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Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

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药物分析学报:英文版 2023年第7期13卷 691-693页

作者： Dan Li Zhou Fang Qiang Shi nicholas zhang Binsheng Gong Weida Tong Ahmet F.Coskun Joshua Xu Division of Bioinformatics and Biostatistics National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGA30332USA Machine Learning Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Division of Systems Biology National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Interdisciplinary Bioengineering Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGA30332USA

Reducing the use of animal models in drug development and safety assessment has long been supported by the *** and Drug Administration(FDA).The report by Royal Society for the Prevention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million *** ethical considerations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predicting human reactions to drug *** animal testing has been the traditional method for assessing the safety and efficacy of drugs.

关键词： money utilizing testing

Fermi Surface Nesting with Heavy Quasiparticles in the Locally Noncentrosymmetric Superconductor CeRh2As2

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Chinese Physics Letters 2024年第9期41卷 107-121页

作者： Yi Wu Yongjun zhang Sailong Ju Yong Hu Yanen Huang Yanan zhang Huali zhang Hao Zheng Guowei Yang Evrard-Ouicem Eljaouhari Baopeng Song nicholas C.Plumb Frank Steglich Ming Shi Gertrud Zwicknagl Chao Cao Huiqiu Yuan Yang Liu Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Institute for Advanced Materials Hubei Normal UniversityHuangshi 435002China Swiss Light Source Paul Scherrer InstitutCH-5232 Villigen PSISwitzerland Institut for Mathematische Physik 38106 BraunschweigGermany Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310058China

The locally noncentrosymmetric heavy fermion superconductor CeRh2As2 has attracted considerable interests due to its rich superconducting phases,accompanied by possible quadrupole density wave and pronounced antiferromagnetic *** understand the underlying physics,here we report measurements from highresolution angle-resolved *** results reveal fine splittings of the conduction bands related to the locally noncentrosymmetric structure,as well as a quasi-two-dimensional Fermi surface(FS)with strong 4𝑓*** FS shows signs of nesting with an in-plane vector q1=(π/α,π/α),which is facilitated by the heavy bands nearˉ𝑋arising from the characteristic conduction-X *** FS nesting provides a natural explanation for the observed antiferromagnetic spin fluctuations at(π/α,π/α),which might be the driving force for its unconventional *** experimental results can be reasonably explained by density functional theory plus dynamical mean field theory calculations,which can capture the strong correlation *** study not only provides spectroscopic signature of the key factors underlying the field-induced superconducting transition,but also uncovers the critical role of FS nesting and lattice Kondo effect in the underlying magnetic fluctuations.

关键词： symmetric Fermi conduction

A General Synthesis Method for Covalent Organic Framework and Inorganic 2D Materials Hybrids

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Precision Chemistry 2024年第8期2卷 398-405页

作者： Yifan Zhu Yunrui Yan Yuren Feng Yifeng Liu Chen-Yang Lin Qing Ai Tianshu Zhai Bongki Shin Rui Xu Hongchen Shen Qiyi Fang Xiang zhang Dayanni Bhagwandin Yimo Han Hanyu Zhu nicholas R.Glavin Pulickel M Ajayan Qilin Li Jun Lou Department of Materials Science and Nanoengineering Rice UniversityHoustonTexas 77005United States Department of Civil and Environmental Engineering Rice UniversityHoustonTexas 77005United States NSF Nanosystems Engineering Research Center Nanotechnology-Enabled Water Treatment Rice UniversityHoustonTexas 77005United States UES Inc.BeavercreekOhio 45432United States Materials and Manufacturing Directorate Air Force Research LaboratoryWright-Patterson AFBOhio 45433United States Department of Chemistry Rice UniversityHoustonTexas 77005United States

Two-dimensional(2D)inorganic/organic hybrids provide a versatile platform for diverse applications,including electronic,catalysis,and energy storage *** recent surge in 2D covalent organic frameworks(COFs)has introduced an organic counterpart for the development of advanced 2D organic/inorganic hybrids with improved electronic coupling,charge separation,and carrier ***,existing synthesis methods have primarily focused on few-layered film structures,which limits scalability for practical ***,we present a general synthesis approach for a range of COF/inorganic 2D material hybrids,utilizing 2D inorganic materials as both catalysts and inorganic building *** leveraging the intrinsic Lewis acid sites on the inorganic 2D materials such as hexagonal boron nitride(hBN)and transition metal dichalcogenides,COFs with diverse functional groups and topologies can grow on the surface of inorganic 2D *** controlled 2D morphology and excellent solution dispersibility of the resulting hybrids allow for easy processing into films through vacuum *** proof of concept,hBN/COF films were employed as filters for Rhodamine 6G removal under flow-through conditions,achieving a removal rate exceeding 93%.The present work provides a simple and versatile synthesis method for the scalable fabrication of COF/inorganic 2D hybrids,offering exciting opportunities for practical applications such as water treatment and energy storage.

关键词： Covalent organic frameworks Transition-metal dichalcogenides Lewis acid catalysts Hexagonal boron nitride Hybrid Materials

Underwater acoustic metamaterials

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National Science Review 2023年第6期10卷 258-280页

作者： Erqian Dong Peizheng Cao Jinhu zhang Sai zhang nicholas X.Fang Yu zhang Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education College of Ocean and Earth Sciences Xiamen University State Key Laboratory of Marine Environmental Science Xiamen University School of Physics and Electronic Engineering Jiangsu University Department of Mechanical Engineering Massachusetts Institute of Technology

Acoustic metamaterials have been widely investigated over the past few decades and have realized acoustic parameters that are not achievable using conventional *** demonstrating that locally resonant acoustic metamaterials are capable of acting as subwavelength unit cells,researchers have evaluated the possibility of breaking the classical limitations of the material mass density and bulk *** with theoretical analysis,additive manufacturing and engineering applications,acoustic metamaterials have demonstrated extraordinary capabilities,including negative refraction,cloaking,beam formation and super-resolution *** to the complexity of impedance boundaries and mode transitions,there are still challenges in freely manipulating acoustic propagation in an underwater *** review summarizes the developments in underwater acoustic metamaterials over the past 20 years,which include underwater acoustic invisibility cloaking,underwater beam formation,underwater metasurfaces and phase engineering,underwater topological acoustics and underwater acoustic metamaterial *** the evolution of underwater metamaterials and the timeline of scientific advances,underwater acoustic metamaterials have demonstrated exciting applications in underwater resource development,target recognition,imaging,noise reduction,navigation and communication.

关键词： underwater acoustic metamaterials invisibility cloaking beam formation topological acoustics metasurfaces absorbers

Cooperation and Contract Design in Project Management with Outsourcing

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Journal of Systems Science and Systems Engineering 2023年第1期32卷 34-70页

作者： Xiaoqiang Cai nicholas G.Hall Siyi Wang Feng zhang School of Data Science The Chinese University of Hong KongShenzhen518172China Shenzhen Research Institute of Big Data Shenzhen518172China Department of Operations&Business Analytics Fisher College of BusinessOhio State UniversityColumbusOhioUSA School of Science and Engineering The Chinese University of Hong KongShenzhen518172China Suning Bank Nanjing210019China

We study a project management problem where the prime contractor needs to outsource tasks to subcontractors with the required *** execution of the project requires proper coordination among the subcontractors,as well as contract design by the prime contractor to incentivize the *** modeling the subcontractors’coordination problem as a cooperative game,we develop a profit sharing scheme to facilitate the subcontractors’*** consider two contract designs for the prime contractor:a uniform contract across all subcontractors,and a nonuniform one that customizes incentives for each *** propose efficient algorithms to solve the implicit optimization problems for optimal contract *** experiments show that the pooling effect of subcontractors’cooperation mitigates the negative impact of poor estimates about the crashing cost and resource *** observe three unexpected results through the randomized computation experiments:(i)the subcontractors’profits may decrease if they provide false information;(ii)it is safer for the prime contractor to overestimate subcontractors’crashing costs than underestimate them;and(iii)uniform contracts deliver more project profit for the subcontractors in the coalitions.

关键词： Project management with outsourcing subcontracting cooperative game contract design

Effect of microporosity on scaffolds for bone tissue engineering

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Regenerative Biomaterials 2018年第2期5卷 115-124页

作者： Ke zhang Yubo Fan nicholas Dunne Xiaoming Li Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 102402China Centre for Medical Engineering Research School of Mechanical and Manufacturing EngineeringDublin City UniversityStokes BuildingCollins AvenueDublin 9Ireland State Key Laboratory of New Ceramic and Fine Processing Tsinghua UniversityBeijing 100084China

Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue *** the exact mechanism,by which it promotes new bone formation,is not well recognized yet,the related hypothesis can be found in many previous *** review presents those possible mechanisms about how the microporosity enhances the osteogenic-related functions of cells in vitro and the osteogenic activity of scaffolds in *** summary,the increased specific surface areas by microporosity can offer more protein adsorption sites and accelerate the release of degradation products,which facilitate the interactions between scaffolds and ***,the unique surface properties of microporous scaffolds have a considerable effect on the protein ***,capillary force generated by the microporosity can improve the attachment of bone-related cells on the scaffolds surface,and even make the cells achieve penetration into the micropores smaller than *** review also pays attention to the relationship between the biological and mechanical properties of microporous *** lots of achievements have been obtained,there is still a lot of work to do,some of which has been proposed in the conclusions and perspectives part.

关键词： bone tissue engineering mechanism microporosity

Asymmetric Transfer and Pressure Hydrogenation with Earth-Abundant Transition Metal Catalysts

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Chinese Journal of Chemistry 2018年第5期36卷 443-454页

作者： Zhenfeng zhang nicholas Andrew Butt Muxing Zhou Delong Liu Wanbin zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Pharmacy Shanghai Jiao Tong University 800 Dongchuan RoadL Shanghai 200240 China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China

The asymmetric transfer and pressure hydrogenation of various unsaturated substrates provides a succinct pathway to important chiral intermediates and products such as chiral alcohols, amines, and alkanes. The use of earth-abundant transition metals such as Fe, Co, Ni, and Cu in hydro- genation reactions provides an attractive alternative to traditionally used metals such as Ru, Rh, Ir, and Pd because they are comparatively inexpensive, less toxic, and as their name suggests, more abundant in nature. Earth-abundant transition metal-catalyzed asymmetric hydrogenation is rapidly becoming an important area of research. This review summarizes advances in the asymmetric hydrogenation of unsaturated bonds （ketones, imines, and alkenes） with earth-abundant transition metals.

关键词： asymmetric hydrogenation earth-abundant transition metals ketones imines alkenes

Physical modeling and validation of porpoises' directional emission via hybrid metamaterials

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National Science Review 2019年第5期6卷 921-928页

作者： Erqian Dong Yu zhang Zhongchang Song Tianye zhang Chen Cai nicholas X.Fang Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education College of Ocean and Earth SciencesXiamen University Department of Mechanical Engineering Massachusetts Institute of Technology State Key Laboratory of Marine Environmental Science Xiamen University Biology Department Woods Hole Oceanographic Institution

In wave physics and engineering, directional emission sets a fundamental limitation on conventional simple sources as their sizes should be sufficiently larger than their *** metamaterial and animal biosonar both show potential in overcoming this *** metamaterials arranged in periodic microstructures face great challenges in realizing complex and multiphase biosonar ***, we proposed a physical directional emission model to bridge the gap between porpoises’ biosonar and artificial *** by the anatomical and physical properties of the porpoise’s biosonar transmission system, we fabricated a hybrid metamaterial system composed of multiple composite *** validated that the hybrid metamaterial significantly increased directivity and main lobe energy over a broad bandwidth both numerically and *** device displayed efficiency in detecting underwater target and suppressing false target *** metamaterial-based physical model may be helpful to achieve the physical mechanisms of porpoise biosonar detection and has diverse applications in underwater acoustic sensing, ultrasound scanning, and medical ultrasonography.

关键词： porpoise’s physical model metamaterials biosonar directional emission

Emerging concern on air pollution and health:Trade-off between air pollution exposure and physical activity

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Eco-Environment & Health 2024年第2期3卷 202-207页

作者： Pengpeng Wu Qian Guo Yuchen Zhao Mengyao Bian Suzhen Cao Junfeng(Jim)zhang Xiaoli Duan School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China China North Artificial Intelligence&Innovation Research Institute Beiing 100072China Collective Intelligence&Collaboration Laboratory Beijing 100072China nicholas School of the Environment and Global Health Institute Duke UniversityDurhamNC 27708USA Duke Kunshan University Kunshan 215316China

Air pollution is a major contributor to the global disease burden,especially affecting respiratory and cardiovascular ***,physical activity is associated with improved lung function,a slower decline in lung function,and lower *** public is more likely to be exposed to air pollution during outdoor physical ***,studies on how long-term and short-term exposure to air pollution interacts with physical activity yield inconsistent results,and the thresholds for air pollution and physical activity remain ***,more studies are needed to provide sufficient evidence to guide the public to safely engage in outdoor physical activity when exposed to air pollution.

关键词： Air pollution Physical activity Interaction Thresholds Exposure