Oxidative stress and diabetes:antioxidative strategies
作者机构：Department of PharmacologyWest China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Department of Biochemistry and Molecular BiologyMonash UniversityClaytonVictoriaAustralia
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2020年第14卷第5期
页 面：583-600页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81770580,81430071,81821002,and 81790251) Sichuan Science and Technology Program(No.2018RZ0133)
主 题：diabetes oxidative stress redox modification antioxidative therapy novel antioxidant delivery
摘 要：Diabetes mellitus is one of the major public health problems *** recent evidence suggests that the cellular reduction-oxidation(redox)imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in p-cell dysfunction and insulin *** oxide species(ROS)can also directly oxidize certain proteins(defined as redox modification)involved in the diabetes *** are a number of potential problems in the clinical application of antioxidant therapies including poor solubility,storage instability and nonselectivity of *** antioxidant delivery systems may overcome pharmacokinetic and stability problem and improve the selectivity of scavenging *** have therefore focused on the role of oxidative stress and antioxidative therapies in the pathogenesis of diabetes *** therapeutic interventions against ROS and downstream targets are now possible and provide important new insights into the treatment of diabetes.
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