicolai Cosack 西北工业大学旋转机械与风能装置测控研究所西安710072 德国斯图加特大学飞行器设计研究所斯图加特D-70550

通过神经网络建立数学模型,利用 Multibrid M5000风力机实测的运行信号对叶片拍打弯矩、叶片弦向弯矩、塔筒弯矩和塔筒转矩的等效载荷进行了评估。同时分析了不同运行参数对评估效果的影响程度。通过与实测结果比较表明,该方法可以在避... 详细信息

通过神经网络建立数学模型,利用 Multibrid M5000风力机实测的运行信号对叶片拍打弯矩、叶片弦向弯矩、塔筒弯矩和塔筒转矩的等效载荷进行了评估。同时分析了不同运行参数对评估效果的影响程度。通过与实测结果比较表明,该方法可以在避免测试风力机载荷的情况下获得载荷的评估结果,具有较高的精度,可以用来预测风力机的寿命。

关键词：等效载荷神经网络风力机疲劳

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Year-round cooling and thermal stabilization of water-saturated soils under engineering structures

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Research in Cold and Arid Regions 2017年第3期9卷 258-260页

作者： Vladimir Moiseev nicolai Vasiliev Tatyana Komarova Olga Komarova Department of Mathematics Emperor Alexander I St.Petersburg State Transport University Static Research of Soils Laboratory B.E.Vedeneev VNIIG JSC DISIST Scientific Center

We consider the problem of year-round cooling of water-saturated soil to freezing temperatures in order to convert it into a state of permafrost.A new soil-cooling apparatus is *** apparatus is to be made in modular form and connected to passive-active thermal piles(thermosyphons).The estimated capacity of one apparatus allows simultaneous use of up to 1,000 thermal piles for ground *** apparatus is based on natural sources of energy:solar radiation and wind;and it can be used for soil *** approach can prevent thawing of soft soils under railways and roads,as well as under buildings or structures,in an area of more than tens of *** apparatus has no mechanical moving parts and can operate for a long time in stand-alone mode without staff involvement.

关键词： thermopiles frozen soil preventing of thawing the apparatus for cooling

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