Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

作     者：Dan Li Zhou Fang Qiang Shi Nicholas Zhang Binsheng Gong Weida Tong Ahmet F.Coskun Joshua Xu Dan Li;Zhou Fang;Qiang Shi;Nicholas Zhang;Binsheng Gong;Weida Tong;Ahmet F.Coskun;Joshua Xu

作者机构：Division of Bioinformatics and BiostatisticsNational Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Wallace H.Coulter Department of Biomedical EngineeringGeorgia Institute of Technology and Emory UniversityAtlantaGA30332USA Machine Learning Graduate ProgramGeorgia Institute of TechnologyAtlantaGA30332USA Division of Systems BiologyNational Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Interdisciplinary Bioengineering Graduate ProgramGeorgia Institute of TechnologyAtlantaGA30332USA Parker H.Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaGA30332USA 

出 版 物：《药物分析学报:英文版》 (Journal of Pharmaceutical Analysis)

年 卷 期：2023年第13卷第7期

页      面：691-693页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 10[医学] 

主　　题：money utilizing testing 

摘      要：Reducing the use of animal models in drug development and safety assessment has long been supported by the *** and Drug Administration(FDA).The report by Royal Society for the Prevention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million *** ethical considerations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predicting human reactions to drug *** animal testing has been the traditional method for assessing the safety and efficacy of drugs.