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Insights and implications of sexual dimorphism in osteoporosis

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Bone Research 2024年第1期12卷 20-49页

作者： Yuan-Yuan Zhang Na Xie Xiao-Dong Sun Edouard C.nice Yih-Cherng Liou Canhua Huang Huili Zhu Zhisen Shen Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVIC 3800Australia Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117543Republic of Singapore Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education Department of Reproductive MedicineWest China Second University Hospital of Sichuan UniversityChengduChina Department of Otorhinolaryngology and Head and Neck Surgery The Affiliated Lihuili HospitalNingbo University315040 NingboZhejiangChina

Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures *** evidence has revealed that sexual dimorphism is a notable feature of osteoporosis,with sex-specific differences in epidemiology and ***,females are more susceptible than males to osteoporosis,while males are more prone to disability or death from the *** date,sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone *** the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and *** literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis,mainly in a population of aging patients,chronic glucocorticoid administration,and ***,we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and ***,the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.

关键词： osteoporosis epidemiology overcome

Microplastics and heavy metals in freshwater fish species in the southwestern region of Bangladesh:An emerging concern for public health

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Emerging Contaminants 2024年第3期10卷 145-157页

作者： Mst Shamima Akter Tapos Kumar Chakraborty Gopal Chandra Ghosh Md Simoon nice Samina Zaman Abu Shamim Khan Department of Environmental Science and Technology Jashore University of Science and TechnologyJashore 7408Bangladesh Environmental Laboratory Asia Arsenic NetworkJashore 7400Bangladesh

Microplastics(MPs)pollution and its associated toxicity raising concerns among scientists as a result of their toxicological impacts on human health and the *** study aims to investigate the microplastics and heavy metals(HMs)contamination in seventeen freshwater fish species collected from the Southwestern region of *** extracted from these species using the hydrogen peroxide digestion method and characterized by Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy(ATR-FTIR).Atomic Absorption Spectrometry(AAS)was used to determine the concentration of HMs in different species for evaluating human health risks.A total of 142 microplastic particles were extracted with an average concentration of 1.13±0.84 items per individual of fish,where the highest microplastics were found in ***(3.43±3.15 items)and lowest in ***(0.14±0.38 items).Identified microplastics were dominated byCu(0.01e1.14;0.50±0.44)>Pb(0.04e0.58;0.22±0.12)>Cd(0.00e0.11;0.03±0.03),*** metals-based human health risk assessment results show that there are no major non-carcinogenic health risks(THI<1),while higher carcinogenic risks are present for consumers.

关键词： Microplastics Edible fish Polymer type Heavy metals Human health risk Bangladesh

TCM-HIN2Vec:A strategy for uncovering biological basis of heart qi deficiency pattern based on network embedding and transcriptomic experiment

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 264-274页

作者： Lihong Diao Xinyi Fan Jiang Yu Kai Huang Edouard C.nice Chao Liu Dong Li Shuzhen Guo School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Department of Biochemistry and Molecular Biology Monash UniversityClayton VIC 3800Australia Beijing Institute of Lifeomics Beijing 102206China State Key Laboratory of Medical Proteomics Beijing 102206China National Center for Protein Sciences(Beijing) Beijing 102206China Beijing Proteome Research Center Beijing 102206China

Objective To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal *** We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic ***,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public ***,we predicted HQD pattern genes using a heterogeneous network-embedding *** then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using ***,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment *** Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune ***,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency ***,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating *** Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD *** our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.

关键词： Qi deficiency pattern Heart failure Biological basis Network embedding Transcriptome

Comparative Analysis of Statistical Thickness Models for the Determination of the External Specific Surface and the Surface of the Micropores of Materials: The Case of a Clay Concrete Stabilized Using Sugar Cane Molasses

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Geomaterials 2024年第2期14卷 13-28页

作者： nice Mfoutou Ngouallat Narcisse Malanda Christ Ariel Ceti Malanda Kris Berjovie Maniongui Erman Eloge Nzaba Madila Paul Louzolo-Kimbembe Mechanics Energy and Engineering Laboratory Higher National Polytechnic School Marien Ngouabi University Brazzaville Republic of the Congo National Institute for Research in Engineering Sciences Innovation and Technology (INRSIIT) Brazzaville Republic of the Congo Higher Institute of Architecture Building Planning and Public Works Denis SASSOU N&#8217GUESSO University Kint&#233l&#233 Republic of the Congo Hydrogen Research Institute University of Quebec in Trois Rivieres Quebec Canada Superior Normal School (ENS) Marien Ngouabi University Brazzaville Republic of the Congo

In this work, four empirical models of statistical thickness, namely the models of Harkins and Jura, Hasley, Carbon Black and Jaroniec, were compared in order to determine the textural properties (external surface and surface of micropores) of a clay concrete without molasses and clay concretes stabilized with 8%, 12% and 16% molasses. The results obtained show that Hasley’s model can be used to obtain the external surfaces. However, it does not allow the surface of the micropores to be obtained, and is not suitable for the case of simple clay concrete (without molasses) and for clay concretes stabilized with molasses. The Carbon Black, Jaroniec and Harkins and Jura models can be used for clay concrete and stabilized clay concrete. However, the Carbon Black model is the most relevant for clay concrete and the Harkins and Jura model is for molasses-stabilized clay concrete. These last two models augur well for future research.

关键词： Statistical Thickness Model External Specific Surface Microporous Surface Clay Concrete Molasses

一封精致的情书Henry Wood House办公大楼改造

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室内设计与装修 2024年第10期 130-135页

作者：无 Jake Curtis(摄影) coco(译) nice Projects

2024年初,位于伦敦市中心的Henry Wood House迎来了全面升级。Fora Space负责对这座野蛮主义地标性建筑进行改造,整个改造面积超过6500m^(2);建筑的内部改造则由nice Projects设计完成。改造后的室内装饰采用了精美的材料,细节之处甚至... 详细信息

2024年初,位于伦敦市中心的Henry Wood House迎来了全面升级。Fora Space负责对这座野蛮主义地标性建筑进行改造,整个改造面积超过6500m^(2);建筑的内部改造则由nice Projects设计完成。改造后的室内装饰采用了精美的材料,细节之处甚至能满足最挑剔的目光。

关键词：地标性建筑室内装饰 House 办公大楼伦敦市中心内部改造 Henry

Moving particle semi-implicit simulation on the molten Wood's metal downward relocation process

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Nuclear Science and Techniques 2021年第8期32卷 110-121页

作者： Anni Nuril Hidayati Abdul Waris asril Pramutadi Andi Mustari Dwi Irwanto Nur Asiah Aprianti Department Faculty of Mathematics and Natural ScienceInstitut Teknologi BandungJalan Ganesha 10Bandung 40132Indonesia Nuclear Physics and Biophysics Research Division Physics DepartmentFaculty of Mathematics and Natural ScienceInstitut Teknologi BandungJalan Ganesha 10Bandung 40132Indonesia

In the case of a severe accident involving nuclear reactors,an important aspect that should be considered is the leakage of molten material from the inside of the reactor into the *** molten materials damage other reactor components,such as electrical tubes,grid plates and core *** this study,the moving particle semi-implicit(MPS)method is adopted and improved to analyze the twodimensional downward relocation process of molten Wood’s metal as a representation of molten material in a nuclear *** molten material impinges the Wood’s metal plate(WMP),which is mounted on a rigid dummy stainless steel in a cylindrical test *** breaching process occurs because of heat transfer between the molten material and *** formed breach areas were in good agreement with the experimental results,and they showed that the molten Wood’s metal spread above the *** solid WMP fraction decreased with time until it reached the termination time of the *** present results show that the MPS method can be applied to simulate and analyze the downward relocation process of molten material in the grid plate of a nuclear reactor.

关键词： Heat transfer Moving particle semi-implicit Phase change Relocation Severe accident

Patient experience of scar assessment and the use of scar assessment tools during burns rehabilitation:a qualitative study

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Burns & Trauma 2021年第1期9卷 441-453页

作者： Kate Price Naiem Moiemen Laura nice Jonathan Mathers College of Medical and Dental Sciences University of BirminghamBirminghamUK Scar Free Foundation Centre for Conflict Wound Research Queen Elizabeth HospitalUniversity Hospitals Birmingham NHS Foundation TrustBirminghamUK NIHR Surgical Reconstruction and Microbiology Research Centre Queen Elizabeth HospitalBirminghamUK Institute of Applied Health Research University of BirminghamBirminghamUK

Background:Scar assessment plays a key role during burns aftercare,to monitor scar remodelling and patients’psychosocial *** aid assessment,subjective scar assessment scales are available that use health-care professionals’and patients’opinions to score scar *** subjective scales are more widely used in clinical practice over objective scar *** date,there is no research that considers patients’views on scar assessment and the role of subjective and objective assessment ***,the aim of this qualitative study was to explore patients’perspectives on scar assessment and the utility of scar assessment tools during burns ***:Semi-structured interviews were conducted with 10 adult burn patients who were being reviewed in clinic for *** were recruited via their clinical care team and research nurses at the Queen Elizabeth Hospital,Birmingham,*** covered during interview included patient experience of scar assessment,the use of scar assessment tools and discussion surrounding important factors to be addressed when assessing scars.A thematic analysis using the Framework Method was ***:Participants identified key subthemes that contribute towards the overarching theme of patient-centred scar *** are:patient-led care;continuity in care;learning how to self-manage scarring;and psychological *** were demonstrated between these subthemes and the remaining themes that describe scar assessment strategies,indicating their potential patient-centred *** subjective opinions of clinicians were found to be valued above the use of subjective or objective scar assessment *** assessment scales were perceived to be a beneficial method for self-reflection in relation to psychosocial ***,minimal feedback and review of completed assessment scales led to uncertainty regarding their *** perceived objective tools to be of

关键词： Burns Scarring Scar assessment Scar assessment scales Qualitative research Interviews Objective scar assessment

Oxidative stress and diabetes:antioxidative strategies

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Frontiers of Medicine 2020年第5期14卷 583-600页

作者： Pengju Zhang Tao Li Xingyun Wu Edouard C.nice Canhua Huang Yuanyuan Zhang Department of Pharmacology West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVictoriaAustralia

Diabetes mellitus is one of the major public health problems *** recent evidence suggests that the cellular reduction-oxidation(redox)imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in p-cell dysfunction and insulin *** oxide species(ROS)can also directly oxidize certain proteins(defined as redox modification)involved in the diabetes *** are a number of potential problems in the clinical application of antioxidant therapies including poor solubility,storage instability and nonselectivity of *** antioxidant delivery systems may overcome pharmacokinetic and stability problem and improve the selectivity of scavenging *** have therefore focused on the role of oxidative stress and antioxidative therapies in the pathogenesis of diabetes *** therapeutic interventions against ROS and downstream targets are now possible and provide important new insights into the treatment of diabetes.

关键词： diabetes oxidative stress redox modification antioxidative therapy novel antioxidant delivery

Comparative transcriptomics of anadromous and resident brook charr Salvelinus fontinalis before their first salt water transition

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Current Zoology 2012年第1期58卷 158-170页

作者： Boulet, Marylène Normandeau, Éric Bougas, Bérénice Audet, Céline Bernatchez, Louis IBIS (Institut de Biologie Intégrative et des Systèmes) Université Laval Québec QC G1V 0A6 Canada ISMER Université du Québec à Rimouski Rimouski QC G5L 3A1 Canada

Most salmonid taxa have an anadromous life history strategy, whereby fish migrate to saltwater habitats for a growth period before returning to freshwater habitats for spawning. Moreover, several species are characterized by different life history tactics whereby resident and anadromous forms may occur in genetically differentiated populations within a same species, as well as polymorphism within a population. The molecular mechanisms underlying the physiological differences between anadromous and resident forms during the first transition from freshwater to saltwater environments are only partially understood. Insofar re- search has typically focused on species of the genus Salmo. Here, using a 16,000 cDNA array, we tested the hypothesis that ana- dromous brook charr Salvelinus fontinalis are characterized by differences in their transcriptome relative to resident brook charr before the anadromous fish migration. Families originating from parapatric populations of anadromous and resident charr were reared in controlled environments mimicking natural temperature and photoperiod, and sampled in spring, while still in fresh wa- ter. While anadromous and resident charr showed similar transcriptome profiles in white muscle, they were characterized by striking differences in their gill transcriptome profiles. Genes that were upregulated in the gills of anadromous charr were princi- pally involved in metabolism （mitochondrial electron transport chain, glucose metabolism, and protein synthesis）, development （tissue differentiation） and innate immunity. We discuss the nature of these transcriptomic differences in relation to molecular mechanisms underlying the expression of anadromous and resident life history tactics and suggest that the anadromous charr express some of the molecular processes present in other migratory salmonids [Current Zoology 58 （1）： 158-170, 2012].

关键词： Transcriptome Life history tactics Anadromy Migration to salt water Ecotypes Salmohids